Chapter 16. Psychopathology: Biological Basis of Behavior Disorders

Follow us on Facebook and Twitter, or subscribe to our mailing list, to receive news updates. Learn more.


Links 41 - 60 of 2078

By MICHAEL M. PHILLIPS Roman Tritz’s memories of the past six decades are blurred by age and delusion. But one thing he remembers clearly is the fight he put up the day the orderlies came for him. “They got the notion they were going to come to give me a lobotomy,” says Mr. Tritz, a World War II bomber pilot. “To hell with them.” The orderlies at the veterans hospital pinned Mr. Tritz to the floor, he recalls. He fought so hard that eventually they gave up. But the orderlies came for him again on Wednesday, July 1, 1953, a few weeks before his 30th birthday. This time, the doctors got their way. The U.S. government lobotomized roughly 2,000 mentally ill veterans—and likely hundreds more—during and after World War II, according to a cache of forgotten memos, letters and government reports unearthed by The Wall Street Journal. Besieged by psychologically damaged troops returning from the battlefields of North Africa, Europe and the Pacific, the Veterans Administration performed the brain-altering operation on former servicemen it diagnosed as depressives, psychotics and schizophrenics, and occasionally on people identified as homosexuals. The VA doctors considered themselves conservative in using lobotomy. Nevertheless, desperate for effective psychiatric treatments, they carried out the surgery at VA hospitals spanning the country, from Oregon to Massachusetts, Alabama to South Dakota. The VA’s practice, described in depth here for the first time, sometimes brought veterans relief from their inner demons. Often, however, the surgery left them little more than overgrown children, unable to care for themselves. Many suffered seizures, amnesia and loss of motor skills. Some died from the operation itself. Mr. Tritz, 90 years old, is one of the few still alive to describe the experience. “It isn’t so good up here,” he says, rubbing the two shallow divots on the sides of his forehead, bracketing wisps of white hair.

Keyword: Schizophrenia; Aggression
Link ID: 19083 - Posted: 12.31.2013

Imagine this: Every day, you can feel people looking at you warily. They want to hurt you. Even the police are out to get you. You try to rid your mind of all the ill-intentioned people, but you can't ignore the other thing that is gnawing at you. Those bugs on your arm won't leave you alone, no matter how often you gouge at them. Such are the hallucinations and paranoia felt by those with a stimulant drug addiction. Sometimes the substance abuse is so severe it causes neurological damage and psychosis becomes a chronic condition. Combine untreated addiction with homelessness and physical health problems, and you get a health emergency. Vancouver police and the region's health authorities are desperately trying to figure out how to help the most vulnerable of mentally ill drug addicts. The province estimates that roughly 130,000 people in British Columbia suffer from a severe addiction and/or mental health illness. But police and emergency workers are increasingly dealing with a much smaller group of people whose brains have been damaged by their stimulant addiction and who appear to be responsible for random violent acts on Vancouver's streets. Dr. Nader Sharifi, addiction medicine lead with the Fraser Health Authority, said there are few good treatment options for those people. "It's a bit of a challenging question, because what we have available isn't necessarily structured for this patient sub-type. It's either structured for addiction, or structured for mental health illness, but not necessarily the two together." © CBC 2013

Keyword: Schizophrenia; Aggression
Link ID: 19075 - Posted: 12.28.2013

By JULIE CRESWELL RALEIGH, N.C. — As darkness fell on a Friday evening over downtown Raleigh, N.C., Michael Lyons, a paramedic supervisor for Wake County Emergency Medical Services, slowly approached the tall, lanky man who was swaying back and forth in a gentle rhythm. In answer to Mr. Lyons’s questions, the man, wearing a red shirt that dwarfed his thin frame, said he was bipolar, schizophrenic and homeless. He was looking for help because he did not think his prescribed medication was working. In the past, paramedics would have taken the man to the closest hospital emergency room — most likely the nearby WakeMed Health and Hospitals, one of the largest centers in the region. But instead, under a pilot program, paramedics ushered him through the doors of Holly Hill Hospital, a commercial psychiatric facility. “He doesn’t have a medical complaint, he’s just a mental health patient living on the street who is looking for some help,” said Mr. Lyons, pulling his van back into traffic. “The good news is that he’s not going to an E.R. That’s saving the hospital money and getting the patient to the most appropriate place for him,” he added. The experiment in Raleigh is being closely watched by other cities desperate to find a way to help mentally ill patients without admitting them to emergency rooms, where the cost of treatment is high — and unnecessary. While there is evidence that other types of health care costs might be declining slightly, the cost of emergency room care for the mentally ill shows no sign of ebbing. Nationally, more than 6.4 million visits to emergency rooms in 2010, or about 5 percent of total visits, involved patients whose primary diagnosis was a mental health condition or substance abuse. That is up 28 percent from just four years earlier, according to the latest figures available from the Agency for Healthcare Research and Quality in Rockville, Md. By one federal estimate, spending by general hospitals to care for these patients is expected to nearly double to $38.5 billion in 2014, from $20.3 billion in 2003. © 2013 The New York Times Company

Keyword: Schizophrenia
Link ID: 19071 - Posted: 12.27.2013

By Sandra G. Boodman, Bebe Bahnsen remembers the night, alone in her small cottage on the Alabama coast, that she felt a strong urge to drink a can of drain cleaner. For years, antidepressants combined with talk therapy had enabled Bahnsen, whose first name is Beatrice, to function well, establishing a thriving public relations business in Washington followed by a career as a newspaper reporter. But those days had been supplanted by a prolonged suicidal depression that had proved impervious to electroshock treatments, periodic hospitalizations and a raft of psychiatric drugs. The phone call in which Bahnsen confided her desire to drink poison seemed to confirm the worst fears of one of her closest friends. “I figured, well, she was one of those people who just was not ever going to get better,” said Paddy Bowman, a folklore specialist who lives in Alexandria. Bahnsen, now 73, traces the beginning of her psychological slide to the mid-1990s, when she decided that, after two decades, she’d had enough of Washington. She moved back to her home state of Georgia and her life slowly began to unravel. She felt estranged from her large and devoted circle of friends, began having problems at work, and grew restless and increasingly depressed. “I felt as though I was on a large island and everyone was slowly moving away and I was there by myself,” Bahnsen recalled. For the first time in her life, she said, she was intermittently psychotic. Periodic suicide attempts, some involving overdoses of prescribed sleeping pills, landed her in a series of mental hospitals. In November 2006 she was hospitalized in Las Vegas, where she was then living with one of her sons. Doctors, baffled by her longstanding failure to improve, decided to take a closer look at her case. What they found resulted in an entirely different treatment, one that had a rapid and dramatic effect on her mental state. © 1996-2013 The Washington Post

Keyword: Depression; Aggression
Link ID: 19069 - Posted: 12.24.2013

By RICHARD A. FRIEDMAN, M.D. When will we ever get depression under control? Of all the major illnesses, mental or physical, depression has been one of the toughest to subdue. Despite the ubiquity of antidepressant drugs — there are now 26 to choose from — only a third of patients with major depression will experience a full remission after the first round of treatment, and successive treatments with different drugs will give some relief to just 20 to 25 percent more. About 30 percent of people with depression have some degree of treatment resistance. And the greater the degree of resistance, the more likely a future relapse, even if the patient continues taking the drug. Although we have learned much about depression — for example, the recent research showing that the successful treatment of insomnia in depressed patients essentially doubles their response to a drug like Prozac — we still don’t understand its fundamental cause. The old idea that the disease results from a deficiency of a single neurotransmitter like serotonin or dopamine is clearly simplistic and wrong. Maybe psychiatrists and neuroscientists have something to learn from the successful hunt for the Higgs boson. Of course a debilitating disease has nothing in common with a subatomic particle, except that both are mysterious and elusive. But it was those very qualities that inspired international teams of physicists to work together for years until they finally identified the boson last year. Among biomedical scientists, who compete for the same research dollars and want to be first across the finish line with an important finding, such cooperation is hardly the norm. But there are signs that this is changing. Not long ago, I sat in at a meeting of the Hope for Depression Research Foundation. Audrey Gruss, the knowledgeable and energetic philanthropist who started the foundation, has corralled a group of senior basic and clinical neuroscientists to look for solutions. (It is not the first to try a collaborative approach; others are being sponsored by the MacArthur Foundation and the Pritzker Consortium.) Copyright 2013 The New York Times Company

Keyword: Depression
Link ID: 19068 - Posted: 12.24.2013

By MICHAEL LUO and MIKE McINTIRE Last April, workers at Middlesex Hospital in Connecticut called the police to report that a psychiatric patient named Mark Russo had threatened to shoot his mother if officers tried to take the 18 rifles and shotguns he kept at her house. Mr. Russo, who was off his medication for paranoid schizophrenia, also talked about the recent elementary school massacre in Newtown and told a nurse that he “could take a chair and kill you or bash your head in between the eyes,” court records show. The police seized the firearms, as well as seven high-capacity magazines, but Mr. Russo, 55, was eventually allowed to return to the trailer in Middletown where he lives alone. In an interview there recently, he denied that he had schizophrenia but said he was taking his medication now — though only “the smallest dose,” because he is forced to. His hospitalization, he explained, stemmed from a misunderstanding: Seeking a message from God on whether to dissociate himself from his family, he had stabbed a basketball and waited for it to reinflate itself. When it did, he told relatives they would not be seeing him again, prompting them to call the police. As for his guns, Mr. Russo is scheduled to get them back in the spring, as mandated by Connecticut law. “I don’t think they ever should have been taken out of my house,” he said. “I plan to get all my guns and ammo and knives back in April.” The Russo case highlights a central, unresolved issue in the debate over balancing public safety and the Second Amendment right to bear arms: just how powerless law enforcement can be when it comes to keeping firearms out of the hands of people who are mentally ill. Connecticut’s law giving the police broad leeway to seize and hold guns for up to a year is actually relatively strict. Most states simply adhere to the federal standard, banning gun possession only after someone is involuntarily committed to a psychiatric facility or designated as mentally ill or incompetent after a court proceeding or other formal legal process. Relatively few with mental health issues, even serious ones, reach this point. © 2013 The New York Times Company

Keyword: Aggression; Aggression
Link ID: 19064 - Posted: 12.23.2013

By Gary Stix Is sleep good for everything? Scientists hate giving unqualified answers. But the more sleep researchers look, the more the answer seems to be tending toward a resounding affirmative. The slumbering brain plays an essential role in learning and memory, one of the findings that sleep researchers have reinforced repeatedly in recent years. But that’s not all. There’s a growing recognition that sleep appears to be involved in regulating basic metabolic processes and even in mental health. Robert Stickgold, a leading sleep researcher based at Harvard Medical School, gives a précis here of the current state of sommeil as it relates to memory, schizophrenia, depression, diabetes—and he even explains what naps are good for. How far have we come in understanding sleep? Although we understood the function of every other basic drive 2,000 years ago, we are still struggling to figure out what the biological functions of sleep are. One of the clearest messages now is that for every two hours humans spend awake during the day, the brain needs an hour offline to process the information it takes in and figure out what to save and what to dump and how to file and what it all means. So what is sleep for? Memories are processed during sleep. But sleep doesn’t have just one function. It’s a little bit like listening to tongue researchers arguing about whether the function of the tongue has to do with taste or speech. And you want to say: ‘Guys, c’mon, it’s both.’ There’s very good evidence now that sleep, besides helping memory, has a role in immune and endocrine functions. There’s a lot of talk about to what extent the obesity epidemic is actually a consequence of too little sleep. © 2013 Scientific American

Keyword: Sleep; Aggression
Link ID: 19061 - Posted: 12.21.2013

Amanda Mascarelli In children with certain gene variants, symptoms similar to common learning disabilities could be omens of serious psychiatric conditions. People who carry high-risk genetic variants for schizophrenia and autism have impairments reminiscent of disorders such as dyslexia, even when they do not yet have a mental illness, a new study has found. The findings offer a window into the brain changes that precede severe mental illness and hold promise for early intervention and even prevention, researchers say. Rare genetic alterations called copy number variants (CNVs), in which certain segments of the genome have an abnormal number of copies, play an important part in psychiatric disorders: Individuals who carry certain CNVs have a several-fold increased risk of developing schizophrenia or autism1. But previous studies were based on individuals who already have a psychiatric disorder, and until now, no one had looked at what effects these CNVs have in the general population. In a study published today in Nature2, researchers report that people with these variants but no diagnosis of autism or a mental illness still show subtle brain changes and impairments in cognitive function. “In psychiatry we always have the problem that disorders are defined by symptoms that patients experience or tell us about, or that we observe,” says study co-author Andreas Meyer-Lindenberg, a psychiatrist and the director the Central Institute of Mental Health in Mannheim, Germany, affiliated with the University of Heidelberg. This work, on the other hand, provides a glimpse into the biological underpinnings of people who are at risk of psychiatric disorders, he says. The team searched a genealogical database of more than 100,000 Icelanders, focusing on 26 genetic variants that have been shown to increase the risk of schizophrenia or autism. They found that 1,178 people in the database, or 1.16% of the sample, carried one or more of these CNVs. © 2013 Nature Publishing Group

Keyword: Schizophrenia; Aggression
Link ID: 19053 - Posted: 12.19.2013

By John Chipman, CBC News Andrew Solomon is not your typical depressive, if such a thing exists. Most people struggling with clinical depression do not like to talk about it. Depression is usually suffered in silence, because of the stigma that still clings to it. Many people still see depression as a sign of weakness, or believe that if you just cheered up or had a better attitude you'd feel so much better. Solomon has heard the wrong-headed chatter most of his life. But rather than shy away, the journalist and best-selling author wrote a book about it, detailing his own struggles with depression. It’s called The Noonday Demon: An Atlas of Depression. And he has become a vocal advocate, calling for more progressive attitudes about the disease so that people suffering from it can step out of the shadows and feel comfortable getting the help they need to survive, and to thrive. So it was with some shock and dismay that Solomon learned about Ellen Richardson, a Canadian woman turned back at the U.S. border last month because she was hospitalized last year for her depression. Richardson was told she could only enter the U.S. if a doctor — not her own, but one from a shortlist of others whom she had never met — signed a document vouching for her. She would also have to pay a fee of $500. U.S. border guards are allowed to bar anyone they deem a threat to themselves, to other Americans, or their property. They have access to police records — including even uneventful encounters with officers — but medical records are supposed to be held in the strictest confidence. © CBC 2013

Keyword: Depression; Aggression
Link ID: 19038 - Posted: 12.16.2013

By ROBERT PEAR WASHINGTON — Psychiatrists are significantly less likely than doctors in other specialties to accept insurance, researchers say in a new study, complicating the push to increase access to mental health care. The study, published Wednesday in the journal JAMA Psychiatry, found that 55 percent of psychiatrists accepted private insurance, compared with 89 percent of other doctors. Likewise, the study said, 55 percent of psychiatrists accept patients covered by Medicare, against 86 percent of other doctors. And 43 percent of psychiatrists accept Medicaid, which provides coverage for low-income people, while 73 percent of other doctors do. The lead author of the study, Dr. Tara F. Bishop of Weill Cornell Medical College in New York, said: “In the wake of the school killings in Newtown, Conn., and other recent mass shootings, the need for increased mental health services is now recognized. But unless patients have deep pockets, they may have a hard time finding a psychiatrist who will treat them.” Mental health care is one of 10 types of “essential health benefits” that must be provided by insurers under the new health care law. A federal rule issued last month requires insurers to cover care for mental health and addiction on the same terms as treatments for physical illnesses, without charging higher co-payments or deductibles or imposing stricter limits on services. Starting next year, Medicare will end a discriminatory policy that for decades has required people to pay a larger share of the bill for mental health care than for other outpatient services. However, the study suggests that expanding coverage may not by itself guarantee access to psychiatrists. “Even if you have good insurance that covers mental health care, you may still have a problem if there’s no doctor who accepts your insurance,” Dr. Bishop said. © 2013 The New York Times Company

Keyword: Depression; Aggression
Link ID: 19031 - Posted: 12.12.2013

By Jeanene Swanson Depression strikes some 35 million people worldwide, according to the World Health Organization, contributing to lowered quality of life as well as an increased risk of heart disease and suicide. Treatments typically include psychotherapy, support groups and education as well as psychiatric medications. SSRIs, or selective serotonin reuptake inhibitors, currently are the most commonly prescribed category of antidepressant drugs in the U.S., and have become a household name in treating depression. The action of these compounds is fairly familiar. SSRIs increase available levels of serotonin, sometimes referred to as the feel-good neurotransmitter, in our brains. Neurons communicate via neurotransmitters, chemicals which pass from one nerve cell to another. A transporter molecule recycles unused transmitter and carries it back to the pre-synaptic cell. For serotonin, that shuttle is called SERT (short for “serotonin transporter”). An SSRI binds to SERT and blocks its activity, allowing more serotonin to remain in the spaces between neurons. Yet, exactly how this biochemistry then works against depression remains a scientific mystery. In fact, SSRIs fail to work for mild cases of depression, suggesting that regulating serotonin might be an indirect treatment only. “There’s really no evidence that depression is a serotonin-deficiency syndrome,” says Alan Gelenberg, a depression and psychiatric researcher at The Pennsylvania State University. “It’s like saying that a headache is an aspirin-deficiency syndrome.” SSRIs work insofar as they reduce the symptoms of depression, but “they’re pretty nonspecific,” he adds. © 2013 Scientific American

Keyword: Depression
Link ID: 19020 - Posted: 12.11.2013

Someday, a smart phone app that asks what you’re feeling 10 times a day may be able to tell you if you’re edging closer to depression—and recommend that you seek preventive therapy or drugs. Scientists have discovered that how quickly someone bounces back from negative feelings, over hours or days, can predict whether that person is at risk of an episode of major depressive disorder. “The holy grail of depression epidemiology is that we want to intervene early to prevent people from having depressive episodes,” says social scientist Stephen Gilman of Harvard University, who was not involved in the study. “Where this work is headed is making an advance in that direction, toward early detection and therefore early intervention.” Researchers asked more than 600 people—some healthy and some with a diagnosis of depression—to track their emotions for 5 or 6 days. Ten times a day, at random intervals, a watch would beep and the subjects would record how strongly they identified with each of four emotions: cheerful, content, sad, and anxious. Six to 8 weeks later, participants filled out a more detailed questionnaire that rated their levels of clinical depression. By the end of the follow-up period, about 13% of the subjects had experienced a shift toward being more depressed, a number consistent with what would be expected in the general population. Trends in the daily mood records, the team discovered, could predict whether a previously healthy person would make that shift toward depression. © 2013 American Association for the Advancement of Science

Keyword: Depression
Link ID: 19015 - Posted: 12.10.2013

By Sandra Steingard, What does it mean that the man who killed 12 people at the Washington Naval Yard had told people that he was “hearing voices”? I have spent 30 years as a psychiatrist treating people who are psychotic. Almost every day I meet with individuals who hear voices that no one else hears, are sure the TV or radio is talking to them or have such confused thinking that it is hard to understand what they are trying to tell me. Sometimes these patients lead quiet lives. But not uncommonly these voices get them into trouble. I’ve had patients who call the police repeatedly, demanding that they stop bugging their phone. And others who stay up all night talking back at the voices. Some accuse family members of being involved in the torment. In many cases, this is a frightening experience — for the people I see and those who love them. And the labels we use — “schizophrenia,” “bipolar disorder,” “psychosis” — only crudely capture these experiences. About 60 years ago, a group of drugs was discovered that appeared to quiet the voices, improve the clarity of thought and lessen the preoccupation with delusion beliefs. Originally called major tranquilizers and later renamed antipsychotic drugs, these have been considered essential for the treatment of people with schizophrenia. Once it was clear that these drugs were helpful in the short term, questions arose over how long people should remain on them. Studies done in the 1970s and 1980s looked at people who were stabilized after being treated with antipsychotic drugs for several months and then followed them for up to two years. Some continued on the drugs, while others stopped taking them. The relapse rate was much higher in the group that stopped the medications. Based on these studies, treatment guidelines now state that people should stay on anti-psychotics indefinitely. The problem with “indefinitely” is that antipsychotic drugs have many troubling side effects. © 1996-2013 The Washington Post

Keyword: Schizophrenia
Link ID: 19011 - Posted: 12.10.2013

By David Nutt Imagine being an astronomer in a world where the telescope was banned. This effectively happened in the 1600s when, for over 100 years, the Catholic Church prohibited access to knowledge of the heavens in a vain attempt to stop scientists proving that the earth was not the center of the universe. ‘Surely similar censorship could never happen today,’ I hear you say—but it does in relation to the use of drugs to study the brain. Scientists and doctors are banned from studying many hundreds of drugs because of outdated United Nations charters dating back to the 1960s and 1970s. Some of the banned drugs include cannabis, psychedelics and MDMA (now widely known as ecstasy). The most remarkable example is that of the psychedelic LSD, a drug accidentally discovered by the Swiss chemist Albert Hofmann while he was working for the pharmaceutical company Sandoz to find new treatments for migraine. Once the ability of LSD to alter brain function became apparent, Hofmann and others realized it had enormous potential as a tool to explore and treat the brain. The immediate effects of LSD to alter brain states offered unique insight into states such as consciousness and psychosis; the long-lasting changes in self-awareness it brought on were seen as potentially useful for conditions such as addiction. Pharmaceutical company Sandoz saw LSD as so important that they chose to make it widely available to researchers in the 1950s. Researchers conducted over 1,000 studies at that time, most of which yielded significant results. However, once young Americans started using the drug recreationally—partly in protest against the Vietnam War—it was banned, both there and all over the world. Since then, research into the science behind the drug and its effects on the brain has come to a halt. Yet, we have begun to rectify the situation using the shorter-acting psychedelic psilocybin (also known as magic mushrooms). In just a couple of experiments, scientists have discovered remarkable and unexpected effects on the brain, leading them to start a clinical trial in depression. Other therapeutic targets for psychedelics are cluster headaches, OCD and addiction. © 2013 Scientific American

Keyword: Drug Abuse; Aggression
Link ID: 18983 - Posted: 11.30.2013

Robert N. McLay, author of At War with PTSD: Battling Post Traumatic Stress Disorder with Virtual Reality, responds: post-traumatic stress disorder (PTSD) can appear after someone has survived a horrific experience, such as war or sexual assault. A person with PTSD often experiences ongoing nightmares, edginess and extreme emotional changes and may view anything that evokes the traumatic situation as a threat. Although medications and talk therapy can help calm the symptoms of PTSD, the most effective therapies often require confronting the trauma, as with virtual-reality-based treatments. These computer programs, similar to a video game, allow people to feel as if they are in the traumatic scenario. Just as a pilot in a flight simulator might use virtual reality to learn how to safely land a plane without the risk of crashing, a patient with PTSD can learn how to confront painful reminders of trauma without facing any real danger. Virtual-reality programs have been built to simulate driving, the World Trade Center attacks, and combat scenarios in Vietnam and Iraq. The level of the technology varies considerably, from a simple headset that displays rather cartoonish images to Hollywood-quality special effects. A therapist typically observes what patients are seeing while they navigate the virtual experience. They can coach a patient to take on increasingly difficult challenges while making sure that the person does not become overwhelmed. To do so, some therapists may connect the subject to physiological monitoring devices; others may use virtual reality along with talk therapy. In the latter scenario, the patient recites the story of the trauma and reflects on it while passing through the simulation. The idea is to desensitize patients to their trauma and train them not to panic, all in a controlled environment. © 2013 Scientific American

Keyword: Stress; Aggression
Link ID: 18963 - Posted: 11.25.2013

By R. Douglas Fields San Diego—Would we have Poe’s Raven today if the tormented author had taken lithium to suppress his bipolar illness? Not likely, considering the high frequency of psychiatric illnesses among writers and artists, concluded psychiatrist Kay Jamison of Johns Hopkins Medical School speaking last week at the Society for Neuroscience annual meeting in San Diego. Madness electrifies the creative process, Jamison concluded, but this difficult drug-use dilemma raises an even more provocative question: Would we have Lucy in the Sky with Diamonds had the Beatles not taken LSD? Lord Tennyson, Virginia Woolf and Vincent Van Gogh are familiar examples of artists and writers who suffered serious mental illnesses, but Jamison explained that psychiatric illness was the cruel engine of their creativity. Tracing their family pedigrees, she showed that many of these artists’ siblings, parents and descendants were institutionalized in mental hospitals, committed suicide, or endured life-long struggles with mania, despair, schizophrenia or other mental disorders. The genetic backbone to mental illness is strong. Ernest Hemingway and his supermodel granddaughter Margaux Hemingway both killed themselves. Separated from one another in environment and experience by a generation, their fates were inevitably tethered by their DNA. In all, seven members of the Hemingway family died at their own hand. This raises the question of why the genes of such devastating brain dysfunctions should persist in the human gene pool. Statistics show that among all categories of creative artists, writers suffer by far the highest incidence of bipolar disorder, outstripping all other artistic professions. Why? Jamison concludes that the manic phase of bipolar disorder infuses the writer with furious energy and limitless stamina. The author foregoes sleep, is driven to take daring risks, expands their imagination and embraces grandiose thinking. © 2013 Scientific American

Keyword: Drug Abuse; Aggression
Link ID: 18961 - Posted: 11.23.2013

By Jason Tetro For millennia, the human race has sought to combat psychological disorders through the intervention of natural – and eventually synthetic – chemicals. Originally, the sources for these psychoactive substances were the various fruits and flowers, including the Areca tree (betel nut), the poppy (opium), and the coca plant (cocaine). But in the 20th Century, new actives were being created in the lab thanks in part to the discovery of lysergic acid, better known as LSD, in 1938. By the middle of the 1950s, the psychiatric community was fascinated by the idea that mental health could be restored through the direct use of drugs or in combination with traditional psychotherapy. The idea took off in the 1960s as research continued to elucidate the biology of psychiatry. It essentially created a new avenue for psychiatric treatment: psychopharmacology. This inevitably led to the synthesis of a new compound, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine, which eventually became known as fluoxetine, and then, as we have all come to know it, Prozac. By the late 1980s, it was known by another name: the wonder drug. Today, pharmacologic compounds for psychiatric treatment are numerous and up to 20% of all Americans are taking some type of psychotropic medication totalling some $34 billion dollars annually. While there have been calls for a reduction in use of these chemicals, primarily due to the fact that many are ineffective, there is a constant pressure from the public to have all their problems solved by a pill.

Keyword: Depression; Aggression
Link ID: 18952 - Posted: 11.21.2013

By BENEDICT CAREY Curing insomnia in people with depression could double their chance of a full recovery, scientists are reporting. The findings, based on an insomnia treatment that uses talk therapy rather than drugs, are the first to emerge from a series of closely watched studies of sleep and depression to be released in the coming year. A student demonstrating equipment at Colleen Carney’s sleep lab at Ryerson University. Dr. Carney is the lead author of a new report about the effects of insomnia treatment on depression. The new report affirms the results of a smaller pilot study, giving scientists confidence that the effects of the insomnia treatment are real. If the figures continue to hold up, the advance will be the most significant in the treatment of depression since the introduction of Prozac in 1987. Depression is the most common mental disorder, affecting some 18 million Americans in any given year, according to government figures, and more than half of them also have insomnia. Experts familiar with the new report said that the results were plausible and that if supported by other studies, they should lead to major changes in treatment. “It would be an absolute boon to the field,” said Dr. Nada L. Stotland, professor of psychiatry at Rush Medical College in Chicago, who was not connected with the latest research. “It makes good common sense clinically,” she continued. “If you have a depression, you’re often awake all night, it’s extremely lonely, it’s dark, you’re aware every moment that the world around you is sleeping, every concern you have is magnified.” The study is the first of four on sleep and depression nearing completion, all financed by the National Institute of Mental Health. They are evaluating a type of talk therapy for insomnia that is cheap, relatively brief and usually effective, but not currently a part of standard treatment. © 2013 The New York Times Company

Keyword: Depression; Aggression
Link ID: 18945 - Posted: 11.19.2013

Daniel Freeman and Jason Freeman Which illness frightens you most? Cancer? Stroke? Dementia? To judge from tabloid coverage, the condition we should really fear isn't physical at all. "Scared of mum's schizophrenic attacks", "Knife-wielding schizophrenic woman in court", "Schizo stranger killed dad", "Rachel murder: schizo accused", and "My schizophrenic son says he'll kill… but he's escaped from secure hospitals 7 times" are just a few of dozens of similar headlines we found in a cursory internet search. Mental illness, these stories imply, is dangerous. And schizophrenia is the most dangerous of all. Such reporting is unhelpful, misleading and manipulative. But it may be even more inaccurate than it first appears. This is because scientists are increasingly doubtful whether schizophrenia – a term invented more than a century ago by the psychiatric pioneer Eugen Bleuler – is a distinct illness at all. This isn't to say that individuals diagnosed with the condition don't have genuine and serious mental health problems. But how well the label "schizophrenia" fits those problems is now a very real question. What's wrong with the concept of schizophrenia? For one thing, research indicates the term may simply be functioning as a catch-all for a variety of separate problems. Six main conditions are typically caught under the umbrella of schizophrenia: paranoia; grandiosity (delusional beliefs that one has special powers or is famous); hallucinations (hearing voices, for example); thought disorder (being unable to think straight); anhedonia or the inability to experience pleasure; and diminished emotional expression (essentially an emotional "numbness"). But how many of these problems a person experiences, and how severely, varies enormously. Having one doesn't mean you'll necessarily develop any of the others. © 2013 Guardian News and Media Limited

Keyword: Schizophrenia
Link ID: 18930 - Posted: 11.16.2013

By Julianne Chiaet Kate wanted to die. She remembers the moment the psychiatrist said “the antidepressant isn’t going to work right away. Can you promise to be here next week and not kill yourself?” “I told her no,” Kate says. “I couldn’t promise my doctor I’d make it a week. That’s how bad my life had to be before I got help. When you’re struggling to stay alive every single day, and then your doctor tells you it’s going to take two to six weeks before the medications they give you are going to work, it’s devastating.” To make matters worse, after those weeks, the drug didn’t work. Kate went through five different anti-depressants over the course of six months before confirming that none of them worked. The debilitating disorder kept her out of school for extended periods of time. The National Center for Health Statistics estimates more than 1 in 10 Americans over the age of 12 took antidepressants between 2005 and 2008, the last time period for which the data are available. The rate of antidepressant use increased 400 percent from 1998 to 2008. Traditional antidepressants go after serotonin neurotransmitters, which sit in the membrane of the brain. Some antidepressants also target norepinephrine and dopamine. The drug keeps the transmitters from performing their normal function of transporting serotonin from the outside to the inside of the brain cells. People with depression have a normal amount of serotonin inside of their brain cells, however they have an insufficient amount on the outside of their cells. Thus by inhibiting the transmitter, the drug blocks the transportation of serotonin being taken into the cell, thus building up the serotonin outside of the cell. © 2013 Scientific American

Keyword: Depression
Link ID: 18919 - Posted: 11.13.2013