Most Recent Links
Follow us on Facebook and Twitter, or subscribe to our mailing list, to receive news updates. Learn more.
By ALEX HUTCHINSON WHEN marketing researchers at the University of Pennsylvania’s Wharton School rigged shopping carts at a major East Coast supermarket with motion-tracking radio-frequency tags, they unwittingly stumbled on a metaphor for our path through the aisles of life. Route data from more than 1,000 shoppers, matched to their purchases at checkout, revealed a clear pattern: Drop a bunch of kale into your cart and you’re more likely to head next to the ice cream or beer section. The more “virtuous” products you have in your basket, the stronger your temptation to succumb to vice. Such hedonic balancing acts are neither unpredictable — who, after all, hasn’t rewarded themselves with a piece of cake or an extra beer after a killer workout? — nor inherently bad. But an emerging body of research into what psychologists call the “licensing effect” suggests that this tit-for-tat tendency is deeply wired in us, operating even when we’re not aware of it. And in a world where we’re bombarded by pitches for an endless array of health-boosting products of dubious efficacy, that can be a problem. The key insight underlying the licensing effect, which was first described in 2006 by Uzma Khan, then a professor of marketing at Carnegie Mellon University, and Ravi Dhar of the Yale School of Management, is that our choices are contingent: Since we each have a fairly stable self-concept of how good/bad, healthy/unhealthy or selfish/altruistic we are, when one decision swings too far from this self-concept, we automatically take action to balance it out. © 2015 The New York Times Company
Dyscalculia is like dyslexia — but for those who have trouble with math instead of reading. But not enough people know about it, according to a neuroscientist. "There is a lack of awareness among teachers and educators," said Daniel Ansari, professor and Canada Research Chair in Developmental Cognitive Neuroscience at the University of Western Ontario. Individuals with dyscalculia have trouble with simple calculations. "If I ask you what is 1 + 3, you don't need to calculate. Four will pop in to your head, it is stored in your long-term memory," he said. But those with dyscalculia will have to use their hands to count. Scientists have known about dyscalculia since the 1940's but little research has been done on it, even though it is probably just as common as dyslexia, says Ansari. Currently, there is no existing universal form of testing for dyscalculia. But Ansari has come up with screening tests for children in kindergarten. He says it's important to diagnose dyscalculia early on, so individuals can learn to adapt and improve their skills before it's too late. "We don't just need math to be good in school but to function in society," said Ansari. He says research has shown poor math skills can lead to an increased chance of unemployment, imprisonment or mortgage default. ©2015 CBC/Radio-Canada.
Link ID: 21564 - Posted: 10.26.2015
By Nicholas Bakalar A new study has found that sleep apnea is associated with an increased risk for gout, a painful disease of the big toe and other joints caused by elevated levels of uric acid in the blood. Observational studies have shown that people with sleep apnea have a higher prevalence of excess uric acid, but until now it has been unclear whether sleep apnea is associated with gout, and how strongly. Using records in a British health database, researchers studied 9,865 people, average age 54, with sleep apnea and matched them to 43,598 controls without the disorder. Because sleep apnea is associated with being overweight, the participants were matched for B.M.I., among many other characteristics. The study is in Arthritis & Rheumatology. After one year, compared with controls, people with sleep apnea were about 50 percent more likely to have had an attack of gout, and the increased risk was found without regard to sex, age or obesity. The conclusion suggests that treating sleep apnea would reduce gout attacks, but the lead author, Yuqing Zhang, a professor of medicine at Boston University, is cautious. “Our findings call for future studies to evaluate the effect of treating sleep apnea on serum uric acid levels and the risk of gout,” he said. © 2015 The New York Times Company
Link ID: 21563 - Posted: 10.26.2015
As we get older, most of us will experience some kind of brain degeneration. Typically, we lose the ability to make new neurons. Another problem is chronic, low-grade inflammation in the brain, which is implicated in many age-related brain disorders. To tackle both problems in one go, Ludwig Aigner at Paracelsus Medical University Salzburg in Austria and his colleagues targeted a set of receptors in the brain that, when activated, trigger inflammation. High numbers of these receptors are found in areas of the brain where neurons are born, suggesting they might also be involved in this process, too. A drug called montelukast (Singulair), regularly prescribed for asthma and allergic rhinitis, blocks these receptors, so Aigner and his colleagues tried it on young and old rats. The team used oral doses equivalent to those taken by people with asthma. The older animals were 20 months old – roughly equivalent to between 65 and 75 in human years. The younger rats were 4 months old – about 17 in human years. The animals were fed the drug daily for six weeks, while another set of young and old rats were left untreated. There were 20 young and 14 old rats in total. The rats took part in a range of learning and memory tests. One of these, for example, involved the rats being placed in a pool of water with a hidden escape platform. At the start of the study, untreated young rats learned to recognise landmarks and quickly find their way to the platform, while the untreated older animals struggled at the task. © Copyright Reed Business Information Ltd.
By R. Douglas Fields “Why can’t you stop drinking?” This week at the Annual Meeting of the Society for Neuroscience in Chicago, researchers from the University of Chicago announced a new finding that provides a fresh answer to this persistent question that plagues people addicted to alcohol. The discovery offers an entirely new approach to treatment. Neuroscientist, Amy Lasek, at the Department of Psychiatry at the University of Illinois, Chicago, and colleagues, report that after binge drinking, neurons in brain circuits responsible for alcohol addiction become encased in a protein material, called a perineuronal net. The impenetrable coating cements neurons involved in alcohol addiction into a circuit that is extremely difficult to break. Current drugs for treating alcohol dependence work by modifying neurotransmitter signaling between neurons, but for many people these treatments cannot break the overwhelming compulsion to drink. Drugs that can break down the glue-like cement in perineuronal nets could offer a new approach to treatment. Lasek’s unusual approach into addiction research stems from her background as a molecular and cell biologist working in the field of cancer research. The root of cancer is changes in specific genes. Small molecules designed to target these aberrant genes is the approach used in cancer therapy. Lasek’s background made her think of finding molecularly targeted therapies for psychiatric disorders. Lasek and her colleagues began by studying fruit flies to search for gene variations that altered the fly’s behavior toward alcohol. She found several genes that had this effect, including an obscure one called ALK (anaplastic lymphoma kinase). Then she suppressed these genes in mice to see if the animal’s response to alcohol was altered. “I got hooked,” she says, “because to me the fact that you can manipulate a single gene in a single brain region and change behavior—like drinking or cocaine reward—was fascinating from a biological point of view!” © 2015 Scientific America
Keyword: Drug Abuse
Link ID: 21561 - Posted: 10.24.2015
By Carrie Arnold Most of the anorexia patients Dr. Joanna Steinglass sees in the inpatient eating-disorders unit at the New York State Psychiatric Institute have been to treatment before. While in the hospital or a residential treatment center, they generally gained weight and began to eat a wider variety of foods. But after they left, their old anorexic habits returned. They began skipping meals again or returning to their extreme exercise routines. All too soon, it seemed, the gains made in treatment and the hope for recovery that went along with it began to evaporate. According to the conventional wisdom around eating disorders, these relapses were really a misguided search for control. Or maybe the patients just weren’t ready for recovery yet. Or perhaps these were signs of self-control gone awry, spurred on by friends who marvel at their seemingly endless willpower. Interesting theories, and yet Steinglass disagreed. “Even when people show up at our hospital and want to make changes, they find it tough,” she said. Now a new study in Nature Neuroscience — which Steinglass co-authored — reveals why people with anorexia often struggle so much to integrate new ways of eating into their lives. In the brain, the behaviors associated with anorexia act a lot like habits, those daily decisions we make without thinking. And habits, according to both the scientific evidence and the colloquial wisdom, are phenomenally difficult to break. This new finding helps explain why anorexia has historically been so hard to treat: Anorexic patients are essentially fighting their own brains in an uphill battle for wellness. But more important, the new research may also point toward new and better ways to help those with the eating disorder overcome it. © 2015, New York Media LLC.
Keyword: Anorexia & Bulimia
Link ID: 21560 - Posted: 10.24.2015
Claire Cain Miller Boys are falling behind. They graduate from high school and attend college at lower rates than girls and are more likely to get in trouble, which can hurt them when they enter the job market. This gender gap exists across the United States, but it is far bigger for poor people and for black people. As society becomes more unequal, it seems, it hurts boys more. New research from social scientists offers one explanation: Boys are more sensitive than girls to disadvantage. Any disadvantage, like growing up in poverty, in a bad neighborhood or without a father, takes more of a toll on boys than on their sisters. That realization could be a starting point for educators, parents and policy makers who are trying to figure out how to help boys — particularly those from black, Latino and immigrant families. “It’s something about family disadvantage itself,” said David Figlio, a Northwestern University economist and co-author of a new paper, presented publicly for the first time on Thursday. “Black people in America are more disadvantaged than white people in America, and if we were to reduce the disadvantage, we may see a reduction in the relative gender gap as well.” Marianne Bertrand, an economist at University of Chicago who with Jessica Pan has studied the gender gap, also found that boys fare worse than girls in disadvantaged homes, and are more responsive than girls to parental time and resources. “Their findings were very consistent: Families that invest more in children are protective for boys,” she said. The reasons that boys react more negatively to disadvantage are varied and hard to pinpoint. Even in utero, boys are more sensitive to extreme stress than girls, and tend to have more unruly temperaments. Society discourages boys from showing vulnerability. Low-income families are often led by single mothers, which has been found to affect boys differently than girls. © 2015 The New York Times Company
By Bob Grant Scientists delving into the neurological underpinnings of traumatic brain injuries (TBI) are finding that there may be crucial differences in the long-term effects of the events that depend not only on the insult, but also on the victim. “No two brain injuries are identical,” University of Pennsylvania neuroscientist Akiva Cohen said during a press conference held at the Society for Neuroscience (SfN) annual meeting in Chicago on Monday (October 19). “Brain injury, like many pathologies these days, constitutes a spectrum.” In addition to a severity spectrum that spans mild to severe, brain injuries may differ in terms of how male and female animals respond to them, according to Ramesh Raghupathi, a neurobiologist at Drexel University. Raghupathi and his colleagues have found that young male mice suffer more depressive behaviors than female mice at both four and eight weeks after mild TBI, and females display more headache-like symptoms after similar insults, which can include concussion. “All of these animals at these times after injury are cognitively normal,” Raghupathi told reporters. “And they do not have any movement problems.” Raghupathi and his colleagues also found molecular differences that may underlie the sex differences in TBI response that they observed. “In the male mice,” he said, “there is a dramatic difference in dopamine transmission” compared to the uninjured mice.” Researchers have previously linked impaired dopamine signaling to depression. Raghupathi’s team tested for the lingering effects of TBI in mice by subjecting the animals to certain swimming tests—which are accepted as proxies for depression—and by using a thin filament to touch the faces of the rodents and recording their sensitivity as a measure of headache-like behaviors.
Elizabeth Blair The muppet Julia has not yet made her TV debut, but the wide-eyed little girl with a big smile is the star of her own "digital storybook" called "We're Amazing, 1,2,3." For over a year now, Sesame Street has been working with organizations such as Autism Speaks and Autism Self Advocacy to help reduce the stigma associated with autism spectrum disorder. As part of the campaign "See Amazing in All Children," the adorable muppet Abby Cadabby explains in one YouTube video, "Lots of kids have autism and that just means their brains work a little differently." Julia is not the first fictional media character with autism. But Michael Robb, Director of Research for Common Sense Media, an organization that rates and reviews media aimed at children, says Sesame Street's move is "pretty groundbreaking." "It can be difficult to start a conversation about children with disabilities. It's even harder when that difference isn't visible," he says. After looking through "We're Amazing, 1,2,3," Robb says the story could help children be more understanding of how Julia is different. "It's very real in terms of talking in simple language. It spells out these things in concrete ways that kids can understand. It shows ways she's just like other kids. It shows how making simple accommodations can help Julia." According to Dr. Jeanette Betancourt, Senior Vice President of U.S. Social Impact at Sesame Workshop, says Sesame Street producers are waiting to hear back from the autism community before introducing Julia to the show on TV. © 2015 npr
Link ID: 21557 - Posted: 10.24.2015
Olivia Maynard It has been described as a ‘disruptive technology’ potentially capable of breaking our fatal relationship with tobacco. So the setting for a public debate on e-cigarettes - a museum part-funded by the tobacco industry, in a city home to the global headquarters of one of the largest tobacco manufacturers - was perhaps ironic. Yet on Wednesday evening, I found myself at the M-Shed in Bristol, watching just that: a debate about whether e-cigarettes could be part of the solution to the tobacco epidemic. To mark the launch of a new Integrative Cancer Epidemiology Programme, linked to the Medical Research Centre Integrative Epidemiology Unit at the University of Bristol, Professor Marcus Munafò (Professor of Biological Psychology at the University of Bristol) and Professor Linda Bauld (Professor of Health Policy at the University of Stirling), both collaborators of mine, discussed e-cigarettes. Professor Gabriel Scally (Public Health Doctor and former Regional Director of Public Health for the South West of England) chaired the discussion. Billed as a debate about whether e-cigarettes might be ‘the key to reducing smoking’, some in the audience may have expected a heated discussion. However, with this line-up of academics, influential in the fields of public health, tobacco and addiction, the discussion was evidence-based and measured. As for the motion of the debate, the panel was unanimous: e-cigarettes may not be the key to reducing smoking, but they are certainly an important part of the solution. © 2015 Guardian News and Media Limited
Keyword: Drug Abuse
Link ID: 21556 - Posted: 10.24.2015
Alzheimer's disease can be detected decades before onset, using a virtual reality test, a study suggests. People aged 18 to 30 were asked to navigate through a virtual maze to test the function of certain brain cells. Those with a high genetic risk of Alzheimer's could be identified by their performance, according to German neuroscientists. The findings could help future research, diagnosis and treatment, they report in the journal Science. The scientists, led by Lukas Kunz of the German Centre for Neurodegenerative Diseases in Bonn, say the high risk group navigated the maze differently and had reduced functioning of a type of brain cell involved in spatial navigation. The findings could give an insight into why people with dementia can find navigating the world around them challenging, they say. "Our results could provide a new basic framework for preclinical research on Alzheimer's disease and may provide a neurocognitive explanation of spatial disorientation in Alzheimer's disease," they report in Science. Although genes play a role in dementia, their effects are complex with many unknowns. Dr Laura Phipps of Alzheimer's Research, said the latest study focused on healthy younger people at higher genetic risk of Alzheimer's, suggesting they may already show alterations in spatial navigation several decades before the disease could start. © 2015 BBC.
Link ID: 21555 - Posted: 10.23.2015
By JAMES GORMAN No offense to tenors, but outside of opera, a high male voice is seldom, if ever, considered seductive. Scientific research has shown that women find deep male voices attractive, and the same is true in other species, like howler monkeys. Stories from Our Advertisers But evolution is often stingy in its gifts, and researchers investigating male competition to reproduce have discovered an intriguing trade-off in some species of howler monkeys: the deeper the call, the smaller the testicles. Jacob Dunn of Cambridge University, one of the leaders of the research, said that species evolved either to make lower-frequency sounds, or have larger testicles, but none had both a very low sound and very large testicles. “It’s a great study,” said Stuart Semple, an evolutionary anthropologist at the University of Roehampton in London who was not involved in the research. “It shows this really clear trade-off.” Dr. Dunn and other researchers, including W. Tecumseh Fitch, of the University of Vienna, and Leslie A. Knapp, of the University of Utah, studied the size of a bone in the vocal apparatus, which is directly related to how deep the calls are, and the size of testicles, to come up for averages in nine species of howlers. They had been intrigued by great variations in both the size of the howlers’ hyoid bones in museum collections and in the size of the monkeys’ testicles as seen in the field. Dr. Knapp said that some of them are large enough that they are quite obvious “when you look up into the trees.” They used the museum samples of the bone and living monkeys in zoos for testicle measurements, and reported their findings Thursday in the journal Current Biology. © 2015 The New York Times Company
Jon Hamilton For a few days this week, a convention center in Chicago became the global epicenter of brain science. Nearly 30,000 scientists swarmed through the vast hallways of the McCormick Place convention center as part of the annual Society for Neuroscience meeting. Among them were Nobel Prize winners, the director of the National Institutes of Health, and scores of researchers regarded as the international rock stars of neuroscience. "It's amazing. I'm a bit overwhelmed," said Kara Furman, a graduate student from Yale who was attending her first Society for Neuroscience meeting. Furman was just one of several hundred neuroscientists I found standing in lines outside the center one afternoon, waiting for shuttle buses. She was pondering a presentation from a few hours earlier that she found "pretty mind-blowing." What was it about? "Using MRI techniques to access dopamine release at the molecular level," she told me, deadpan. Welcome to the five-day annual event that's become known simply as "The Neuro Meeting." It's where brain scientists from around the world come to present their own work and discover the "mind-blowing" research others are doing. And there are thousands of presentations to choose from. "I prepared an itinerary based on my interests and that ran into 20 pages," said Srinivas Bharath from the National Institute of Mental Health and Neurosciences in Bangalore, India. © 2015 npr
Link ID: 21553 - Posted: 10.23.2015
By Melissa Dahl Next time you feel you are in danger of losing an argument, make some obscure reference to the brain. Any nod to neuroscience will do, even if it doesn’t actually illuminate the problem at hand or prove anything that halfway resembles a point. People tend to find explanations that include references to the brain very convincing, even if those references are mostly nonsense, according to the latest episode of "Psych Crunch," a podcast hosted by psychologist (and Science of Us contributor) Christian Jarrett. Jarrett interviews Sara Hodges, a research psychologist at the University of Oregon and the co-author of a study published this May on the appeal of “superfluous neuroscience information.” In it, Hodges and her colleagues presented students with a variety of explanations for various psychological phenomena. Some of these explanations were not really explanations at all, but rather just a restatement of the facts already presented. The students considered explanations for various quirks of human behavior from the fields of social science, biological science, and neuroscience, and rated how convincing they found each explanation. “The social sciences would refer to something about how people were raised, and the hard-science explanation referred to changes in DNA, the structure of DNA,” Hodges explained to Jarrett. The neuroscience explanation, on the other hand, would pretty much just name an area of the brain thought to be associated with the behavior at hand and leave matters at that, without really explaining anything. Even still, Hodges said, the “neuroscience explanations always came out on top — better than no explanation, better than social science, better than the hard science.” © 2015, New York Media LLC
Link ID: 21552 - Posted: 10.23.2015
By Karen Weintraub The short answer is: not yet, but treatments are getting better. Getting older is the leading risk factor for age-related macular degeneration, the leading cause of vision loss in the United States. Macular degeneration comes in two forms: dry and wet. The dry form is milder and usually has no symptoms, but it can degenerate into the wet form, which is characterized by the growth of abnormal blood vessels in the back of the eye, potentially causing blurriness or vision loss in the center of the field of vision. The best treatment for wet macular degeneration is prevention, said Dr. Rahul N. Khurana, a clinical spokesman for the American Academy of Ophthalmology and a retina specialist practicing in Mountain View, Calif. Not smoking, along with eating dark green vegetables and at least two servings of fish a week, may help reduce the risk of macular degeneration, he said. An annual eye exam can catch macular degeneration while it is still in the dry form, Dr. Khurana said, and vitamins can help prevent it from progressing into the wet form, the main cause of vision loss. Dr. Joan W. Miller, chief of ophthalmology at Massachusetts Eye and Ear, said anyone with a family history of the disease should get a retina check at age 50. People should also get an eye exam if they notice problems like trouble adjusting to the dark or needing more light to read. The federally funded Age-Related Eye Disease Study, published in 2001 and updated in 2013, found that people at high risk for advanced age-related macular degeneration could cut that risk by about 25 percent by taking a supplement that included 500 milligrams of vitamin C, 400 I.U.s of vitamin E, 10 milligrams of lutein, 2 milligrams of zeaxanthin, 80 milligrams of zinc, and 2 milligrams of copper. © 2015 The New York Times Company
Link ID: 21551 - Posted: 10.23.2015
By Hanae Armitage CHICAGO, ILLINOIS—When prairie voles choose a mate, there’s no turning back—the “love chemical” oxytocin increases in their brains and they devote themselves to only each other. Although scientists have observed the behavioral and chemical side of prairie vole love, the neural networks behind commitment are still a mystery. Now, a group of scientists are working toward clearing up the neuronal backdrop of long-term love, and yesterday, presented their findings here at the annual meeting of the Society for Neuroscience. Studies have long suggested the nucleus accumbens, a part of the brain involved in reward processing, plays a crucial role in this type of devotion. To get a better look at the neuronal activity of this region, the scientists mounted a small-scale microscope that monitors calcium flux on top of a male prairie vole’s head (the more calcium into the neuron, the more neuronal activity). They saw that when male prairie voles interacted with their special lady vole, neuronal activity in the nucleus accumbens jumped 20% compared with when they interacted with a random female. Upon closer inspection, scientists saw that specific neurons that fired when the voles interacted with their mates stayed silent when they interacting with a different female. The result, though preliminary, indicates that mates stimulate the brain’s reward center in ways that nonmates cannot. © 2015 American Association for the Advancement of Science.
By Hanae Armitage CHICAGO, ILLINOIS—Aside from a few animals—like pythons and vampire bats—that can sense infrared light, the world of this particular electromagnetic radiation has been off-limits to most creatures. But now, researchers have engineered rodents to see infrared light by implanting sensors in their visual cortex—a first-ever feat announced here yesterday at the annual meeting of the Society for Neuroscience. Before they wired rats to see infrared light, Duke University neuroscientist Miguel Nicolelis and his postdoc Eric Thomson engineered them to feel it. In 2013, they surgically implanted a single infrared-detecting electrode into an area of the rat’s brain that processes touch called the somatosensory cortex. The other end of the sensor, outside the rat’s head, surveyed the environment for infrared light. When it picked up infrared, the sensor sent electrical messages to the rats’ brains that seemed to give them a physical sensation. At first, the rats would groom and rub their whiskers repeatedly whenever the light went on. But after a short while, they stopped fidgeting. They even learned to associate infrared with a reward-based task in which they followed the light to a bowl of water. In the new experiment, the team inserted three additional electrodes, spaced out equally so that the rats could have 360 degrees of infrared perception. When they were primed to perform the same water-reward task, they learned it in just 4 days, compared to 40 days with the single implant. “Frankly, this was a surprise,” Thomson says. “I thought it would be really confusing for [the rats] to have so much stimulation all over their brain, rather than [at] one location.” © 2015 American Association for the Advancement of Science.
By Jonathan Webb Science reporter, BBC News Crocodiles can sleep with one eye open, according to a study from Australia. In doing so they join a list of animals with this ability, which includes some birds, dolphins and other reptiles. Writing in the Journal of Experimental Biology, the researchers say the crocs are probably sleeping with one brain hemisphere at a time, leaving one half of the brain active and on the lookout. Consistent with this idea, the crocs in the study were more likely to leave one eye open in the presence of a human. They also kept that single eye trained directly on the interloper, said senior author John Lesku. "They definitely monitored the human when they were in the room. But even after the human left the room, the animal still kept its open eye… directed towards the location where the human had been - suggesting that they were keeping an eye out for potential threats." The experiments were done in an aquarium lined with infrared cameras, to monitor juvenile crocodiles day and night. "These animals are not particularly amenable to handling; they are a little snippy. So we had to limit all of our work to juvenile crocodiles, about 40-50cm long," said Dr Lesku, from La Trobe University in Melbourne. As well as placing a human in the room for certain periods, the team tested the effect of having other young crocs around. Sure enough, these also tended to attract the gaze of any reptiles dozing with only one eye. This matches what is known of "unihemispheric sleep" in aquatic mammals, such as walruses and dolphins, which seem to use one eye to make sure they stick together in a group. © 2015 BBC.
By Nicholas Bakalar Sleep apnea may be even more dangerous for women than for men, a new study suggests. Epidemiological studies have linked sleep apnea to heart disease in men, but the differences in risk between men and women have been largely unexplored. For the current study, researchers measured sleep quality electronically in 737 men and 879 women, average age 63, who were free of cardiovascular disease at the start of the study. They also tested all of them for troponin T, a protein that can be released into the bloodstream if the heart is damaged, and whose presence in otherwise healthy people indicates an increased risk for heart disease. They tracked the participants for 14 years, recording incidents of coronary artery disease, heart failure and death from cardiovascular disease or other causes. The study was published in Circulation. Obstructive sleep apnea was independently associated with increased troponin T, heart failure and death in women, but not in men. And in women, but not men, sleep apnea was associated with an enlarged heart, another risk factor for cardiovascular disease. “Most people who have sleep apnea have a lot of other risks for heart disease,” said the lead author, Dr. Amil M. Shah, an assistant professor of medicine at Harvard. “But in women, the relationship between sleep apnea and heart disease persisted even after accounting for the other risks.” “Even among women with sleep apnea who don’t get heart failure,” he continued, “it’s associated with changes in the heart that lead to worse outcomes.” © 2015 The New York Times Company
By Roni Jacobson After many lawsuits and a 2012 U.S. Department of Justice settlement, last month an independent review found that antidepressant drug Paxil (paroxetine) is not safe for teenagers. The finding contradicts the conclusions of the initial 2001 drug trial, which the manufacturer GlaxoSmithKline had funded, then used its results to market Paxil as safe for adolescents. The original trial, known as Study 329, is but one high-profile example of pharmaceutical industry influence known to pervade scientific research, including clinical trials the U.S. Food and Drug Administration requires pharma companies to fund in order to assess their products. For that reason, people who read scientific papers as part of their jobs have come to rely on meta-analyses, supposedly thorough reviews summarizing the evidence from multiple trials, rather than trust individual studies. But a new analysis casts doubt on that practice as well, finding that the vast majority of meta-analyses of antidepressants have some industry link, with a corresponding suppression of negative results. The latest study, published in the Journal of Clinical Epidemiology, which evaluated 185 meta-analyses, found that one third of them were written by pharma industry employees. “We knew that the industry would fund studies to promote its products, but it’s very different to fund meta-analyses,” which “have traditionally been a bulwark of evidence-based medicine,” says John Ioannidis, an epidemiologist at Stanford University School of Medicine and co-author of the study. “It’s really amazing that there is such a massive influx of influence in this field.” © 2015 Scientific American
Link ID: 21546 - Posted: 10.22.2015