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By Catherine Matacic How does sign language develop? A new study shows that it takes less than five generations for people to go from simple, unconventional pantomimes—essentially telling a story with your hands—to stable signs. Researchers asked a group of volunteers to invent their own signs for a set of 24 words in four separate categories: people, locations, objects, and actions. Examples included “photographer,” “darkroom,” and “camera.” After an initial group made up the signs—pretending to shoot a picture with an old-fashioned camera for “photographer,” for example—they taught the signs to a new generation of learners. That generation then played a game where they tried to guess what sign another player in their group was making. When they got the answer right, they taught that sign to a new generation of volunteers. After a few generations, the volunteers stopped acting out the words with inconsistent gestures and started making them in ways that were more systematic and efficient. What’s more, they added markers for the four categories—pointing to themselves if the category were “person” or making the outline of a house if the category were “location,” for example—and they stopped repeating gestures, the researchers reported last month at the Evolution of Language conference in New Orleans, Louisiana. So in the video above, the first version of “photographer” is unpredictable and long, compared with the final version, which uses the person marker and takes just half the time. The researchers say their finding supports the work of researchers in the field, who have found similar patterns of development in newly emerging sign languages. The results also suggest that learning and social interaction are crucial to this development. © 2016 American Association for the Advancement of Science

Keyword: Language
Link ID: 22084 - Posted: 04.09.2016

Sara Reardon Prozac (fluoxetine) and similar antidepressants are among the most prescribed drugs in the United States, but scientists still don’t know exactly how they work. Now one piece of that puzzle — the structure of a protein targeted by several widely used antidepressants — has been solved. The finding, reported on 6 April in Nature1, could enable the development of better, more-targeted depression drugs. But it may come too late for drug companies, many of which have abandoned the search for depression treatments. Prozac and its kin — drugs called selective serotonin reuptake inhibitors (SSRIs) — were first discovered2 in 1972. They address one hallmark of depression: low levels of the molecule serotonin, which neurons use to signal one another. By preventing a protein called serotonin transporter (SERT) form absorbing the serotonin back into neurons that release it, the drugs boost serotonin levels in the junctions between cells. But the details of this mechanism have long eluded researchers, who have sought to crystallize and visualize the SERT protein since the early 1990s. “It’s tough to make, and once you make it, it tends to fall apart in your hands,” says Eric Gouaux, a crystallographer at Oregon Health & Science University in Portland. Gouaux and his colleagues finally succeeded by creating small mutations in the SERT gene to make the protein more stable. For the first time, they were able to see the pocket in which two SSRIs — Paxil (paroxetine) and Lexapro (escitalopram) — bind. They also identified a second pocket, called an allosteric site. When escitalopram binds to both sites, the transporter protein and the drug bond more tightly, which increases the medicine's effect. © 2016 Nature Publishing Group

Keyword: Depression
Link ID: 22083 - Posted: 04.07.2016

JUST say no. That’s supposed to be our reaction to recreational drugs. The trouble is, lots of people say yes please. As a result, the world’s governments have been waging a war on drugs for more than a century. Since 1961, the battle has been orchestrated via international treaties targeting all parts of the supply chain, from the producers to the smugglers, the sellers to the buyers. Yet this supposedly united front has developed some conspicuous cracks. Now those countries backing a different approach have called a UN meeting later this month to make the case for change. The question is whether the UN is ready to soften its stance or whether it will plough on despite mountains of evidence suggesting its zero-tolerance approach has failed. As the reformers collate this to present at the meeting, New Scientist looks at how the approaches taken by different countries stack up (see “Drugs around the world”, below), and asks what can happen next. Some nations are already taking change into their own hands. Portugal allows personal use of any drug – including cocaine and heroin – and several South and Central American countries are moving in the same direction. As for cannabis, the number of places where its open sale has been decriminalised in some form grows ever larger. © Copyright Reed Business Information Ltd.

Keyword: Drug Abuse
Link ID: 22082 - Posted: 04.07.2016

By Chris Brown, Chris Corday, Canada's infatuation with getting a legal high may soon lead straight to Mary Jean Dunsdon's Vancouver kitchen. The self-described diva of cooking with cannabis has been baking and selling intoxicating edibles for the better part of 20 years. "I've easily sold 700,000 to one million cookies," she told CBC News recently in her kitchen. To her customers, Dunsdon, best known by her nickname Watermelon, is a trusted brand. Package "I've done it all: 'nice cream cones', marijuana bacon, I've made 'weedish meatballs'," she said. With legalization on the way in Canada, Dunsdon is hoping her underground bakery and the goodies she sells to a loyal base of medical and recreational customers will finally emerge from the shadows and capture a slice of a new market for marijuana edibles. She has good reason to be optimistic about her future in the business of bud. In the U.S. states where recreational marijuana is already legal, edibles — basically any food or drinks containing marijuana — are the fastest growing segment of the market. New Frontier Financials, which tracks the growth of the U.S. marijuana industry, says Washington state's sale of about 280,000 units of edible marijuana in March is double what it was just 10 months ago. For Canada, it's a trend line that offers a glimpse into the future and also a cautionary tale. "Edibles will be more popular. Way more popular than smoking," said Dunsdon. Watermelon During our visit, Dunsdon ground up marijuana leaf and bud and sprinkled the herb mixture over a fillet of wild B.C. chinook salmon. The topping bears a striking resemblance to pesto. "If you eat it, and eat just the right amount, it's probably the nicest thing you've ever felt," she said. ©2016 CBC/Radio-Canada.

Keyword: Drug Abuse
Link ID: 22081 - Posted: 04.07.2016

By DAN BILEFSKY LONDON — The model in the Gucci ad is young and waiflike, her frail body draped in a geometric-pattern dress as she leans back in front of a wall painted with a tree branch that appears to mimic the angle of her silhouette. On Wednesday, the Advertising Standards Authority of Britain ruled that the ad was “irresponsible” and that the model looked “unhealthily thin,” fanning a perennial debate in the fashion industry over when thin is too thin. The regulator said that the way the woman in the image had posed elongated her torso and accentuated her waist, so that it appeared to be very small. It said her “somber facial expression and dark makeup, particularly around her eyes, made her face look gaunt.” It said the offending image — a still photograph of the model that appeared in an online video posted on the website of The Times of London in December — should not appear again in its current form. The specific image was removed from the video on Gucci’s YouTube channel, though the model still appears in the ad directed by Glen Luchford. The image deemed "irresponsible" by the Advertising Standards Authority of Britain appeared at the end of this online video, but has been taken out. Video by Gucci The Italian fashion brand, for its part, had defended the ad, saying it was part of a video that portrayed a dance party and that was aimed at an older and sophisticated audience. Nowhere in the ads were any models’ bones visible, it said, and they were all “toned and slim.” It noted that “it was, to some extent, a subjective issue as to whether a model looked unhealthily thin,” according to the authority. The decision by the advertising authority, an independent industry regulatory group, barred Gucci from using the image in advertisements in Britain. The ruling comes amid a longstanding debate on both sides of the Atlantic about the perils of overly thin models projecting an unhealthy body image for women. As when critics lashed out against idealized images of “heroin chic” in the early 1990s, some have voiced concern that fashion houses are encouraging potentially hazardous behaviors by glamorizing models who are rail-thin. © 2016 The New York Times Company

Keyword: Anorexia & Bulimia
Link ID: 22080 - Posted: 04.07.2016

by Sarah Zielinski Spring has finally arrived, and birds’ nests all over the country will soon be filling up with eggs and then nestlings. Watch a nest long enough (the Science News staff is partial to the DC Eagle Cam) and you’ll see itty bitty baby birds begging for a meal. But mama birds don’t always reward that begging with food. In some species, like the tree swallow, birds that beg more will get more food. But in others, like the hoopoe, mom ignores who is begging and gives more food to the biggest chicks, researchers have found. This lack of an overall pattern has confounded ornithologists, but it seems that they may have been missing a key piece of the puzzle. A new study finds that the quality of the birds’ environment determines whether a mama bird can afford to feed all of her kids or if she has to ignore some to make sure the others survive. The study appears March 29 in Nature Communications. Stuart West of the University of Oxford and colleagues compiled data from 306 studies that looked at 143 bird species. When the birds were living in a good environment — one that had plenty of resources or a high amount of predictability — then mom would feed the chicks that beg the most, which were often the ones that needed the most help. But when the environment was poor in quality or unpredictable, then mama bird responded less to begging. |© Society for Science & the Public 2000 - 2016.

Keyword: Sexual Behavior
Link ID: 22079 - Posted: 04.07.2016

By JOANNA KLEIN Misconception: Migraines are psychological manifestations of women’s inability to manage stress and emotions Actually: Neurologists are very clear that migraines are a real, debilitating medical condition related to temporary abnormal brain activity. The fact that they may be more common for some women during “that time of the month” has nothing to do with emotions. For centuries, doctors explained migraines as a woman’s problem caused by emotional disturbances like hysteria, depression or stress. “Bizarrely, the recommended cure was marriage!” said Dr. Anne MacGregor, the lead author of the British Association for the Study of Headache’s guidelines for diagnosing and managing migraines. While that prescription may be far behind us, the misconception that migraines are fueled by a woman’s inability to cope persists. “It was considered psychological, or that I was a nervous overachiever, so I would never tell people that I have them,” said Lorie Novak, an artist in her sixties who has suffered from migraines since she was 8. After reading Joan Didion’s 1968 essay “In Bed,” about the writer’s struggle with migraines, Ms. Novak decided to tackle the representation of these debilitating headaches. Starting in 2009, Ms. Novak photographed herself every time she got a migraine. Under the hashtag #notjustaheadache, hundreds of others on Twitter and Instagram have demonstrated their own frustration with a widespread lack of understanding of the reality of migraines. © 2016 The New York Times Company

Keyword: Pain & Touch; Emotions
Link ID: 22078 - Posted: 04.07.2016

Laura Sanders NEW YORK — Lip-readers’ minds seem to “hear” the words their eyes see being formed. And the better a person is at lipreading, the more neural activity there is in the brain’s auditory cortex, scientists reported April 4 at the annual meeting of the Cognitive Neuroscience Society. Earlier studies have found that auditory brain areas are active during lipreading. But most of those studies focused on small bits of language — simple sentences or even single words, said study coauthor Satu Saalasti of Aalto University in Finland. In contrast, Saalasti and colleagues studied lipreading in more natural situations. Twenty-nine people read the silent lips of a person who spoke Finnish for eight minutes in a video. “We can all lip-read to some extent,” Saalasti said, and the participants, who had no lipreading experience, varied widely in their comprehension of the eight-minute story. In the best lip-readers, activity in the auditory cortex was quite similar to that evoked when the story was read aloud, brain scans revealed. The results suggest that lipreading success depends on a person’s ability to “hear” the words formed by moving lips, Saalasti said. Citations J. Alho et al. Similar brain responses to lip-read, read and listened narratives. Cognitive Neuroscience Society annual meeting, New York City, April 4, 2016. Further Reading © Society for Science & the Public 2000 - 2016.

Keyword: Language
Link ID: 22077 - Posted: 04.07.2016

Laura Sanders NEW YORK — Cells in a brain structure known as the hippocampus are known to be cartographers, drawing mental maps of physical space. But new studies show that this seahorse-shaped hook of neural tissue can also keep track of social space, auditory space and even time, deftly mapping these various types of information into their proper places. Neuroscientist Rita Tavares described details of one of these new maps April 2 at the annual meeting of the Cognitive Neuroscience Society. Brain scans had previously revealed that activity in the hippocampus was linked to movement through social space. In an experiment reported last year in Neuron, people went on a virtual quest to find a house and job by interacting with a cast of characters. Through these social interactions, the participants formed opinions about how much power each character held, and how kindly they felt toward him or her. These judgments put each character in a position on a “social space” map. Activity in the hippocampus was related to this social mapmaking, Tavares and colleagues found. It turns out that this social map depends on the traits of the person who is drawing it, says Tavares, of Icahn School of Medicine at Mount Sinai in New York City. People with more social anxiety tended to give more power to characters they interacted with. What’s more, these people's social space maps were smaller overall, suggesting that they explored social space less, Tavares says. Tying these behavioral traits to the hippocampus may lead to a greater understanding of social behavior — and how this social mapping may go awry in psychiatric conditions, Tavares said. © Society for Science & the Public 2000 - 2016.

Keyword: Learning & Memory
Link ID: 22076 - Posted: 04.06.2016

Emily Anthes Type 'depression' into the Apple App Store and a list of at least a hundred programs will pop up on the screen. There are apps that diagnose depression (Depression Test), track moods (Optimism) and help people to “think more positive” (Affirmations!). There's Depression Cure Hypnosis (“The #1 Depression Cure Hypnosis App in the App Store”), Gratitude Journal (“the easiest and most effective way to rewire your brain in just five minutes a day”), and dozens more. And that's just for depression. There are apps pitched at people struggling with anxiety, schizophrenia, post-traumatic stress disorder (PTSD), eating disorders and addiction. This burgeoning industry may meet an important need. Estimates suggest that about 29% of people will experience a mental disorder in their lifetime1. Data from the World Health Organization (WHO) show that many of those people — up to 55% in developed countries and 85% in developing ones — are not getting the treatment they need. Mobile health apps could help to fill the gap (see 'Mobilizing mental health'). Given the ubiquity of smartphones, apps might serve as a digital lifeline — particularly in rural and low-income regions — putting a portable therapist in every pocket. “We can now reach people that up until recently were completely unreachable to us,” says Dror Ben-Zeev, who directs the mHealth for Mental Health Program at the Dartmouth Psychiatric Research Center in Lebanon, New Hampshire. Public-health organizations have been buying into the concept. In its Mental Health Action Plan 2013–2020, the WHO recommended “the promotion of self-care, for instance, through the use of electronic and mobile health technologies.” And the UK National Health Service (NHS) website NHS Choices carries a short list of online mental-health resources, including a few apps, that it has formally endorsed. © 2016 Nature Publishing Grou

Keyword: Depression; Schizophrenia
Link ID: 22075 - Posted: 04.06.2016

By Sandhya Somashekhar African Americans are routinely under-treated for their pain compared with whites, according to research. A study released Monday sheds some disturbing light on why that might be the case. Researchers at the University of Virginia quizzed white medical students and residents to see how many believed inaccurate and at times "fantastical" differences about the two races -- for example, that blacks have less sensitive nerve endings than whites or that black people's blood coagulates more quickly. They found that fully half thought at least one of the false statements presented was possibly, probably or definitely true. Moreover, those who held false beliefs often rated black patients' pain as lower than that of white patients and made less appropriate recommendations about how they should be treated. The study, published in the Proceedings of the National Academy of Sciences, could help illuminate one of the most vexing problems in pain treatment today: That whites are more likely than blacks to be prescribed strong pain medications for equivalent ailments. A 2000 study out of Emory University found that at a hospital emergency department in Atlanta, 74 percent of white patients with bone fractures received painkillers compared with 50 percent of black patients. Similarly, a paper last year found that black children with appendicitis were less likely to receive pain medication than their white counterparts. And a 2007 study found that physicians were more likely to underestimate the pain of black patients compared with other patients.

Keyword: Pain & Touch; Attention
Link ID: 22074 - Posted: 04.06.2016

By Kj Dell’Antonia If you tell your child’s pediatrician that your child is having trouble sleeping, she might respond by asking you how well you sleep yourself. A team of Finnish researchers found that parents with poor sleep quality tended to report more sleep-related difficulties in their children than parents who slept well. But when the researchers looked at an objective monitor of the children’s sleep, using a bracelet similar to a commercial fitness tracker that monitored movement acceleration, a measure of sleep quality, they found that the parents were often reporting sleep problems in their children that didn’t seem to be there. “The only thing that was associated with sleeping problems, as reported by the parents, was their own reported sleeping problems,” said Marko Elovainio, a professor of psychology at the University of Helsinki and one of the authors of the study, which was published this month in the journal Pediatrics. The study was relatively small, involving 100 families with children aged 2 to 6. But the findings suggest that parents’ report of sleep problems in their children are influenced by their own attitudes and behaviors surrounding sleep. The researchers were inspired to do their study, in part, by research showing that mothers with depression over-report behavioral problems in their children, seeing issues that teachers do not see. In pediatrics, the researchers noted, doctors rely heavily on parental reports for information — and if that information is biased by a parent’s own experience, diagnosis becomes more difficult. “Sleep is a good measure of stress,” said Dr. Elovaino, and it is one tool doctors use to evaluate how much stress a child is experiencing. But when making a diagnosis involving a child’s sleeping patterns, “we can’t rely on reports of parents. We need to use more objective measures.” One reason to look at sleep in this context, he said, is that unlike other possible markers of stress, it can be measured objectively. © 2016 The New York Times Company

Keyword: Sleep
Link ID: 22073 - Posted: 04.06.2016

by Daniel Galef Footage from a revolutionary behavioural experiment showed non-primates making and using tools just like humans. In the video, a crow is trying to get food out of a narrow vessel, but its beak is too short for it to reach through the container. Nearby, the researchers placed a straight wire, which the crow bent against a nearby surface into a hook. Then, holding the hook in its beak, it fished the food from the bottle. Corvids—the family of birds that includes crows, ravens, rooks, jackdaws, and jays—are pretty smart overall. Although not to the level of parrots and cockatoos, ravens can also mimic human speech. They also have a highly developed system of communication and are believed to be among the most intelligent non-primate animals in existence. McGill Professor Andrew Reisner recalls meeting a graduate student studying corvid intelligence at Oxford University when these results were first published in 2015. “I had read early in the year that some crows had been observed making tools, and I mentioned this to him,” Reisner explained. “He said that he knew about that, as it had been he who had first observed it happening. Evidently the graduate students took turns watching the ‘bird box,’ […] and the tool making first occurred there on his shift.”

Keyword: Evolution; Intelligence
Link ID: 22072 - Posted: 04.06.2016

By Roni Caryn Rabin Alzheimer’s disease is a progressive brain disorder that causes dementia, destroying memory, cognitive skills, the ability to care for oneself, speak and walk, said Ruth Drew, director of family and information services at the Alzheimer’s Association. “And since the brain affects everything, Alzheimer’s ultimately affects everything,” she said, “including the ability to swallow, cough and breathe.” Once patients reach the advanced stages of Alzheimer’s, they may stop eating and become weak and susceptible to infections, said Dr. Jason Karlawish, a professor of medicine at the University of Pennsylvania. Unable to swallow or cough, they are at high risk of choking, aspirating food particles or water into the lungs and developing pneumonia, which is often the immediate cause of death, he said. “You see a general decline in the contribution the brain makes, not just in thinking, but in maintaining the body’s homeostasis,” Dr. Karlawish said. Using a feeding tube to nourish patients and hospitalizing them for infections does not significantly extend life at the advanced stages of the disease and is discouraged because it can prolong suffering with no hope of recovery, he said. Alzheimer's is the sixth leading cause of death in the United States, according to the Centers for Disease Control and Prevention, but that figure may underestimate the actual number of cases, Dr. Karlawish said, since some deaths may be attributed to other causes like pneumonia. © 2016 The New York Times Company

Keyword: Alzheimers
Link ID: 22071 - Posted: 04.06.2016

Philip Ball James Frazer’s classic anthropological study The Golden Bough1 contains a harrowing chapter on human sacrifice in rituals of crop fertility and harvest among historical cultures around the world. Frazer describes sacrificial victims being crushed under huge toppling stones, slow-roasted over fires and dismembered alive. Frazer’s methods of analysis wouldn't all pass muster among anthropologists today (his work was first published in 1890), but it is hard not to conclude from his descriptions that what industrialized societies today would regard as the most extreme psychopathy has in the past been seen as normal — and indeed sacred — behaviour. In almost all societies, killing within a tribe or clan has been strongly taboo; exemption is granted only to those with great authority. Anthropologists have suspected that ritual human sacrifice serves to cement power structures — that is, it signifies who sits at the top of the social hierarchy. The idea makes intuitive sense, but until now there has been no clear evidence to support it. In a study published in Nature2, Joseph Watts, a specialist in cultural evolution at the University of Auckland in New Zealand, and his colleagues have analysed 93 traditional cultures in Austronesia (the region that loosely embraces the many small and island states in the Pacific and Indonesia) as they were before they were influenced by colonization and major world religions (generally in the late 19th and early 20th centuries). © 2016 Nature Publishing Group

Keyword: Aggression; Evolution
Link ID: 22070 - Posted: 04.05.2016

Feel like you haven’t slept in ages? If you’re one of the 5 per cent of the population who has severe insomnia – trouble sleeping for more than a month – then your brain’s white matter might be to blame. The cell bodies and synapses of our brain cells make up our brain’s grey matter, while bundles of their tails that connect one brain region to another make up the white matter. These nerve cell tails – axons – are cloaked in a fatty myelin sheath that helps transmit signals. Radiologist Shumei Li from Guangdong No. 2 Provincial People’s Hospital in Guangzhou, China, and her team, scanned the brains of 30 healthy sleepers and 23 people with severe insomnia using diffusion tensor imaging MRI. This imaging technique lights up the white matter circuitry. Axons unsheathed They found that in the brains of the people with severe insomnia, the regions in the right hemisphere that support learning, memory, smell and emotion were less well connected compared with healthy sleepers. They attribute this break down in circuitry to the loss of the myelin sheath in the white matter. A study in November suggested that smoking could be one cause for myelin loss. The team also found that the insomniacs had poorer connections in the white matter of the thalamus, a brain region that regulates consciousness, alertness and sleep. The study proposes a potential mechanism for insomnia but there could be other factors, says Max Wintermark, a radiologist at Stanford. He says it’s not possible to say whether the poor connections are the cause of result of insomnia. © Copyright Reed Business Information Ltd.

Keyword: Sleep
Link ID: 22069 - Posted: 04.05.2016

Laura Sanders NEW YORK — Sometimes forgetting can be harder than remembering. When people forced themselves to forget a recently seen image, select brain activity was higher than when they tried to remember that image. Forgetting is often a passive process, one in which the memory slips out of the brain, Tracy Wang of the University of Texas at Austin said April 2 at the annual meeting of the Cognitive Neuroscience Society. But in some cases, forgetting can be deliberate. Twenty adults saw images of faces, scenes and objects while an fMRI scanner recorded their brains’ reactions to the images. If instructed to forget the preceding image, people were less likely to remember that image later. Researchers used the scan data to build a computer model that could infer how strongly the brain responds to each particular kind of image. In the ventral temporal cortex, a part of the brain above the ear, brain patterns elicited by a particular image were stronger when a participant was told to forget the sight than when instructed to remember it. Of course, everyone knows that it’s easy to forget something without even trying. But these results show that intentional forgetting isn’t a passive process — the brain has to actively work to wipe out a memory on purpose. Citations T.H. Wang et al. Forgetting is more work than remembering. Annual meeting of the Cognitive Neuroscience Society, New York City, April 2, 2016. © Society for Science & the Public 2000 - 2016

Keyword: Learning & Memory
Link ID: 22068 - Posted: 04.05.2016

Mo Costandi This spectacular image – which took the best part of a year to create – shows the fine structure of a nerve terminal at high resolution, revealing, for the very first time, an intricate network of fine filaments that controls the movements of synaptic vesicles. The brain is soft and wet, with the consistency of a lump of jelly. Yet, it is the most complex and highly organized structure that we know of, containing hundreds of billions of neurons and glial cells, and something on the order of one quadrillion synaptic connections, all of which are arranged in a very specific manner. This high degree of specificity extends down to the deepest levels of brain organization. Just beneath the membrane at the nerve terminal, synaptic vesicles store neurotransmitter molecules, and await the arrival of a nervous impulse, whereupon they fuse with the membrane and release their contents into the synaptic cleft, the miniscule gap at the junction between nerve cells, and diffuse across it to bind to receptor protein molecules embedded at the surface of the partner cell. 3D model of a nerve terminal in atomic detail The process of neurotransmitter release is tightly orchestrated. Ready vesicles are ‘docked’ in the ‘active zone’ lying beneath the cell membrane, and are depleted when they fuse with the membrane, only to be replenished from a reservoir of pre-prepared vesicles located further inside the cell. Spent vesicles are quickly pulled back out of the membrane, reformed, refilled with neurotransmitter molecules, and then returned to the reservoir, so that they can be shuttled into the active zone when needed. An individual nerve cell may use up hundreds, or perhaps thousands, of vesicles every second, and so this recycling process occurs continuously to maintain the signalling between nerve cells. © 2016 Guardian News and Media Limited

Keyword: Development of the Brain
Link ID: 22067 - Posted: 04.04.2016

Helen Shen Clamping an electrode to the brain cell of a living animal to record its electrical chatter is a task that demands finesse and patience. Known as ‘whole-cell patch-clamping’, it is reputedly the “finest art in neuroscience”, says neurobiologist Edward Boyden, and one that only a few dozen laboratories around the world specialize in. But researchers are trying to demystify this art by turning it into a streamlined, automated technique that any laboratory could attempt, using robotics and downloadable source code. “Patch-clamping provides a unique view into neural circuits, and it’s a very exciting technique but is really underused,” says neuroscientist Karel Svoboda at the Howard Hughes Medical Institute’s Janelia Research Campus in Ashburn, Virginia. “That’s why automation is a really, really exciting direction.” On 3 March, Boyden, at the Massachusetts Institute of Technology in Cambridge, and his colleagues published detailed instructions on how to assemble and operate an automated system for whole-cell patch-clamping1, a concept that they first described in 20122. The guide represents the latest fruits of Boyden’s partnership with the laboratory of Craig Forest, a mechanical engineer at the Georgia Institute of Technology in Atlanta who specializes in robotic automation for research. © 2016 Nature Publishing Group

Keyword: Brain imaging
Link ID: 22066 - Posted: 04.04.2016

By DONALD G. McNEIL Jr The World Health Organization said on Thursday that there is “strong scientific consensus” that Zika virus is a cause of microcephaly, unusually small heads with brain damage in infants, as well as other neurological disorders. Yet a surge in microcephaly has been reported only in Brazil; a small increase was reported in French Polynesia, and a cluster of 32 cases is now under investigation in Colombia. For proof of the connection between infection with the virus and birth defects, scientists are waiting for the results of a large study of 5,000 pregnant women, most of them in Colombia. Women with past Zika infections will be compared with similar women without infections to see if they have more microcephalic children. The epidemic peaked in Colombia in early February, according to the W.H.O. Most of the women in the study are due to give birth in May and June. Virtually all public health agencies already believe the virus is to blame for these birth defects and are giving medical advice based on that assumption. Here are the lines of evidence they cite. As early as last August, hospitals in northeast Brazil realized that something unheard of was happening: Neonatal wards that normally saw one or two microcephalic babies a year were seeing five or more at the same time. Doctors learned from the mothers that many of them had had Zika symptoms months earlier. © 2016 The New York Times Company

Keyword: Development of the Brain
Link ID: 22065 - Posted: 04.04.2016