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By ANDREW POLLACK An experimental drug for Alzheimer’s disease sharply slowed the decline in mental function in a small clinical trial, researchers reported Friday, reviving hopes for an approach to therapy that until now has experienced repeated failures. The drug, being developed by Biogen Idec, could achieve sales of billions of dollars a year if the results from the small trial are replicated in larger trials that Biogen said it hoped to begin this year. Experts say that there are no really good drugs now to treat Alzheimer’s. Biogen’s stock has risen about 50 percent since early December, when the company first announced that the drug had slowed cognitive decline in the trial, without saying by how much. Analysts and investors had been eagerly awaiting the detailed results, some of them flying to France to hear Biogen researchers present them at a neurology meeting on Friday. The drug, called aducanumab, met and in some cases greatly exceeded Wall Street expectations in terms of how much the highest dose slowed cognitive decline. However, there was a high incidence of a particular side effect that might make it difficult to use the highest dose. Still, the net impression was positive. “Out-of-the-ballpark efficacy, acceptable safety,” Ravi Mehrotra, an analyst at Credit Suisse, wrote on Friday. Shares of Biogen rose $42.33, or 10 percent, to $475.98. Alzheimer’s specialists were impressed, but they cautioned that it was difficult to read much from a small early-stage, or Phase 1, trial that was designed to look at safety, not the effect on cognition. Also, other Alzheimer’s drugs that had looked promising in early studies ended up not working in larger trials. “It’s certainly encouraging,” said Dr. Samuel Gandy, director of the Center for Cognitive Health at Mount Sinai Hospital in New York, who was not involved in the study. He said the effect of the highest dose was “pretty impressive.” © 2015 The New York Times Company
Link ID: 20709 - Posted: 03.21.2015
by Emiko Jozuka Touch, says David J. Linden, is something we take for granted. "It's very hard to imagine it gone," he tells WIRED.co.uk. "You can imagine what it's like to be blind or deaf, or have no sense of smell, but there's no way to turn off touch". Touch might not be an obvious starting point for Linden, who is a professor of neuroscience at the John Hopkins University, studying learning and memory. But according to the professor, "the story of the neuroscience underlying touch has yet to be told". Pointing to the advances made in touch research over the last 20 years, Linden tells us that his own interest in the topic was sparked over lunch by colleagues working in the School of Medicine. Making the complex links between the brain and our sense of touch accessible to a wider audience is no easy feat. Yet in his recent book entitled, Touch: The Science of Hand, Heart, and Mind, Linden offers anecdotal and factual ways in to exploring different aspects of touch, whether that be in the form of pain, itches, hot and cold sensations or caresses. "We think of touch as being a one sense modality, but it's many different sensors in the skin acting in parallel," says Linden. He explains how the information in the form of, for example, an itch, pain or caress relays to the brain, dividing them into either discriminative or emotional forms of touch. The discriminative touch allows a person to understand where the body is being touched, or to understand if an object is textured, smooth or 3D. While emotional touch is what makes pain feel emotionally negative, or an orgasm feel positive, says Linden.
Keyword: Pain & Touch
Link ID: 20708 - Posted: 03.21.2015
By JENEEN INTERLANDI Nyiregyhaza (pronounced NEAR-re-cha-za) is a medium-size city tucked into the northeastern corner of Hungary, about 60 miles from the Ukrainian border. It has a world-class zoo, several museums and universities and a new Lego Factory. It also has two Roma settlements, or “Gypsy ghettos.” The larger of these settlements is Gusev, a crumbling 19th-century military barracks separated from the city proper by a railway station and a partly defunct industrial zone. Gusev is home to more than 1,000 Roma. Its chief amenities include a small grocery store and a playground equipped with a lone seesaw and a swingless swing set. There’s also a freshly painted elementary school, where approximately 60 students are currently enrolled. Almost all those students are Roma and almost all of them live in Gusev. Officially, most of the schools in Nyiregyhaza are integrated. Roma students have access to the same facilities as non-Roma students, and the ethnic balance of any given facility largely reflects the ethnic balance of the neighborhoods it serves. In practice, things are muddier. While many families in Gusev have been assigned to perfectly reputable schools, there is no busing program, and most schools are not within walking distance. For families living on just 60,000 forints ($205) a month, the schools are also too expensive to reach by public transit. “Everything is fine on paper,” Adel Kegye, an attorney with the Chance for Children Foundation (C.F.C.F.), told me when I visited Hungary this past fall. “But in reality, they make it very hard for the Roma to go anywhere but the settlement school.” ..... In the past two decades, with the advent of f.M.R.I. technology, neuroscientists also began to tackle such questions. Emile Bruneau, a cognitive neuroscientist at the Massachusetts Institute of Technology, has spent the past seven years studying intractable conflicts around the world. © 2015 The New York Times Company
Christian Jarrett November 2013, I proudly launched the Brain Watch blog here at WIRED. This will be my final post. For seventeen months I’ve used the blog to report on new neuroscience findings, to reflect on how neuroscience is influencing the public and media, to investigate the claims of brain products, to explore neurological abnormality and death, and to debunk misconceptions about the brain. I loved reading your comments and I was thrilled when I found my ideas from here quoted in other publications. It’s been a lot of fun. Here’s some of what I learned: Brain myths die hard When the movie Lucy came out last year, it provided me an opportunity to challenge the 10% brain myth and explore its origins (the idea we only use 10% of our brains is a premise of the film). With such tired myths, it’s easy to wonder if anybody believes them anymore. Writing this blog, I learned not to underestimate their staying power! Consider the vitriol my 10% post attracted from a neuroscience grad student at Yale. In an email dripping with disdain she told me “You … should feel ashamed for releasing such a misinformed article. … There are misinformed and uneducated people all over the internet trying to disprove this 10% notion, but that is expected. This is certainly NOT something I expected from someone allegedly as well educated as yourself.” Brain science is confusing and complicated Hardly a revelation, you might say. But writing this blog brought home to me the messy reality of neuroscience. Consider how tabloid papers like dividing the world into those activities and technologies that cause brain shrinkage and those that cause brain growth – the implicit assumption always being that growth is good and shrinkage bad.
Link ID: 20706 - Posted: 03.21.2015
by Michael Slezak What were we talking about? Oh yes, brain-training programmes may be useful for helping inattentive people focus on tasks in their daily life. At least, that's the implication of an analysis looking at one particular programme. It's the latest salvo in a field that has seen the battles lines drawn between those who believe there is no compelling scientific evidence that training the brain to do a specific task better can offer wider cognitive improvements, and those that think it can work in some cases. The party line is that brain training improves only that which it exercises, says Jared Horvath from the University of Melbourne in Australia. "What this means is, if the training programme uses a working memory game, you get better at working memory games and little else." But an analysis by Megan Spencer-Smith of Monash University in Melbourne, Australia, and Torkel Klingberg at the Karolinska Institute in Stockholm, Sweden, claims to show that there are benefits for daily life – at least for people with attention deficit hyperactivity disorder or other problems related to attentiveness. They focused on a programme called Cogmed, which Klingberg has helped develop, and combined the results of several smaller studies. Cogmed is designed to improve how much verbal or visual information you can temporarily remember and work with. © Copyright Reed Business Information Ltd.
By Martin Enserink The Human Brain Project (HBP) has listened to the critics, the reviewers, and the mediators. At a meeting in Paris, the board of directors of the €1 billion project yesterday approved a series of recommendations for reform, proposed by a mediation committee, which will change both HBP’s governance and its research program. Critics of the troubled project welcome the move. “We are absolutely delighted that the board has adopted these recommendations,” says computational neuroscientist Peter Dayan of University College London, one of the hundreds of researchers who signed an open letter last year calling for a major reorganization of HBP. Dayan was a member of the mediation committee charged with finding a way out of the crisis after the publication of the letter. That panel’s report—a summary of which was released on 10 March—roundly acknowledges that the critics were right. The committee “largely supports and emphasizes the critique voiced by parts of the scientific community regarding objectives, scientific approach, governance and management practices,” the report says. The mediation committee said that HBP, now administered by the Swiss Federal Institute of Technology in Lausanne (EPFL), should be run by a new, international entity. “In a first concrete step towards implementing that vision, the board [of directors] has created a governance working group composed of former or current heads of international scientific organisations,” an HBP press release issued today said. (They include CERN, the European Space Agency, and the European Molecular Biology Laboratory.) © 2015 American Association for the Advancement of Science
Keyword: Brain imaging
Link ID: 20704 - Posted: 03.21.2015
Elie Dolgin The southern city of Guangzhou has long held the largest eye hospital in China. But about five years ago, it became clear that the Zhongshan Ophthalmic Center needed to expand. More and more children were arriving with the blurry distance vision caused by myopia, and with so many needing eye tests and glasses, the hospital was bursting at the seams. So the centre began adding new testing rooms — and to make space, it relocated some of its doctors and researchers to a local shopping mall. Now during the summer and winter school holidays, when most diagnoses are made, “thousands and thousands of children” pour in every day, says ophthalmologist Nathan Congdon, who was one of those uprooted. “You literally can't walk through the halls because of all the children.” East Asia has been gripped by an unprecedented rise in myopia, also known as short-sightedness. Sixty years ago, 10–20% of the Chinese population was short-sighted. Today, up to 90% of teenagers and young adults are. In Seoul, a whopping 96.5% of 19-year-old men are short-sighted. Other parts of the world have also seen a dramatic increase in the condition, which now affects around half of young adults in the United States and Europe — double the prevalence of half a century ago. By some estimates, one-third of the world's population — 2.5 billion people — could be affected by short-sightedness by the end of this decade. “We are going down the path of having a myopia epidemic,” says Padmaja Sankaridurg, head of the myopia programme at the Brien Holden Vision Institute in Sydney, Australia. The condition is more than an inconvenience. Glasses, contact lenses and surgery can help to correct it, but they do not address the underlying defect: a slightly elongated eyeball, which means that the lens focuses light from far objects slightly in front of the retina, rather than directly on it. © 2015 Nature Publishing Group
Michaeleen Doucleff Malaria is one of the oldest scourges of mankind. Yet it's been a mystery how the deadliest form of the disease kills children. One doctor in Michigan has dedicated her life to figuring that out. Now she and her team report their findings in this week's issue of the New England Journal of Medicine. The key to solving the mystery was looking inside the brain. Most of the time malaria causes a bad fever and body aches. But in rare cases — often in children — the parasite gets stuck in the capillaries of the brain. The child has a seizure, goes into a coma and can die. This all happens in only two or three days, says Dr. Terrie Taylor of Michigan State University. "These are bright, happy children who are suddenly felled by a disease that quickly renders them unconscious. And quickly kills them. It's a catastrophe." The sudden death of a child devastates not just the family but the whole community, Taylor says: "Imagine the ripple effects on their friends and their siblings. Suddenly their friends are gone. Just gone." Since 1986, Taylor has been treating children with severe malaria at Queen Elizabeth Central Hospital in Blantyre, Malawi. Seeing so many families deal with these huge losses, year after year, made Taylor focus her career on one goal: Figuring out why some children die from cerebral malaria but others soon recover. © 2015 NPR
Keyword: Development of the Brain
Link ID: 20702 - Posted: 03.19.2015
|By Erez Ribak and The Conversation UK The human eye is optimised to have good colour vision at day and high sensitivity at night. But until recently it seemed as if the cells in the retina were wired the wrong way round, with light travelling through a mass of neurons before it reaches the light-detecting rod and cone cells. New research presented at a meeting of the American Physical Society has uncovered a remarkable vision-enhancing function for this puzzling structure. About a century ago, the fine structure of the retina was discovered. The retina is the light-sensitive part of the eye, lining the inside of the eyeball. The back of the retina contains cones to sense the colours red, green and blue. Spread among the cones are rods, which are much more light-sensitive than cones, but which are colour-blind. Before arriving at the cones and rods, light must traverse the full thickness of the retina, with its layers of neurons and cell nuclei. These neurons process the image information and transmit it to the brain, but until recently it has not been clear why these cells lie in front of the cones and rods, not behind them. This is a long-standing puzzle, even more so since the same structure, of neurons before light detectors, exists in all vertebrates, showing evolutionary stability. Researchers in Leipzig found that glial cells, which also span the retinal depth and connect to the cones, have an interesting attribute. These cells are essential for metabolism, but they are also denser than other cells in the retina. In the transparent retina, this higher density (and corresponding refractive index) means that glial cells can guide light, just like fibre-optic cables. © 2015 Scientific American
By Nicholas Weiler Where did the thief go? You might get a more accurate answer if you ask the question in German. How did she get away? Now you might want to switch to English. Speakers of the two languages put different emphasis on actions and their consequences, influencing the way they think about the world, according to a new study. The work also finds that bilinguals may get the best of both worldviews, as their thinking can be more flexible. Cognitive scientists have debated whether your native language shapes how you think since the 1940s. The idea has seen a revival in recent decades, as a growing number of studies suggested that language can prompt speakers to pay attention to certain features of the world. Russian speakers are faster to distinguish shades of blue than English speakers, for example. And Japanese speakers tend to group objects by material rather than shape, whereas Koreans focus on how tightly objects fit together. Still, skeptics argue that such results are laboratory artifacts, or at best reflect cultural differences between speakers that are unrelated to language. In the new study, researchers turned to people who speak multiple languages. By studying bilinguals, “we’re taking that classic debate and turning it on its head,” says psycholinguist Panos Athanasopoulos of Lancaster University in the United Kingdom. Rather than ask whether speakers of different languages have different minds, he says, “we ask, ‘Can two different minds exist within one person?’ ” Athanasopoulos and colleagues were interested in a particular difference in how English and German speakers treat events. © 2015 American Association for the Advancement of Science
A long-term study has pointed to a link between breastfeeding and intelligence. The research in Brazil traced nearly 3,500 babies, from all walks of life, and found those who had been breastfed for longer went on to score higher on IQ tests as adults. Experts say the results, while not conclusive, appear to back current advice that babies should be exclusively breastfed for six months. But they say mothers should still have a choice about whether or not to do it. Regarding the findings - published in The Lancet Global Health - they stress there are many different factors other than breastfeeding that could have an impact on intelligence, although the researchers did try to rule out the main confounders, such as mother's education, family income and birth weight. Dr Bernardo Lessa Horta, from the Federal University of Pelotas in Brazil, said his study offers a unique insight because in the population he studied, breastfeeding was evenly distributed across social class - not something just practised by the rich and educated. Most of the babies, irrespective of social class, were breastfed - some for less than a month and others for more than a year. Those who were breastfed for longer scored higher on measures of intelligence as adults. They were also more likely to earn a higher wage and to have completed more schooling. Dr Horta believes breast milk may offer an advantage because it is a good source of long-chain saturated fatty acids which are essential for brain development. But experts say the study findings cannot confirm this and that much more research is needed to explore any possible link between breastfeeding and intelligence. © 2015 BBC.
Jane Brody The Holy Grail in any progressive disease is to find it early enough to start effective treatment before irreversible damage has occurred. For Parkinson’s disease, which afflicts 1.5 million Americans and growing, a new study has brought this goal a little closer. The study, conducted among more than 54,000 British men and women, identified a slew of symptoms that were more likely to be present in people who years later were diagnosed with Parkinson’s. The findings underscore the prevailing view among neurologists that the damage caused by this disease begins long before classic symptoms like tremors, rigidity and an unsteady gait develop and a definite diagnosis can be made. The study, by Dr. Anette Schrag and fellow neurologists at the University College London, was published in The Lancet in January. As many as five years before a diagnosis of Parkinson’s, those who developed it were more likely to have experienced tremor, balance problems, constipation, low blood pressure, dizziness, erectile and urinary dysfunction, fatigue, depression and anxiety. In addition, Dr. Claire Henchcliffe, director of the Parkinson’s Disease and Movement Disorders Institute at Weill Cornell Medical Center, said that REM sleep behavior disorder, characterized by a tendency to act out one’s dreams while asleep, is one of the strongest prediagnostic symptoms, along with a lost sense of smell and subtle changes in cognition. Dr. Melissa J. Nirenberg, a Parkinson’s disease specialist at New York University Medical Center, said, “Up to 80 percent of people with the sleep disorder get Parkinson’s or a similar neurodegenerative disease.” © 2015 The New York Times Company
Jon Hamilton Since his birth 33 years ago, Jonathan Keleher has been living without a cerebellum, a structure that usually contains about half the brain's neurons. This exceedingly rare condition has left Jonathan with a distinctive way of speaking and a walk that is slightly awkward. He also lacks the balance to ride a bicycle. But all that hasn't kept him from living on his own, holding down an office job and charming pretty much every person he meets. "I've always been more into people than anything else," Jonathan tells me when I meet him at his parents' house in Concord, Mass., a suburb of Boston. "Why read a book or why do anything when you can be social and talk to people?" Jonathan is also making an important contribution to neuroscience. By allowing scientists to study him and his brain, he is helping to change some long-held misconceptions about what the cerebellum does. And that, in turn, could help the hundreds of thousands of people whose cerebellums have been damaged by a stroke, infection or disease. For decades, the cerebellum has been the "Rodney Dangerfield of the brain," says Dr. Jeremy Schmahmann, a professor of neurology at Harvard and Massachusetts General Hospital. It gets no respect because most scientists only know about its role in balance and fine motor control. © 2015 NPR
Jon Hamilton A new understanding of the brain's cerebellum could lead to new treatments for people with problems caused by some strokes, autism and even schizophrenia. That's because there's growing evidence that symptoms ranging from difficulty with abstract thinking to emotional instability to psychosis all have links to the cerebellum, says Jeremy Schmahmann, a professor of neurology at Harvard and Massachusetts General Hospital. "The cerebellum has all these functions we were previously unaware of," Schmahmann says. Scientists once thought the cerebellum's role was limited to balance and coordinating physical movements. In the past couple of decades, though, there has been growing evidence that it also plays a role in thinking and emotions. As described in an earlier post, some of the most compelling evidence has come from people like Jonathan Keleher, people born without a cerebellum. "I'm good at routine (activities) and (meeting) people," says Keleher, who is 33. He also has good long-term memory. What he's not good at is strategizing and abstract thinking. But remarkably, Keleher's abilities in these areas have improved dramatically over time. "I'm always working on how to better myself," he says. "And it's a continuous struggle." © 2015 NPR
By PAM BELLUCK What happens to forgotten memories — old computer passwords, friends’ previous phone numbers? Scientists have long held two different theories. One is that memories do not diminish but simply get overshadowed by new memories. The other is that older memories become weaker, that pulling to mind new passwords or phone numbers degrades old recollections so they do not interfere. The difference could be significant. If old memories stay strong and are merely papered over by new ones, they may be easier to recover. That could be positive for someone trying to remember an acquaintance’s name, but difficult for someone trying to lessen memories of abuse. It could suggest different strategies for easing traumatic memories, evaluating witness testimony about crimes, or helping students study for tests. Now, a study claims to provide evidence of memory’s weakening by showing that people’s ability to remember something and the pattern of brain activity that thing generates both appear to diminish when a competing memory gets stronger. Demonstrating sophisticated use of brain scans in memory research, authors of the study, published Monday in the journal Nature Neuroscience, appear to have identified neural fingerprints of specific memories, distinguishing brain activity patterns produced when viewing a picture of a necklace, say, from a picture of binoculars or other objects. The experiment, conducted by scientists in Birmingham and Cambridge, England, involved several stages with 24 participants first trained to associate words to two unrelated black and white pictures from lists of famous people, ordinary objects or scenes. © 2015 The New York Times Company
Keyword: Learning & Memory
Link ID: 20695 - Posted: 03.17.2015
Brian Owens Our choice between two moral options might be swayed by tracking our gaze, and asking for a decision at the right moment. People asked to choose between two written moral statements tend to glance more often towards the option they favour, experimental psychologists say. More surprisingly, the scientists also claim it’s possible to influence a moral choice: asking for an immediate decision as soon as someone happens to gaze at one statement primes them to choose that option. It’s well known that people tend to look more towards the option they are going to choose when they are choosing food from a menu, says Philip Pärnamets, a cognitive scientist from Lund University in Sweden. He wanted to see if that applied to moral reasoning as well. “Moral decisions have long been considered separately from general decision-making,” he says. “I wanted to integrate them.” In a paper published today in the Proceedings of the National Academy of Sciences1, Pärnamets and his colleagues explain how they presented volunteers with a series of moral statements, such as 'murder is sometimes justified,' 'masturbating with the aid of a willing animal is acceptable' and 'paying taxes is a good thing.' Then the psychologists tracked the volunteers’ gaze as two options appeared on a screen. Once the tracker had determined that a person had spent at least 750 milliseconds looking at one answer and 250 milliseconds at the other, the screen changed to prompt them to make a decision. Almost 60% of the time, they chose the most viewed option — indicating, says Pärnamets, that eye gaze tracks an unfolding moral decision. © 2015 Nature Publishing Group,
By BENEDICT CAREY Behind all those canned compliments for older adults — spry! wily! wise! — is an appreciation for something that scientists have had a hard time characterizing: mental faculties that improve with age. Knowledge is a large part of the equation, of course. People who are middle-aged and older tend to know more than young adults, by virtue of having been around longer, and score higher on vocabulary tests, crossword puzzles and other measures of so-called crystallized intelligence. Still, young adults who consult their elders (mostly when desperate) don’t do so just to gather facts, solve crosswords or borrow a credit card. Nor, generally, are they looking for help with short-term memory or puzzle solving. Those abilities, called fluid intelligence, peak in the 20s. No, the older brain offers something more, according to a new paper in the journal Psychological Science. Elements of social judgment and short-term memory, important pieces of the cognitive puzzle, may peak later in life than previously thought. The postdoctoral fellows Joshua Hartshorne of M.I.T. and Laura Germine of Harvard and Massachusetts General Hospital analyzed a huge trove of scores on cognitive tests taken by people of all ages. The researchers found that the broad split in age-related cognition — fluid in the young, crystallized in the old — masked several important nuances. “This dichotomy between early peaks and later peaks is way too coarse,” Dr. Hartshorne said. “There are a lot more patterns going on, and we need to take those into account to fully understand the effects of age on cognition.” The new paper is hardly the first challenge to the scientific literature on age-related decline, and it won’t be the last. A year ago, German scientists argued that cognitive “deficits” in aging were caused largely by the accumulation of knowledge — that is, the brain slows down because it has to search a larger mental library of facts. That idea has stirred some debate among scientists. Experts said the new analysis raised a different question: Are there distinct, independent elements of memory and cognition that peak at varying times of life? © 2015 The New York Times Company
By Camilla Turner It is one of life’s most enduring mysteries. A question that music, poetry, myth and legend has, for thousands of years, tried but failed to answer. However, we may now be a step closer to discovering what love is, thanks to a scientific study that has obtained the first empirical evidence of love-related alterations in the brain. A team of researchers from universities in China and New York used MRI scans to track the physical effects of love on the brain and has pieced together a “love map” of the human mind. The study found that several areas of the brain showed increased activity in those who were in love, including in the parts of the brain linked to reward and motivation. The researchers said their results shed light on the “underlying mechanisms of romantic love” and would pave the way for a brain scan that could act as a “love test”. Scientists recruited 100 students from Southwest University in Chongqing, China, who were divided into three groups according to their relationship status: an “in-love” group, comprised of those who were in love at the time; an “ended-love” group, who had recently ended loving relationships; and a “single” group, who had never been in love. Participants were told not to think of anything while their brains were scanned, so that researchers could monitor the differences between the brains of students in all three groups. © Copyright of Telegraph Media Group Limited 2015
Keyword: Sexual Behavior
Link ID: 20692 - Posted: 03.17.2015
By RENEE ENGELN ON Tuesday, in the wake of an online petition signed by thousands of people, Facebook announced that it was removing “feeling fat” from its list of status update emoticons. The petition argued that the offending emoticon, with its chubby cheeks and double chin, reinforced negative body images, and Facebook seemed to agree. Is it really such a big deal if you tell everyone how fat you feel? After all, a simple “I’m so fat!” can result in a chorus of empathetic voices, saying, “Me, too!” or “You’re beautiful just the way you are!” And that will help you feel better, and help others feel better, too — right? Wrong. As someone who studies this type of public body self-disparagement, known as “fat talk,” I can say that it probably will make you feel worse. And it may drag down other people with you. Conversational shaming of the body has become practically a ritual of womanhood (though men also engage in it). In a survey that a colleague and I reported in 2011 in the Psychology of Women Quarterly, we found that more than 90 percent of college women reported engaging in fat talk — despite the fact that only 9 percent were actually overweight. In another survey, which we published in December in the Journal of Health Psychology, we canvassed thousands of women ranging in age from 16 to 70. Contrary to the stereotype of fat talk as a young woman’s practice, we found that fat talk was common across all ages and all body sizes. Most important, fat talk is not a harmless social-bonding ritual. According to an analysis of several studies that my colleagues and I published in 2012 in the Psychology of Women Quarterly, fat talk was linked with body shame, body dissatisfaction and eating-disordered behavior. Fat talk does not motivate women to make healthier choices or take care of their bodies; in fact, the feelings of shame it brings about tend to encourage the opposite. © 2015 The New York Times Company
Keyword: Anorexia & Bulimia
Link ID: 20691 - Posted: 03.17.2015
By Emily Underwood Deep brain stimulation, which now involves surgically inserting electrodes several inches into a person's brain and connecting them to a power source outside the skull, can be an extremely effective treatment for disorders such as Parkinson's disease, obsessive compulsive disorder, and depression. The expensive, invasive procedure doesn't always work, however, and can be risky. Now, a study in mice points to a less invasive way to massage neuronal activity, by injecting metal nanoparticles into the brain and controlling them with magnetic fields. Major technical challenges must be overcome before the approach can be tested in humans, but the technique could eventually provide a wireless, nonsurgical alternative to traditional deep brain stimulation surgery, researchers say. "The approach is very innovative and clever," says Antonio Sastre, a program director in the Division of Applied Science & Technology at the National Institute of Biomedical Imaging and Bioengineering in Bethesda, Maryland. The new work provides "a proof of principle." The inspiration to use magnets to control brain activity in mice first struck materials scientist Polina Anikeeva while working in the lab of neuroscientist-engineer Karl Deisseroth at Stanford University in Palo Alto, California. At the time, Deisseroth and colleagues were refining optogenetics, a tool that can switch specific ensembles of neurons on and off in animals with beams of light. © 2015 American Association for the Advancement of Science.
Keyword: Brain imaging
Link ID: 20690 - Posted: 03.14.2015