Activity 7.4 Patterns and Dynamics of SVZ Cell Migration 1

Glial cells are produced throughout life. Around the time of birth in rats, glial progenitor cells are manufactured in the forebrain subventricular zone and migrate into surrounding structures. In this video, glial progenitors that have been tagged with green fluorescent protein (GFP) migrate through the cortex. Note that most cells migrate radially toward the pia mater (toward top of screen), but one cell migrates tangentially, and one cell changes direction.

Textbook Reference: Development of the Nervous System Can Be Divided into Six Distinct Stages pp. 179–191

Courtesy of Kakita, A. and Goldman, J.E.; Neuron, Vol. 23, 461-472, July, 1999