Chapter 10. Vision: From Eye to Brain
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|By Esther Landhuis Whereas cholesterol levels measured in a routine blood test can serve as a red flag for heart disease, there’s no simple screen for impending Alzheimer’s. A new Silicon Valley health start-up hopes to change that. A half million Americans die of Alzheimer’s disease each year. Most are diagnosed after a detailed medical workup and extensive neurological and psychological tests that gauge mental function and rule out other causes of dementia. Yet things begin going awry some 10 to 15 years before symptoms show. Spinal fluid analyses and positron emission tomography (PET) scans can detect a key warning sign—buildup of amyloid-beta protein in the brain. Studies suggest that adults with high brain amyloid have elevated risk for Alzheimer’s and stand the best chance of benefiting from treatments should they become available. Getting Alzheimer’s drugs to market requires long and costly clinical studies, which some experts say have failed thus far because experimental drugs were tested too late in the disease process. By the time people show signs of dementia, their brains have lost neurons and no current therapy can revive dead cells. That is why drug trials are looking to recruit seniors with preclinical Alzheimer’s who are on the verge of decline but otherwise look healthy. This poses a tall order. Spinal taps are cumbersome and PET costs $3,000 per scan. “There’s no cheap, fast, noninvasive test that can accurately identify people at risk of Alzheimer’s,” says Brad Dolin, chief technology officer of Neurotrack. The company is developing a computerized visual test that might fit the bill. © 2015 Scientific American
by Jacob Aron Ever struggled to tell the difference between two shades of paint? When it comes to colour, one person's peach is another's puce, but there are 11 basic colours that we all agree on. Now it seems two more should be in the mix: lilac and turquoise. In 1969, two researchers looked at 100 languages and found that all had words for black, white, red, green, yellow, blue, brown, purple, pink, orange and grey. These terms pass a number of tests: they refer to easily distinguishable colours, are widely used and are single words. The chart divided into basic colours (Image: D.Mylonas/L.MacDonald) We might quibble over which shade is cream or peach, for example, but everyone knows yellow when they see it. There are exceptions - Russian and Greek speakers have separate words for light and dark blue. Now Dimitris Mylonas of Queen Mary University of London and Lindsay MacDonald of University College London says the same applies to two more colours, in the case of English-speakers, at least. For the past seven years, they've been running an online test in which people name a range of shades – you can try it for yourself. Results from 330 participants were analysed to pick out basic names. These were ranked in a number of ways, such as how often each colour name came up and whether the name was unique to one shade or common to many. Lilac and turquoise came ninth and tenth overall, beating white, red and orange. The only measure turquoise didn't score highly on was the time it took people to enter an answer, says Mylonas. "Our observers had problems spelling it correctly." © Copyright Reed Business Information Ltd.
Link ID: 20550 - Posted: 02.05.2015
By Viviane Callier In the deep sea, where light is dim and blue, animals with bigger eyes see better—but bigger eyes are more conspicuous to predators. In response, the small (10 mm to 17 mm), transparent crustacean Paraphronima gracilis has evolved a unique eye structure. Researchers collected the animals from 200- to 500-meter deep waters in California’s Monterey Bay using a remote-operated vehicle. They then characterized the pair of compound eyes, discovering that each one was composed of a single row of 12 distinct red retinas. Reporting online on 15 January in Current Biology, the researchers hypothesize that each retina captures an image that is transmitted to the crustacean’s brain, which integrates the 12 images to increase brightness and contrast sensitivity, adapting to changing light levels. Future work will focus on how images are processed by the neural connections between the retinas and the brain. © 2015 American Association for the Advancement of Science.
|By Matthew H. Schneps Many of the etchings by artist M. C. Escher appeal because they depict scenes that defy logic. His famous “Waterfall” shows a waterwheel powered by a cascade pouring down from a brick flume. Water turns the wheel and is redirected uphill back to the mouth of the flume, where it can once again pour over the wheel in an endless cycle. The drawing shows us an impossible situation that violates nearly every law of physics. In 2003 a team of psychologists led by Catya von Károlyi of the University of Wisconsin–Eau Claire made a discovery using such images. When the researchers asked people to pick out impossible figures from similarly drawn illustrations, they found that participants with dyslexia were among the fastest at this task. Dyslexia is often called a learning disability. And it can indeed present learning challenges. Although its effects vary widely, some children with dyslexia read so slowly that it would typically take them months to read the same number of words that their peers read in a day. Therefore, the fact that people with this difficulty were so adept at rapidly picking out the impossible figures puzzled von Károlyi. The researchers had stumbled on a potential upside to dyslexia, one that investigators have just begun to understand. Scientists had long suspected dyslexia might be linked to creativity, but laboratory evidence for this was rare. In the years to follow, sociologist Julie Logan of Cass Business School in London showed that there is a higher incidence of dyslexia among entrepreneurs than in the general population. Meanwhile cognitive scientist Gadi Geiger of the Massachusetts Institute of Technology found that people with dyslexia could attend to multiple auditory inputs at once. © 2015 Scientific American
|By Karen Hopkin Sometimes it’s hard to see the light. Especially if it lies outside the visible spectrum, like x-rays or ultraviolet radiation. But if you long to see the unseeable, you might be interested to hear that under certain conditions people can catch a glimpse of usually invisible infrared light. That’s according to a study in the Proceedings of the National Academy of Sciences. [Grazyna Palczewska et al, Human infrared vision is triggered by two-photon chromophore isomerization] Our eyes are sensitive to elementary particles called photons that have sufficient energy to excite light-sensitive receptor proteins in our retinas. But the photons in infrared radiation don’t have enough oomph. We can detect these lower energy photons using what are sometimes called night-vision goggles or cameras. But the naked eye is usually blind to infrared radiation. But recently researchers in a laser lab noticed that they sometimes saw flashes of light while working with devices that emitted brief infrared pulses. So they filled a test tube with retinal cells and zapped it with their lasers. When the light pulses rapidly enough, the receptors can get hit with two photons at the same time—which supplies enough energy to excite the receptor. This double dose makes the infrared visible. One application of the finding is that it could give doctors a new tool to diagnose diseases of the retina. So they could eyeball trouble before it might otherwise be seen.
Link ID: 20458 - Posted: 01.08.2015
By SINDYA N. BHANOO That bats use echolocation to navigate and to find food is well known. But some blind people use the technique, too, clicking their tongues and snapping fingers to help identify objects. Now, a study reports that human echolocators can experience illusions, just as sighted individuals do. Gavin Buckingham, a psychology lecturer at Heriot-Watt University in Scotland, and his colleagues at the University of Western Ontario asked 10 study subjects to pick up strings attached to three boxes of identical weight but different sizes. Overwhelmingly, the sighted individuals succumbed to what is known as the “size-weight illusion.” The bigger boxes felt lighter to them. Blind study subjects who picked up each of the three strings did not experience the illusion. They correctly surmised that the boxes were of equal weight. But blind participants who relied on echolocation to get a sense of the box sizes before picking up the strings fell into the same trap as the sighted subjects and misjudged the weights. The research, published in the journal Psychological Science, supports other research suggesting that echolocation techniques may stimulate the brain in ways that resemble visual input. “It does mean this is more than a functional tool,” Dr. Buckingham said. Echolocation “doesn’t help them appreciate art or tell the difference between the color red or color blue, but it’s a step in that direction.” © 2015 The New York Times Company
By Stephanie M. Lee Decorating the house has always been challenging for Sheila Carter. Like other color-blind people, she limits her wardrobe to a few bold hues that can be easily mixed and matched, like blue and black. But a new pair of glasses she recently started wearing, she said, has changed her worldview. Carter owns high-tech eyewear made by EnChroma, a Berkeley startup that wants to help people with color deficiency see the full spectrum of the rainbow. Carter is among an estimated 32 million Americans who are color-blind, either from birth or as a result of some condition, like head trauma. The condition is most prevalent among people of Northern European descent, affecting 8 percent of men and 0.5 percent of women. EnChroma makes color-enhancing sunglasses for the vast majority of such people, who have trouble seeing red or green due to a genetic defect. The company has sold more than 1,000 pairs in two years. Last month, it introduced glasses with polycarbonate lenses for children, athletes and prescription- and nonprescription-wearers at prices ranging from $325 to $450. The proprietary lens contains a filter that blocks a portion of the spectrum where the overlap between the two cones occurs and restores the separation between them. “It’s essentially taking out that stuff that’s confusing the signal,” said Andy Schmeder, vice president of technology.
Link ID: 20450 - Posted: 01.01.2015
|By Stephen L. Macknik and Susana Martinez-Conde To a neuroscientist, the trouble with cocktail parties is not that we do not love cocktails or parties (many neuroscientists do). Instead what we call “the cocktail party problem” is the mystery of how anyone can have a conversation at a cocktail party at all. Consider a typical scene: You have a dozen or more lubricated and temporarily uninhibited adults telling loud, improbable stories at increasing volumes. Interlocutors guffaw and slap backs. Given the decibel level, it is a minor neural miracle that any one of these revelers can hear and parse one word from any other. The alcohol does not help, but it is not the main source of difficulties. The cocktail party problem is that there is just too much going on at once: How can our brain filter out the noise to focus on the wanted information? This problem is a central one for perceptual neuroscience—and not just during cocktail parties. The entire world we live in is quite literally too much to take in. Yet the brain does gather all of this information somehow and sorts it in real time, usually seamlessly and correctly. Whereas the physical reality consists of comparable amounts of signal and noise for many of the sounds and sights around you, your perception is that the conversation or object that interests you remains in clear focus. So how does the brain accomplish this feat? One critical component is that our neural circuits simplify the problem by actively ignoring—suppressing—anything that is not task-relevant. Our brain picks its battles. It stomps out irrelevant information so that the good stuff has a better chance of rising to awareness. This process, colloquially called attention, is how the brain sorts the wheat from the chaff. © 2014 Scientific American
by Andy Coghlan To catch agile prey on the wing, dragonflies rely on the same predictive powers we use to catch a ball: that is, anticipating by sight where the ball will go and readying body and hand to snatch it from mid-air. Until now, dragonflies were thought to catch their prey without this predictive skill, instead blindly copying every steering movement made by their prey, which can include flies and bees. Now, sophisticated laboratory experiments have tracked the independent body and eye movements of dragonflies as they pursue prey, showing for the first time that dragonflies second guess where their prey will fly to next and then steer their flight accordingly. Throughout the pursuit, they lock on to their target visually while they orient their bodies and flight path for ultimate interception, rather than copying each little deviation in their prey's flight path in the hope of ultimately catching up with it. "The dragonfly lines up its body axis in the flight direction of the prey, but keeps the eyes in its head firmly fixed on the prey," says Anthony Leonardo of the Howard Hughes Medical Institute in Ashburn, Virginia. "It enables the dragonfly to catch the prey from beneath and behind, the prey's blind spot," he says. © Copyright Reed Business Information Ltd.
Link ID: 20412 - Posted: 12.13.2014
Jia You Ever wonder how cockroaches scurry around in the dark while you fumble to switch on the kitchen light? Scientists know the insect navigates with its senses of touch and smell, but now they have found a new piece to the puzzle: A roach can also see its environment in pitch darkness, by pooling visual signals from thousands of light-sensitive cells in each of its compound eyes, known as photoreceptors. To test the sensitivity of roach vision, researchers created a virtual reality system for the bugs, knowing that when the environment around a roach rotates, the insect spins in the same direction to stabilize its vision. First, they placed the roach on a trackball, where it couldn’t navigate with its mouthpart or antennae. Then the scientists spun black and white gratings around the insect, illuminated by light at intensities ranging from a brightly lit room to a moonless night. The roach responded to its rotating environment in light as dim as 0.005 lux, when each of its photoreceptors was picking up only one photon every 10 seconds, the researchers report online today in The Journal of Experimental Biology. They suggest that the cockroach must rely on unknown neural processing in the deep ganglia, an area in the base of the brain involved in coordinating movements, to process such complex visual information. Understanding this mechanism could help scientists design better imaging systems for night vision. © 2014 American Association for the Advancement of Science.
Link ID: 20389 - Posted: 12.04.2014
Katharine Sanderson Although we do not have X-ray vision like Superman, we have what could seem to be another superpower: we can see infrared light — beyond what was traditionally considered the visible spectrum. A series of experiments now suggests that this little-known, puzzling effect could occur when pairs of infrared photons simultaneously hit the same pigment protein in the eye, providing enough energy to set in motion chemical changes that allow us to see the light. Received wisdom, and the known chemistry of vision, say that human eyes can see light with wavelengths between 400 (blue) and 720 nanometres (red). Although this range is still officially known as the 'visible spectrum', the advent of lasers with very specific infrared wavelengths brought reports that people were seeing laser light with wavelengths above 1,000 nm as white, green and other colours. Krzysztof Palczewski, a pharmacologist at Case Western Reserve University in Cleveland, Ohio, says that he has seen light of 1,050 nm from a low-energy laser. “You see it with your own naked eye,” he says. To find out whether this ability is common or a rare occurrence, Palczewski scanned the retinas of 30 healthy volunteers with a low-energy beam of light, and changed its wavelength. As the wavelength increased into the infrared (IR), participants found the light at first harder to detect, but at around 1,000 nm the light became easier to see. How humans can do this has puzzled scientists for years. Palczewski wanted to test two leading hypotheses to explain infrared vision. © 2014 Nature Publishing Group,
Link ID: 20388 - Posted: 12.03.2014
By Amy Ellis Nutt Scientists say the "outdoor effect" on nearsighted children is real: natural light is good for the eyes. (Photo by Bill O'Leary/The Washington Post) It's long been thought kids are more at risk of nearsightedness, or myopia, if they spend hours and hours in front of computer screens or fiddling with tiny hand-held electronic devices. Not true, say scientists. But now there is research that suggests that children who are genetically predisposed to the visual deficit can improve their chances of avoiding eyeglasses just by stepping outside. Yep, sunshine is all they need -- more specifically, the natural light of outdoors -- and 14 hours a week of outdoor light should do it. Why this is the case is not exactly clear. "We don't really know what makes outdoor time so special," said Donald Mutti, the lead researcher of the study from Ohio State University College of Optometry, in a press release. "If we knew, we could change how we approach myopia." What is known is that UVB light, (invisible ultraviolet B rays), plays a role in the cellular production of vitamin D, which is believed to help the eyes focus light on the retina. However, the Ohio State researchers think there is another possibility. "Between the ages of five and nine, a child's eye is still growing," said Mutti. "Sometimes this growth causes the distance between the lens and the retina to lengthen, leading to nearsightedness. We think these different types of outdoor light may help preserve the proper shape and length of the eye during that growth period."
By Amy Ellis Nutt In a novel use of video game playing, researchers at Ohio State have found a Pac-Man-like game, when played repetitively, can improve vision in both children and adults who have "lazy eye" or poor depth perception. In the Pac-Man-style game, players wear red-green 3-D glasses that filter images to the right and left eyes. The lazy or weak eye sees two discs containing vertical, horizontal or diagonal lines superimposed on a background of horizontal lines. The dominant eye sees a screen of only horizontal lines. The player controls the larger, Pac-man-like disc and chases the smaller one. In another game, the player must match discs with rows based on the orientation of their lines. Ten Leng Ooi, professor of optometry at Ohio State University, presented her research findings at last week's annual meeting of the Society for Neuroscience. Only a handful of test subjects were involved in the experimental training, but all saw weak-eye improvement to 20/20 vision or better and for a period of at least eight months. Lazy eye, or amblyopia, affects between 2 and 3 percent of the U.S. population. The disorder usually occurs in infancy when the neural pathway between the brain and one eye (or sometimes both) fails to fully develop. Often the cause of lazy eye is strabismus, in which the eyes are misaligned or "crossed." To prevent double vision, the brain simply blocks the fuzzy images from one eye, thereby causing incomplete visual development. The result: lazy eye.
By Victoria Colliver Marianne Austin watched her mother go blind from age-related macular degeneration, an eye disease that affects about 10 million older Americans. Now that Austin has been diagnosed with the same condition, she wants to avoid her mother’s experience. “I’ve seen what can happen and the devastation it can cause,” said Austin, 67, of Atherton, who found out she had the disease last year. “I call it having seen the movie. I don’t like that ending, I want to change the movie, and I don’t want to wait 10 years until something is proven in research.” About 10 percent of patients diagnosed with age-related macular degeneration will develop the form of the disease that causes permanent blindness. It’s unclear just how much genetics plays a role, so there’s no definitive way to predict who will progress to that stage or when that would happen. But a team of Stanford doctors think they may have found a way. In a study, published this month in the medical journal Investigative Ophthalmology and Visual Science, researchers analyzed data from 2,146 retinal scans from 244 macular degeneration patients at Stanford from 2008 to 2013. They then created an algorithm that predicted whether a particular patient would be likely to develop the form of the disease that causes blindness within less than a year, three years or up to five years. For those with macular degeneration to go blind, the disease has to advance from what is known as the “dry” form to the “wet” form. The sooner a doctor can notice changes, the better chance there is to save a patient’s vision.
By Laura Geggel A major pathway of the human brain involved in visual perception, attention and movement — and overlooked by many researchers for more than a century — is finally getting its moment in the sun. In 2012, researchers made note of a pathway in a region of the brain associated with reading, but "we couldn't find it in any atlas," said Jason Yeatman, a research scientist at the University of Washington's Institute for Learning and Brain Sciences. "We'd thought we had discovered a new pathway that no one else had noticed before." A quick investigation showed that the pathway, known as the vertical occipital fasciculus (VOF), was not actually unknown. Famed neuroscientist Carl Wernicke discovered the pathway in 1881, during the dissection of a monkey brain that was most likely a macaque. [10 Things You Didn't Know About the Brain] But besides Wernicke's discovery, and a few other mentions throughout the years, the VOF is largely absent from studies of the human brain. This made Yeatman and his colleagues wonder, "How did a whole piece of brain anatomy get forgotten?" he said. The researchers immersed themselves in century-old brain atlases and studies, trying to decipher when and why the VOF went missing from mainstream scientific literature. They also scanned the brains of 37 individuals, and found an algorithm that can help present-day researchers pinpoint the elusive pathway.
By Paula Span A few days after I wrote about conditions that can mimic dementia, reader Sue Murray emailed me from Westchester County. Her subject line: “Have you heard of Charles Bonnet Syndrome?” I hadn’t, and until about six months ago, neither had Ms. Murray. Her mother Elizabeth, who is 91, has glaucoma and macular degeneration, and has been gradually losing her vision, Ms. Murray explained. So at first, her family was excited when Elizabeth seemed to be seeing things more clearly. Maybe, they thought, her vision was returning. But the things she was seeing — patterns and colors, strangers, a green man — weren’t there. She insisted that “there were people in the cellar, people on the porch, people in the house,” Ms. Murray said. “She’d point and say, ‘Don’t you see them?’ And she’d get mad when we didn’t.” Elizabeth and her husband Victor, 95, live in Connecticut, in a house they bought 50 years ago. For a while, the Green Man, as Elizabeth began calling him, seemed to have moved in, too. “She’d start hiding things in the closet so the Green Man wouldn’t take them,” Ms. Murray said. “There wasn’t any real fear; it was just, ‘Look at that!’” Elizabeth’s ophthalmologist promptly supplied the name for this condition: Charles Bonnet Syndrome, named for a Swiss philosopher who described such visual hallucinations in the 18th century. “We were relieved,” said Ms. Murray. What they feared, of course, was mental illness or dementia. “To have an eye doctor say, ‘I’m familiar with this,’ it’s still jarring but it’s not so terrible.” Bonnet Syndrome (pronounced Boh-NAY) isn’t terribly rare, it turns out. Oliver Sacks described several cases in his 2012 book, “Hallucinations.” Dr. Abdhish Bhavsar, a clinical spokesperson for the American Academy of Ophthalmology and a retina specialist in Minneapolis, estimates that he has probably seen about 200 patients with the syndrome over 17 years of practice. © 2014 The New York Times Company
By SINDYA N. BHANOO BERKELEY, CALIF. — Lilith Sadil, 12, climbs into an examination chair here at the Myopia Control Center at the University of California. “Do you know why you are here?” asks Dr. Maria Liu, an optometrist. “Because my eyes are changing fast,” Lilith says. “Do you read a lot?” Dr. Liu asks. “Yes.” “Do you use the computer a lot?” “Yes.” Lilith is an active child who practices taekwondo. But like an increasing number of children, she has myopia — she can see close up but not farther away. Her mother, Jinnie Sadil, has brought her to the center because she has heard about a new treatment that could help. Eye specialists are offering young patients special contact lenses worn overnight that correct vision for the next day. Myopia has become something of a minor epidemic: More than 40 percent of Americans are nearsighted, a 16 percent increase since the 1970s. People with so-called high myopia — generally, blurry vision beyond about five inches — face an increased likelihood of developing cataracts and glaucoma, are at higher risk for retinal detachments that can result in blindness. Exactly what is causing the nationwide rise in nearsightedness is not known. “It can’t be entirely genetic, because genes don’t change that fast,” said Susan Vitale, an epidemiologist at the National Institutes of Health who studies myopia. “It’s probably something that’s environmental, or a combination of genetic and environmental factors.” Some research indicates that “near work” — reading, computer work, playing video games, and using tablets and smartphones — is contributing to the increase. A recent study found that the more educated a person is, the more likely he or she will be nearsighted. A number of other studies show that children who spend time outdoors are less likely to develop high myopia. But no one is certain whether the eye benefits from ultraviolet light or whether time outside simply means time away from near work. © 2014 The New York Times Company
Linda Carroll TODAY contributor For years Larry Hester lived in darkness, his sight stolen by a disease that destroyed the photoreceptor cells in his retinas. But last week, through the help of a “bionic eye,” Hester got a chance to once again glimpse a bit of the world around him. Video: Larry Hester has been without sight for decades, but with the help of a new tool called the "bionic eye," researchers at Duke University have found a way to restore some of his sight. Hester is the seventh patient to receive an FDA-approved device that translates video signals into data the optic nerve can process. The images Hester and others “see” will be far from full sight, but experts hope it will be enough to give a little more autonomy to those who had previously been completely blind. Hester’s doctors at Duke University Eye Center believe that as time goes on the 66-year-old tire salesman from Raleigh, N.C., will be able to “see” more and more. After only five days, there has been remarkable progress. “I hope that [after some practice] he will be able to do things he can’t do today: maybe walk around a little more independently, see doorways or the straight line of a curb. We don’t expect him to be able to make out figures on TV. But we hope he’ll be more visually connected.” said Dr. Paul Hahn, an assistant professor of ophthalmology at the university in Durham.
2014 by Andy Coghlan Seeing is definitely believing when it comes to stem cell therapy. A blind man has recovered enough sight to ride his horse. A woman who could see no letters at all on a standard eye test chart can now read the letters on the top four lines. Others have recovered the ability to see colour. All have had injections of specialised retinal cells in their eyes to replace ones lost through age or disease. A trial in 18 people with degenerative eye conditions is being hailed as the most promising yet for a treatment based on human embryonic stem cells. "We've been hearing about their potential for more than a decade, but the results have always been in mice and rats, and no one has shown they're safe or effective in humans long term," says Robert Lanza of Advanced Cell Technology in Marlborough, Massachusetts, the company that carried out the stem cell intervention. "Now, we've shown both that they're safe and that there's a real chance these cells can help people." Ten years ago, the team at Advanced Cell Technology announced that it had successfully converted human embryonic stem cells into retinal pigment epithelial cells. These cells help keep the eyes' light-detecting rods and cones healthy. But when retinal pigment epithelial cells deteriorate, blindness can occur. This happens in age-related macular degeneration and Stargardt's macular dystrophy. In a bid to reverse this, Lanza's team injected retinal cells into one of each of the 18 participants' eyes, half of whom had age-related macular degeneration and half had Stargardt's. A year later, 10 people's eyes had improved, and the eyes of the others had stabilised. Untreated eyes had continued to deteriorate. © Copyright Reed Business Information Ltd.
David Cyranoski A Japanese patient with a debilitating eye disease is about to become the first person to be treated with induced pluripotent stem cells, which have generated enthusiastic expectations and earned their inventor a Nobel Prize. A health-ministry committee has vetted researchers' safety tests and cleared the team to begin the experimental procedure. Masayo Takahashi, an ophthalmologist at the RIKEN Center for Developmental Biology (CDB) in Kobe, has been using induced pluripotent stem (iPS) cells to prepare a treatment for age-related macular degeneration. Unlike embryonic stem cells, iPS cells are produced from adult cells, so they can be genetically tailored to each recipient. They are capable of becoming any cell type in the body, and have the potential to treat a wide range of diseases. The CDB trial will be the first opportunity for the technology to prove its clinical value. In age-related macular degeneration, extra blood vessels form in the eye, destabilizing a supportive base layer of the retina known as the retinal pigment epithelium. This results in the loss of the light-sensitive photoreceptors that are anchored in the epithelium, and often leads to blindness. Takahashi took skin cells from people with the disease and converted them to iPS cells. She then coaxed these cells to become retinal pigment epithelium cells, and then to grow into thin sheets that can be transplanted to the damaged retina. Takahashi and her collaborators have shown in monkey studies1 that iPS cells generated from the recipients' own cells do not provoke an immune reaction that causes them to be rejected. There have been concerns that iPS cells could cause tumours, but Takahashi's team has found that to be unlikely in mice2 and monkeys1. © 2014 Nature Publishing Group