Activity 17.10 Morris Water Maze, PDAPP Mouse
(Trial 5)

In this water maze task, a mouse must find a platform located below the opaque water surface. Mice can use cues surrounding the maze, such as posters on the wall, to learn the location of the platform and find it more quickly on successive trials. Two mice appear in these videos: One is a normal, nontransgenic mouse, the other a transgenic mouse engineered as an animal model of Alzheimer's disease. Such transgenic (PDAPP) mice develop beta-amyloid plaques similar to those found in the brains of human Alzheimer's patients. Both mice were "middle-aged" (about 17 months) at the time of the trials.

This video shows the fifth trial for the transgenic mouse. The mouse does not perform significantly better than it did on the first trial, still taking 29.1 seconds to find the platform.

Textbook Reference: Synaptic Plasticity Can Be Measured in Simple Hippocampal Circuits, p. 539

Video courtesy of Stephen Martin and Richard Morris, Department of Neuroscience, University of Edinburgh.