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By Melissa Dahl Considering its origin story, it’s not so surprising that hypnosis and serious medical science have often seemed at odds. The man typically credited with creating hypnosis, albeit in a rather primitive form, is Franz Mesmer, a doctor in 18th-century Vienna. (Mesmer, mesmerize. Get it?) Mesmer developed a general theory of disease he called “animal magnetism,” which held that every living thing carries within it an internal magnetic force, in liquid form. Illness arises when this fluid becomes blocked, and can be cured if it can be coaxed to flow again, or so Mesmer’s thinking went. To get that fluid flowing, as science journalist Jo Marchant describes in her recent book, Cure, Mesmer “simply waved his hands to direct it through his patients’ bodies” — the origin of those melodramatic hand motions that stage hypnotists use today.” After developing a substantial following — “mesmerism” became “the height of fashion” in late 1780s Paris, writes Marchant — Mesmer became the subject of what was essentially the world’s first clinical trial. King Louis XVI pulled together a team of the world’s top scientists, including Benjamin Franklin, who tested mesmerism and found its capacity to “cure” was, essentially, a placebo effect. “Not a shred of evidence exists for any fluid,” Franklin wrote. “The practice … is the art of increasing the imagination by degrees.” Maybe so. But that doesn’t mean it doesn’t work. © 2016, New York Media LLC.

Keyword: Attention; Pain & Touch
Link ID: 22931 - Posted: 11.30.2016

By David Grimm Animal research has a publication problem. About half of all animal experiments in academic labs, including those testing for cancer and heart drugs, are never published in scientific journals, and those that are have been notoriously hard to replicate. That’s part of the reason that most drugs that work in animals don’t work in people—only 11% of oncology compounds that show promise in mice are ever approved for humans—despite billions of dollars spent by pharmaceutical and biotech companies. Meanwhile, academic labs waste money, mice, and other resources on experiments that, unbeknownst to them, have already been done but were never reported. In response to similar concerns about human studies, the U.S Food and Drug Administration (FDA) in 2007 mandated that researchers conducting human clinical trials preregister the details in an online database like ClinicalTrials.gov. Now, some scientists are wondering whether a similar approach makes sense for animal experiments. In a study published this month in PLOS Biology, Daniel Strech, a bioethicist at Hannover Medical School in Germany, and colleagues investigated the idea of so-called animal study registries. They scoured the literature and interviewed nearly two dozen scientists to determine the pros and cons of such registries—and whether they would actually make a difference. Strech chatted with Science to discuss the group’s findings. This interview has been edited for clarity and length. Q: What would these registries look like? © 2016 American Association for the Advancement of Science

Keyword: Animal Rights
Link ID: 22930 - Posted: 11.30.2016

By NICHOLAS BAKALAR Stroke rates have been declining in older people over the past 20 years — but have sharply increased in those under 55. Researchers at Rutgers University used data from the New Jersey Department of Health on more than 227,000 hospitalizations for stroke from 1995 through 2014, calculating incidence by age over five-year periods. The findings appeared in the Journal of the American Heart Association. Compared with the 1995-99 period, the rate of stroke in 2010-14 increased by 147 percent in people 35 to 39, by 101 percent in people 40 to 44, by 68 percent in those 45 to 49, and by 23 percent in the 50 to 54 group. Stroke is still far more common in older people. But the rate decreased by 11 percent in those 55 to 59, by 22 percent in the 60 to 64 group, and by 18 percent in people 65 to 69. The reasons are unclear, but the lead author, Joel N. Swerdel, now an epidemiologist with Janssen Pharmaceuticals, said that increasing obesity and diabetes in younger people are probably involved. “For a person 30 to 50, the good news is you ain’t dead yet,” he said. “With behavioral changes, changing diet, increasing exercise, there’s still hope for you. Behavioral change is hard, but this study is an early warning sign.” © 2016 The New York Times Company

Keyword: Stroke
Link ID: 22929 - Posted: 11.30.2016

By Virginia Morell If you’ve ever watched ants, you’ve probably noticed their tendency to “kiss,” quickly pressing their mouths together in face-to-face encounters. That’s how they feed each other and their larvae. Now, scientists report that the insects are sharing much more than food. They are also communicating—talking via chemical cocktails designed to shape each other and the colonies they live in. The finding suggests that saliva exchange could play yet-undiscovered roles in many other animals, from birds to humans, says Adria LeBoeuf, an evolutionary biologist at the University of Lausanne in Switzerland, and the study’s lead author. “We’ve paid little attention to what besides direct nutrition is being transmitted” in ants or other species, adds Diana Wheeler, an evolutionary biologist at the University of Arizona in Tucson, who was not involved with the work. Social insects—like ants, bees, and wasps—have long been known to pass food to one another through mouth-to-mouth exchange, a behavior known as trophallaxis. They store liquid food in “social stomachs,” or crops, from which they can regurgitate it later. It’s how nutrients are passed from foraging ants to nurse ants, and from nurses to the larvae in a colony. Other research has suggested that ants also use trophallaxis to spread the colony’s odor, helping them identify their own nest mates. © 2016 American Association for the Advancement of Science

Keyword: Chemical Senses (Smell & Taste)
Link ID: 22928 - Posted: 11.29.2016

By John Horgan Asked for a comment on the language-acquisition theory of Noam Chomsky (in photo above), psychologist Steven Pinker says: “Chomsky has been a piñata, where anyone who finds some evidence that some aspect of language is learned (and there are plenty), or some grammatical phenomenon varies from language to language, claims to have slain the king. It has not been a scientifically productive debate, unfortunately.” Credit: Ministerio de Cultura de la Nación Argentina Flickr (CC BY-SA 2.0) Noam Chomsky’s political views attract so much attention that it’s easy to forget he’s a scientist, one of the most influential who ever lived. Beginning in the 1950s, Chomsky contended that all humans possess an innate capacity for language, activated in infancy by minimal environmental stimuli. He has elaborated and revised his theory of language acquisition ever since. Chomsky’s ideas have profoundly affected linguistics and mind-science in general. Critics attacked his theories from the get-go and are still attacking, paradoxically demonstrating his enduring dominance. Some attacks are silly. For example, in his new book A Kingdom of Speech Tom Wolfe asserts that both Darwin and “Noam Charisma” were wrong. (See journalist Charles Mann’s evisceration of Wolfe.) © 2016 Scientific American

Keyword: Language
Link ID: 22927 - Posted: 11.29.2016

By Sarah Kaplan I don't know if the holidays are as emotional for you as they are for me, but I have never been able to get through this season without shedding buckets of tears. Why do we cry in the first place? Does it actually do anything to make us feel better? Here's what science has to say: Girl, we feel you. (Or guy. Guys can cry, too. And psychologists say that emotional control probably isn't good for men. So go ahead and let it out.) Anyway. You shouldn't feel shame about shedding tears of emotion. Weeping is part of what makes you human. Although other animals may yelp or whimper in pain or fear, and many creatures have tear ducts in their eyes to help flush out dirt and irritants, humans are the only species known to cry for emotional reasons. And scientists aren't really sure why. One theory is that tears are a communication tool. Before they learn to speak, babies cry to get attention. They start out with tearless wails, but at around three or four months, they start to weep when upset as well. Evolutionary psychologists have argued that infants' tears are related to the distress vocalizations produced by other young animals: Crying conveys their need for parental care. It's also thought that a baby's crying has evolved to be especially evocative for parents — something few stressed-out, sleep-deprived parents of newborns would disagree with. This theory would explain the loud, chaotic tantrums thrown by children when hurt or distressed. But what about adult emotional tears, which are usually much quieter? In those cases, crying could be a method of “conspecific communication” — a way of alerting sympathetic neighbors that something is wrong, without attracting the attention of a predator. © 1996-2016 The Washington Post

Keyword: Emotions
Link ID: 22926 - Posted: 11.29.2016

Nancy Shute Getting the flu while pregnant doesn't appear to increase the child's risk of being diagnosed with autism later on, a study finds, and neither does getting a flu shot while pregnant. The study, published Tuesday in JAMA Pediatrics, tries to tease apart subtle questions of risk and risk avoidance. Some smaller, earlier studies have found an association between serious viral infections in pregnancy or maternal fever in pregnancy and increased autism risk. This much larger study finds no such ties, though the authors note that it shouldn't be the last word on the topic. This study examined the health records of 196,929 children who were born at Kaiser Permanente facilities in Northern California between 2000 and 2010. They found that 3,101 children, or 1.6 percent, had been diagnosed with autism through June 2015. The researchers then looked at the mothers' health records to see if they had been diagnosed with flu while pregnant and whether they'd gotten a flu shot. Less than 1 percent of women had the flu; about 23 percent got a flu shot while pregnant, a number that rose from 6 percent in 2000 to 58 percent in 2010. They found no correlation overall between having the flu while pregnant and increased autism risk in children. © 2016 npr

Keyword: Autism; Neuroimmunology
Link ID: 22925 - Posted: 11.29.2016

By Louisa J. Steinberg “You've got to be kidding me, Doc. I can barely keep my eyes open as it is, and you want me to pull an all-nighter?” I smiled. “Yes, exactly that. Maybe even two or three.” It started out benignly enough. Jodi (not the patient's real name) had been feeling more stressed between meeting the growing demands of her high-stakes job in business management and shouldering more chores while her husband was away on business trips. Strapped for time, she started neglecting her usual self-care routines—eating healthy, exercising, taking time to relax. Not surprisingly, her mood was poor. Things soon grew worse. She no longer enjoyed activities that were usually the highlight of her day: story time with her children, chatting on the phone with her mom, reading a book. Although she was constantly exhausted, she could not get a good night's sleep; she would toss and turn and still feel tired even when she slept in. Her performance at work had also been suffering; she began missing days because she just couldn't get out of bed. Jodi knows she should have recognized these warning signs sooner. She had experienced major depression twice before, once in college and again in her late 20s after a breakup. Now in her late 30s, she had been off antidepressants for years. Yet she found herself back in that dark place, barely eating and unable to concentrate enough to read even a short paragraph. Her thoughts circled around the same unpleasant memories and nagging fears. She felt hopeless and guilty. © 2016 Scientific American

Keyword: Depression; Sleep
Link ID: 22924 - Posted: 11.29.2016

By Smitha Mundasad Health reporter About 9,000 stroke patients a year are missing out on a treatment that can prevent disability following a stroke, say UK experts. Clot retrieval can restore blood flow to the brain, preventing some lasting damage, but currently only 600 patients a year get this therapy, they estimate. A national stroke audit reveals part of the problem is a lack of skilled staff to do the procedure. NHS England says stroke patients are receiving high quality care. During a stroke, the blood supplying vital parts of the brain is interrupted. The most common reason is a clot blocking a major blood vessel in the head, although some strokes are caused by a bleed. The longer a part of the brain is starved of blood, the more likely lasting damage - such as paralysis and speech problems - will occur. Expanding mesh While many people with a stroke caused by a clot currently get drugs to help dissolve the blockage, this does not always work completely. Thrombectomy - or clot retrieval - is another method, which aims to remove the clot mechanically. It is a highly skilled operation, and stroke services need to be set up to be able to deliver the treatment. A thin metal wire housing a mesh is inserted into a major artery in the leg and, under X-ray guidance, it is directed to the site of the problem in the brain. The mesh is then expanded, like a miniature fishing net, to trap and remove the clot. 'Once the clot was out, the damage stopped' © 2016 BBC

Keyword: Stroke
Link ID: 22923 - Posted: 11.29.2016

By Ben Andrew Henry As a graduate student in the field of olfactory neuroscience, conducting what his former mentor describes as ambitiously clever research, Jason Castro felt something was missing. “I wanted to use science to make a connection with people,” he says, not just to churn out results. In 2012, the 34-year-old Castro accepted a faculty position at Bates College, a small liberal arts school in Maine, in order to “do the science equivalent of running a mom-and-pop—a small operation, working closely with students, and staying close to the data and the experiments myself,” he says. Students who passed through his lab or his seminars recall Castro as a dedicated mentor. “He spent hours with me just teaching me how to code,” recalled Torben Noto, a former student who went on to earn a PhD in neuroscience. After he arrived at Bates, Castro, along with two computational scientists, enlisted big-data methodologies to search for the olfactory equivalent of primary colors: essential building blocks of the odors we perceive. Their results, based on a classic set of data in which thousands of participants described various odors, identify 10 basic odor categories.1 Castro launched another project a few months later, when a paper published in Science reported that humans could discriminate between at least a trillion different odors. A friend from grad school, Rick Gerkin, smelled something fishy about the findings and gave Castro a call. “We became obsessed with the topic,” says Gerkin, now at Arizona State University. The researchers spent almost two years pulling apart the statistical methods of the study, finding that little tweaks to parameters such as the number of test subjects created large swings in the final estimate—a sign that the results were not robust.2 This August, the original study’s authors published a correction in Science. © 1986-2016 The Scientist

Keyword: Chemical Senses (Smell & Taste)
Link ID: 22922 - Posted: 11.29.2016

By C. CLAIBORNE RAY Q. Is a night’s sleep physiologically beneficial even if it includes emotionally disturbing nightmares? A. Almost certainly yes, said Dr. Neomi Shah, a specialist at the Mount Sinai Integrative Sleep Center in New York. Despite the problems nightmares can cause, sleeping and having them is better than not sleeping, research suggests. Nightmares can make it difficult to sleep and interfere with daytime functioning, but physiological indicators of sleep patterns and quality do not differ in people who have nightmares, Dr. Shah said. Frequent long, distressing and vivid dreams often wake people and cause problems like insomnia and poor sleep quality, she said. Research has also consistently demonstrated that nightmares can harm general well-being, affect mood and elevate stress. Some studies suggest there are measurable sleep problems for people who have nightmares, while others show no difference. The studies that show such a link found that people who woke up stayed awake longer and that certain stages of sleep did not last as long. But people in those studies who had nightmares also had longer periods of rapid eye movement, or REM, sleep, when most dreaming occurs. A weakness of these studies is that they were not conducted in the subjects’ normal sleeping environment. A more recent study in such an environment found no differences in so-called sleep architecture, sleep-cycle and REM durations, or sleep patterns for just the nights with nightmares. © 2016 The New York Times Company

Keyword: Sleep
Link ID: 22921 - Posted: 11.29.2016

By Yasemin Saplakoglu Even if you don’t have rhythm, your pupils do. In a new study, neuroscientists played drumming patterns from Western music, including beats typical in pop and rock, while asking volunteers to focus on computer screens for an unrelated fast-paced task that involved pressing the space bar as quickly as possible in response to a signal on the screen. Unbeknownst to the participants, the music omitted strong and weak beats at random times. (You can listen below for an example of a music clip they used. If you listen carefully, you can hear bass and hi-hat beats omitted throughout.) Eye scanners tracked the dilations of the subjects’ pupils as the music played. Their pupils enlarged when the rhythms dropped certain beats, even though the participants weren’t paying attention to the music. The biggest dilations matched the omissions of the beats in the most prominent locations in the music, usually the important first beat in a repeated set of notes. The results suggest that we may have an automatic sense of “hierarchical meter”—a pattern of strong and weak beats—that governs our expectations of music, the researchers write in the February 2017 issue of Brain and Cognition. Perhaps, the authors say, our eyes reveal clues into the importance that music and rhythm plays in our lives. © 2016 American Association for the Advancement of Science

Keyword: Attention; Hearing
Link ID: 22920 - Posted: 11.29.2016

By PAGAN KENNEDY Abby Solomon suffers from a one-in-a-billion genetic syndrome: After just about an hour without food, she begins to starve. She sleeps in snatches. In her dreams she gorges on French fries. But as soon as she wakes up and nibbles a few bites, she feels full, so she ends up consuming very few calories. At 5 feet 10 inches tall, she weighs 99 pounds. Now 21 years old, she is one of the few people in the world to survive into adulthood with neonatal progeroid syndrome, a condition that results from damage to the FBN1 gene. This mutation mangles noses and eyes and destroys the layer of fat under the skin so that even teenagers look middle-aged. It also interferes with the body’s ability to make a hormone called asprosin, which regulates blood sugar. Atul Chopra, a medical geneticist at Baylor College of Medicine, told me that people with the disorder don’t experience ordinary hunger — instead they waver on the edge of hypoglycemia and must constantly snack to keep from passing out. And yet when I asked Ms. Solomon if she wished she could magically repair her damaged gene, she answered without hesitation: “I wouldn’t change it for anything.” This is because her painful body may hold the clues to a lifesaving treatment for millions of people with obesity and diabetes. Dr. Chopra told me that, as far as medical science is concerned, Abby Solomon is worth thousands of the rest of us. By observing her, scientists can see how a hormone deficiency affects a living person, from her thoughts to her liver function. Several years ago, she spent a day inside a metabolic chamber in a lab so that Dr. Chopra could measure everything she breathed and ate. The results showed that Ms. Solomon takes in about half the calories of a typical woman her age, and also expends half as much energy. “Nothing comes close to starting with people who are naturally different,” he said. This is why he searches out patients at the extreme ends of the spectrum — those who are wired to weigh 80 pounds or 380 pounds. He said, “We have the opportunity to help a bigger swath of humanity when we learn from these outliers.” © 2016 The New York Times Company

Keyword: Obesity; Genes & Behavior
Link ID: 22919 - Posted: 11.28.2016

Gabrielle Emanuel "It's frustrating that you can't read the simplest word in the world." Thomas Lester grabs a book and opens to a random page. He points to a word: galloping. "Goll—. G—. Gaa—. Gaa—. G—. " He keeps trying. It is as if the rest ­­of the word is in him somewhere, but he can't sound it out. "I don't ... I quit." He tosses the book and it skids along the table. Despite stumbling over the simplest words, Thomas – a 4th grader – is a bright kid. In fact, that's an often-misunderstood part of dyslexia: It's not about lacking comprehension, having a low IQ or being deprived of a good education. It's about having a really hard time reading. Dyslexia is the most common learning disability in the United States. It touches the lives of millions of people, including me and Thomas. Just like Thomas, I spent much of my childhood sitting in a little chair across from a reading tutor. Today, Thomas is working with his tutor in an office building on the northwest side of Washington, D.C. The suite they're in is an oasis of white couches and overstuffed pillows. In the waiting area, a kid is curled up sucking her thumb, and a mom reads a magazine quietly. In the back of the suite — a Lindamood Bell Reading Center — Thomas fidgets with everything in arm's reach. "Alright, I am going to give you some air-writing words," the tutor says to Thomas, speaking rapidly as if daring Thomas to keep pace. She spells the first one out loud: "C-O-R-T." With his index finger, Thomas writes the letters sloppily in the air. Then, his tutor asks a question: What sound do the two middle letters make? "Eer? Aar?" Thomas squints at whatever visual memory he can retain from the letters he's just scribbled in the air. Then, with a burst of enthusiasm, he stumbles on the answer: "Or!" © 2016 npr

Keyword: Dyslexia
Link ID: 22918 - Posted: 11.28.2016

By Nicole Ireland, CBC News Ten years ago, litigation lawyer Michele Hollins was a "perpetually happy person," with twin daughters and a partnership in her Calgary law firm. Then, depression struck. For a while, Hollins was able to hide her illness at work, then go home and "become a complete automaton," she says, unable to eat or even muster the energy to get ready for bed. At its worst, the depression crippled her at work, to the point where Hollins would walk into her office, say hello to her assistant and then "close the door and lay on the floor and cry for hours." At her lowest point, she says she would "spend most of the day trying to figure out how to collect myself enough to get to my car and get home." That raw vulnerability doesn't match the general impression society has of lawyers as tough and ambitious. But research suggests that they are at much higher risk of depression, anxiety and substance abuse issues than people in the broader population — and may even be more susceptible than those in other high-stress professions, such as medicine. A U.S. study published in the Journal of Addiction Medicine last February found the rate of problem drinking among lawyers was between two and three times higher than among other highly educated professionals, including physicians. The study was funded by the American Bar Association and the Hazelden Betty Ford Foundation. The rate of depression was about three times higher than the general population in the U.S., according to lead researcher Patrick Krill, who will be presenting his research to lawyers and law students in Toronto on Monday at a professional development session hosted by the Law Society of Upper Canada. ©2016 CBC/Radio-Canada.

Keyword: Depression; Drug Abuse
Link ID: 22917 - Posted: 11.28.2016

By Tracy Vence Lose weight, gain it back. That’s the frustrating routine for many individuals who have experienced only short-term success with diets. To examine the microbial and metabolic factors underlying this weight loss-regain cycle, researchers at the Weizmann Institute of Science in Rehovot, Israel, ran a series of experiments using a mouse model of recurrent obesity. The composition of a mouse’s microbiome is predictive of post-diet weight regain, which is in part modulated by metabolites released by the bugs, the researchers found. Their results were published today (November 24) in Nature. “This work adds some insight on how the microbiome acts as a buffer to changes in our diet,” study coauthor Eran Segal of the Weizmann Institute said during a press briefing this week (November 22). In particular, the researchers found evidence to suggest that mice that were once obese tend to experience alterations in microbiome composition that persist during and after weight loss. They also linked the metabolic health of mice to levels of the dietary flavonoids apigenin and naringenin, among other metabolites exchanged between the host and microbiome. See “How Diet Influences Host-Microbiome Communication in Mice” There is hope, however. Segal and colleagues also reported that microbiome- and metabolite-mediating therapies—such as antibiotic treatment, fecal transplant, or postbiotic supplementation—can ameliorate the rate of weight regain in mice predisposed to recurrent obesity. © 1986-2016 The Scientist

Keyword: Obesity
Link ID: 22916 - Posted: 11.26.2016

By Julie Hecht If you assume dogs are always ready for more food, try again. Like you, dogs make decisions about which types of food to eat. For example, if someone shows you two plates, one with a glorious piece of your favorite pie and another plate with a piece of your favorite pie with a side of carrots, many of you are going to go for the pie alone. You'd adopt a less-is-more strategy because pie plus carrots is kinda gross. Monkeys do this too. In 2012, Kralik and colleagues found that while monkeys will eat grapes on their own and cucumbers on their own, when given the choice between a grape alone and a grape accompanied by a slice of cucumber, monkeys preferred the grape alone. It’s not that monkeys won't eat cucumbers, they’d just prefer grapes by themselves. Monkeys based their choice not on the overall quantity of the food, but instead on a qualitative decision. How about dogs? A recent study by Kristina Pattison and Thomas Zentall of the University of Kentucky examined whether companion dogs also adopt a less-is-more strategy. The researchers first determined whether dogs had a preference between two foods, in this case carrots and cheese. Ten companion dogs—all of whom would voluntarily eat both string cheese and baby carrots—were found to prefer the cheese over the carrots (all the dogs occasionally chose carrots, suggesting that carrots are not valueless). But when given the choice to eat a piece of cheese on its own or a piece of cheese together with carrot, dogs chose a single piece of cheese over a piece of cheese "tainted" by the presence of carrot. © 2016 Scientific American,

Keyword: Obesity
Link ID: 22915 - Posted: 11.26.2016

By Dwayne Godwin, Jorge Cham © 2016 Scientific American,

Keyword: Development of the Brain; Trophic Factors
Link ID: 22914 - Posted: 11.26.2016

By NICHOLAS BAKALAR Having one or two alcoholic drinks a day is associated with a lower risk of stroke, a review of studies has found. But drinking more than that increases the risk. The analysis, in BMC Medicine, used data from 27 studies. Compared with nondrinkers or occasional drinkers, people who had one or two drinks a day had an 8 percent reduced risk of ischemic stroke. Ischemic strokes, caused by blockage of an artery supplying blood to the brain, account for about 87 percent of all strokes. Heavier drinking, however, increased stroke risk. Having up to four daily drinks led to an 8 percent increased risk of ischemic stroke, and at more than four drinks, the risk increased by 14 percent. Drinking more than four drinks a day also increased the risk of hemorrhagic stroke, the result of a burst or leaking blood vessel in or near the brain, by up to 82 percent. More moderate drinking did not raise hemorrhagic stroke risk. The lead author, Susanna C. Larsson, an associate professor of epidemiology at the Karolinska Institutet in Sweden, warned that alcohol is not health food. “Nondrinkers should not start to drink as a health measure,” she said. “And I wouldn’t recommend that a person who has a drink or two on the weekend increase his consumption.” © 2016 The New York Times Company

Keyword: Stroke; Drug Abuse
Link ID: 22913 - Posted: 11.26.2016

Alison Abbott & Elie Dolgin A drug that was seen as a major test of the leading theory behind Alzheimer’s disease has failed in a large trial of people with mild dementia. Critics of the ‘amyloid hypothesis’, which posits that the disease is triggered by a build-up of amyloid protein in the brain, have seized on the results as evidence of its weakness. But the jury is still out on whether the theory will eventually yield a treatment. Proponents of the theory note that the particular way in which solanezumab, the drug involved in the trial, works could have led to the failure, rather than a flaw in the hypothesis itself. And many trials are ongoing to test whether solanezumab — or others that target amyloid — could work in people at risk of the disease who have not yet shown symptoms, or even in people with Alzheimer’s, despite the latest negative result. “I’m extremely disappointed for patients, but this, for me, doesn’t change the way I think about the amyloid hypothesis,” says Reisa Sperling, a neurologist at the Brigham and Women’s Hospital in Boston, Massachusetts. She is leading one of several ongoing ‘prevention’ trials that is testing solanezumab, and other drugs that aim to reduce the build-up of amyloid ‘plaques’, in people at risk of developing Alzheimer’s. Solanezumab is an antibody that mops up amyloid proteins from the blood and cerebrospinal fluid. The proteins can go on to form plaques in the brain. Eli Lilly, the company that developed solanezumab, announced on 23 November that it would abandon the drug as a treatment for patients with mild dementia. The outcome adds to a long list of promising Alzheimer’s drugs that have flopped in the clinic, many of which, like solanezumab, targeted amyloid. © 2016 Macmillan Publishers Limited

Keyword: Alzheimers
Link ID: 22912 - Posted: 11.25.2016