Chapter 10. Biological Rhythms and Sleep
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Emily Underwood Since swine flu swept the globe in 2009, scientists have scrambled to determine why a small percentage of children in Europe who received the flu vaccine Pandemrix developed narcolepsy, an incurable brain disorder that causes irresistible sleepiness. This week, a promising explanation was dealt a setback when prominent sleep scientist Emmanuel Mignot of Stanford University in Palo Alto, California, and colleagues retracted their influential study reporting a potential link between the H1N1 virus used to make the vaccine and narcolepsy. Some researchers were taken aback. “This was one of the most important pieces of work on narcolepsy that has come out,” says neuroimmunologist Lawrence Steinman, a close friend and colleague of Mignot’s, who is also at Stanford. The retraction, announced in Science Translational Medicine (STM), “really caught me by surprise,” he says. Others say that journal editors should have detected problems with the study’s methodology. The work provided the first substantiation of an autoimmune mechanism for narcolepsy, which could explain the Pandemrix side effect, researchers say. The vaccine, used only in Europe, seems to have triggered the disease in roughly one out of 15,000 children who received it. The affected children carried a gene variant for a particular human leukocyte antigen (HLA) type—a molecule that presents foreign proteins to immune cells—considered necessary for developing narcolepsy. In the 18 December 2013 issue of STM, Mignot and colleagues reported that T cells from people with narcolepsy, but not from healthy controls, are primed to attack by hypocretin, a hormone that regulates wakefulness. They also showed molecular similarities between fragments of the H1N1 virus and the hypocretin molecule and suggested that these fragments might fool the immune system into attacking hypocretin-producing cells. © 2014 American Association for the Advancement of Science
By PAULA SPAN Call me nuts, but I want to talk more about sleeping pill use. Hold your fire for a few paragraphs, please. Just a week after I posted here about medical efforts to help wean older patients off sleeping pills — causing a flurry of comments, many taking exception to the whole idea as condescending or dismissive of the miseries of insomnia — researchers at the Centers for Disease Control and Prevention and Johns Hopkins published findings that reinforce concerns about these drugs. I say “reinforce” because geriatricians and other physicians have fretted for years about the use of sedative-hypnotic medications, including benzodiazepines (like Ativan, Klonopin, Xanax and Valium) and the related “Z-drugs” (like Ambien) for treating insomnia. “I’m not comfortable writing a prescription for these medications,” said Dr. Cara Tannenbaum, the geriatrician at the University of Montreal who led the weaning study. “I haven’t prescribed a sedative-hypnotic in 15 years.” In 2013, the American Geriatrics Society put sedative-hypnotics on its first Choosing Wisely campaign list of “Five Things Physicians and Patients Should Question,” citing heightened fall and fracture risks and automobile accidents in older patients who took them. Now the C.D.C. has reported that a high number of emergency room visits are associated with psychiatric medications in general, and zolpidem — Ambien — in particular. They’re implicated in 90,000 adult E.R. visits annually because of adverse reactions, the study found; more than 19 percent of those visits result in hospital admissions. Among those taking sedatives and anxiety-reducing drugs, “a lot of visits were because people were too sleepy or hard to arouse, or confused,” said the lead author, Dr. Lee Hampton, a medical officer at the C.D.C. “And there were also a lot of falls.” © 2014 The New York Times Company
|By Jillian Rose Lim and LiveScience People who don't get enough sleep could be increasing their risk of developing false memories, a new study finds. In the study, when researchers compared the memory of people who'd had a good night's sleep with the memory of those who hadn't slept at all, they found that, under certain conditions, sleep-deprived individuals mix fact with imagination, embellish events and even "remember" things that never actually happened. False memories occur when people's brains distort how they remember a past event — whether it's what they did after work, how a painful relationship ended or what they witnessed at a crime scene. Memory is not an exact recording of past events, said Steven Frenda, a psychology Ph.D. student at the University of California, Irvine, who was involved in the study. Rather, fresh memories are constructed each time people mentally revisit a past event. During this process, people draw from multiple sources — like what they've been told by others, what they've seen in photographs or what they know as stereotypes or expectations, Frenda said. The new findings "have implications for people's everyday lives —recalling information for an exam, or in work contexts, but also for the reliability of eyewitnesses who may have experienced periods of restricted or deprived sleep," said Frenda, who noted that chronic sleep deprivation is on the rise. In a previous study, Frenda and his colleagues observed that people with restricted sleep (less than 5 hours a night) were more likely to incorporate misinformation into their memories of certain photos, and report they had seen video footage of a news event that didn't happen. In the current study, they wanted to see how a complete lack of sleep for 24 hours could influence a person's memory. © 2014 Scientific American
By James Gallagher Health editor, BBC News website Even low levels of light in bedrooms may stop breast cancer drugs from working, US researchers have warned. Animal tests showed light, equivalent to that from street lamps, could lead to tumours becoming resistant to the widely used drug Tamoxifen. The study, published in the journal Cancer Research, showed the light affected sleep hormones, which in turn altered cancer cell function. UK experts said it was an intriguing finding, but not proven in people. Tamoxifen has transformed the treatment of breast cancer by extending lives and increasing survival times. It stops the female hormone oestrogen fuelling the growth of tumours although the cancerous cells may eventually become resistant to the drug. Light Researchers at the Tulane University School of Medicine investigated the role of the body clock in Tamoxifen resistance. They focused their research on the sleep-promoting hormone melatonin, which normally begins to rise in the evening and continues through the night, before falling away as dawn approaches. However, light in the evening - such as from a smartphone, tablet or artificial lights - can lower melatonin levels. Rats, with human breast cancer and treated with Tamoxifen, were left to sleep in a completely dark cage or one that had dim light. The scientists showed that in dim light, melatonin levels were lower, the tumours were bigger and were resistant to Tamoxifen. A second set of tests showed that giving those mice melatonin supplements kept Tamoxifen working and resulted in smaller tumours. BBC © 2014
Keyword: Biological Rhythms
Link ID: 19881 - Posted: 07.26.2014
By DONALD G. MCNEIL Where was I? Sorry — must have nodded off for a decade. Ten years ago, I spent two nights in a sleep lab at SUNY Downstate Medical Center, taking the test for sleep apnea, and wrote about it for Science Times. Back then, “sleep technicians” wired me up like the Bride of Frankenstein: 15 sensors glued or clamped to my scalp, lip, eye sockets, jaw, index finger, chest and legs, two belts around my torso, and a “snore mike” on my neck. As I slept, an infrared camera watched over me. And I ended up spending 23 hours in that hospital bed because the test wasn’t over until you could lie in a dark room for 20 minutes without dozing off. I had such a sleep deficit that I kept conking out, not just all night, but all the next day. So this year, when a company called NovaSom offered to let me try out a new home sleep-test kit that promises to streamline the process, I said yes. In the decade since my ordeal, the pendulum has swung sharply in the direction of the home test, said Dr. M. Safwan Badr, past president of the American Academy of Sleep Medicine, which first recognized home testing for apnea in 2007. Insurers prefer it because it costs only about $300, about one-tenth that of a hospital test, and many patients like it, too. “Lots of people are reluctant to let a stranger watch them sleep,” said Dr. Michael Coppola, a former president of the American Sleep Apnea Association who is now the chief medical officer at NovaSom. Doctors estimate that 18 million Americans have moderate to severe apnea and 75 percent of them do not know it. Home testing is not recommended for those with heart failure, emphysema, seizures and a few other conditions. And because it does not record brain waves as a hospital lab does, a home test can be fooled by someone who just lies awake all night staring at the ceiling. But it’s useful for many people who exhibit the warning signs of apnea, such as waking up exhausted after a full night’s sleep or dozing off at the wheel in bright daylight. And severe apnea can be lethal: starving the brain of oxygen all night quadruples the risk of stroke. © 2014 The New York Times Company
Link ID: 19865 - Posted: 07.22.2014
By Kelly Clancy In one important way, the recipient of a heart transplant ignores its new organ: Its nervous system usually doesn’t rewire to communicate with it. The 40,000 neurons controlling a heart operate so perfectly, and are so self-contained, that a heart can be cut out of one body, placed into another, and continue to function perfectly, even in the absence of external control, for a decade or more. This seems necessary: The parts of our nervous system managing our most essential functions behave like a Swiss watch, precisely timed and impervious to perturbations. Chaotic behavior has been throttled out. Or has it? Two simple pendulums that swing with perfect regularity can, when yoked together, move in a chaotic trajectory. Given that the billions of neurons in our brain are each like a pendulum, oscillating back and forth between resting and firing, and connected to 10,000 other neurons, isn’t chaos in our nervous system unavoidable? The prospect is terrifying to imagine. Chaos is extremely sensitive to initial conditions—just think of the butterfly effect. What if the wrong perturbation plunged us into irrevocable madness? Among many scientists, too, there is a great deal of resistance to the idea that chaos is at work in biological systems. Many intentionally preclude it from their models. It subverts computationalism, which is the idea that the brain is nothing more than a complicated, but fundamentally rule-based, computer. Chaos seems unqualified as a mechanism of biological information processing, as it allows noise to propagate without bounds, corrupting information transmission and storage. © 2014 Nautilus,
Keyword: Biological Rhythms
Link ID: 19859 - Posted: 07.21.2014
by Azeen Ghorayshi Food could be a new weapon in shaking off the effects of jet lag after research in mice showed that the insulin released as a result of eating can be a key factor in restoring a disrupted body clock. Miho Sato and her colleagues at The Research Institute for Time Studies at Yamaguchi University in Japan did experiments in mice and tissue cultures to show, for the first time, that increases in insulin affect circadian rhythms. These daily rhythms affect alertness, sleep patterns, and mediate many other physiological processes. Your biological clock is regulated by two broad factors: first, the central rhythm is reset daily by light, as sensory input from the eyes is processed by a small part of the brain called the suprachiasmatic nucleus. The rise and fall of hormones linked to sleep, for example, match this rhythm. But circadian rhythms are also present in peripheral "clocks" in a wide range of cell types in the body. Some of these can be influenced by food. Sato demonstrated the role of insulin by shifting the peripheral body clock in the livers of mice by feeding them only at night. They then split the mice into two groups, supressed insulin levels in one group, and returned all the mice to daytime feeding. Four days later, the livers of the non-supressed mice had readjusted to a normal daily rhythm, as revealed by the daily rise and fall of liver-gene expression. The livers of the insulin-suppressed mice had still not returned to normal. © Copyright Reed Business Information Ltd.
Keyword: Biological Rhythms
Link ID: 19830 - Posted: 07.15.2014
|By William Skaggs Jet lag is a pain. Besides the inconvenience and frustration of traveling more than a few time zones, jet lag likely causes billions of dollars in economic losses. The most effective treatment, according to much research, is structured exposure to light, although the drug melatonin may also sometimes be helpful at bedtime. Both approaches have been used for more than 20 years, and during that time no viable new interventions have appeared. Recently, however, research into the molecular biology of circadian rhythms has raised the prospect of developing new drugs that might produce better results. Jet lag occurs when the “biological clock” in the brain becomes misaligned with the local rhythm of daily activity. The ultimate goal of circadian medicine is a treatment that instantly resets the brain's clock. Failing that, it would be helpful to have treatments that speed the rate of adjustment. Four recent discoveries suggest new possibilities. The first involves vasopressin, which is the main chemical signal used to synchronize cellular rhythms of activity in the brain area that is responsible for our biological clock. Blocking vasopressin makes it much easier to reset this clock. Potentially, a drug that interferes with vasopressin could work as a fast-acting treatment for jet lag. The second and third possibilities involve a pair of brain chemicals called salt-inducible kinase 1 (SIK1) and casein kinase 1ε (CK1ε), both of which limit the ability of light to reset the brain's clock. Drugs already exist that interfere with their action and greatly increase the effectiveness of light exposure. The existing drugs are not viable jet-lag treatments, because they are hard to administer and have unpleasant side effects, but researchers hope better drugs can be developed that work in a similar way. © 2014 Scientific American,
By Fredrick Kunkle Sleep disturbances such as apnea may increase the risk of Alzheimer’s disease, while moderate exercise in middle age and mentally stimulating games, such as crossword puzzles, may prevent the onset of the dementia-causing disease, according to new research to be presented Monday. The findings — which are to be introduced during the six-day Alzheimer’s Association International Conference in Copenhagen — bolster previous studies that suggest sleep plays a critical role in the aging brain’s health, perhaps by allowing the body to cleanse itself of Alzheimer's-related compounds during down time. The studies also add to a growing body of literature that suggests keeping the brain busy keeps it healthy. The battle against Alzheimer’s disease has become more urgent for the United States and other developing nations as their populations turn increasingly gray. The disease is the leading cause of dementia in older people and afflicts more than 5 million Americans. At its current pace, the number is expected to soar to 16 million people by 2050. In 2012, the United States adopted a national plan to combat the disease and the G-8 nations last year adopted a goal of providing better treatment and prevention by 2025. Erin Heintz, a spokeswoman for the Alzheimer’s Association, said U.S. government funding to combat the disease now stands at about $500 million a year. To reach its 2025 goal, the United States should be spending $2 billion a year, she said.
Carmen Fishwick Do you have difficulty getting enough sleep? Sleep problems affect one in three of us at any one time, and about 10% of the population on a chronic basis. Of Guardian readers who responded to a recent poll, 23% reported that they sleep between four and six hours a night. With continued lack of sufficient sleep, the part of the brain that controls language and memory is severely impaired, and 17 hours of sustained wakefulness is equivalent to performing on a blood alcohol level of 0.05% – the UK's legal drink driving limit. In 2002, American researchers analysed data from more than one million people, and found that getting less than six hours' sleep a night was associated with an early demise – as was getting over eight hours. Studies have found that blood pressure is more than three times greater among those who sleep for less than six hours a night, and women who have less than four hours of sleep are twice as likely to die from heart disease. Other research suggests that a lack of sleep is also related to the onset of diabetes, obesity, and cancer. Are you worried about how much sleep you get? Professor Russell Foster, chair of circadian neuroscience and head of the Sleep and Circadian Neuroscience Institute at the University of Oxford, and professor Colin Espie, professor of sleep medicine at the University of Oxford and lead researcher on the Great British Sleep Survey, answered reader questions. © 2014 Guardian News and Media Limited
Link ID: 19724 - Posted: 06.14.2014
by Moheb Costandi Rest easy after learning a new skill. Experiments in mice suggest that a good night's sleep helps us lay down memories by promoting the growth of new connections between brain cells. Neuroscientists believe that memory involves the modification of synapses, which connect brain cells, and numerous studies published over the past decade have shown that sleep enhances the consolidation of newly formed memories in people. But exactly how these observations were related was unclear. To find out, Wenbiao Gan of the Skirball Institute of Biomolecular Medicine at New York University Medical School and his colleagues trained 15 mice to run backwards or forwards on a rotating rod. They allowed some of them to fall asleep afterwards for 7 hours, while the rest were kept awake. The team monitored the activity and microscopic structure of the mice's motor cortex, the part of the brain that controls movement, through a small transparent "window" in their skulls. This allowed them to watch in real time how the brain responded to learning the different tasks. Sprouting spines They found that learning a new task led to the formation of new dendritic spines – tiny structures that project from the end of nerve cells and help pass electric signals from one neuron to another – but only in the mice left to sleep. This happened during the non-rapid eye movement stage of sleep. Each task caused a different pattern of spines to sprout along the branches of the same motor cortex neurons. © Copyright Reed Business Information Ltd.
Damage to certain parts of the brain can lead to a bizarre syndrome called hemispatial neglect, in which one loses awareness of one side of their body and the space around it. In extreme cases, a patient with hemispatial neglect might eat food from only one side of their plate, dress on only one side of their body, or shave or apply make-up to half of their face, apparently because they cannot pay attention to anything on that the other side. Research published last week now suggests that something like this happens to all of us when we drift off to sleep each night. The work could help researchers to understand the causes of hemispatial neglect, and why it affects one side far more often than the other. It also begins to reveal the profound changes in conscious experience that take place while we fall asleep, and the brain changes that accompany them. Hemispatial neglect is a debilitating condition that occurs often in people who suffer a stroke, where damage to the left hemisphere of the brain results in neglect of the right half of space, and vice versa. It can occur as a result of damage to certain parts of the frontal lobes, which are involved in alertness and attention, and the parietal lobes, which process information about the body and its surrounding space. In clinical tests, patients with hemispatial neglect are typically unaware of all kinds of stimuli in one half of space – they fail to acknowledge objects placed in the affected half of their visual field, for example and cannot state the location of touch sensations on the affected side of their body. Some may stop using the limbs on the affected side, or even deny that the limbs belong to them. Patients with neglect can usually see perfectly well, but information from the affected side just does not reach their conscious awareness. © 2014 Guardian News and Media Limited
By Brady Dennis The Food and Drug Administration is worried that a sleeping pill you take tonight could make for a riskier drive to work tomorrow. In its latest effort to make sure that the millions of Americans taking sleep medications don’t drowsily endanger themselves or others, the agency on Thursday said it will require the manufacturer of the popular drug Lunesta to lower the recommended starting dose, after data showed that people might not be alert enough to drive the morning after taking the drug, even if they feel totally awake. The current recommended starting dose of eszopiclone, the drug marketed as Lunesta, is 2 milligrams at bedtime for both men and women. The FDA said that initial dose should be cut in half to 1 milligram, though it could be increased if needed. People currently taking 2 and 3 milligram doses should ask a doctor about how to safely continue taking the medication, as higher doses are more likely to impair driving and other activities that require alertness the following morning, the agency said. “To help ensure patient safety, health care professionals should prescribe, and patients should take, the lowest dose of a sleep medicine that effectively treats their insomnia,” Ellis Unger, of FDA’s Center for Drug Evaluation and Research, said in a statement. In 2013, the FDA said, approximately 3 million prescriptions of Lunesta were dispensed to nearly a million patients in the United States. Lunesta, made by Sunovion Pharmaceuticals, also recently became available in generic form. The new rules, including changes to existing labels, will apply both to the brand-name and generic forms of the drug. FDA officials said the decision came, in part, after seeing findings from a study of 91 healthy adults between the ages 25 and 40. Compared to patients on a placebo, those taking a 3 milligram dose of Lunesta were associated with “severe next-morning psychomotor and memory impairment in both men and women,” the agency said. The study found that even people taking the recommended dose could suffer from impaired driving skills, memory and coordination as long as 11 hours after taking the drug. Even scarier: The patients often claimed that they felt completely alert, with no hint of drowsiness. © 1996-2014 The Washington Post
Link ID: 19622 - Posted: 05.15.2014
by Helen Thomson If you liked Inception, you're going to love this. People have been given the ability to control their dreams after a quick zap to their head while they sleep. Lucid dreaming is an intriguing state of sleep in which a person becomes aware that they are dreaming. As a result, they gain some element of control over what happens in their dream – for example, the dreamer could make a threatening character disappear or decide to fly to an exotic location. Researchers are interested in lucid dreaming because it can help probe what happens when we switch between conscious states, going from little to full awareness. In 2010, Ursula Voss at the J.W. Goethe University in Frankfurt, Germany, and her colleagues trained volunteers to move their eyes in a specific pattern during a lucid dream. By scanning their brains while they slept, Voss was able to show that lucid dreams coincided with elevated gamma brainwaves. This kind of brainwave occurs when groups of neurons synchronise their activity, firing together about 40 times a second. The gamma waves occurred mainly in areas situated towards the front of the brain, called the frontal and temporal lobes. Perchance to dream The team wanted to see whether gamma brainwaves caused the lucid dreams, or whether both were side effects of some other change. So Voss and her colleagues began another study in which they stimulated the brain of 27 sleeping volunteers, using a non-invasive technique called transcranial alternating current. © Copyright Reed Business Information Ltd.
|By Ariel Van Brummelen The presence of light may do more for us than merely allow for sight. A study by Gilles Vandewalle and his colleagues at the University of Montreal suggests that light affects important brain functions—even in the absence of vision. Previous studies have found that certain photoreceptor cells located in the retina can detect light even in people who do not have the ability to see. Yet most studies suggested that at least 30 minutes of light exposure is needed to significantly affect cognition via these nonvisual pathways. Vandewalle's study, which involved three completely blind participants, found that just a few seconds of light altered brain activity, as long as the brain was engaged in active processing rather than at rest. First the experimenters asked their blind subjects whether a blue light was on or off, and the subjects answered correctly at a rate significantly higher than random chance—even though they confirmed they had no conscious perception of the light. Using functional MRI, the researchers then determined that less than a minute of blue light exposure triggered changes in activity in regions of their brain associated with alertness and executive function. Finally, the scientists found that if the subjects received simultaneous auditory stimulation, a mere two seconds of blue light was enough to modify brain activity. The researchers think the noise engaged active sensory processing, which allowed the brain to respond to the light much more quickly than in previous studies when subjects rested while being exposed to light. The results confirm that the brain can detect light in the absence of working vision. They also suggest that light can quickly alter brain activity through pathways unrelated to sight. The researchers posit that this nonvisual light sensing may aid in regulating many aspects of human brain function, including sleep/wake cycles and threat detection. © 2014 Scientific American,
One of our most mysterious and intriguing states of consciousness is the dream. We lose consciousness when we enter the deep waters of sleep, only to regain it as we emerge into a series of uncanny private realities. These air pockets of inner experience have been difficult for psychologists to study scientifically and, as a result, researchers have mostly resorted to measuring brain activity as the sleeper lies passive. But interest has recently returned to a technique that allows real-time communication from within the dream world. The rabbit hole between these worlds of consciousness turns out to be the lucid dream, where people become aware that they are dreaming and can influence what happens within their self-generated world. Studies suggest that the majority of people have had a lucid dream at some point in their life but that the experience is not common. As a result, there is now a minor industry in technologies and training techniques that claim to increase your chance of having a lucid dream although a recent scientific review estimated that the effect of any particular strategy is moderate at best. Some people, however, can reliably induce lucid dreams and it's these people who are allowing us to conduct experiments inside dreams. When trying to study an experience or behaviour, cognitive scientists usually combine subjective reports, what people describe about their experience, with behavioural experiments, to see what effect a particular state has on how people reason, act or remember. But both are difficult in dreamers, because they can't tell you much until they wake up and active participation in experiments is difficult when you are separated from the world by a blanket of sleep-induced paralysis. This paralysis is caused by neurons in the brainstem that block signals from the action-generating areas in the brain to the spinal nerves and muscles. The shutdown happens when Rapid Eye Movement or REM sleep starts, meaning that dreaming of even the most energetic actions results in no more than a slight twitch. One of the few actions that are not paralysed, however, is eye movement. This is where REM sleep gets its name from and this window of free action provides the lucid dreamer a way of signalling to the outside world. © 2014 Guardian News and Media Limited
Link ID: 19543 - Posted: 04.28.2014
By Ariel Van Brummelen The presence of light may do more for us than merely allow for sight. A study by Gilles Vandewalle and his colleagues at the University of Montreal suggests that light affects important brain functions—even in the absence of vision. Previous studies have found that certain photoreceptor cells located in the retina can detect light even in people who do not have the ability to see. Yet most studies suggested that at least 30 minutes of light exposure is needed to significantly affect cognition via these nonvisual pathways. Vandewalle's study, which involved three completely blind participants, found that just a few seconds of light altered brain activity, as long as the brain was engaged in active processing rather than at rest. First the experimenters asked their blind subjects whether a blue light was on or off, and the subjects answered correctly at a rate significantly higher than random chance—even though they confirmed they had no conscious perception of the light. Using functional MRI, the researchers then determined that less than a minute of blue light exposure triggered changes in activity in regions of their brain associated with alertness and executive function. Finally, the scientists found that if the subjects received simultaneous auditory stimulation, a mere two seconds of blue light was enough to modify brain activity. The researchers think the noise engaged active sensory processing, which allowed the brain to respond to the light much more quickly than in previous studies when subjects rested while being exposed to light. The results confirm that the brain can detect light in the absence of working vision. They also suggest that light can quickly alter brain activity through pathways unrelated to sight. The researchers posit that this nonvisual light sensing may aid in regulating many aspects of human brain function, including sleep/wake cycles and threat detection. © 2014 Scientific American
By Dwayne Godwin and Jorge Cham ABOUT THE AUTHOR(S) Dwayne Godwin is a neuroscientist at the Wake Forest University School of Medicine. Jorge Cham draws the comic strip Piled Higher and Deeper at www.phdcomics.com. © 2014 Scientific American
Link ID: 19473 - Posted: 04.12.2014
by Meghan Rosen Shaking off jet lag could be as easy as downloading an app. Researchers developed the iPhone app, called Entrain, using mathematical analyses of humans’ daily rhythms to calculate the quickest way to adjust to new time zones. Users plug in their destination and arrival time, and Entrain advises times of the day to soak up or stay out of the light. The schedules are surprisingly simple, says mathematical biologist Daniel Forger, of the University of Michigan in Ann Arbor. “They might say, ‘Hey you should keep the lights on in your room until midnight,’” he says. “Or ‘you should stay in darkness until 10 a.m.’” Scientists have previously created mathematical equations that describe how humans’ internal clocks respond to light, Forger says. He and a colleague used a computer program to solve the tricky problem of finding the best lighting schedules for more than 1,000 possible trips. To do so, the researchers asked a question: If a traveler wants to move their body’s clock from New York to London time, for instance, what lighting schedule gets them there fastest? The pair reports the results April 10 in PLOS Computational Biology. K. Serkh and D.B. Forger. Optimal schedules of light exposure for rapidly correcting circadian misalignment. PLOS Computational Biology. Vol.10, April 10, 2014, p. e1003525. Doi: 10.1371/journal.pcbi.1003523. © Society for Science & the Public 2000 - 2013.
Keyword: Biological Rhythms
Link ID: 19472 - Posted: 04.12.2014
By JoNel Aleccia The engineer who drove a speeding commuter train off the rails in New York last year may have suffered from the most severe form of a dangerous sleep disorder, but health experts say he has plenty of company. As many as 22 million people in the U.S. — or up to 7 percent of the population — may suffer from obstructive sleep apnea, experts say. It’s a condition that causes airways to collapse during sleep, cutting off breathing dozens or sometimes hundreds of times a night, leaving them bleary-eyed and drowsy, even after a full night’s rest. William Rockefeller, 46, was diagnosed after the December 2013 crash that killed four and injured more than 70 with severe obstructive sleep apnea, documents released this week show. On a scale where as few as five sleep disruptions an hour can make someone sleepy, and 30 episodes are considered severe, Rockefeller logged about 66 arousals an hour, doctors said. “His sleep was really fragmented,” said Dr. Phyllis Zee, a sleep expert with the Northwestern Medicine Sleep and Circadian Rhythms Research Program. “Even if he were to sleep seven or eight hours, he would be sleep-deprived.” Zee and her colleagues suspected that Rockefeller might suffer from sleep deprivation. He was obese, records show, and there’s a certain fatigued look that she saw in news photos of the engineer. “That was one of my thoughts, ‘Oh my goodness, he has (OSA),’” she said.
Link ID: 19457 - Posted: 04.08.2014