Chapter 7. Vision: From Eye to Brain
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By Hanae Armitage Cataracts cloud the eyes of tens of millions of people around the world and nearly 17.2% of Americans over the age of 40. Currently, the only treatment is surgery—lasers or scalpels cut away the molecular grout that builds in the eye as cataracts develop, and surgeons sometimes replace the lens. But now, a team of scientists and ophthalmologists has tested a solution in dogs that may be able to dissolve the cataract right out of the eye’s lens. And the solution is itself a solution: a steroid-based eye drop. Though scientists don’t fully understand how cataracts form, they do know that the “fog” often seen by patients is a glob of broken proteins, stuck together in a malfunctioning clump. When healthy, these proteins, called crystallins, help the eye’s lens keep its structure and transparency. But as humans and animals alike get older, these crystallin proteins start to come unglued and lose their ability to function. Then they clump together and form a sheathlike obstruction in the lens, causing the signature “steamy glass” vision that accompanies cataracts. Coming up with a solution other than surgery has been tough. Scientists have been hunting for years for mutations in crystallin proteins that might offer new insights and pave the way to an alternate therapy. Now, it looks like a team led by University of California (UC), San Diego, molecular biologist Ling Zhao may have done just that. Her team came up with the eye drop idea after finding that children with a genetically inherited form of cataracts shared a mutation that stopped the production of lanosterol, an important steroid in the body. When their parents did not have the same mutation, the adults produced lanosterol and had no cataracts. © 2015 American Association for the Advancement of Science.
Link ID: 21205 - Posted: 07.23.2015
It’s a good combination. Gene therapy to reverse blindness repairs damaged cells in the eye and also rearranges the brain to help process the new information. Visual pathways in the brain are made up of millions of interconnected neurons. When sensory signals are sent along them, the connections between neurons become strong. If underused – for example, as people lose their sight – the connections become weak and disorganised. Over the past few years, a type of gene therapy – injecting healthy genes into the eye to repair mutations – has emerged as a promising way to treat congenital and degenerative blindness. One of the first successful trials began in 2007. It involved 10 blind volunteers with a hereditary disease called Leber’s congenital amaurosis. The condition causes the retina to degenerate and leaves people completely blind early in life. Mutations in at least 19 genes can cause the disease, but all of the people in the trial had mutations in a gene called RPE65. The participants got an injection of a harmless virus in one of their eyes. The virus inserted healthy copies of RPE65 into their retina. Some of the volunteers went from straining to see a hand waving half a metre from their face to being able to read six lines on a sight chart. Others were able to navigate around an obstacle course in dim light – something that would have been impossible before the therapy. © Copyright Reed Business Information Ltd.
By Chris Foxx Technology reporter Twitter has responded to an epilepsy charity that said two of its online adverts were "irresponsible". The social media giant had uploaded two short videos on Vine that featured a looping, rapid succession of flashing colours. "Twitter's ads were dangerous to people living with photo-sensitive epilepsy," said Epilepsy Action's deputy chief executive, Simon Wigglesworth. Twitter told the BBC it had removed the videos on Friday morning. Around one in 3,500 people in the UK has photosensitive epilepsy, according to Epilepsy Action. Seizures can be triggered by flashing lights and bold patterns. An episode of Japanese cartoon Pokemon was famously blamed for triggering convulsions in 1997. "Eighty seven people are diagnosed with epilepsy every day and that first seizure can often come out of nowhere," said Mr Wigglesworth. "For a huge corporation like Twitter to take that risk was irresponsible." The Advertising Standards Authority told the BBC that "marketing communications", even those uploaded on a company's own website, should not include "visual effects or techniques that are likely to adversely affect members of the public with photosensitive epilepsy". It said both online and broadcast adverts in the UK had to adhere to rules made by the Committees of Advertising Practice. "We take very seriously ads in online media that might cause harm to people with photosensitive epilepsy," an ASA spokeswoman told the BBC. Twitter's flashing Vine videos were online for 18 hours before the company removed them. © 2015 BBC
Spider-like cells inside the brain, spinal cord and eye hunt for invaders, capturing and then devouring them. These cells, called microglia, often play a beneficial role by helping to clear trash and protect the central nervous system against infection. But a new study by researchers at the National Eye Institute (NEI) shows that they also accelerate damage wrought by blinding eye disorders, such as retinitis pigmentosa. NEI is part of the National Institutes of Health. “These findings are important because they suggest that microglia may provide a target for entirely new therapeutic strategies aimed at halting blinding eye diseases of the retina,” said NEI Director, Paul A. Sieving, M.D. “New targets create untapped opportunities for preventing disease-related damage to the eye, and preserving vision for as long as possible.” The findings were published in the journal EMBO Molecular Medicine. Retinitis pigmentosa, an inherited disorder that affects roughly 1 in 4,000 people, damages the retina, the light-sensitive tissue at the back of the eye. Research has shown links between retinitis pigmentosa and several mutations in genes for photoreceptors, the cells in the retina that convert light into electrical signals that are sent to the brain via the optic nerve. In the early stages of the disease, rod photoreceptors, which enable us to see in low light, are lost, causing night blindness. As the disease progresses, cone photoreceptors, which are needed for sharp vision and seeing colors, can also die off, eventually leading to complete blindness.
by Michael Le Page It is perhaps the most extraordinary eye in the living world – so extraordinary that no one believed the biologist who first described it more than a century ago. Now it appears that the tiny owner of this eye uses it to catch invisible prey by detecting polarised light. This suggestion is also likely to be greeted with disbelief, for the eye belongs to a single-celled organism called Erythropsidinium. It has no nerves, let alone a brain. So how could it "see" its prey? Fernando Gómez of the University of São Paulo, Brazil, thinks it can. "Erythropsidinium is a sniper," he told New Scientist. "It is waiting to see the prey, and it shoots in that direction." Erythropsidinium belongs to a group of single-celled planktonic organisms known as dinoflagellates. They can swim using a tail, or flagellum, and many possess chloroplasts, allowing them to get their food by photosynthesis just as plants do. Others hunt by shooting out stinging darts similar to the nematocysts of jellyfishMovie Camera. They sense vibrations when prey comes near, but they often have to fire off several darts before they manage to hit it, Gómez says. Erythropsidinium and its close relatives can do better, Gómez thinks, because they spot prey with their unique and sophisticated eye, called the ocelloid, which juts out from the cell. "It knows where the prey is," he says. At the front of the ocelloid is a clear sphere rather like an eyeball. At the back is a dark, hemispherical structure where light is detected. The ocelloid is strikingly reminiscent of the camera-like eyes of vertebrates, but it is actually a modified chloroplast. © Copyright Reed Business Information Ltd.
By Stephen L. Macknik, Susana Martinez-Conde and Bevil Conway This past February a photograph of a dress nearly broke the Internet. It all started when a proud mother-in-law-to-be snapped a picture of the dress she planned to wear to her daughter's wedding. When she shared her picture with her daughter and almost-son-in-law, the couple could not agree on the color: she saw white and gold, but he saw blue and black. A friend of the bride posted the confusing photo on Tumblr. Followers then reposted it to Twitter, and the image went viral. “The Dress” pitted the opinions of superstar celebrities against one another (Kanye and Kim disagreed, for instance) and attracted millions of views on social media. The public at large was split into white-and-gold and blue-and-black camps. So much attention was drawn, you would have thought the garment was conjured by a fairy godmother and accessorized with glass slippers. To sort out the conundrum, the media tapped dozens of neuroscientists and psychologists for comment. Pride in our heightened relevance to society gave way to embarrassment as we realized that our scientific explanations for the color wars were not only diverse but also incomplete. Especially perplexing was the fact that people saw it differently on the same device under the same viewing conditions. This curious inconsistency suggests that The Dress is a new type of perceptual phenomenon, previously unknown to scientists. Although some early explanations for the illusion focused on individual differences in the ocular structure of the eye, such as the patterning and function of rod and cone photoreceptor cells or the light-filtering properties internal to the eye, the most important culprit may be the brain's color-processing mechanisms. These might vary from one person to the next and can depend on prior experiences and beliefs. © 2015 Scientific American
Link ID: 21053 - Posted: 06.15.2015
by Penny Sarchet Simon Sponberg of Georgia Institute of Technology in Atlanta and his team have figured out the secret to the moths' night vision by testing them with robotic artificial flowers (see above). By varying the speed of a fake flower's horizontal motion and changing brightness levels, the team tested moths' abilities under different conditions. It has been theorised that the moth brain slows down, allowing their visual system to collect light for longer, a bit like lengthening a camera's exposure. But the strategy might also introduce blur, making it hard to detect fast movement. If the moths were using this brain-slowing tactic, they would be expected to react to fast flower movements more slowly in darker conditions. The team found that there was indeed a lag. It helped them see motion in the dark while still allowing them to keep up with flowers swaying at normal speeds. The size of the lags matched the expected behaviour of a slowed nervous system, providing evidence that moths could be slowing down the action of neurons in their visual system. Previously, placing hawkmoths in a virtual obstacle courseMovie Camera revealed that they vary their navigation strategies depending on visibility conditions. Journal reference: Science, DOI: 10.1126/science.aaa3042 © Copyright Reed Business Information Ltd
Link ID: 21041 - Posted: 06.13.2015
Mo Costandi According to the old saying, the eyes are windows into the soul, revealing deep emotions that we might otherwise want to hide. Although modern science precludes the existence of the soul, it does suggest that there is a kernel of truth in this saying: it turns out the eyes not only reflect what is happening in the brain but may also influence how we remember things and make decisions. Our eyes are constantly moving, and while some of those movements are under conscious control, many of them occur subconsciously. When we read, for instance, we make a series of very quick eye movements called saccades that fixate rapidly on one word after another. When we enter a room, we make larger sweeping saccades as we gaze around. Then there are the small, involuntary eye movements we make as we walk, to compensate for the movement of our head and stabilise our view of the world. And, of course, our eyes dart around during the ‘rapid eye movement’ (REM) phase of sleep. What is now becoming clear is that some of our eye movements may actually reveal our thought process. Research published last year shows that pupil dilation is linked to the degree of uncertainty during decision-making: if somebody is less sure about their decision, they feel heightened arousal, which causes the pupils to dilate. This change in the eye may also reveal what a decision-maker is about to say: one group of researchers, for example, found that watching for dilation made it possible to predict when a cautious person used to saying ‘no’ was about to make the tricky decision to say ‘yes’. © 2015 Guardian News and Media Limited
Rebecca Hersher Greg O'Brien sees things that he knows aren't there, and these visual disturbances are becoming more frequent. That's not uncommon; up to 50 percent of people who have Alzheimer's disease experience hallucinations, delusions or psychotic symptoms, recent research suggests. At first, he just saw spider-like forms floating in his peripheral vision, O'Brien says. "They move in platoons." But in the last year or so, the hallucinations have been more varied, and often more disturbing. A lion. A bird. Sprays of blood among the spiders. Over the past five months, O'Brien has turned on an audio recorder when the hallucinations start, in hopes of giving NPR listeners insight into what Alzheimer's feels like. For now, he says, "I'm able to function. But I fear the day, which I know will come, when I can't." Interview Highlights [It's] St. Patrick's Day, about 9 o'clock in the morning in my office, and they're coming again. Those hallucinations. Those things that just come into the mind when the mind plays games. And then I see the bird flying in tighter and tighter and tighter circles. And all of a sudden, the bird — beak first — it darted almost in a suicide mission, exploding into my heart. Today I'm just seeing this thing in front of me. It looks like a lion, almost looks like something you'd see in The Lion King, and there are birds above it. It's floating, and it disintegrates ... it disintegrates ... it disintegrates.
by Clare Wilson A new study has discredited the theory that dyslexia is caused by visual problems. So what does cause the condition and how can it be treated? What kind of visual problems are claimed to cause dyslexia? A huge variety. They include difficulties in merging information from both eyes, problems with glare from white pages or the text blurring or "dancing" on the page. A host of products claim to relieve this so-called visual stress, especially products that change the background colour of the page, such as tinted glasses and coloured overlays. Others advise eye exercises that supposedly help people with dyslexia track words on the page. Despite lack of evidence that these approaches work, some people with dyslexia say they help – more than half of university students with dyslexia have used such products. What are the new findings? That there's no evidence visual stress is linked with dyslexia. Nearly 6000 UK children aged between 7 and 9 had their reading abilities tested as well as performing a battery of visual tests. About 3 per cent of them had serious dyslexia, in line with the national average. But in the visual tests, the differences between the students with and without dyslexia were minimal. In two of the 11 tests, about 16 per cent of the children with dyslexia scored poorly, compared with 10 per cent for children with normal reading abilities. But that small difference could be caused by the fact that they read less, says author Alexandra Creavin of the University of Bristol, UK. And more importantly, the 16 per cent figure is so low, it can't be the main explanation for dyslexia. © Copyright Reed Business Information Ltd.
Carl Zimmer Octopuses, squid and cuttlefish — a group of mollusks known as cephalopods — are the ocean’s champions of camouflage. Octopuses can mimic the color and texture of a rock or a piece of coral. Squid can give their skin a glittering sheen to match the water they are swimming in. Cuttlefish will even cloak themselves in black and white squares should a devious scientist put a checkerboard in their aquarium. Cephalopods can perform these spectacles thanks to a dense fabric of specialized cells in their skin. But before a cephalopod can take on a new disguise, it needs to perceive the background that it is going to blend into. Cephalopods have large, powerful eyes to take in their surroundings. But two new studies in The Journal Experimental Biology suggest that they have another way to perceive light: their skin. It’s possible that these animals have, in effect, evolved a body-wide eye. When light enters the eye of a cephalopod, it strikes molecules in the retina called opsins. The collision starts a biochemical reaction that sends an electric signal from the cephalopod’s eye to its brain. (We produce a related form of opsins in our eyes as well.) In 2010, Roger T. Hanlon, a biologist at the Marine Biological Laboratory in Woods Hole, Mass., and his colleagues reported that cuttlefish make opsins in their skin, as well. This discovery raised the tantalizing possibility that the animals could use their skin to sense light much as their eyes do. Dr. Hanlon teamed up with Thomas W. Cronin, a visual ecologist at the University of Maryland Baltimore County, and his colleagues to take a closer look. © 2015 The New York Times Company
By Camille Bains, Imagine being able to see three times better than 20/20 vision without wearing glasses or contacts — even at age 100 or more — with the help of bionic lenses implanted in your eyes. Dr. Garth Webb, an optometrist in British Columbia who invented the Ocumetics Bionic Lens, says patients would have perfect vision and that driving glasses, progressive lenses and contact lenses would become a dim memory as the eye-care industry is transformed. Dr. Garth Webb says the bionic lens would allow people to see to infinity and replace the need for eyeglasses and contact lenses. (Darryl Dyck/Canadian Press) Webb says people who have the specialized lenses surgically inserted would never get cataracts because their natural lenses, which decay over time, would have been replaced. Perfect eyesight would result "no matter how crummy your eyes are," Webb says, adding the Bionic Lens would be an option for someone who depends on corrective lenses and is over about age 25, when the eye structures are fully developed. "This is vision enhancement that the world has never seen before," he says, showing a Bionic Lens, which looks like a tiny button. "If you can just barely see the clock at 10 feet, when you get the Bionic Lens you can see the clock at 30 feet away," says Webb, demonstrating how a custom-made lens that folded like a taco in a saline-filled syringe would be placed in an eye, where it would unravel itself within 10 seconds. He says the painless procedure, identical to cataract surgery, would take about eight minutes and a patient's sight would be immediately corrected. ©2015 CBC/Radio-Canada.
Link ID: 20950 - Posted: 05.19.2015
By Angus Chen Jumping spiders are the disco dancers of the arachnid world. The males thump and throb their brightly patterned legs and abdomens at the ladies like in the video above. Yet most of these bright colors should be impossible for the arachnids to see. That’s because their eyes have only two types of color-sensitive cone cells, which are designed to detect just ultraviolet and green light. Now, researchers report today in Current Biology that the North American genus of jumping spiders sees extra colors via a small, thin layer of red-pigmented cells partially covering the center of their retinas. The layer acts as a filter, allowing only red light to pass through and activate retinal cells just below the layer. This essentially converts a few of their green-sensitive cells into red-sensitive cells, allowing the spiders to build palates from three colors much the same way humans do—we have blue, green, and red cone cells. These jumping spiders have some limitations, though. Because their red filter is a small dot over the center of their retinas, they can see red only if they look directly at it. And because the filter blocks out any light that’s not red, anything that they look at has to be pretty bright before they can see any redness on it. Luckily for them, they like to spend time dancing in the sun. © 2015 American Association for the Advancement of Science
Link ID: 20947 - Posted: 05.19.2015
By Tina Hesman Saey A man who had been blind for 50 years allowed scientists to insert a tiny electrical probe into his eye. The man’s eyesight had been destroyed and the photoreceptors, or light-gathering cells, at the back of his eye no longer worked. Those cells, known as rods and cones, are the basis of human vision. Without them, the world becomes gray and formless, though not completely black. The probe aimed for a different set of cells in the retina, the ganglion cells, which, along with the nearby bipolar cells, ferry visual information from the rods and cones to the brain. No one knew whether those information-relaying cells still functioned when the rods and cones were out of service. As the scientists sent pulses of electricity to the ganglion cells, the man described seeing a small, faint candle flickering in the distance. That dim beacon was a sign that the ganglion cells could still send messages to the brain for translation into images. That 1990s experiment and others like it sparked a new vision for researcher Zhuo-Hua Pan of Wayne State University in Detroit. He and his colleague Alexander Dizhoor wondered if, instead of tickling the cells with electricity, scientists could transform them to sense light and do what rods and cones no longer could. The approach is part of a revolutionary new field called optogenetics. Optogeneticists use molecules from algae or other microorganisms that respond to light or create new molecules to do the same, and insert them into nerve cells that are normally impervious to light. By shining light of certain wavelengths on the molecules, researchers can control the activity of the nerve cells. © Society for Science & the Public 2000 - 2015
Link ID: 20938 - Posted: 05.16.2015
by Rachel Ehrenberg It was the dress that launched a million tweets. In February, a mother-in-law-to-be sent a picture of a dress she was considering wearing to her daughter’s Grace’s wedding to Grace and her fiancé. The couple couldn’t agree on the dress’s color: was it blue and black or white and gold? (White and gold, obviously.) The disagreement prompted the daughter to post the picture on social media, recruiting other opinions. That post caused such a stir that BuzzFeed picked it up, asking the masses to weigh in. And then the Internet went haywire. Within a few days, the original BuzzFeed article had more than 37 million hits. Serious news outlets interviewed neuroscientists and psychologists about color perception and optical illusions. Bevil Conway, a neuroscientist at Wellesley College, was one of those scientists. At the time, he thought the hullabaloo was interesting mostly because it showed how passionately people feel about color (as in, insanely riled-up and deeply offended by alternative views). He joked with NPR’s Robert Siegel, off air, that the story was “fluff,” Conway told me. Well, there’s nothing like a little research to turn fluff into gold (or blue or black). Conway, coauthor of a study appearing online May 14 in Current Biology that explores people’s perceptions of the dress, now calls the phenomenon “profound.” “I think it will go down as one of the most important discoveries in color vision in the last 10 years,” Conway says. “And all because of a crazy photograph.” In those February interviews, Conway (and some other scientists) explained the disparity of opinions on the dress in terms of “color constancy,” a feature of perception that allows us to identify colors under different lighting conditions. If we see a red poisonous snake or a red delicious apple, we need to be able to identify it as red (and dangerous or delicious), whether in bright sunlight or the gloom of clouds. © Society for Science & the Public 2000 - 2015
Link ID: 20937 - Posted: 05.16.2015
By C. CLAIBORNE RAY Q. I heard that people can’t look at a color in one room and then pick it out of a set of similar colors in the next room. But there are people with perfect pitch, so are there people with “perfect hue”? A. “The short answer is no,” said Mark D. Fairchild, director of the program of color science at the Munsell Color Science Laboratory of Rochester Institute of Technology. “Color is almost always judged relative to other colors,” Dr. Fairchild said, and the human ability to remember colors over any period of time, or even from room to room, is extremely poor. “Based on memory alone, we can probably reliably identify tens of colors, with some people perhaps able to study hard and get up to a hundred or so,” he said. “If we were to learn a systematic way to scale colors, we might be able to get up to several hundred.” If colors are compared side by side, however, “then we can easily distinguish several thousand colors, and some estimate more than a million,” Dr. Fairchild said. Such ability is somewhat analogous to differentiating tones in hearing, he said. Almost everyone can distinguish tones when they are compared in close succession, he said, but only a very small percentage of people have what is called perfect pitch or absolute pitch: the ability to recall and identify tones after a considerable period of time, without a reference tone for comparison. “Unfortunately, color appearance seems to be even more difficult to remember,” Dr. Fairchild said, “to the point that we don’t speak of anyone as having perfect hue.” © 2015 The New York Times Company
Link ID: 20916 - Posted: 05.13.2015
by Bethany Brookshire Certain images conjure up intense emotion: crying children, a bloody face, a snake rearing for a strike. When people take in pictures that hold deep meaning for them, they actually see the images more vividly. For them, emotion gives the world an extra burst of Technicolor and increases the odds that they will remember the scene. But the amount of visual boost — called emotionally enhanced vividness — varies from person to person. Some of this variability is in our genes, a new study finds, suggesting that people really do see the world in different ways. Many of us are familiar with the chemical messenger norepinephrine as a stress chemical. But it doesn’t just dictate whether we fight or flee, says Rebecca Todd, a cognitive neuroscientist at the University of British Columbia in Vancouver. Norepinephrine is also very important for emotional memory. “It’s important in the initial perception of emotional stimuli,” she explains. “It weighs down emotional memories so they burn brighter.” Norepinephrine is produced in an area of the brain called the locus coeruleus. In an ideal system, the cells in this area produce norepinephrine in response to a signal such as stress. The norepinephrine signals pass to other areas of the brain, but some chemical messenger remains, binding to receptors called alpha2b adrenoreceptors on cells in the locus coeruleus. These adrenoreceptors act as a brake, stopping the production of norepinephrine before things get out of hand. The receptors are produced by the gene ADRA2b. But a substantial proportion of Europeans and Africans have a variation on ADRA2b that deletes the alpha2b adrenoreceptor, possibly cutting some of the wires on the norepinephrine brakes. People with this deletion had stronger memories of emotionally charged events, a 2007 study found. Todd and graduate student Mana Ehlers wanted to see if this deletion might affect how people perceived emotional images. © Society for Science & the Public 2000 - 2015.
by Laura Sanders On a test of visual perception, children with autism perceive moving dots with more clarity than children without the disorder. The results, published in the May 6 Journal of Neuroscience, reveal a way in which children with autism see the world differently. When asked to determine the overall direction of a mess of dots moving in slightly different directions, children with autism outperformed children without the disorder. Other tests of motion detection didn’t turn up any differences. The results suggest that children with autism may be taking in and combining more motion information than children without autism, says study coauthor Catherine Manning of the University of Oxford. This heightened ability may contribute to feelings of sensory overload, the researchers suggest. © Society for Science & the Public 2000 - 2015
By Jocelyn Kaiser One of the most heralded successes of gene therapy may not be the permanent fix that many had hoped. Leaders of two clinical trials report this week that a treatment that restored some vision to blind patients begins to fade within a few years. A third group, however, says their patients, who received a different version of the therapy, are retaining their improved vision, and a company is moving ahead with efforts to gain regulatory approval for their treatment. It is not a huge surprise that the treatment effects may not last, says eye disease researcher Mark Pennesi of Oregon Health & Science University in Portland, who is running a similar trial. “These are complex diseases and everything that’s been done is sort of first generation,” he says. “The fact that there was biological activity at all is a milestone.” At issue is gene therapy for a rare form of inherited blindness known as Leber’s congenital amaurosis (LCA) that results in complete vision loss by about age 40. About 10% of cases are due to a mutation in retinal pigment epithelium 65 (RPE65), a gene that codes for an enzyme that helps retinal cells make rhodopsin. The pigment is needed by photoreceptor cells—the retina’s light-sending rods and cones—and when RPE65 is mutated, the photoreceptor cells gradually die. In 2007, in the first-ever effort to use gene therapy to treat people with blindness, three separate teams in the United States and the United Kingdom launched clinical trials for the RPE65 type of LCA. A surgeon injected one eye of each patient with a solution containing a harmless virus that ferried a good copy of RPE65 into retinal cells. © 2015 American Association for the Advancement of Science
Link ID: 20892 - Posted: 05.05.2015
By Gretchen Vogel BERLIN—A German neuroscientist who has been the target of animal rights activists says he is giving up on primate research. Nikos Logothetis, a director at the Max Planck Institute for Biological Cybernetics in Tübingen, Germany, says he will conclude his current experiments on macaques “as quickly as possible” and then shift his research to rodent neural networks. In a letter last week to fellow primate researchers, Logothetis cites a lack of support from colleagues and the wider scientific community as key factors in his decision. In particular, he says the Max Planck Society—and other organizations—should pursue criminal charges against the activists who target researchers. Logothetis’s research on the neural mechanisms of perception and object recognition has used rhesus macaques with electrode probes implanted in their brains. The work was the subject of a broadcast on German national television in September that showed footage filmed by an undercover animal rights activist working at the institute. The video purported to show animals being mistreated. Logothetis has said the footage is inaccurate, presenting a rare emergency situation following surgery as typical and showing stress behaviors deliberately prompted by the undercover caregiver. (His written rebuttal is here.) The broadcast triggered protests, however, and it prompted several investigations of animal care practices at the institute. Investigations by the Max Planck Society and animal protection authorities in the state of Baden-Württemberg found no serious violations of animal care rules. A third investigation by local Tübingen authorities that led to a police raid at the institute in late January is still ongoing. © 2015 American Association for the Advancement of Science.