Chapter 13. Homeostasis: Active Regulation of the Internal Environment
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By Elizabeth Pennisi The microbes that live in your body outnumber your cells 10 to one. Recent studies suggest these tiny organisms help us digest food and maintain our immune system. Now, researchers have discovered yet another way microbes keep us healthy: They are needed for closing the blood-brain barrier, a molecular fence that shuts out pathogens and molecules that could harm the brain. The findings suggest that a woman's diet or exposure to antibiotics during pregnancy may influence the development of this barrier. The work could also lead to a better understanding of multiple sclerosis, in which a leaky blood-brain barrier may set the stage for a decline in brain function. The first evidence that bacteria may help fortify the body’s biological barriers came in 2001. Researchers discovered that microbes in the gut activate genes that code for gap junction proteins, which are critical to building the gut wall. Without these proteins, gut pathogens can enter the bloodstream and cause disease. In the new study, intestinal biologist Sven Pettersson and his postdoc Viorica Braniste of the Karolinska Institute in Stockholm decided to look at the blood-brain barrier, which also has gap junction proteins. They tested how leaky the blood-brain barrier was in developing and adult mice. Some of the rodents were brought up in a sterile environment and thus were germ-free, with no detectable microbes in their bodies. Braniste then injected antibodies—which are too big to get through the blood-brain barrier—into embryos developing within either germ-free moms or moms with the typical microbes, or microbiota. © 2014 American Association for the Advancement of Science
Link ID: 20338 - Posted: 11.20.2014
By Nicholas Bakalar Exposure to secondhand smoke and roadway traffic may be tied to increased body mass index in children and adolescents, a new study suggests. Researchers studied 3,318 children in 12 Southern California communities beginning at an average age of 10, and then followed them through age 18. They used parental questionnaires to establish exposure to smoking, and data on traffic volume and levels of nitrogen dioxide, ozone and particulates to track pollution. The study, in Environmental Health Perspectives, controlled for many other factors: sex, initial B.M.I., asthma, physical activity, insurance status, parental education and income, acres of parks and open space nearby, percentage of people living in poverty in each community. But even after accounting for these issues and more, they found that compared with children exposed to no secondhand smoke or near-roadway air pollution, B.M.I. was 0.80 higher in children exposed to pollution alone, 0.85 higher in those exposed to secondhand smoke alone, and 2.15 higher in those exposed to both. A normal B.M.I. for adults is 18.5 to 24.9. Higher than 25 is considered overweight, and above 30 obese. “It would be interesting to know more about the mechanism,” said the lead author, Dr. Rob McConnell, a professor of preventive medicine at the University of Southern California. “But the finding challenges the view that obesity is due solely to increased caloric intake and reduced physical activity. That’s not the whole story.” © 2014 The New York Times Company
By Adam Brimelow Health Correspondent, BBC News A Mediterranean diet may be a better way of tackling obesity than calorie counting, leading doctors have said. Writing in the Postgraduate Medical Journal (PMJ), the doctors said a Mediterranean diet quickly reduced the risk of heart attacks and strokes. And they said it may be better than low-fat diets for sustained weight loss. Official NHS advice is to monitor calorie intake to maintain a healthy weight. Last month NHS leaders stressed the need for urgent action to tackle obesity and the health problems that often go with it. The PMJ editorial argues a focus on food intake is the best approach, but it warns crash dieting is harmful. Signatories of the piece included the chair of the Academy of Medical Royal Colleges, Prof Terence Stephenson, and Dr Mahiben Maruthappu, who has a senior role at NHS England. They criticise the weight-loss industry for focusing on calorie restriction rather than "good nutrition". And they make the case for a Mediterranean diet, including fruit and vegetables, nuts and olive oil, citing research suggesting it quickly reduces the risk of heart attacks and strokes, and may be better than low-fat diets for sustained weight loss. The lead author, cardiologist Dr Aseem Malhotra, says the scientific evidence is overwhelming. "What's more responsible is that we tell people to concentrate on eating nutritious foods. "It's going to have an impact on their health very quickly. We know the traditional Mediterranean diet, which is higher in fat, proven from randomised controlled trials, reduces the risk of heart attack and stroke even within months of implementation." The article also says adopting a Mediterranean diet after a heart attack is almost three times as effective at reducing deaths as taking cholesterol-lowering statin medication. BBC © 2014
Link ID: 20316 - Posted: 11.17.2014
Sara Reardon Companies selling ‘probiotic’ foods have long claimed that cultivating the right gut bacteria can benefit mental well-being, but neuroscientists have generally been sceptical. Now there is hard evidence linking conditions such as autism and depression to the gut’s microbial residents, known as the microbiome. And neuroscientists are taking notice — not just of the clinical implications but also of what the link could mean for experimental design. “The field is going to another level of sophistication,” says Sarkis Mazmanian, a microbiologist at the California Institute of Technology in Pasadena. “Hopefully this will shift this image that there’s too much commercial interest and data from too few labs.” This year, the US National Institute of Mental Health spent more than US$1 million on a new research programme aimed at the microbiome–brain connection. And on 19 November, neuroscientists will present evidence for the link in a symposium at the annual Society for Neuroscience meeting in Washington DC called ‘Gut Microbes and the Brain: Paradigm Shift in Neuroscience’. Although correlations have been noted between the composition of the gut microbiome and behavioural conditions, especially autism1, neuroscientists are only now starting to understand how gut bacteria may influence the brain. The immune system almost certainly plays a part, Mazmanian says, as does the vagus nerve, which connects the brain to the digestive tract. Bacterial waste products can also influence the brain — for example, at least two types of intestinal bacterium produce the neurotransmitter γ-aminobutyric acid (GABA)2. © 2014 Nature Publishing Group
By Katy Waldman How much control do you have over how much control you think you have? The researchers Michael R. Ent and Roy F. Baumeister have been studying what makes a person more or less likely to believe in free will. Is it a deep connection to the philosophy of David Hume? An abiding faith in divine omnipotence? Try a really, really full bladder. In an online survey, 81 adults ages 18 to 70 reported the extent to which they felt hungry, tired, desirous of sex, and desirous of a toilet. They then rated the extent to which they considered themselves in command of their destinies. People experiencing intense physical needs were less likely to say they believed in free will. People who were not inexplicably taking an online survey while desperately holding in their pee (or starving, or wanting sex, or trying to stay awake) mostly claimed that the universe had handed them the keys to their lives. Also, people who brought their laptops with them into the bathroom to fill out the survey reported that they were God. (I kid on that last part.) Ent and Baumeister also used a survey to take the free will temperature of 23 people with panic disorder, 16 people with epilepsy, and 35 healthy controls. Those suffering from the two conditions—both of which can unpredictably plunge the mind into chaos—tended to put less stock in the notion of mental autonomy. There was a third experiment, too. I said earlier that people not taking an online survey while jonesing for various creature comforts mostly claimed that they wore the metaphysical pants. However, despite robust results for horniness, fatigue, and needing-to-go-ness, Ent and Baumeister didn’t initially see much correlation between people’s philosophical visions and their hunger levels. So they re-administered the survey to 112 new volunteers, some of whom were dieting and some of whom were not. © 2014 The Slate Group LLC.
Link ID: 20294 - Posted: 11.10.2014
By James Gallagher Health editor, BBC News website Weight loss surgery can dramatically reduce the odds of developing type 2 diabetes, according to a major study. Doctors followed nearly 5,000 people as part of a trial to assess the health impact of the procedure. The results, published in the Lancet Diabetes and Endocrinology journal, showed an 80% reduction in type 2 diabetes in those having surgery. The UK NHS is considering offering the procedure to tens of thousands of people to prevent diabetes. Obesity and type 2 diabetes are closely tied - the bigger someone is, the greater the risk of the condition. The inability to control blood sugar levels can result in blindness, amputations and nerve damage. Around a tenth of NHS budgets are spent on managing the condition. Surgery The study followed 2,167 obese adults who had weight loss - known as bariatric - surgery. They were compared to 2,167 fellow obese people who continued as they were. There were 38 cases of diabetes after surgery compared with 177 in people left as they were - a reduction of nearly 80%. Around 3% of morbidly obese people develop type 2 each year, however, surgery reduced the figure to around 0.5%, which is the background figure for the whole population. Bariatric surgery, also known as weight loss surgery, is used as a last resort to treat people who are dangerously obese and carrying an excessive amount of body fat. This type of surgery is available on the NHS only to treat people with potentially life-threatening obesity when other treatments have not worked. Around 8,000 people a year currently receive the treatment. The two most common types of weight loss surgery are: Gastric band, where a band is used to reduce the size of the stomach so a smaller amount of food is required to make someone feel full Gastric bypass, where the digestive system is re-routed past most of the stomach so less food is digested to make someone feel full BBC © 2014
Link ID: 20269 - Posted: 11.03.2014
Daniel Duane, Men's Journal For more than half a century, the conventional wisdom among nutritionists and public health officials was that fat is dietary enemy No. 1 — the leading cause of obesity and heart disease. It appears the wisdom was off. And not just off. Almost entirely backward. According to a new study from the National Institutes of Health, a diet that reduces carbohydrates in favor of fat — including the saturated fat in meat and butter — improves nearly every health measurement, from reducing our waistlines to keeping our arteries clear, more than the low-fat diets that have been recommended for generations. "The medical establishment got it wrong," says cardiologist Dennis Goodman, director of Integrative Medicine at New York Medical Associates. "The belief system didn't pan out." It's not the conclusion you would expect given the NIH study's parameters. Lead researcher Lydia Bazanno, of the Tulane University School of Public Health, pitted this high-fat, low-carb diet against a fat-restricted regimen prescribed by the National Cholesterol Education Program. "We told both groups to get carbs from green, leafy vegetables, because those are high in nutrients and fiber to keep you sated," Bazanno says. "We also told everyone to stay away from trans fats." The fat-restricted group continued to eat carbs, including bread and cereals, while keeping saturated fat — common in animal products — below 7 percent of total calories. By contrast, the high-fat group cut carbs in half and did not avoid butter, meat, and cheese. Most important, both groups ate as much as they wanted — no calorie counting, no going hungry.
Link ID: 20251 - Posted: 10.28.2014
By Gary Stix Scott Small, a professor of neurology at Columbia University’s College of Physicians and Surgeons, researches Alzheimer’s, but he also studies the memory loss that occurs during the normal aging process. Research on the commonplace “senior moments” focuses on the hippocampus, an area of the brain involved with formation of new memories. In particular, one area of the hippocampus, the dentate gyrus, which helps distinguish one object from another, has lured researchers on age-related memory problems. In a study by Small and colleagues published Oct. 26 in Nature Neuroscience, naturally occurring chemicals in cocoa increased dentate gyrus blood flow. Psychological testing showed that the pattern recognition abilities of a typical 60-year-old on a high dose of the cocoa phytochemicals in the 37-person study matched those of a 30-or 40-year old after three months. The study received support from the food company Mars, but Small cautions against going out to gorge on Snickers Bars, as most of the beneficial chemicals, or flavanols, are removed when processing cocoa. An edited transcript of an interview with Small follows: Can you explain what you found in your study? The main motive of the study was to causally establish an anatomical source of age-related memory loss. A number of labs have shown in the last 10 years that there’s one area of the brain called the dentate gyrus that is linked to the aging process. But no one has tested that concept. Until now the observations have been correlational. There is decreased function in that region and, to prove causation, we were trying to see if we could reverse that. © 2014 Scientific American
Keyword: Learning & Memory
Link ID: 20245 - Posted: 10.27.2014
By GABRIELE OETTINGEN MANY people think that the key to success is to cultivate and doggedly maintain an optimistic outlook. This belief in the power of positive thinking, expressed with varying degrees of sophistication, informs everything from affirmative pop anthems like Katy Perry’s “Roar” to the Mayo Clinic’s suggestion that you may be able to improve your health by eliminating “negative self-talk.” But the truth is that positive thinking often hinders us. More than two decades ago, I conducted a study in which I presented women enrolled in a weight-reduction program with several short, open-ended scenarios about future events — and asked them to imagine how they would fare in each one. Some of these scenarios asked the women to imagine that they had successfully completed the program; others asked them to imagine situations in which they were tempted to cheat on their diets. I then asked the women to rate how positive or negative their resulting thoughts and images were. A year later, I checked in on these women. The results were striking: The more positively women had imagined themselves in these scenarios, the fewer pounds they had lost. My colleagues and I have since performed many follow-up studies, observing a range of people, including children and adults; residents of different countries (the United States and Germany); and people with various kinds of wishes — college students wanting a date, hip-replacement patients hoping to get back on their feet, graduate students looking for a job, schoolchildren wishing to get good grades. In each of these studies, the results have been clear: Fantasizing about happy outcomes — about smoothly attaining your wishes — didn’t help. Indeed, it hindered people from realizing their dreams. © 2014 The New York Times Company
Clare Pain Eating a high fat and high carb diet resulted in inflammation in the brain - at least in male mice. We'll have to wait to see if the same process applies to male humans. The detrimental impact of junk food seems to be connected to inflammation in the brains of male mice, with the brains of females protected by oestrogen, according to research published today in Cell Reports. Dr Deborah Clegg, who led the study while at University of Texas Southwestern Medical Centre, Dallas, USA, was building on existing research that links brain inflammation with obesity and heart disease in male mice. "We embarked on this research because [the link with inflammation] had been shown in male mice, so we asked ourselves, do the same processes occur in females?" explains Clegg. Previous research has shown that one cause of inflammation in the hypothalamus - the part of the brain that controls energy balance - is palmitic acid, a saturated fatty acid found in palm oil, dairy products and meat, and common in high fat food. The team looked at male and female mice, fed either their normal diet or a 'high fat' diet. Besides containing 42 per cent fat, the high fat diet was also high in carbohydrates making it a good correlate of human junk food, says Clegg. © 2014 ABC
By ALEX STONE Smell is one of the oldest human faculties, yet it was one of the last to be understood by scientists. It was not until the early 1990s that biologists first described the inner workings of olfactory receptors — the chemical sensors in our noses — in a discovery that won a Nobel Prize. Since then, the plot has thickened. Over the last decade or so, scientists have discovered that odor receptors are not solely confined to the nose, but found throughout body — in the liver, the heart, the kidneys and even sperm — where they play a pivotal role in a host of physiological functions. Now, a team of biologists at Ruhr University Bochum in Germany has found that our skin is bristling with olfactory receptors. “More than 15 of the olfactory receptors that exist in the nose are also found in human skin cells,” said the lead researcher, Dr. Hanns Hatt. Not only that, but exposing one of these receptors (colorfully named OR2AT4) to a synthetic sandalwood odor known as Sandalore sets off a cascade of molecular signals that appears to induce healing in injured tissue. In a series of human tests, skin abrasions healed 30 percent faster in the presence of Sandalore, a finding the scientists think could lead to cosmetic products for aging skin and to new treatments to promote recovery after physical trauma. The presence of scent receptors outside the nose may seem odd at first, but as Dr. Hatt and others have observed, odor receptors are among the most evolutionarily ancient chemical sensors in the body, capable of detecting a multitude of compounds, not solely those drifting through the air. “If you think of olfactory receptors as specialized chemical detectors, instead of as receptors in your nose that detect smell, then it makes a lot of sense for them to be in other places,” said Jennifer Pluznick, an assistant professor of physiology at Johns Hopkins University who in 2009 found that olfactory receptors help control metabolic function and regulate blood pressure in the kidneys of mice. © 2014 The New York Times Company
Keyword: Chemical Senses (Smell & Taste)
Link ID: 20206 - Posted: 10.14.2014
By MOISES VELASQUEZ-MANOFF WHEN Andre H. Lagrange, a neurologist at Vanderbilt University in Nashville, saw the ominous white spots on the patient’s brain scan, he considered infection or lymphoma, a type of cancer. But tests ruled out both. Meanwhile, anti-epilepsy drugs failed to halt the man’s seizures. Stumped, Dr. Lagrange turned to something the mother of the 30-year-old man kept repeating. The fits coincided, she insisted, with spells of constipation and diarrhea. That, along with an odd rash, prompted Dr. Lagrange to think beyond the brain. Antibody tests, followed by an intestinal biopsy, indicated celiac disease, an autoimmune disorder of the gut triggered by the gluten proteins in wheat and other grains. Once on a gluten-free diet, the man’s seizures stopped; those brain lesions gradually disappeared. He made a “nearly complete recovery,” Dr. Lagrange told me. I began encountering case descriptions like this some years ago as I researched autoimmune disease. The first few seemed like random noise in an already nebulous field. But as I amassed more — describing seizures, hallucinations, psychotic breaks and even, in one published case, what looked like regressive autism, all ultimately associated with celiac disease — they began to seem less like anomalies, and more like a frontier in celiac research. They tended to follow a similar plot. What looked like neurological or psychiatric symptoms appeared suddenly. The physician ran through a diagnostic checklist without success. Drugs directed at the brain failed. Some clue suggestive of celiac disease was observed. The diagnosis was made. And the patient recovered on a gluten-free diet. The cases highlighted, in an unusually concrete fashion, the so-called gut-brain axis. The supposed link between the intestinal tract and the central nervous system is much discussed in science journals, often in the context of the microbial community inhabiting the gut. But it’s unclear how, really, we can leverage the link to improve health. © 2014 The New York Times Company
Link ID: 20200 - Posted: 10.13.2014
BY Ashley Yeager A protein made by gut bacteria may trigger a chain of interactions in the body that contribute to eating disorders such as anorexia and bulimia. When the protein is produced, the body makes antibodies to bind to it, but the antibodies also attach to a hormone that controls fullness. In tests, mice given bacteria that produce the protein changed how much they ate compared with mice given bacteria that did not make the protein, a new study shows. Researchers also found that the antibodies to the protein were higher in patients with anorexia and bulimia. The results, which appear October 7 in Translational Psychiatry, seem to be some of the earliest to link gut bacteria to eating disorders. © Society for Science & the Public 2000 - 2014.
Keyword: Anorexia & Bulimia
Link ID: 20188 - Posted: 10.11.2014
|By Bret Stetka Multiple sclerosis (MS) is an electrical disorder, or rather one of impaired myelin, a fatty, insulating substance that better allows electric current to bolt down our neurons and release the neurotransmitters that help run our bodies and brains. Researchers have speculated for some time that the myelin degradation seen in MS is due, at least in part, to autoimmune activity against the nervous system. Recent work presented at the MS Boston 2014 Meeting suggests that this aberrant immune response begins in the gut. Eighty percent of the human immune system resides in the gastrointestinal tract. Alongside it are the trillions of symbiotic bacteria, fungi and other single-celled organisms that make up our guts’ microbiomes. Normally everyone wins: The microorganisms benefit from a home and a steady food supply; we enjoy the essential assistance they provide in various metabolic and digestive functions. Our microbiomes also help calibrate our immune systems, so our bodies recognize which co-inhabitants should be there and which should not. Yet mounting evidence suggests that when our resident biota are out of balance, they contribute to numerous diseases, including diabetes, rheumatoid arthritis, autism and, it appears, MS by inciting rogue immune activity that can spread throughout the body and brain. One study presented at the conference, out of Brigham and Women’s Hospital (BWH), reported a single-celled organism called methanobrevibacteriaceae that activates the immune system is enriched in the gastrointestinal tracts of MS patients whereas bacteria that suppress immune activity are depleted. Other work, which resulted from a collaboration among 10 academic researcher centers across the U.S. and Canada, reported significantly altered gut flora in pediatric MS patients while a group of Japanese researchers found that yeast consumption reduced the chances of mice developing an MS-like disease by altering gut flora. © 2014 Scientific American
Keyword: Multiple Sclerosis
Link ID: 20186 - Posted: 10.09.2014
by Laura Starecheski From the self-affirmations of Stuart Smalley on Saturday Night Live to countless videos on YouTube, saying nice things to your reflection in the mirror is a self-help trope that's been around for decades, and seems most often aimed at women. The practice, we're told, can help us like ourselves and our bodies more, and even make us more successful — allow us to chase our dreams! Impressed, but skeptical, I took this self-talk idea to one of the country's leading researchers on body image to see if it's actually part of clinical practice. David Sarwer is a psychologist and clinical director at the Center for Weight and Eating Disorders at the University of Pennsylvania. He says that, in fact, a mirror is one of the first tools he uses with some new patients. He stands them in front of a mirror and coaches them to use gentler, more neutral language as they evaluate their bodies. "Instead of saying, 'My abdomen is disgusting and grotesque,' " Sarwer explains, he'll prompt a patient to say, " 'My abdomen is round, my abdomen is big; it's bigger than I'd like it to be.' " The goal, he says, is to remove "negative and pejorative terms" from the patient's self-talk. The underlying notion is that it's not enough for a patient to lose physical weight — or gain it, as some women need to — if she doesn't also change the way her body looks in her mind's eye. This may sound weird. You're either a size 4 or a size 8, right? Not mentally, apparently. In a 2013 study from the Netherlands, scientists watched women with anorexia walk through doorways in a lab. The women, they noticed, turned their shoulders and squeezed sideways, even when they had plenty of room. © 2014 NPR
BY Bethany Brookshire In this sweet, sweet world we live in, losing weight can be a dull and flavorless experience. Lovely stove-popped popcorn drenched in butter gives way to dry microwaved half-burnt kernels covered in dusty yellow powder. The cookies and candy that help us get through the long afternoons are replaced with virtuous but boring apples and nuts. Even the sugar that livens up our coffee gets a skeptical eye: That’s an extra 23 calories per packet you shouldn’t be eating. What makes life sweet for those of us who are counting calories is artificial sweeteners. Diet soda gives a sweet carbonated fix. A packet of artificial sweetener in your coffee or tea makes it a delicious morning dose. But a new study, published September 17 in Nature, found that the artificial sweetener saccharin has an unintended side effect: It alters the bacterial composition of the gut in mice and humans. The new bacterial neighborhood brings with it higher blood glucose levels, putting the humans and the murine counterparts at risk for diabetes. Many people wondered if the study’s effects were real. We all knew that sugar was bad, but now the scientists are coming for our Splenda! It seems more than a little unfair. But this study was a long time coming. The scientific community has been studying artificial sweeteners and their potential hazards for a long time. And while the new study adds to the literature, there are other studies, currently ongoing and planned for the future, that will determine the extent and necessity of our artificially sweetened future. © Society for Science & the Public 2000 - 2014.
|By Melinda Wenner Moyer Autism is primarily a disorder of the brain, but research suggests that as many as nine out of 10 individuals with the condition also suffer from gastrointestinal problems such as inflammatory bowel disease and “leaky gut.” The latter condition occurs when the intestines become excessively permeable and leak their contents into the bloodstream. Scientists have long wondered whether the composition of bacteria in the intestines, known as the gut microbiome, might be abnormal in people with autism and drive some of these symptoms. Now a spate of new studies supports this notion and suggests that restoring proper microbial balance could alleviate some of the disorder's behavioral symptoms. At the annual meeting of the American Society for Microbiology held in May in Boston, researchers at Arizona State University reported the results of an experiment in which they measured the levels of various microbial by-products in the feces of children with autism and compared them with those found in healthy children. The levels of 50 of these substances, they found, significantly differed between the two groups. And in a 2013 study published in PLOS ONE, Italian researchers reported that, compared with healthy kids, those with autism had altered levels of several intestinal bacterial species, including fewer Bifidobacterium, a group known to promote good intestinal health. One open question is whether these microbial differences drive the development of the condition or are instead a consequence of it. A study published in December 2013 in Cell supports the former idea. When researchers at the California Institute of Technology incited autismlike symptoms in mice using an established paradigm that involved infecting their mothers with a viruslike molecule during pregnancy, they found that after birth, the mice had altered gut bacteria compared with healthy mice. © 2014 Scientific American,
Link ID: 20104 - Posted: 09.23.2014
By Nicholas Bakalar Average waist circumference — but not body mass index— increased significantly in the United States between 1999 and 2012, a new study reports. Abdominal obesity — a “beer belly” or “beer gut” — is caused by fat around the internal organs. It is one of the indicators of metabolic syndrome, a group of five conditions that raises the risk for heart disease and diabetes. After adjusting for age, the overall mean waist circumference increased to 38.7 inches in 2012 from 37.5 in 1999. The increases were significant for men, women, non-Hispanic whites, non-Hispanic blacks and Mexican-Americans. They were greatest among non-Hispanic whites in their 40s, and non-Hispanic black men in their 30s. “I would encourage people to keep track of their waists,” said the lead author of the study, Dr. Earl S. Ford, a medical officer with the Centers for Disease Control and Prevention. “Standing on the scale every day is all good and well, but you can have a steady weight and still have an expanding waist. And that should be a signal for people to start looking at their diet and physical activity.” In 2012, 54.2 percent of Americans had abdominal obesity (defined as an age-adjusted waist circumference of more than 40 inches for men and more than 34.6 for women) compared with 46.4 percent in 1999. The study was published in JAMA. © 2014 The New York Times Company
Link ID: 20103 - Posted: 09.23.2014
by Rachel Ehrenberg Eating artificial sweeteners may spur the very health problems that dieters try to avoid. A new multipronged study of mice and a small number of people finds that saccharin meddles with the gut’s microbial community, setting in motion metabolic changes that are associated with obesity and diabetes. Other zero-calorie sweeteners may cause the same problems, researchers say September 17 in Nature. Though the finding is preliminary, four of seven human volunteers eating a diet high in saccharin developed impaired glucose metabolism, a warning sign for type 2 diabetes. “This is very interesting and scary if it really does hold for humans,” says Robert Margolskee of the Monell Chemical Senses Center in Philadelphia, who was not involved with the work. “There could be unintended consequences of these artificial sweeteners.” Until recently, most sugar substitutes were thought to pass through the gut undigested, exerting little to no effect on intestinal cells. As ingredients in diet soda, sugar-free desserts and a panoply of other foods, the sweeteners are touted as a way for people with diabetes and weight problems to enjoy a varied diet. But the new study, led by computational biologist Eran Segal and immunologist Eran Elinav of the Weizmann Institute of Science in Rehovot, Israel, suggests that rather than helping people, the sweeteners may promote problems. © Society for Science & the Public 2000 - 2014.
by Bethany Brookshire Most of us wish we ate better. I know I certainly do. But when hunger strikes, and you’re standing in line at the grab-and-go food joint, that salad seems really lackluster sitting next to that tasty-looking cookie. I can’t help but think that my diet — and my waistline — would look a lot better if I just craved lettuce a little more. Now a new study shows that although we may never cease to love cookies, we might be able to make that carrot a little more appealing. In overweight people, a behavioral intervention was associated with changes in how their brains responded to high- and low-calorie foods. The small pilot study is intriguing, but with just 13 participants, a larger study is needed before scientists will know if training the brain can make us abstain. “Everyone responds more strongly to high-calorie foods than low-calorie foods. It’s just normal,” says study coauthor Susan Roberts, a behavioral nutrition scientist from Tufts University in Medford, Mass. While most people prefer brownies over beets, people who are overweight or obese have a harder time avoiding high-calorie foods, she says. “When someone becomes overweight, there’s a dampening effect on a number of brain structures, including the reward system,” she says. “It’s harder to enjoy food generally, and so when someone becomes overweight, they really want to eat those high-calorie foods, because those are the foods that activate reward systems to the biggest extent.” Craving is a particular issue. Craving is distinct from hunger and focuses on a particular food, often foods that are high calorie. Other studies show that people who are obese have more cravings than those who are not. © Society for Science & the Public 2000 - 2014