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'Language Gene' Has a Partner

Few genes have made the headlines as much as FOXP2. The first gene associated with language disorders , it was later implicated in the evolution of human speech. Girls make more of the FOXP2 protein, which may help explain their precociousness in learning to talk. Now, neuroscientists have figured out how one of its molecular partners helps Foxp2 exert its effects.

The findings may eventually lead to new therapies for inherited speech disorders, says Richard Huganir, the neurobiologist at Johns Hopkins University School of Medicine in Baltimore, Maryland, who led the work. Foxp2 controls the activity of a gene called Srpx2, he notes, which helps some of the brain's nerve cells beef up their connections to other nerve cells. By establishing what SRPX2 does, researchers can look for defective copies of it in people suffering from problems talking or learning to talk.

Until 2001, scientists were not sure how genes influenced language. Then Simon Fisher, a neurogeneticist now at the Max Planck Institute for Psycholinguistics in Nijmegen, the Netherlands, and his colleagues fingered FOXP2 as the culprit in a family with several members who had trouble with pronunciation, putting words together, and understanding speech. These people cannot move their tongue and lips precisely enough to talk clearly, so even family members often can?t figure out what they are saying. It “opened a molecular window on the neural basis of speech and language,” Fisher says.

Photo credit: Yoichi Araki, Ph.D.


Links 1 - 20 of 20080

Hannah Devlin, science correspondent Psychedelic drugs could prove to be highly effective treatments for depression and alcoholism, according to a study which has obtained the first brain scans of people under the influence of LSD. Early results from the trial, involving 20 people, are said to be “very promising” and add to existing evidence that psychoactive drugs could help reverse entrenched patterns of addictive or negative thinking. However, Prof David Nutt, who led the study, warned that patients are missing out on the potential benefits of such treatments due to prohibitive regulations on research into recreational drugs. Speaking at a briefing in London, the government’s former chief drugs adviser, said the restrictions amounted to “the worst censorship in the history of science”. After failing to secure conventional funding to complete the analysis of the latest study on LSD, Nutt and colleagues at Imperial College London, are now attempting to raise £25,000 through the crowd-funding site Walacea.com. “These drugs offer the greatest opportunity we have in mental health,” he said. “There’s little else on the horizon.” There has been a resurgence of medical interest in LSD and psilocybin, the active ingredient in magic mushrooms, after several recent trials produced encouraging results for conditions ranging from depression in cancer patients to post-traumatic stress disorder. © 2015 Guardian News and Media Limited

Keyword: Depression; Drug Abuse
Link ID: 20656 - Posted: 03.05.2015

Zoe Cormier Data from population surveys in the United States challenge public fears that psychedelic drugs such as LSD can lead to psychosis and other mental-health conditions and to increased risk of suicide, two studies have found1, 2. In the first study, clinical psychologists Pål-Ørjan Johansen and Teri Suzanne Krebs, both at the Norwegian University of Science and Technology in Trondheim, scoured data from the US National Survey on Drug Use and Health (NSDUH), an annual random sample of the general population, and analysed answers from more than 135,000 people who took part in surveys from 2008 to 2011. Of those, 14% described themselves as having used at any point in their lives any of the three ‘classic’ psychedelics: LSD, psilocybin (the active ingredient in so-called magic mushrooms) and mescaline (found in the peyote and San Pedro cacti). The researchers found that individuals in this group were not at increased risk of developing 11 indicators of mental-health problems such as schizophrenia, psychosis, depression, anxiety disorders and suicide attempts. Their paper appears in the March issue of the Journal of Psychopharmacology1. The findings are likely to raise eyebrows. Fears that psychedelics can lead to psychosis date to the 1960s, with widespread reports of “acid casualties” in the mainstream news. But Krebs says that because psychotic disorders are relatively prevalent, affecting about one in 50 people, correlations can often be mistaken for causations. “Psychedelics are psychologically intense, and many people will blame anything that happens for the rest of their lives on a psychedelic experience.” © 2015 Nature Publishing Group,

Keyword: Drug Abuse; Schizophrenia
Link ID: 20655 - Posted: 03.05.2015

by Jan Piotrowski It's not the most charismatic fossil ever found, but it may reveal secrets of our earliest evolution. Unearthed in Ethiopia, the broken jaw with greying teeth suggests that the Homo lineage – of which modern humans are the only surviving member – existed up to 400,000 years earlier than previously thought. The fragment dates from around 2.8 million years ago, and is by far the most ancient specimen to bear the Homo signature. The earliest such fossil was one thought to be up to 2.4 million years ages old. Showing a mixture of traits, the new find pinpoints the time when humans began their transition from primitive, apelike Australopithecus to the big-brained conquerer of the world, says Brian Villmoare from the University of Nevada, Las Vegas, whose student made the find. Geological evidence from the same area, also reported this week in a study led by Erin DiMaggio from Pennsylvania State University, shows that the jaw's owner lived just after a major climate shift in the region: forests and waterways rapidly gave way to arid savannah, leaving only the occasional crocodile-filled lake. Except for the sabre-toothed big cat that once roamed these parts, the environment ended up looking much like it does today. It was probably the pressure to adapt to this new world that jump-started our evolution into what we see looking back at us in the mirror today, according to Villmoare. © Copyright Reed Business Information Ltd.

Keyword: Evolution
Link ID: 20654 - Posted: 03.05.2015

Loss of sensation in the eye that gradually leads to blindness has been prevented with an innovative technique, Canadian surgeons say. Abby Messner, 18, of Stouffville, Ont., lost feeling in her left eye after a brain tumour was removed, along with a nerve wrapped around it, when she was 11. Messner said she didn’t notice the loss of feeling until she scratched the eye. Messner wasn’t able to feel pain in the eye, a condition called corneal anaesthesia. Despite her meticulous care, the eye wouldn’t blink to protect itself when confronted by dust. A scar formed on her cornea, burrowed through, and formed a scar doctors feared would eventually obliterate her vision. "Everyone was like, 'Wow, she had a brain tumour and she’s fine," Messner recalled. "You don't really think that everything that is holding me back is my eye." Messner had to give up competitive swimming because of irritation from the chlorine, playing hockey, spending time outdoors where wind was a hazard or inside dry shopping malls. Over time, ophthalmology surgeon Dr. Asam Ali at SickKids introduced the idea of a nerve graft to restore feeling in the eye. "She started getting feeling back at about the two, three-month mark and that was a real surprise to her and we were very happy at that point because that was a lot faster than anything that had been reported before," Ali said. ©2015 CBC/Radio-Canada.

Keyword: Pain & Touch; Regeneration
Link ID: 20653 - Posted: 03.05.2015

By Will Boggs MD NEW YORK (Reuters Health) - Adolescents with a history of childhood trauma show different neural responses to subjective anxiety and craving, researchers report. "I think the finding of increased activation of insula, anterior cingulate, and prefrontal cortex in response to stress cues in the high- relative to low-trauma group, while arguably not necessarily unexpected, is important as it suggests that youth exposed to higher levels of trauma may experience different brain responses to similar stressors," Dr. Marc N. Potenza from Yale University, New Haven, Connecticut told Reuters Health by email. Childhood trauma has been associated with anxiety and depression, as well as obesity, risky sexual behavior, and substance use. Previous imaging studies have not investigated neural responses to personalized stimuli, Dr. Potenza and his colleagues write in Neuropsychopharmacology, online January 8. The team used functional MRI to assess regional brain activations to personalized appetitive (favorite food), aversive (stress), and neutral/relaxing cues in 64 adolescents, including 33 in the low-trauma group and 31 in the high-trauma group. Two-thirds of the adolescents had been exposed to cocaine prenatally, with prenatal cocaine exposure being significantly over-represented in the high-trauma group. Compared with the low-trauma group, the high-trauma group showed increased responsivity in several cortical regions in response to stress, as well as decreased activation in the cerebellar vermis and right cerebellum in response to neutral/relaxing cues. But the two groups did not differ significantly in their responses to favorite-food cues, the researchers found. © 2015 Scientific American

Keyword: Stress; Development of the Brain
Link ID: 20652 - Posted: 03.05.2015

Alison Abbott Europe’s ambitious but contentious €1-billion Human Brain Project (HBP) has announced changes to its organization in a response to criticisms of its management and scientific trajectory by many high-ranking neuroscientists. On 26 February, the HBP's Board of Directors voted narrowly to disband the three-person executive committee that had run the project, which launched in October 2013 and is intended to boost digital technologies such as supercomputing through collaboration with neuroscience. That decision is expected to be endorsed by HBP’s 85 or so partner universities and research institutes by the end of this week. The revamp comes seven months after 150 top neuroscientists signed a protest letter to the European Commission, charging, among other things, that the committee was acting autocratically and running the project's scientific plans off course. Led by the charismatic but divisive figure of Henry Markram, a neuroscientist at the Swiss Federal Institute of Technology in Lausanne (EPFL) which coordinates the HBP, the committee had stirred up anger last spring when it revealed plans to cut cognitive neuroscience from the initiative. The neuroscientists vowed to boycott the HBP's future phases if their concerns were ignored. An independent mediation committee was established to look into the charges and make recommendations. Its report, which is expected to further shake up the HBP's management, will be published in the next few weeks. In the meantime, the three-person committee's responsibilities will be taken on by the HBP's Board of Directors (currently a 22-strong team of scientists that includes the disbanded executive committee, although they do not have voting rights). © 2015 Nature Publishing Group

Keyword: Brain imaging
Link ID: 20651 - Posted: 03.05.2015

Children who attend school in heavy traffic areas may show slower cognitive development and lower memory test scores, Spanish researchers have found. About 21,000 premature deaths are attributed to air pollution in Canada each year, according to the Canadian Medical Association. The detrimental effects of air pollution on cardiovascular health and on the lungs are well documented and now researchers are looking at its effects on the brain. To that end, Dr. Jordi Sunyer and his colleagues from the Centre for Research in Environmental Epidemiology in Barcelona measured three aspects of memory and attentiveness in more than 2,700 primary school children every three months over 12 months. "What was surprising for us is among our children, we see very robust, consistent effects," Sunyer said Tuesday from Rome. The associations between slower cognitive development and higher levels of air pollutants remained after the researchers took factors such as parents’ education, commuting time, smoking in the home and green spaces at school into account. The researchers measured air pollutants from traffic twice, in the school courtyard and inside the classroom for schools with high and low traffic-related air pollution. Pollutants from burning fossil fuels, carbon, nitrogen dioxide and ultrafine particles were measured. For example, working memory improved 7.4 per cent among children in highly polluted schools compared with 11.5 per cent among those in less polluted schools. ©2015 CBC/Radio-Canada.

Keyword: Development of the Brain; Neurotoxins
Link ID: 20650 - Posted: 03.04.2015

Lights, sound, action: we are constantly learning how to incorporate outside sensations into our reactions in specific situations. In a new study, brain scientists have mapped changes in communication between nerve cells as rats learned to make specific decisions in response to particular sounds. The team then used this map to accurately predict the rats’ reactions. These results add to our understanding of how the brain processes sensations and forms memories to inform behavior. “We’re reading the memories in the brain,” said Anthony Zador, M.D., Ph.D., professor at Cold Spring Harbor Laboratory, New York, and senior author of the study, published in Nature. The work was funded by the National Institutes of Health and led by Qiaojie Xiong, Ph.D., a former postdoctoral researcher in Dr. Zador’s laboratory. “For decades scientists have been trying to map memories in the brain,” said James Gnadt, Ph.D., a program director at the National Institute of Neurological Disorders and Stroke (NINDS), one of the NIH institutes that funded the study. “This study shows that scientists can begin to pinpoint the precise synapses where certain memories form and learning occurs.” The communication points, or synapses, that Dr. Zador’s lab studied were in the striatum, an integrating center located deep inside the brain that is known to play an important role in coordinating the translation of thoughts and sensations into actions. Problems with striatal function are associated with certain neurological disorders such as Huntington’s disease in which affected individuals have severely impaired skill learning.

Keyword: Hearing; Learning & Memory
Link ID: 20649 - Posted: 03.04.2015

By Nicholas Bakalar Gout, a form of arthritis, is extremely painful and associated with an increased risk for cardiovascular problems. But there is a bright side: It may be linked to a reduced risk for Alzheimer’s disease. Researchers compared 59,204 British men and women with gout to 238,805 without the ailment, with an average age of 65. Patients were matched for sex, B.M.I., smoking, alcohol consumption and other characteristics. The study, in The Annals of the Rheumatic Diseases, followed the patients for five years. They found 309 cases of Alzheimer’s among those with gout and 1,942 among those without. Those with gout, whether they were being treated for the condition or not, had a 24 percent lower risk of Alzheimer’s disease. The reason for the connection is unclear. But gout is caused by excessive levels of uric acid in the blood, and previous studies have suggested that uric acid protects against oxidative stress. This may play a role in limiting neuron degeneration. “This is a dilemma, because uric acid is thought to be bad, associated with heart disease and stroke,” said the senior author, Dr. Hyon K. Choi, a professor of medicine at Harvard. “This is the first piece of data suggesting that uric acid isn’t all bad. Maybe there is some benefit. It has to be confirmed in randomized trials, but that’s the interesting twist in this story.” © 2015 The New York Times Company

Keyword: Alzheimers; Neuroimmunology
Link ID: 20648 - Posted: 03.04.2015

By Abby Phillip Jan Scheuermann, who has quadriplegia, brings a chocolate bar to her mouth using a robot arm guided by her thoughts. Research assistant Elke Brown watches in the background. (University of Pittsburgh Medical Center) Over at the Defense Advanced Research Projects Agency, also known as DARPA, there are some pretty amazing (and often top-secret) things going on. But one notable component of a DARPA project was revealed by a Defense Department official at a recent forum, and it is the stuff of science fiction movies. According to DARPA Director Arati Prabhakar, a paralyzed woman was successfully able use her thoughts to control an F-35 and a single-engine Cessna in a flight simulator. It's just the latest advance for one woman, 55-year-old Jan Scheuermann, who has been the subject of two years of groundbreaking neurosignaling research. First, Scheuermann began by controlling a robotic arm and accomplishing tasks such as feeding herself a bar of chocolate and giving high fives and thumbs ups. Then, researchers learned that -- surprisingly -- Scheuermann was able to control both right-hand and left-hand prosthetic arms with just the left motor cortex, which is typically responsible for controlling the right-hand side. After that, Scheuermann decided she was up for a new challenge, according to Prabhakar.

Keyword: Robotics
Link ID: 20647 - Posted: 03.04.2015

Tristram Wyatt This Valentine’s Day, like every year, there was a rash of stories in the news about sexy smells and pheromones. You could be forgiven for thinking that human ‘sex pheromones’, in particular the ‘male molecule’ androstadienone, were well established: countless ‘human pheromones’ websites sell it and there are tens of apparently scientific studies on androstadienone published in science journals. These studies are cited hundreds of times and have ended up being treated as fact in books on sexual medicine and even commentary on legislation. The birth place of the pheromone myth was a 1991 conference in Paris sponsored by a US corporation, EROX, which had an interest in patenting androstadienone and another molecule - estratetraenol, from women - as ‘human pheromones’. Unwittingly, leading mammalian olfaction scientists lent the conference credibility. Slotted into the programme and conference proceedings was the short ‘study-zero’ paper on the ‘Effect of putative pheromones on the electrical activity of the human vomeronasal organ and olfactory epithelium’. To my surprise, the authors gave no details at all of how these molecules had been extracted, identified, and tested in bioassays - all routinely required steps in the exhaustive process before any molecule can be shown to be a species-wide chemical signal, a pheromone. Instead there was just a footnote: ‘These putative pheromones were supplied by EROX Corporation’. The missing, essential details were never published. (The claim by EROX-sponsored scientists that adult humans have a functioning vomeronasal organ, against all the evidence, is a story for another day). © 2015 Guardian News and Media Limited

Keyword: Chemical Senses (Smell & Taste); Sexual Behavior
Link ID: 20646 - Posted: 03.04.2015

by Catherine de Lange You won't believe you do it, but you do. After shaking hands with someone, you'll lift your hands to your face and take a deep sniff. This newly discovered behaviour – revealed by covert filming – suggests that much like other mammals, humans use bodily smells to convey information. We know that women's tears transmit chemosensory signals - their scent lowers testosterone levels and dampens arousal in men - and that human sweat can transmit fear. But unlike other mammals, humans don't tend to go around sniffing each other. Wondering how these kinds of signals might be exchanged, Noam Sobel and his colleagues at the Weizmann Institute of Science in Rehovot, Israel turned to one of the most common ways in which people touch each other - shaking hands. "We started looking at people and noticed that afterwards, the hand somehow inadvertently reached the face," says Sobel. To find out if people really were smelling their hands, as opposed to scratching their nose, for example, his team surreptitiously filmed 153 volunteers. Some were wired up to a variety of physiological instruments so that airflow to the nose could be measured without them realising this was the intention. The volunteers were filmed as they greeted a member of the team, either with or without a handshake. The researchers recorded how often the volunteers lifted their hands close to their nose, and how long they kept them there, the minute before and after the greeting. © Copyright Reed Business Information Ltd.

Keyword: Chemical Senses (Smell & Taste)
Link ID: 20645 - Posted: 03.04.2015

|By Charles Schmidt The notion that the state of our gut governs our state of mind dates back more than 100 years. Many 19th- and early 20th-century scientists believed that accumulating wastes in the colon triggered a state of “auto-intoxication,” whereby poisons emanating from the gut produced infections that were in turn linked with depression, anxiety and psychosis. Patients were treated with colonic purges and even bowel surgeries until these practices were dismissed as quackery. The ongoing exploration of the human microbiome promises to bring the link between the gut and the brain into clearer focus. Scientists are increasingly convinced that the vast assemblage of microfauna in our intestines may have a major impact on our state of mind. The gut-brain axis seems to be bidirectional—the brain acts on gastrointestinal and immune functions that help to shape the gut's microbial makeup, and gut microbes make neuroactive compounds, including neurotransmitters and metabolites that also act on the brain. These interactions could occur in various ways: microbial compounds communicate via the vagus nerve, which connects the brain and the digestive tract, and microbially derived metabolites interact with the immune system, which maintains its own communication with the brain. Sven Pettersson, a microbiologist at the Karolinska Institute in Stockholm, has recently shown that gut microbes help to control leakage through both the intestinal lining and the blood-brain barrier, which ordinarily protects the brain from potentially harmful agents. Microbes may have their own evolutionary reasons for communicating with the brain. They need us to be social, says John Cryan, a neuroscientist at University College Cork in Ireland, so that they can spread through the human population. © 2015 Scientific American

Keyword: Obesity; Neuroimmunology
Link ID: 20644 - Posted: 03.03.2015

By Roni Caryn Rabin When my mother, Pauline, was 70, she lost her sense of balance. She started walking with an odd shuffling gait, taking short steps and barely lifting her feet off the ground. She often took my hand, holding it and squeezing my fingers. Her decline was precipitous. She fell repeatedly. She stopped driving, and she could no longer ride her bike in a straight line along the C&O Canal. The woman who taught me the sidestroke couldn’t even stand in the shallow end of the pool. “I feel like I’m drowning,” she’d say. A retired psychiatrist, my mother had numerous advantages — education, resources and insurance — but, still, getting the right diagnosis took nearly 10 years. Each expert saw the problem through the narrow prism of a single specialty. Surgeons recommended surgery. Neurologists screened for common incurable conditions. The answer was under their noses, in my mother’s hunches and her family history. But it took a long time before someone connected the dots. My mother was using a walker by the time she was told she had a rare condition that causes gait problems and cognitive loss, and is one of the few treatable forms of dementia. The bad news was that it had taken so long to get the diagnosis that some of the damage might not be reversible. “This should be one of the first things physicians look for in an older person,” my mother said recently. “You can actually do something about it.”

Keyword: Alzheimers
Link ID: 20643 - Posted: 03.03.2015

By Felicity Muth Visual illusions are fun: we know with our rational mind that, for example, these lines are parallel to each other, yet they don’t appear that way. Similarly, I could swear that squares A and B are different colours. But they are not. This becomes clearer when a connecting block is drawn between the two squares (see the image below). Illusions aren’t just fun tricks for us to play with, they can also tell us something about our minds. Things in the world look to us a certain way, but that doesn’t mean that they are that way in reality. Rather, our brain represents the world to us in a particular way; one that has been selected over evolutionary time. Having such a system means that, for example, we can see some animals running but not others; we couldn’t see a mouse moving from a mile away like a hawk could. This is because there hasn’t been the evolutionary selective pressures on our visual system to be able to do such a thing, whereas there has on the hawk’s. We can also see a range of wavelengths of light, represented as particular colours in our brain, while not being able to see other wavelengths (that, for example, bees and birds can see). Having a system limited by what evolution has given us means that there are many things we are essentially blind to (and wouldn’t know about if it weren’t for technology). It also means that sometimes our brain misrepresents physical properties of the external world in a way that can be confusing once our rational mind realises it. Of course, all animals have their own representation of the world. How a dog visually perceives the world will be different to how we perceive it. But how can we know how other animals perceive the world? What is their reality? One way we can try to get this is through visual illusions. © 2015 Scientific American

Keyword: Vision; Evolution
Link ID: 20642 - Posted: 03.03.2015

By Nicholas Bakalar Sleeping more than eight hours a day is associated with a higher risk for stroke, a new study has found. Researchers studied 9,692 people, ages 42 to 81, who had never had a stroke. The study tracked how many hours a night the people slept at the beginning of the study and how much nightly sleep they were getting four years later. Over the 10-year study, 346 of the study subjects suffered strokes. After controlling for more than a dozen other health and behavioral variables, the researchers found that people who slept more than eight hours a day were 46 percent more likely to have had a stroke than those who slept six to eight hours. The study, published online last week in Neurology, also found that the risk of stroke was higher among people who reported that their need for sleep had increased over the study period. The authors caution that the data on sleep duration depended on self-reports, which can be unreliable. In addition, the study identified an association between sleep and stroke risk, rather than cause and effect. Sleeping more may be an early symptom of disease that leads to stroke, rather than a cause. “It could be that there’s already something happening in the brain that precedes the stroke risk and of which excessive sleep is an early sign,” said the lead author, Yue Leng, a doctoral candidate at the University of Cambridge. In any case, she added, “we don’t have enough evidence to apply this in clinical settings. We don’t want people to think if they sleep longer it will necessarily lead to stroke.” © 2015 The New York Times Company

Keyword: Sleep; Stroke
Link ID: 20641 - Posted: 03.03.2015

|By Christof Koch In the Dutch countryside, a tall, older man, dressed in a maroon sports coat, his back slightly stooped, stands out because of his height and a pair of extraordinarily bushy eyebrows. His words, inflected by a British accent, are directed at a middle-aged man with long, curly brown hair, penetrating eyes and a dark, scholarly gown, who talks in only a halting English that reveals his native French origins. Their strangely clashing styles of speaking and mismatched clothes do not seem to matter to them as they press forward, with Eyebrows peering down intently at the Scholar. There is something distinctly odd about the entire meeting—a crossing of time, place and disciplines. Eyebrows: So I finally meet the man who doubts everything. The Scholar: (not missing a beat) At this time, I admit nothing that is not necessarily true. I'm famous for that! Eyebrows: Is there anything that you are certain of? (sotto voce) Besides your own fame? The Scholar: (evading the sarcastic jibe) I can't be certain of my fame. Indeed, I can't even be certain that there is a world out there, for I could be dreaming or hallucinating it. I can't be certain about the existence of my own body, its shape and extension, its corporality, for again I might be fooling myself. But now what am I, when I suppose that there is some supremely powerful and, if I may be permitted to say so, malicious deceiver who deliberately tries to fool me in any way he can? Given this evil spirit, how do I know that my sensations about the outside world—that is, it looks, feels and smells in a particular way—are not illusions, conjured up by Him to deceive me? It seems to me that therefore I can never know anything truly about the world. Nothing, rien du tout. I have to doubt everything. © 2015 Scientific American

Keyword: Consciousness
Link ID: 20640 - Posted: 03.03.2015

By JULIE HOLLAND WOMEN are moody. By evolutionary design, we are hard-wired to be sensitive to our environments, empathic to our children’s needs and intuitive of our partners’ intentions. This is basic to our survival and that of our offspring. Some research suggests that women are often better at articulating their feelings than men because as the female brain develops, more capacity is reserved for language, memory, hearing and observing emotions in others. These are observations rooted in biology, not intended to mesh with any kind of pro- or anti-feminist ideology. But they do have social implications. Women’s emotionality is a sign of health, not disease; it is a source of power. But we are under constant pressure to restrain our emotional lives. We have been taught to apologize for our tears, to suppress our anger and to fear being called hysterical. The pharmaceutical industry plays on that fear, targeting women in a barrage of advertising on daytime talk shows and in magazines. More Americans are on psychiatric medications than ever before, and in my experience they are staying on them far longer than was ever intended. Sales of antidepressants and antianxiety meds have been booming in the past two decades, and they’ve recently been outpaced by an antipsychotic, Abilify, that is the No. 1 seller among all drugs in the United States, not just psychiatric ones. As a psychiatrist practicing for 20 years, I must tell you, this is insane. At least one in four women in America now takes a psychiatric medication, compared with one in seven men. Women are nearly twice as likely to receive a diagnosis of depression or anxiety disorder than men are. For many women, these drugs greatly improve their lives. But for others they aren’t necessary. The increase in prescriptions for psychiatric medications, often by doctors in other specialties, is creating a new normal, encouraging more women to seek chemical assistance. Whether a woman needs these drugs should be a medical decision, not a response to peer pressure and consumerism. © 2015 The New York Times Company

Keyword: Emotions; Sexual Behavior
Link ID: 20639 - Posted: 03.02.2015

By ROBERT PEAR WASHINGTON — Federal investigators say they have found evidence of widespread overuse of psychiatric drugs by older Americans with Alzheimer’s disease, and are recommending that Medicare officials take immediate action to reduce unnecessary prescriptions. The findings will be released Monday by the Government Accountability Office, an arm of Congress, and come as the Obama administration has already been working with nursing homes to reduce the inappropriate use of antipsychotic medications like Abilify, Risperdal, Zyprexa and clozapine. But in the study, investigators said officials also needed to focus on overuse of such drugs by people with dementia who live at home or in assisted living facilities. The Department of Health and Human Services “has taken little action” to reduce the use of antipsychotic drugs by older adults living outside nursing homes, the report said. Doctors sometimes prescribe antipsychotic drugs to calm patients with dementia who display disruptive behavior like hitting, yelling or screaming, the report said. Researchers said this was often the case in nursing homes that had inadequate numbers of employees. Dementia is most commonly associated with a decline in memory, but doctors say it can also cause changes in mood or personality and, at times, agitation or aggression. Experts have raised concern about the use of antipsychotic drugs to address behavioral symptoms of Alzheimer’s and other forms of dementia. The Food and Drug Administration says antipsychotic drugs are often associated with an increased risk of death when used to treat older adults with dementia who also have psychosis. © 2015 The New York Times Company

Keyword: Alzheimers; Schizophrenia
Link ID: 20638 - Posted: 03.02.2015

By Neuroskeptic In an interesting short paper just published in Trends in Cognitive Science, Caltech neuroscientist Ralph Adolphs offers his thoughts on The Unsolved Problems of Neuroscience. Here’s Adolphs’ list of the top 23 questions (including 3 “meta” issues), which, he says, was inspired by Hilbert’s famous set of 23 mathematical problems: Problems that are solved, or soon will be: I. How do single neurons compute? II. What is the connectome of a small nervous system, like that of Caenorhabitis elegans (300 neurons)? III. How can we image a live brain of 100,000 neurons at cellular and millisecond resolution? IV. How does sensory transduction work? Problems that we should be able to solve in the next 50 years: V. How do circuits of neurons compute? VI. What is the complete connectome of the mouse brain (70,000,000 neurons)? VII. How can we image a live mouse brain at cellular and millisecond resolution? VIII. What causes psychiatric and neurological illness? IX. How do learning and memory work? X. Why do we sleep and dream? XI. How do we make decisions? XII. How does the brain represent abstract ideas? Problems that we should be able to solve, but who knows when: XIII. How does the mouse brain compute? XIV. What is the complete connectome of the human brain (80,000,000,000 neurons)? XV. How can we image a live human brain at cellular and millisecond resolution? XVI. How could we cure psychiatric and neurological diseases? XVII. How could we make everybody’s brain function best? Problems we may never solve: XVIII. How does the human brain compute? XIX. How can cognition be so flexible and generative? XX. How and why does conscious experience arise? Meta-questions: XXI. What counts as an explanation of how the brain works? (and which disciplines would be needed to provide it?) XXII. How could we build a brain? (how do evolution and development do it?) XXIII. What are the different ways of understanding the brain? (what is function, algorithm, implementation?) Adolphs R (2015). The unsolved problems of neuroscience. Trends in cognitive sciences PMID: 25703689

Keyword: Consciousness
Link ID: 20637 - Posted: 03.02.2015