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Adults with extreme obesity have increased risks of dying at a young age from cancer and many other causes including heart disease, stroke, diabetes, and kidney and liver diseases, according to results of an analysis of data pooled from 20 large studies of people from three countries. The study, led by researchers from the National Cancer Institute (NCI), part of the National Institutes of Health, found that people with class III (or extreme) obesity had a dramatic reduction in life expectancy compared with people of normal weight. The findings appeared July 8, 2014, in PLOS Medicine. “While once a relatively uncommon condition, the prevalence of class III, or extreme, obesity is on the rise. In the United States, for example, six percent of adults are now classified as extremely obese, which, for a person of average height, is more than 100 pounds over the recommended range for normal weight,” said Cari Kitahara, Ph.D., Division of Cancer Epidemiology and Genetics, NCI, and lead author of the study. “Prior to our study, little had been known about the risk of premature death associated with extreme obesity.” In the study, researchers classified participants according to their body mass index (BMI), which is a measure of total body fat and is calculated by dividing a person’s weight in kilograms by their height in meters squared. The 20 studies that were analyzed included adults from the United States, Sweden and Australia. These groups form a major part of the NCI Cohort Consortium, which is a large-scale partnership that identifies risk factors for cancer death. After excluding individuals who had ever smoked or had a history of certain diseases, the researchers evaluated the risk of premature death overall and the risk of premature death from specific causes in more than 9,500 individuals who were class III obese and 304,000 others who were classified as normal weight.

Keyword: Obesity
Link ID: 19812 - Posted: 07.10.2014

Associated Press Scientists at the Massachusetts Institute of Technology are developing an audio reading device to be worn on the index finger of people whose vision is impaired, giving them affordable and immediate access to printed words. The so-called FingerReader, a prototype produced by a 3-D printer, fits like a ring on the user's finger, equipped with a small camera that scans text. A synthesized voice reads words aloud, quickly translating books, restaurant menus and other needed materials for daily living, especially away from home or office. Reading is as easy as pointing the finger at text. Special software tracks the finger movement, identifies words and processes the information. The device has vibration motors that alert readers when they stray from the script, said Roy Shilkrot, who is developing the device at the MIT Media Lab. For Jerry Berrier, 62, who was born blind, the promise of the FingerReader is its portability and offer of real-time functionality at school, a doctor's office and restaurants. "When I go to the doctor's office, there may be forms that I want to read before I sign them," Berrier said. He said there are other optical character recognition devices on the market for those with vision impairments, but none that he knows of that will read in real time. Berrier manages training and evaluation for a federal program that distributes technology to low-income people in Massachusetts and Rhode Island who have lost their sight and hearing. He works from the Perkins School for the Blind in Watertown, Mass. Developing the gizmo has taken three years of software coding, experimenting with various designs and working on feedback from a test group of visually impaired people. Much work remains before it is ready for the market, Shilkrot said, including making it work on cell phones. © 2014 Hearst Communications, Inc.

Keyword: Vision; Aggression
Link ID: 19811 - Posted: 07.10.2014

By BENEDICT CAREY PHILADELPHIA — The man in the hospital bed was playing video games on a laptop, absorbed and relaxed despite the bustle of scientists on all sides and the electrodes threaded through his skull and deep into his brain. “O.K., that’s enough,” he told doctors after more than an hour. “All those memory tests, it’s exhausting.” The man, Ralph, a health care worker who asked that his last name be omitted for privacy, has severe epilepsy; and the operation to find the source of his seizures had provided researchers an exquisite opportunity to study the biology of memory. The Department of Defense on Tuesday announced a $40 million investment in what has become the fastest-moving branch of neuroscience: direct brain recording. Two centers, one at the University of Pennsylvania and the other at the University of California, Los Angeles, won contracts to develop brain implants for memory deficits. Their aim is to develop new treatments for traumatic brain injury, the signature wound of the wars in Iraq and in Afghanistan. Its most devastating symptom is the blunting of memory and reasoning. Scientists have found in preliminary studies that they can sharpen some kinds of memory by directly recording, and stimulating, circuits deep in the brain. Unlike brain imaging, direct brain recording allows scientists to conduct experiments while listening to the brain’s internal dialogue in real time, using epilepsy patients like Ralph or people with Parkinson’s disease as active collaborators. The technique has provided the clearest picture yet of how neural circuits function, and raised hopes of new therapies for depression and anxiety as well as cognitive problems. But experts also worry about the possible side effects of directly tampering with memory. © 2014 The New York Times Company

Keyword: Learning & Memory; Aggression
Link ID: 19810 - Posted: 07.09.2014

The modern idea of stress began on a rooftop in Canada, with a handful of rats freezing in the winter wind. This was 1936 and by that point the owner of the rats, an endocrinologist named Hans Selye, had become expert at making rats suffer for science. "He would subject them to extreme temperatures, make them go hungry for long periods, or make them exercise a lot," the medical historian says. "Then what he would do is kill the rats and look at their organs." What was interesting to Selye was that no matter how different the tortures he devised for the rats were — from icy winds to painful injections — when he cut them open to examine their guts it appeared that the physical effects of his different tortures were always the same. "Almost universally these rats showed a particular set of signs," Jackson says. "There would be changes particularly in the adrenal gland. So Selye began to suggest that subjecting an animal to prolonged stress led to tissue changes and physiological changes with the release of certain hormones, that would then cause disease and ultimately the death of the animal." And so the idea of stress — and its potential costs to the body — was born. But here's the thing: The idea of stress wasn't born to just any parent. It was born to Selye, a scientist absolutely determined to make the concept of stress an international sensation. © 2014 NPR

Keyword: Stress
Link ID: 19809 - Posted: 07.09.2014

By Helen Briggs Health editor, BBC News website The same genes drive maths and reading ability, research suggests. Around half of the genes that influence a child's aptitude for reading also play a role in how easily they learn maths, say scientists. The study of 12-year-old British twins from 3,000 families, reported in Nature Communications, adds to the debate about the role of genes in education. An education expert said the work had little relevance for public policy as specific genes had not been identified. Past research suggests both nature and nurture have a similar impact on how children perform in exams. One study found genes explained almost 60% of the variation in GCSE exam results. However, little is known about which genes are involved and how they interact. The new research suggests a substantial overlap between the genetic variations that influence mathematics and reading, say scientists from UCL, the University of Oxford and King's College London. But non-genetic factors - such as parents, schools and teachers - are also important, said Prof Robert Plomin of King's College London, who worked on the study. "The study does not point to specific genes linked to literacy or numeracy, but rather suggests that genetic influence on complex traits, like learning abilities, and common disorders, like learning disabilities, is caused by many genes of very small-effect size," he said. BBC © 2014

Keyword: Language; Aggression
Link ID: 19808 - Posted: 07.09.2014

By JOSHUA A. KRISCH The Human Brain Project is Europe’s flagship contribution to neuroscience. Established last year and funded by the European Commission, the project was meant to rally scientists and computer engineers around developing better tools to study how the brain works. But its most ambitious goal — a computer simulation of the entire brain — came under attack on Monday when hundreds of neuroscientists from around the world sent an open letter to the commission condemning what they see as an absence of feasibility and transparency. The letter said that the project’s “overly narrow approach” threatened to set Europe back in terms of its scientific progress and its investment, about $130 million a year over the next 10 years. “It’s like a moonshot, but before we knew how to build an airplane,” said Zachary Mainen, a neuroscientist at the Champalimaud Center for the Unknown, in Lisbon, and an author of the letter. “We can’t simulate the 302 neurons in a nematode brain. It’s a bit premature to simulate the 100 billion neurons in a human brain.” The letter expressed concern over the recent dissolution of the project’s Cognitive Architectures branch, which would have explored the larger behavioral implications of the research. “It’s the departure of the entire cognitive neuroscience aspect of the H.B.P.,” Dr. Mainen said. “It’s not clear why they would throw that out.” Henry Markram, a neuroscientist at the Swiss Federal Institute of Technology and the director of the Human Brain Project, said he considered the letter “a big wake-up call.” © 2014 The New York Times Company

Keyword: Brain imaging
Link ID: 19807 - Posted: 07.09.2014

Europe’s ambitious project to unpick the workings of the human brain faces a crisis less than a year after it was launched with great fanfare at the Swiss Federal Institute of Technology (EPFL) in Lausanne. Some neuroscientists involved in the billion-euro Human Brain Project (HBP) are furious that much of their research into how the brain executes its cognitive functions is to be sidelined as the initiative enters its next phase. Arguments over the strategy and direction of mega-science projects are nothing new. But the acrimony over this project is particularly unfortunate, given its status as one of two European Union (EU) flagship programmes designed to cross some of the widest interdisciplinary barriers and solve societal problems — such as brain disease. Already, some leading scientists have walked away. If more follow, the project could waste a golden opportunity to understand the brain. Dissent in the ranks about what the project should encompass and who should decide this has been raging for months. But it peaked in late May, when the project’s leaders made clear that they intended to exclude studies on cognition from their core future plans. The first funding, or ‘ramp-up’, phase of the brain project began in October last year with €54 million (US$73 million) from the European Commissionand is scheduled to run for three years. The second phase of the ten-year project will be funded to the tune of around €100 million per year for two or three years. But in their detailed plans for this second stage, submitted on 10 June to the commission for approval, the project managers eliminated research on human cognitive architecture. © 2014 Nature Publishing Group

Keyword: Brain imaging
Link ID: 19806 - Posted: 07.09.2014

By NICHOLAS BAKALAR Can too much studying ruin your eyesight? Maybe. A German study has found that the more education a person has, the greater the likelihood that he will be nearsighted. The researchers did ophthalmological and physical examinations on 4,685 people ages 35 to 74. About 38 percent were nearsighted. But of those who graduated after 13 years in the three-tiered German secondary school system, about 60.3 percent were nearsighted, compared with 41.6 percent of those who graduated after 10 years, 27.2 percent of those who graduated after nine years and 26.9 percent of those who never graduated. The percentage of myopic people was also higher among university graduates than among graduates of vocational schools or those who had no professional training at all. The study was published online in Ophthalmology. The association remained after adjusting for age, gender and many known myopia-associated variations in DNA sequences. “The effect on myopia of the genetic variations is much less than the effect of education,” said the lead author, Dr. Alireza Mirshahi, an ophthalmologist at the University Medical Center in Mainz. “We used to think that myopia was predetermined by genetics. This is one proof that environmental factors have a much higher effect than we thought.” © 2014 The New York Times Company

Keyword: Vision
Link ID: 19805 - Posted: 07.09.2014

By Virginia Morell Many moth species sing courtship songs, and until now, scientists knew of only two types of such melodies. Some species imitate attacking bats, causing a female to freeze in place, whereas others croon tunes that directly woo the ladies. But the male yellow peach moth (Conogethes punctiferalis, pictured) belts out a combination song, scientists report online today in the Proceedings of the Royal Society B. These tiny troubadours, which are found throughout Asia, emit ultrasonic refrains composed of short and long pulses by contracting their abdominal tymbals, sound-producing membranes. (Listen to a male’s courtship song above.) The short pulses, the scientists say, are similar to the hunting calls of insectivorous horseshoe bats. However, unlike other moth species, these males aren’t directing the batlike tunes at females, but rather at rival males. Using playback experiments, the scientists showed that a male drives away competitors with the short pulses of his ditty, while inducing a female to mate with the long note. Indeed, a receptive virgin female moth (1 to 3 days old) typically raises her wings after hearing this part of the male’s song—a sign that she accepts the male, the scientists say. It is thus the first moth species known to have a dual-purpose melody. © 2014 American Association for the Advancement of Science

Keyword: Sexual Behavior; Aggression
Link ID: 19804 - Posted: 07.09.2014

Alison Abbott The European Union’s high-profile, €1-billion Human Brain Project (HBP), launched last October, has come under fire from neuroscientists, who claim that poor management has run part of the effort’s scientific plans off course. Around 150 scientists have signed a protest letter that was delivered to the European Commission on 7 July. The letter requests that the commission seriously consider whether the project is still fit for purpose as it reviews proposals for the second round of funding, to be awarded in 2016. The HBP was originally designed to promote digital technologies by supporting and learning from neuroscience. A key element of the project, which has inspired other brain-research initiatives around the world (see Nature 503, 26–28; 2013), is to develop supercomputers that neuroscientists will use to try to simulate the brain. But as the initiative has developed, its goal has become more and more diffuse. And after months of often fractious discussions about the programme’s scientific scope, tempers boiled over at the end of May, when the HBP’s three-man executive board decided to cut parts of the project, including one on cognitive neuroscience, from the second phase — in a manner that the signatories say was autocratic and scientifically inappropriate. Stanislas Dehaene, director of the Cognitive Neuroimaging Unit run by the French Institute of Health and Medical Research (INSERM) and the French Alternative Energies and Atomic Energy Commission (CEA) in Paris and one of the winners of this year’s prestigious Brain Prize, had led this part of the effort. On 30 May, he withdrew his participation from the second phase, citing lack of confidence in some of the decisions being made and in the programme’s management; he has not signed the letter. © 2014 Nature Publishing Group

Keyword: Brain imaging
Link ID: 19803 - Posted: 07.08.2014

by Helen Thomson A blood test for Alzheimer's might be just two years away. Abdul Hye at King's College London and his colleagues have identified 10 proteins in blood that can predict who will develop Alzheimer's disease a year after having mild memory problems. Its accuracy is almost 90 per cent. That could prove a huge boost for researchers seeking treatments. So far, trials of Alzheimer's drugs are thought to have failed because they have been given too late in the course of the disease to halt progression. The new blood test will initially be used to identify those people with mild cognitive impairment who are likely to get Alzheimer's disease and so might be good candidates for clinical trials to find drugs that halt disease progression. "Having a blood test is a really big step forward," says team member Ian Pike of Proteome Sciences in Cobham, UK. "The most important thing we can do is get the correct patients into clinical trials so we can tell, for example, whether it is a drug that is slowing the progression of the disease or the fact that we just happen to have a group of patients who have a slow progressing form of the disease." "This [blood test] is a technical tour de force," says Eric Karran, director of research at the Alzheimer's Research UK charity. However, he remains cautious about its use beyond clinical research. For every 10 people who take the test, one will get an incorrect result. "Alzheimer's is the most feared diagnosis, so we have to be careful, particularly in the absence of any treatment," he says. © Copyright Reed Business Information Ltd.

Keyword: Alzheimers
Link ID: 19802 - Posted: 07.08.2014

By EMILY ANTHES It was love at first pet when Laurel Braitman and her husband adopted a 4-year-old Bernese mountain dog, a 120-pound bundle of fur named Oliver. The first few months were blissful. But over time, Oliver’s troubled mind slowly began to reveal itself. He snapped at invisible flies. He licked his tail until it was wounded and raw. He fell to pieces when he spied a suitcase. And once, while home alone, he ripped a hole in a screen and jumped out of a fourth-floor window. To everyone’s astonishment, he survived. Oliver’s anguish devastated Dr. Braitman, a historian of science, but it also awakened her curiosity and sent her on an investigation deep into the minds of animals. The result is the lovely, big-hearted book “Animal Madness,” in which Dr. Braitman makes a compelling case that nonhuman creatures can also be afflicted with mental illness and that their suffering is not so different from our own. In the 17th century, Descartes described animals as automatons, a view that held sway for centuries. Today, however, a large and growing body of research makes it clear that animals have never been unthinking machines. We now know that species from magpies to elephants can recognize themselves in the mirror, which some scientists consider a sign of self-awareness. Rats emit a form of laughter when they’re tickled. And dolphins, parrots and dogs show clear signs of distress when their companions die. Together, these and many other findings demonstrate what any devoted pet owner has probably already concluded: that animals have complex minds and rich emotional lives. Unfortunately, as Dr. Braitman notes, “every animal with a mind has the capacity to lose hold of it from time to time.” © 2014 The New York Times Company

Keyword: Emotions; Aggression
Link ID: 19801 - Posted: 07.08.2014

Check out the winner of the 2014 Best Illusion of the Year Contest. Created by psychologists at the University of Nevada, Reno, this optical illusion starts with an image of a circle surrounded by other circles. As the video begins and the exterior circles grow and shrink, it looks like the center circle is changing size, too—but it isn’t. Dubbed “The Dynamic Ebbinghaus,” the trick is a spinoff of the original Ebbinghaus mirage created in the 1800s.

Keyword: Vision
Link ID: 19800 - Posted: 07.08.2014

By JOSHUA A. KRISCH Excessive alcohol consumption, including binge drinking, is responsible for 10 percent of deaths among working-age adults in the United States, according to a recent study from the Centers for Disease Control and Prevention. The researchers used an online tool called the Alcohol-Related Disease Impact application to estimate alcohol-related deaths ranging from car crashes and alcohol poisoning to liver and heart disease. They defined binge drinking as at least five consecutive drinks for men and four consecutive drinks for women. One in six adults from 20 to 65 reported binge drinking at least four times a month; the actual number is likely higher because subjects tend to underreport their drinking habits, the researchers said. The number of Americans who binge drink skyrocketed during the 1990s and leveled off in 2001, but the average frequency of binge drinking episodes is still rising. Excessive drinking is the fourth leading cause of preventable death in the United States, after smoking, poor nutrition and physical inactivity. “It’s a huge public health problem any way you slice it,” said Robert D. Brewer, a co-author of the paper and the director of the alcohol program at the C.D.C.“There are things that we can do about it,” like raising the alcohol tax and encouraging doctors to talk to their patients about alcohol abuse, “but a lot of those strategies tend to be underused.” © 2014 The New York Times Company

Keyword: Drug Abuse
Link ID: 19799 - Posted: 07.08.2014

|By Emilie Reas A poor diet can eat away at brain health. Now a study in Neurology helps elucidate why. It suggests that eating a lot of sugar or other carbohydrates can be hazardous to both brain structure and function. Diabetes, which is characterized by chronically high levels of blood glucose, has been linked to an elevated risk of dementia and a smaller hippocampus, a brain region critical for memory. The new study sought to identify whether glucose had an effect on memory even in people without the disease because having it could induce other brain changes that confound the data. In the experiment, researchers at the Charité University Medical Center in Berlin evaluated both short- and long-term glucose markers in 141 healthy, nondiabetic older adults. The participants performed a memory test and underwent imaging to assess the structure of their hippocampus. Higher levels on both glucose measures were associated with worse memory, as well as a smaller hippocampus and compromised hippocampal structure. The researchers also found that the structural changes partially accounted for the statistical link between glucose and memory. According to study co-author Agnes Flöel, a neurologist at Charité, the results “provide further evidence that glucose might directly contribute to hippocampal atrophy,” but she cautions that their data cannot establish a causal relation between sugar and brain health. These findings indicate that even in the absence of diabetes or glucose intolerance, higher blood sugar may harm the brain and disrupt memory function. Future research will need to characterize how glucose exerts these effects and whether dietary or lifestyle interventions might reverse such pathological changes. © 2014 Scientific American

Keyword: Obesity
Link ID: 19798 - Posted: 07.08.2014

Priyanka Pulla Not everyone who is obese is unhealthy. So say some researchers, who note that a small fraction of overweight people have normal blood sugar levels and blood pressure, and are thus “healthy obese.” Now, scientists have identified a single protein that seems to determine whether obesity is harmful or benign. The protein is a new player in our understanding of how obesity leads to disease, says Alan Saltiel, a cell biologist at the University of Michigan, Ann Arbor, who was not involved in the study. It is well known that obesity leads to a wide range of health problems, from diabetes to heart disease to cancer. So established is the link between extra pounds and illness that last year the American Medical Association voted to classify obesity itself as a disease. Although some researchers have suggested that a small number of obese people are healthy, that idea remains controversial. Instead, the emerging consensus is that healthy obesity is a transient phase, says Ravi Retnakaran, an endocrinologist at the Leadership Sinai Centre for Diabetes in Toronto, Canada. Sooner or later, he says, these outliers will develop metabolic syndrome, a condition in which glucose, cholesterol, and lipid levels soar, causing diabetes and heart disease. In fact, so-called healthy obese people may already have early signs of disease, which are too muted to show up on routine tests. In a study of more than 14,000 metabolically healthy Korean people last year, scientists found early plaque buildup in the arteries of obese subjects more often than they did in the lean ones. © 2014 American Association for the Advancement of Science

Keyword: Obesity
Link ID: 19797 - Posted: 07.04.2014

By ALEX HALBERSTADT Dr. Vint Virga likes to arrive at a zoo several hours before it opens, when the sun is still in the trees and the lanes are quiet and the trash cans empty. Many of the animals haven’t yet slipped into their afternoon ma­laise, when they retreat, appearing to wait out the heat and the visitors and not do much of anything. Virga likes to creep to the edge of their enclosures and watch. He chooses a spot and tries not to vary it, he says, “to give the animals a sense of control.” Sometimes he watches an animal for hours, hardly moving. That’s because what to an average zoo visitor looks like frolicking or restlessness or even boredom looks to Virga like a lot more — looks, in fact, like a veritable Russian novel of truculence, joy, sociability, horniness, ire, protectiveness, deference, melancholy and even humor. The ability to interpret animal behavior, Virga says, is a function of temperament, curiosity and, mostly, decades of practice. It is not, it turns out, especially easy. Do you know what it means when an elephant lowers her head and folds her trunk underneath it? Or when a zebra wuffles, softly blowing air between her lips; or when a colobus monkey snuffles, sounding a little like a hog rooting in the mud; or when a red fox screams, sounding disconcertingly like an infant; or when red fox kits chatter at one another; or when an African wild dog licks and nibbles at the lips of another; or when a California sea lion resting on the water’s surface stretches a fore flipper and one or both rear flippers in the air, like a synchronized swimmer; or when a hippopotamus “dung showers” by defecating while rapidly flapping its tail? Virga knows, because it is his job to know. He is a behaviorist, and what he does, expressed plainly, is see into the inner lives of animals. The profession is an odd one: It is largely unregulated, and declaring that you are an expert is sometimes enough to be taken for one. Most behaviorists are former animal trainers; some come from other fields entirely. Virga happens to be a veterinarian, very likely the only one in the country whose full-time job is tending to the psychological welfare of animals in captivity. © 2014 The New York Times Company

Keyword: Animal Rights; Aggression
Link ID: 19796 - Posted: 07.04.2014

|By Jessica Wright and SFARI.org CHD8, a gene that regulates the structure of DNA, is the closest thing so far to an ‘autism gene,’ suggests a study published today in Cell. People with mutations in this gene all have the same cluster of symptoms, including a large head, constipation and characteristic facial features; nearly all also have have autism. Autism is notoriously heterogeneous, perhaps involving mutations in any of hundreds of genes. Typically, researchers begin by studying people with similar symptoms and working backward to identify what causes those symptoms. But that approach has not been particularly productive. “We’ve tried for so long to identify subtypes of autism based on behavior alone and we’ve done abysmally at that,” says lead researcher Raphael Bernier, associate professor of psychiatry at the University of Washington in Seattle. The reverse approach — that is, beginning with people who all have mutations in the same gene and characterizing their symptoms — may prove to be more useful for simplifying autism’s complexity. For example, identifying subtypes of autism may help researchers develop drugs tailored to that particular cause, says Evan Eichler, professor of genome sciences at the University of Washington, who spearheaded the genetics side of the study. “I think the most important realization is that not all autisms are created equal,” he says. © 2014 Scientific American,

Keyword: Autism; Aggression
Link ID: 19795 - Posted: 07.04.2014

By GABRIELLE GLASER When their son had to take a medical leave from college, Jack and Wendy knew they — and he — needed help with his binge drinking. Their son’s psychiatrist, along with a few friends, suggested Alcoholics Anonymous. He had a disease, and in order to stay alive, he’d have to attend A.A. meetings and abstain from alcohol for the rest of his life, they said. But the couple, a Manhattan reporter and editor who asked to be identified only by their first names to protect their son’s privacy, resisted that approach. Instead, they turned to a group of psychologists who specialize in treating substance use and other compulsive behaviors at the Center for Motivation and Change. The center, known as the C.M.C., operates out of two floors of a 19th-century building on 30th Street and Fifth Avenue. It is part of a growing wing of addiction treatment that rejects the A.A. model of strict abstinence as the sole form of recovery for alcohol and drug users. Instead, it uses a suite of techniques that provide a hands-on, practical approach to solving emotional and behavioral problems, rather than having abusers forever swear off the substance — a particularly difficult step for young people to take. And unlike programs like Al-Anon, A.A.’s offshoot for family members, the C.M.C.’s approach does not advocate interventions or disengaging from someone who is drinking or using drugs. “The traditional language often sets parents up to feel they have to make extreme choices: Either force them into rehab or detach until they hit rock bottom,” said Carrie Wilkens, a psychologist who helped found the C.M.C. 10 years ago. “Science tells us those formulas don’t work very well.” When parents issue edicts, demanding an immediate end to all substance use, it often lodges the family in a harmful cycle, said Nicole Kosanke, a psychologist at the C.M.C. Tough love might look like an appropriate response, she said, but it often backfires by further damaging the frayed connections to the people to whom the child is closest. © 2014 The New York Times Company

Keyword: Drug Abuse
Link ID: 19794 - Posted: 07.04.2014

By Helen Briggs Health editor, BBC News website More than 99% of drug trials for Alzheimer's disease during the past decade have failed, according to a study. There is an urgent need to increase the number of potential therapies being investigated, say US scientists. Only one new medicine has been approved since 2004, they report in the journal Alzheimer's Research & Therapy. The drug failure rate is troubling and higher than for other diseases such as cancer, says Alzheimer's Research UK. Dr Jeffrey Cummings, of the Cleveland Clinic Lou Ruvo Center for Brain Health, in Las Vegas, and colleagues, examined a public website that records clinical trials. Between 2002 and 2012, they found 99.6% of trials of drugs aimed at preventing, curing or improving the symptoms of Alzheimer's had failed or been discontinued. This compares with a failure rate of 81% for cancer drugs. The failure rate was "especially troubling" given the rising numbers of people with dementia, said Dr Simon Ridley, of Alzheimer's Research UK. "The authors of the study highlight a worrying decline in the number of clinical trials for Alzheimer's treatments in more recent years," he said. "There is a danger that the high failure rates of trials in the past will discourage pharmaceutical companies from investing in dementia research. BBC © 2014

Keyword: Alzheimers
Link ID: 19793 - Posted: 07.04.2014