Chapter 11. Emotions, Aggression, and Stress
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By BENEDICT CAREY The surge of emotion that makes memories of embarrassment, triumph and disappointment so vivid can also reach back in time, strengthening recall of seemingly mundane things that happened just beforehand and that, in retrospect, are relevant, a new study has found. The report, published Wednesday in the journal Nature, suggests that the television detective’s standard query — “Do you remember any unusual behavior in the days before the murder?” — is based on solid brain science, at least in some circumstances. The findings fit into the predominant theory of memory: that it is an adaptive process, continually updating itself according to what knowledge may be important in the future. The new study suggests that human memory has, in effect, a just-in-case file, keeping seemingly trivial sights, sounds and observations in cold storage for a time in case they become useful later on. But the experiment said nothing about the effect of trauma, which shapes memory in unpredictable ways. Rather, it aimed to mimic the arousals of daily life: The study used mild electric shocks to create apprehension and measured how the emotion affected memory of previously seen photographs. In earlier work, researchers had found plenty of evidence in animals and humans of this memory effect, called retroactive consolidation. The new study shows that the effect applies selectively to related, relevant information. “The study provides strong evidence for a specific kind of retroactive enhancement,” said Daniel L. Schacter, a professor of psychology at Harvard who was not involved in the research. “The findings go beyond what we’ve found previously in humans.” © 2015 The New York Times Company
By Rachel Feltman Fear is one of our most basic evolutionary instincts, a sudden physical jolt to help us react to danger more quickly. In the modern world, fear often seems excessive -- in the absence of wild animals to flee, we're left screaming over roller coasters and scary movies. But for at least one woman, fear is unobtainable. And while she lives a normal life, her fearlessness is actually a handicap. The researchers who study her keep her closely guarded, using the code-name "SM" when publishing papers about her brave brainpower. And until this year, she'd never been interviewed. "Tell me what fear is," Tranel began. "Well, that's what I'm trying to -- to be honest, I truly have no clue," SM said, her voice raspy. That's actually a symptom of the condition that stole fear from her. Urbach-Wieth disease, which is characterized by a hoarse voice, small bumps around the eyes, and calcium deposits in the brain is rare in its own right -- only 400 people on the planet are known to have it -- but in SM's case, some of those brain-deposits happened to take over her amygdalae. These almond-shaped structures deep inside the brain are crucial to human fear response. And in SM's case, they've been totally calcified since she was a young woman. Now in her 40s, her fear-center is as good as gone. "It's a little bit as if you would go to this region and literally scoop it out," Antonio Damasio, another neuroscientist who studies SM, told "Invisibilia" hosts Lulu Miller and Alix Spiegel.
Link ID: 20504 - Posted: 01.21.2015
By Amy Ellis Nutt Scientists have discovered what a traumatic brain injury, or TBI, suffered by a quarter-million combat veterans of Iraq and Afghanistan looks like, and it’s unlike anything they’ve seen before: a honeycomb pattern of broken connections, primarily in the frontal lobes, our emotional control center and the seat of our personality. “In some ways it’s a 100-year-old problem,” said Vassilis Koliatsos, a Johns Hopkins pathologist and neuropsychiatrist. He was referring to the shell-shock victims of World War I, tens of thousands of soldiers who returned home physically sound but mentally wounded, haunted by their experiences and unable to fully resume their lives. “When we started shelling each other on the Western Front of World War I, it created a lot of sick people . . . . [In a way,] we’ve gone back to the Western Front and created veterans who come back and do poorly, and we’re back to the Battle of the Somme,” he said. “They have mood changes, commit suicide, substance abuse, just like in World War I, and they really do poorly and can’t function. It’s a huge problem.” Many of the lingering symptoms of shell shock, or what today is known as neurotrauma, are the same as they were a century ago. Only the nature of the blast has changed, from artillery to improvised explosive devices. Koliatsos and colleagues, who published their findings in the journal Acta Neuropathologica Communications in November, examined the brains of five recent U.S. combat veterans, all of whom suffered a traumatic brain injury from an IED but died of unrelated causes back home. Their controls included the brains of people with a history of auto accidents and of those with no history of auto accidents or TBI. Koliatsos says he was prompted to do this study because he is both a pathologist and a neuropsychiatrist, and he sees many TBI cases, both in veterans and in young people with sports concussions.
By Tia Ghose Being around strangers can cause people stress and, in turn, make them less able to feel others' pain, new research suggests. But giving people a drug that blocks the body's stress response can restore that sense of empathy, scientists said. What's more, the same effect shows up in both humans and mice. "In some sense, we've figured out what to do about increasing empathy as a practical matter," said Jeffrey Mogil, a neuroscientist at McGill University in Montreal. "We've figured out what stops it from happening and, therefore, the solution to make it happen more between strangers." Decreasing stress by doing a shared activity could be a simple way to increase empathy between people who don't know each other, the findings suggest. Past studies had found that mice seemed to feel the pain of familiar mice but were less responsive to foreign mice. Other studies found that, in both humans and mice, stress levels tended to rise around strangers. To see how stress and empathy are connected, Mogil and his colleagues placed two mice together in a cage, then inflicted a painful stimulus on one of them. When the mice were cage mates, the unaffected mouse showed more signs of pain than when they were strangers. But when the team gave the mice a drug called metyrapone, which blocks the formation of the stress hormone cortisol, the mice responded equally to the strangers' pain.
Link ID: 20491 - Posted: 01.17.2015
by Bethany Brookshire Drugs that treat anxiety can be real downers. While they may help you feel less anxious, drugs such as Valium and Xanax can leave you drowsy and unfocused. Long-term use of these compounds, a class of drugs called the benzodiazepines, can lead to dependence and tolerance. And patients often need higher and higher doses to calm their anxiety. Getting off the drugs requires careful weaning to avoid insomnia, tremors and other nasty withdrawal effects. But Subhashis Banerjee and colleagues at the Scripps Research Institute in Jupiter, Fla., have identified a potential new target for anti-anxiety drugs that avoids the drowsiness and other side effects that come with the standard treatments. The target is an integral part of the body’s internal clock, and in tests in mice, compounds aimed at it reduced measures of anxiety while keeping the mice awake. The possibilities show how basic science questions, such as how the body produces sleep and internal rhythms, could have clinical applications. But it’s important to remember that it’s a long way between mice and people. The proteins REV-ERB alpha and REV-ERB beta are found in cell nuclei throughout the body. These proteins are receptors that sense levels of heme, subsections of chemicals in the body containing iron atoms. Levels of heme rise and fall based on a cell’s activity. REV-ERB responds to these heme level changes by controlling the activation of genes within the cell’s nucleus that govern the cell’s 24-hour internal clock. This circadian rhythm plays an important role in controlling our sleep. © Society for Science & the Public 2000 - 2015.
by Jessica Hamzelou YOU'RE not imagining the pain. But your brain might be behind it, nonetheless. For the first time, it is possible to distinguish between brain activity associated with pain from a physical cause, such as an injury, and that associated with pain linked to your state of mind. A fifth of the world's population is thought to experience some kind of chronic pain – that which has lasted longer than three months. If the pain has no clear cause, people can find themselves fobbed off by doctors who they feel don't believe them, or given ineffective or addictive painkillers. But a study led by Tor Wager at the University of Colorado, Boulder, now reveals that there are two patterns of brain activity related to pain. One day, brain scans could be used to work out your relative components of each, helping to guide treatment. "Pain has always been a bit of a puzzle," says Ben Seymour, a neuroscientist at the University of Cambridge. Hearing or vision, for example, can be traced from sensory organs to distinct brain regions, but pain is more complex, and incorporates thoughts and emotions. For example, studies have linked depression and anxiety to the development of pain conditions, and volunteers put in bad moods have a lower tolerance for pain. So does this mean we can think our way into or out of pain? To find out, Wager and his colleagues used fMRI to look at the brain activity of 33 healthy adults while they were feeling pain. First, the team watched the changing activity as they applied increasing heat to the volunteers' arms. As the heat became painful, a range of brain structures lit up. The pattern was common to all the volunteers, so Wager's team called it the neurologic pain signature. © Copyright Reed Business Information Ltd.
By Richard Leiby NEWPORT BEACH, Calif. — The headquarters of Oakley, a maker of recreational and military gear, looks as if it belongs in a war zone. It’s a massive bunker with exposed steel pipes, girders and blast walls. Even the dais in the auditorium is armored. But on a recent afternoon, the talk inside the building, set atop an arid, inland hillside in Orange County, is not about fighting wars but about caring for warriors. Doctors, scientists and veterans approach the podium at a conference to present some of the latest tools to help vets recover from wounds both mental and physical: bionics, virtual reality, magnetic waves. A session called “Healing the Warrior Brain” features a trim, bleach-blond former Army staff sergeant named Jonathan Warren, who recounts on video his struggle with post-traumatic stress disorder after combat in Iraq. His flashbacks, panic attacks and booze benders were well chronicled: For a year, the Los Angeles Times tracked Warren’s efforts to find peace, including via Department of Veterans Affairs therapy. It didn’t work, he says. But now a different Jon Warren is here to say that he is finally free of symptoms, one year after that 2013 story ran. No longer does his worst memory of the Iraq war — failing to rescue his best friend, who nearly burned to death after their Humvee hit a roadside bomb in 2006 — grasp his psyche and inflict guilt. That’s because of a revolutionary new treatment that retuned his brain, he says, and set “my frequencies right.” Now he’s able to proudly embrace his military service, “to keep the memory, to be able to go there,” Warren tells the audience, “and not be controlled by it.”
Link ID: 20474 - Posted: 01.13.2015
By Nicholas Weiler A friend can make even the shiest creature bold. Rats usually fear strange open spaces, but having a companion by their side makes the rodents more intrepid, scientists report in the current issue of Animal Cognition. Researchers tracked rats’ exploration of a large, unfamiliar room, first alone, then again 2 days later either alone or paired with a familiar cagemate. On their own, rats made short, hesitant forays into the open space before darting back to huddle by the door. Solitary rats’ anxiety in the room didn’t improve on their second visit. But adding a friend, even one who’d never seen the room before, gave the pair the confidence to actively explore, covering 50% more ground and running significantly faster than the control rats. And exploring with company seemed to boost the rats’ sense of security permanently. Placed in the room a third time, once more alone, the socialized rats boldly explored more new places than ever, while solo rats continued to cower. This illustrates that for communal animals like rats—and perhaps humans—friendship can be the best antidote to fear. © 2015 American Association for the Advancement of Scienc
Link ID: 20462 - Posted: 01.10.2015
By Susan Milius Whole scientific careers have gone into understanding why a harmless handful of fluff like a California ground squirrel taunts rattlesnakes. Now Rulon Clark and his team at San Diego State University are exploring the puzzle of why the squirrels also seem to taunt rocks, sticks and the occasional shrub. On spotting a snake, a California ground squirrel (Otospermophilus beecheyi) stares and sniffs, or if the snake is uncoiled, may even kick sand at it. And in bursts, the squirrel flags its tail left and right “like a windshield wiper,” Clark says. A rattler can strike a target 30 centimeters away in less than 70 milliseconds. But ground squirrels twist and dodge fast enough to have a decent chance of escape. Also, adult squirrels from snake country have evolved some resistance to venom. So taunting is worth the risks as a signal to neighboring squirrels and to the snake that its ambush attempt has been discovered. After getting publicly and lengthily squirreled, snakes often just slip away. Yet the squirrels also nyah-nyah tail flag at places where snakes might be but aren’t. To see if flagging indicates wariness, Clark and his colleagues built a squirrel startler that shoots out a cork using the classic spring that launches gag snakes out of cans (see video below). At spots with no sign of real snakes, squirrels mostly nibbled seeds in apparent tranquility with only a rare tail flag. The pop of a cork typically sent these squirrels scampering off on four speed-blurred paws. © Society for Science & the Public 2000 - 2014.
By KEVIN RANDALL MILWAUKEE — When two financiers purchased the Milwaukee Bucks for $550 million last April, they promised to pour not only money and new management into the moribund franchise, but also the same kind of creative and critical thinking that had helped make them hedge fund billionaires. It was not enough to increase the franchise’s sales force or beef up the team’s analytics department — the Bucks were looking for a more elusive edge. So in May, the team hired Dan Hill, a facial coding expert who reads the faces of college prospects and N.B.A. players to determine if they have the right emotional attributes to help the Bucks. The approach may sound like palm reading to some, but the Bucks were so impressed with Hill’s work before the 2014 draft that they retained him to analyze their players and team chemistry throughout this season. With the tenets of “Moneyball” now employed in the front offices of every major sport, perhaps it was inevitable that professional teams would turn to emotion metrics and neuroscience tools to try to gain an edge in evaluating players. Many sports teams have adopted advanced data analytics to help determine a player’s athletic abilities and value. And now, some are taking it a step further — trying to analyze the psychological aspects of the players as well. “We spend quite a bit of time evaluating the players as basketball players and analytically,” said David Morway, Milwaukee’s assistant general manager, who works for the owners Wesley Edens and Marc Lasry. “But the difficult piece of the puzzle is the psychological side of it, and not only psychological, character and personality issues, but also team chemistry issues.” © 2014 The New York Times Company
Link ID: 20445 - Posted: 12.27.2014
By Maria Konnikova Last year, Dimitris Xygalatas, the head of the experimental anthropology lab at the University of Connecticut, decided to conduct a curious experiment in Mauritius, during the annual Thaipusam festival, a celebration of the Hindu god Murugan. For the ten days prior to the festival, devotees abstain from meat and sex. As the festival begins, they can choose to show their devotion in the form of several communal rituals. One is fairly mild. It involves communal prayer and singing beside the temple devoted to Murugan, on the top of a mountain. The other, however—the Kavadi—is one of the more painful modern religious rituals still in practice. Participants must pierce multiple parts of their bodies with needles and skewers and attach hooks to their backs, with which they then drag a cart for more than four hours. After that, they climb the mountain where Murugan’s temple is located. Immediately after each ritual was complete, the worshippers were asked if they would be willing to spend a few minutes answering some questions in a room near the temple. Xygalatas had them rate their experience, their attitude toward others, and their religiosity. Then he asked them a simple question: They would be paid two hundred rupees for their participation (about two days’ wages for an unskilled worker); did they want to anonymously donate any of those earnings to the temple? His goal was to figure out if the pain of the Kavadi led to increased affinity for the temple. For centuries, societies have used pain as a way of creating deep bonds. There are religious rites, such as self-flagellation, solitary pilgrimages, and physical mutilation.
by Bethany Brookshire Rats stink. First there’s the poop smell and the urine. And then there’s just that smell of rat — a kind of dusty, hairy little smell. But it turns out that rats don’t smell quite the same all the time. When they are stressed, they produce a different odor, one that makes other rats anxious. Now, Hideaki Inagaki and colleagues at the University of Tokyo in Japan have isolated the particular stress-related odor and identified the two specific chemicals behind it. The results reveal the first evidence of an isolated anxiety pheromone in rats, and give reason for scientists to look at — or maybe sniff — their behavioral experiments cautiously. And the findings could also offer glimmerings of a new flavor of rat-be-gone. Pheromones are chemicals that give off distinct odors that allow an animal to communicate within its own ranks. In rats, as in many other animals, many pheromones activate the vomeronasal organ, a small patch of cells at the base of the nasal cavity. Other researchers have found evidence of pheromones in maternal behavior and in the response of rat pups to their mothers. In the new study, the pheromones in question are about alarm and anxiety. Study coauthor Yasushi Kiyokawa of The University of Tokyo says he first came across the alarm odor when he was a graduate student. “I noticed the rats released a specific odor when I handled them for the first time, as they were stressed by the novel handling procedure,” he recalls. He went sniffing to find the source. “I found that the intensity of the odor was strongest around the anal region,” he says. Many mammals have glands around the anus that produce oils and odors. Since that first whiff of a clue, Kiyokawa and colleagues at the University of Tokyo have been working with what they called the “alarm pheromone.” While rats may be smelly to some, Kiyokawa says this particular smell isn’t unpleasant. “Like a hay or dried grass,” he says. “At least for me.” © Society for Science & the Public 2000 - 2014
Richard Stephens ‘The curve that sets everything straight” was how comedian Phyllis Diller once described the smile. And it’s true that there’s something charming, trustworthy and disarming about a smile – but this can be misleading. Dig a little deeper and you will understand a much less wholesome side. Because, ladies and gentleman, the smile is one of the biggest fakes going. I know what you’re thinking: we all pull a false smile now and again to appease our fellows and avoid unnecessary conflict. On the other hand, a genuine smile of true enjoyment is something different. Psychologists have named such a smile after the French neurologist Guillaume-Benjamin-Amand Duchenne de Boulogne. The Duchenne smile, utilising the muscles around the eyes that lift the cheeks to produce crow’s feet, has long been held as an inimitable sign of true human emotion. Or at least it was until 2013, when a team of researchers from Northeastern University, Boston, broke that hoodoo. Sarah Gunnery and her colleagues asked one group of volunteers to imitate smiles on photographs, and another group of volunteers to rate them. Some of the photographs depicted mouth-only smiles but others were Duchenne smiles, using mouth and eye muscles together. Surprisingly, a high proportion of individuals – two-thirds – could fake a Duchenne smile – and those that could do this were better able to put on false expressions in their everyday lives. This straightforward study indicates that even the sacrosanct Duchenne smile can be convincingly simulated. So much for smiling being an inimitable sign of true human emotion. So why are we so good at faking smiles? The answer isn’t necessarily sinister – some research shows you can actually smile yourself into a better mood. © 2014 Guardian News and Media Limited
Link ID: 20438 - Posted: 12.23.2014
by Helen Thomson HAVE you read this before? A 23-year-old man from the UK almost certainly feels like he has – he's the first person to report persistent déjà vu stemming from anxiety rather than any obvious neurological disorder. Nobody knows exactly how or why déjà vu happens, but for most of us it is rare. Some people experience it more often, as a side effect associated with epileptic seizures or dementia. Now, researchers have discovered the first person with what they call "psychogenic déjà vu" – where the cause appears to be psychological. The man's episodes began just after he started university, a period when he felt anxious and was also experiencing obsessive compulsions. As time went on, his déjà vu became more and more prolonged, and then fairly continuous after he tried LSD. Now, he avoids television and radio, and finds newspapers distressing as the content feels familiar. There are different theories as to what is going on, says Christine Wells at Sheffield Hallam University in the UK, who has written a paper on the man's experiences. "The general theory is that there's a misfiring of neurons in the temporal lobes – which deal with recollection and familiarity. That misfiring during the process of recollection means we interpret a moment in time as something that has already been experienced," she says. Surprisingly, when Wells gave the man a standard recall test, he scored more similarly to people of his own age without the condition than those with epilepsy-related déjà vu. An MRI and an EEG scan of his brain activity also showed no abnormalities. © Copyright Reed Business Information Ltd.
By David Noonan It was the day before Christmas, and the normally busy MIT laboratory on Vassar Street in Cambridge was quiet. But creatures were definitely stirring, including a mouse that would soon be world famous. Steve Ramirez, a 24-year-old doctoral student at the time, placed the mouse in a small metal box with a black plastic floor. Instead of curiously sniffing around, though, the animal instantly froze in terror, recalling the experience of receiving a foot shock in that same box. It was a textbook fear response, and if anything, the mouse’s posture was more rigid than Ramirez had expected. Its memory of the trauma must have been quite vivid. Which was amazing, because the memory was bogus: The mouse had never received an electric shock in that box. Rather, it was reacting to a false memory that Ramirez and his MIT colleague Xu Liu had planted in its brain. “Merry Freaking Christmas,” read the subject line of the email Ramirez shot off to Liu, who was spending the 2012 holiday in Yosemite National Park. The observation culminated more than two years of a long-shot research effort and supported an extraordinary hypothesis: Not only was it possible to identify brain cells involved in the encoding of a single memory, but those specific cells could be manipulated to create a whole new “memory” of an event that never happened. “It’s a fantastic feat,” says Howard Eichenbaum, a leading memory researcher and director of the Center for Neuroscience at Boston University, where Ramirez did his undergraduate work. “It’s a real breakthrough that shows the power of these techniques to address fundamental questions about how the brain works.” In a neuroscience breakthrough, the duo implanted a false memory in a mouse
|By Bret Stetka When University of Bonn psychologist Monika Eckstein designed her latest published study, the goal was simple: administer a hormone into the noses of 62 men in hopes that their fear would go away. And for the most part, it did. The hormone was oxytocin, often called our “love hormone” due to its crucial role in mother-child relationships, social bonding, and intimacy (levels soar during sex). But it also seems to have a significant antianxiety effect. Give oxytocin to people with certain anxiety disorders, and activity in the amygdala—the primary fear center in human and other mammalian brains, two almond-shaped bits of brain tissue sitting deep beneath our temples—falls. The amygdala normally buzzes with activity in response to potentially threatening stimuli. When an organism repeatedly encounters a stimulus that at first seemed frightening but turns out to be benign—like, say, a balloon popping—a brain region called the prefrontal cortex inhibits amygdala activity. But in cases of repeated presentations of an actual threat, or in people with anxiety who continually perceive a stimulus as threatening, amygdala activity doesn’t subside and fear memories are more easily formed. To study the effects of oxytocin on the development of these fear memories, Eckstein and her colleagues first subjected study participants to Pavlovian fear conditioning, in which neutral stimuli (photographs of faces and houses) were sometimes paired with electric shocks. Subjects were then randomly assigned to receive either a single intranasal dose of oxytocin or a placebo. Thirty minutes later they received functional MRI scans while undergoing simultaneous fear extinction therapy, a standard approach to anxiety disorders in which patients are continually exposed to an anxiety-producing stimulus until they no longer find it stressful. In this case they were again exposed to images of faces and houses, but this time minus the electric shocks. © 2014 Scientific American
by Andy Coghlan How does this make you feel? Simply asking people to think about emotion-laden actions as their brains are scanned could become one of the first evidence-based tests for psychiatric illness. Assessing people in this way would be a step towards a more scientific approach to diagnosis, away from that based on how someone behaves or how they describe their symptoms. The US National Institute of Mental Health has had such a goal in mind since 2013. Marcel Just of Carnegie Mellon University in Pittsburgh, Pennsylvania, and his colleagues developed the brain scanning technique and used it to identify people with autism. "This gives us a whole new perspective to understanding psychiatric illnesses and disorders," says Just. "We've discovered a biological thought-marker for autism." The technique builds on work by the group showing that specific thoughts and emotions are represented in the brain by certain patterns of neural activation. The idea is that deviations from these patterns, what Just refers to as thought-markers, can be used to diagnose different psychiatric conditions. The team asked a group of adults to imagine 16 actions, some of which required emotional involvement, such as "hugging", "persuading" or "adoring", while they lay in an fMRI scanner. © Copyright Reed Business Information Ltd.
By Gabe Bergado It's not news that reading has countless benefits: Poetry stimulates parts of the brain linked to memory and sparks self-reflection; kids who read the Harry Potter books tend to be better people. But what about people who only read newspapers? Or people who scan Twitter all day? Are those readers' brains different from literary junkies who peruse the pages of 19th century fictional classics? Short answer: Yes — reading enhances connectivity in the brain. But readers of fiction? They're a special breed. The study: A 2013 Emory University study looked at the brains of fiction readers. Researchers compared the brains of people after they read to the brains of people who didn't read. The brains of the readers — they read Robert Harris' Pompeii over a nine-day period at night — showed more activity in certain areas than those who didn't read. Specifically, researchers found heightened connectivity in the left temporal cortex, part of the brain typically associated with understanding language. The researchers also found increased connectivity in the central sulcus of the brain, the primary sensory region, which helps the brain visualize movement. When you visualize yourself scoring a touchdown while playing football, you can actually somewhat feel yourself in the action. A similar process happens when you envision yourself as a character in a book: You can take on the emotions they are feeling. It may sound hooey hooey, but it's true: Fiction readers make great friends as they tend to be more aware of others' emotions. Copyright © Mic Network Inc.
By Anna North What is depression? Anyone who has dealt with the condition knows what it can feel like — but what causes it, what sustains it, and what’s the best way to make it subside? Despite the prevalence of the disorder — in one Centers for Disease Control and Prevention study, 9.1 percent of adults met the criteria for depression — experts haven’t fully answered these questions. And to fully do so, some say we need new ways of thinking about depression entirely. For Turhan Canli, a professor of integrative neuroscience at Stony Brook University, that means looking at the possibility that depression could be caused by an infection. “I’ve always been struck by the fact that the treatment options did not seem to have dramatically improved over the course of decades,” Dr. Canli told Op-Talk. “I always had a feeling that somehow we seem to be missing the actual treatment of the disease.” He was intrigued by research showing a connection between depression and inflammation in the body, and he started to think about the known causes of inflammation — among them pathogens like bacteria, viruses and parasites. In a paper published in the journal Biology of Mood and Anxiety Disorders, he lays out his case for rethinking depression as a response to infection. He notes that the symptoms of depression are similar to those of infection: “Patients experience loss of energy; they commonly have difficulty getting out of bed and lose interest in the world around them. Although our Western conceptualization puts affective symptoms front-and-center, non-Western patients who meet DSM criteria for major depression report primarily somatic symptoms.” © 2014 The New York Times Company
by Bethany Brookshire We all experience stress, but some handle it better than others. A lot of research has focused on what makes animals and people susceptible to stress and how that, in turn, can trigger depression. It makes sense to study the condition, not the people that don’t experience it. Depression and susceptibility are the broken state. Resilience seems normal by comparison. But resilience is not just the absence of susceptibility. It turns out that a protein called beta-catenin plays an active role in resilience. A new study, from Eric Nestler’s laboratory at the Mount Sinai School of Medicine in New York City, also identifies a large number of new targets that could help scientists understand why some people are susceptible to stress — and how they might be made more resilient. “When people study stress responses, we often just assume that in an animal that’s stressed, there’s an active process that creates these depression-like behaviors,” says Andre Der-Avakian, a neuroscientist at the University of California, San Diego. “But this study and studies from others have shown that resilience is also an active process.” The nucleus accumbens is an area of the brain most often linked with reward and pleasure from items we enjoy, such as food or drugs. But the area also shows changes in people with depression. “It makes sense — here’s a region important in responding to rewards,” Nestler explains. “One of the symptoms of people with depression is that they don’t derive pleasure from things in life.” © Society for Science & the Public 2000 - 2014