Chapter 5. Hormones and the Brain
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By Nathan Seppa HOUSTON — Men with low testosterone who are given replacement doses of the hormone shed weight steadily for years, researchers in Germany reported June 23 at a meeting of the Endocrine Society. Study participants, nearly all of whom were overweight or obese at the start of the study, lost 36 pounds on average. “This was an unintended effect,” said study coauthor Farid Saad, a research endocrinologist at Bayer Pharma in Berlin. “The big surprise was that when we analyzed the data [we found] that these men had lost weight continuously...year by year.” The men didn’t diet as part of the study, and any increase in their activity was voluntary, Saad said. He and his colleagues studied 116 men, average age 61, who had low testosterone levels. Each received quarterly injections of the hormone for five years. At the start, 71 percent were obese and another 24 percent were overweight. After five years, 97 percent of the men showed a reduction in waist circumference, on average losing “three to four trouser sizes,” Saad said. Average weight dropped from 236 pounds to about 200. “This definitely offers some insight that we can apply to our clinical practices,” said Vineeth Mohan, a clinical endocrinologist at Cleveland Clinic Florida in Weston. High testosterone levels have been linked to prostate cancer risk (SN: 10/8/05, p. 238), and a small portion of men taking high doses of it experience mania (SN: 2/19/00, p. 119). But in this study, Saad said, men received testosterone in doses just high enough to bring them back to normal levels. Three men in the test group were diagnosed with prostate cancer during the study, a rate lower than the incidence found in routine screening programs for men that age, he said. © Society for Science & the Public 2000 - 2012
by Michael Balter Many studies in humans and animals suggest that chronic stress is bad for one’s health, in part because it suppresses the immune system. But nearly 30 years of data on wild baboons shows that top-ranking males, despite showing signs of increased stress, recover more quickly than low-ranking baboons from wounds and illness. The results may help explain why some people escape from the negative effects of stress while others do not. Most studies in humans have shown a clear correlation between higher socioeconomic status and lower risk of death or illness from stress-related diseases such as heart attacks and diabetes. Some of the most famous of these are the so-called Whitehall studies of the British Civil Service, which showed that death and illness rates decreased in a step-wise fashion the higher an employee was on the service’s 6-grade pay and responsibility scale. These and other studies also have found that being at the bottom of the totem pole leads to greater stress as a result of increased work loads and time pressures, as well as more job insecurity. But studies of animals, especially other primates, have shown that the relationship between stress and status largely depends on the social organization of the species in question. For example, in species such as baboons that have rigid social rankings and hierarchies, with so-called alpha males dominating other males and females over extended periods of time, it can apparently be more stressful at the top. In a study reported last year in Science, a team that included ecologist Jeanne Altmann of Princeton University revealed that baboon alpha males had the highest levels of glucocorticoid hormones, such as cortisol, as well as testosterone in their feces, indicators that they were under greater stress than lower-ranking individuals. © 2010 American Association for the Advancement of Science.
Shannon Pettypiece Testosterone replacement has long been prescribed for men who suffer from abnormally low levels of the male sex hormone, but overuse can lead to infertility and can even speed the growth of prostate cancer. That hasn't stopped Michael Murray, a healthy 43-year-old home stager who works in New York and Chicago, from getting frequent testosterone injections to raise his energy level and give his bodybuilding regime a boost. "Am I making a deal with the devil? A little bit, but I have to think about my quality of life," Murray explains. "It is like I'm in my 20s again." In what may become one of the most sought-after lifestyle drugs since the introduction of Pfizer's Viagra 14 years ago, new testosterone drugs from Eli Lilly, Abbott Laboratories, and other drugmakers are hot. Prescriptions for testosterone replacement therapies have more than doubled since 2006 to 5.6 million last year, according to data compiled by Bloomberg. Sales are expected to triple to $5 billion by 2017, forecasts Global Industry Analysts. As many as 13.8 million men older than 45 in the United States have low levels of testosterone, according to a 2006 study in the International Journal of Clinical Practice. The male sex hormone begins to decline after age 30, and tends to drop about 1 percent each year. Lower-than-normal levels can lead to a loss of libido, a decrease in bone and muscle mass, and depression. © 2012 Hearst Communications Inc.
Older obese men could shift excess weight by taking testosterone supplements, suggest findings announced at the European Congress on Obesity. In a study, hormone-deficient men were given testosterone supplements in a similar way to HRT for older women. Men lost an average of 16kg over five years when testosterone levels were increased back to normal. But experts warn that supplements may not be the answer due to possible risks of prostate cancer and heart disease. Prof Richard Sharpe from the University of Edinburgh Centre for Reproductive Health said: "The notion that this is a quick fix for obese older men is, as always, simplistic. It is far more sensible and safer for men to reduce their food intake, reduce their obesity, which will then elevate their own testosterone." The findings announced at the conference also suggest that raising testosterone levels could reduce waist circumference and blood pressure. Dr Farid Saad, lead author of the study said: "We came across this by accident. These men were being given testosterone for a hormone deficiency - they had a range of problems - erectile dysfunction, fatigue and lack of energy. BBC © 2012
By LISA SANDERS, M.D. On Thursday I challenged Well readers to figure out a medical mystery involving a middle-aged woman who learned she had an unusual disease after visiting an ophthalmologist. The case was surprising because the woman didn’t feel sick, yet the doctor made the diagnosis just by looking at her and asking her a few simple questions that confirmed his diagnostic suspicions. The first reader to figure it out completely was Dr. Eric Gierke, a neurologist at Swedish Medical Center in Seattle. He said he recognized the condition because he had a patient who had acromegaly and only a few very subtle physical changes. In submitting his answer, Dr. Gierke also guessed one of the questions that the diagnosing physician asked the patient — “Has your shoe size changed recently?” — making him the clear winner. A few other readers also guessed both the questions and the diagnosis, but Dr. Gierke was first and the most specific. In all, 16 readers figured out the correct diagnosis. Well done! Acromegaly is a disease caused by a tumor, usually found in the pituitary gland, that secretes an excess of growth hormone, the blood chemical that tells our bodies to grow. Children with acromegaly can grow to extraordinary stature. André the Giant, the French professional wrestler and actor whose height was billed at 7 feet 4 inches, and Richard Kiel, the 7-foot-2 actor who played the villain Jaws in two James Bond movies, both had acromegaly from childhood. Their distinctive faces reveal some of the characteristic acromegalic changes: Their brows are prominent, and they have wide, square chins and large noses. Copyright 2012 The New York Times Company
by Daniel Strain Sharks may be known as terrors of the sea, but in some cases they're more like night lights. That's because many deep-sea sharks, like the smalleye pygmy shark (Squaliolus aliae), can make their own light, glowing from tail to snout as a possible means of camouflage. Now, a new study shows how this predator, the world's smallest shark, powers its luminescence. Smalleye pygmy sharks aren't just petite—they grow no more than 22 centimeters long—they're also hard to find, says study co-author Julien Claes, a shark biologist at the Catholic University of Louvain in Belgium. These fish swim hundreds of meters below the water's surface in the Indian and western Pacific oceans. When scientists do manage to pull one of these animals up, they sometimes catch an odd sight: a blue glow coming mostly from the shark's belly. Claes co-authored a paper in 2009 that showed that a second group of luminescent sharks, called lantern sharks (Etmopterus spinax), trigger their own glow using two hormones common in many animals: melatonin and prolactin. But it wasn't clear if smalleye pygmy sharks and their close relatives relied on the same molecules. So Claes and his colleagues launched a second survey, collecting 27 pygmy sharks off the coast of Taiwan. To determine what controlled their unearthly glow, the researchers took patches of the fish's skin and soaked them in various chemicals known to cue luminescence in other species. They then recorded the resulting glow—often so faint that it was tricky to see at a distance even in a dark room—using a light detector. And sure enough, when Claes tried melatonin, which in people helps to control cycles of sleep and waking, voila! There was light. © 2010 American Association for the Advancement of Science.
By Janelle Weaver A micrograph view of crystallized oxytocin. Image: Alfred Pasieka/Photo Researchers, Inc. When we meet new people, we assess their character by watching their gestures and facial expressions. Now a study in the Proceedings of the National Academy of Sciences USA suggests that those nonverbal cues are communicating the presence of a specific form of a gene that makes us more or less responsive to others’ needs. The gene determines which type of receptor a person has for the hormone oxytocin. Oxytocin has been implicated in a variety of positive traits, such as trust, empathy and generosity. The hormone is detected by our body’s cells via their oxytocin receptors. In a past study, psychologist Sarina Rodrigues Saturn of Oregon State University and her collaborators found that people who have a certain variation of the receptor gene are more empathetic than those with the alternative form of the gene. In the new study, Saturn and her team showed volunteers 20-second silent video clips of individuals who were listening to their romantic partner recount an upsetting experience. The study participants watched for nonverbal behaviors, such as head nods and smiles, and rated every individual on a number of character traits. Those with the form of the oxytocin receptor gene associated with empathy were judged by the volunteers as being more trustworthy, compassionate and kind than those with the alternative form of the gene. “These slight genetic variations do have a big impact on not only how you feel internally but also how people perceive you,” Saturn says, adding that impressions based on nonverbal cues can help individuals quickly choose compatible friends or romantic partners. © 2012 Scientific American,
By Stephani Sutherland If you have ever jumped at a loud noise and felt an adrenaline rush, you have experienced the effects of corticotropin-releasing hormone (CRH). In the body, this hormone triggers the familiar fight-or-flight response—racing heart, shortness of breath, sweaty palms. In the brain, however, it acts as a chemical messenger, playing a role in anxiety and depression. That role, a new study suggests, is more complex than anyone expected. Because animal research from the past decade found that CRH contributes to anxiety and depression, drugs were developed that would block its actions in the brain. Clinical trials of these antianxiety and antidepressant drugs in human patients, however, have been disappointing. The new study, published last September in Science, shows why. Jan M. Deussing, a molecular biologist at the Max Planck Institute of Psychiatry in Munich, and his colleagues genetically altered mice so that some of their brain cells would be unable to detect the presence of CRH because they lacked the proper receptors. When the receptors were missing from neurons that produce the neurotransmitter glutamate, the mice displayed less anxiety, as expected. Yet when the receptors were missing from neurons that produce dopamine, the mice became more anxious. These two different neuron types, when interacting with CRH, “have exactly opposite effects in terms of anxiety-related behavior,” Deussing says. Because the unsuccessful drugs limited the amount of the hormone available to all types of neurons, they ended up blocking its actions at neurons that both produce and prevent anxiety. The finding reaffirms scientists’ growing understanding that mood disorders do not result from a simple chemical imbalance—too much or too little of one neurotransmitter—but rather from subtle changes in many systems in the brain. “The network is much more complex than we thought before,” Deussing says. © 2012 Scientific American
Roger Dobson It is the chemical that has been described by women as a "cuddle drug". Now scientists have discovered that its effect on men is more rampant and long-lasting than just the desire for a quick hug. Oxytocin, a hormone traditionally used to induce labour, is as sexually arousing to men as Viagra, according to new research. Studies conducted in the US found that a married man who sniffed a nasal spray containing oxytocin twice daily became more affectionate to friends and colleagues and recorded a marked improvement in his sexual performance. According to the actual breakdown of results, the man's libido went from "weak to strong", while arousal went from "difficult to easy". Ego certainly wasn't hurt either: sexual performance, according to feedback from his wife, was classed as "very satisfying". Scientists at the University of California believe the findings provide strong support for the idea that oxytocin improves sexual performance and, unlike Viagra, remains a chemical glue within the brain to cement relationships between people. Just how it works is not clear, but some studies have suggested that oxytocin levels rise naturally during arousal. The hormone is also thought to interact with the dopamine system, which is involved in the rewarding aspects of sexual activity. © independent.co.uk
By Janelle Weaver Birth-control pills are known to affect women’s taste in men, at least in laboratory experiments. Now a study of real-world couples suggests that this pill-related preference change could have long-term consequences for a relationship’s quality and outcome. In the lab, women using oral contraceptives show a weaker preference for masculine men—those with high testosterone levels and the corresponding physical hallmarks—than their non-pill-using counterparts. To investigate this issue in a real-world setting, psychologist S. Craig Roberts of the University of Stirling in Scotland and his collaborators gave online surveys to more than 2,500 women from various countries. According to the results, published online October 12 in the Proceedings of the Royal Society B: Biological Sciences, participants who used hormonal contraceptives while choosing their partner were less attracted to him and less sexually satisfied during their relationship than were individuals who did not use hormonal birth control. Pill users were happier with their mate’s financial support and other nonsexual aspects of the relationship, however, and they were less likely to separate. This relationship stability might be caused by the bias of women on the pill toward low-testosterone men, who tend to be more faithful. Roberts suggests that women who met their mate while taking the pill might want to switch to nonhormonal contraceptives several months before getting married to test whether their feelings for their partner remain the same. © 2012 Scientific American,
By Katherine Harmon Years of surgeries and medications were unable to stop Sultan Kosen’s runaway growth. In 2010 at age 27 and a height of 2.46 meters (eight feet, one inch), he became the world’s tallest living man, according to Guinness World Records. But he wasn’t done growing. Kosen had been diagnosed with a growth disorder at age 10 after doctors in his native Turkey found a tumor on his pituitary gland. The tumor triggered the gland to release too much growth hormone. As a result, he has suffered from both gigantism, a condition in which too much growth hormone is secreted during childhood, and acromegaly, a condition caused by too much growth hormone in adulthood. The tumor was technically benign, but it was lodged near the bottom of his brain, making it difficult to operate on. Thus ensconced, the tumor—along with Kosen’s whole body—continued to grow to dangerous proportions. sultan kosen uva surgery So in May 2010, doctors at the University of Virginia Medical Center put Kosen on new medication to limit growth hormone production. Perhaps more importantly, they were also able to perform gamma-knife radiosurgery on his hard-to-reach tumor. Guided by MRI, the doctors used this super-precise technique, which harnesses high-power gamma rays, to disable the tumor without having to do more dangerous invasive surgery. © 2012 Scientific American
Keyword: Hormones & Behavior
Link ID: 16529 - Posted: 03.17.2012
By Jeanna Bryner Managing editor Give a male garter snake a taste of estrogen and watch out, as the hormone turns these lads into the sexiest thing on the block, attracting dozens of other males eager to mate. The finding, published in the Journal of Experimental Biology, has implications for understanding the environmental impact of compounds that mimic the effect of estrogen, found in some chemicals and pesticides. Estrogen, the researchers found, is key to a female's release of pheromones and thus, reproduction. Here's how it works: For the red-sided garter snake, picking up a mate takes but a second and a flick of the tongue. When a male detects a possible mate nearby, he licks the female with a quick flick of his tongue. Researchers say that the chemical cues exuded by the females, called pheromones, are so strong that it takes but an instant for the male to determine the other snake's species, sex, population, reproduction condition, size and age. In fact, the males are totally dependent on these pheromones for snake reproduction. Every spring, tens of thousands of these garter snakes emerge from their limestone caves north of Manitoba, Canada, for mating. Intense competition ensues, as males swarm (and tongue) female snakes in an effort to be the first to mate with her. The frenzy appears as twisting balls of snakes called mating balls. © 2012 msnbc.com
By ANAHAD O'CONNOR Your daily dose of caffeine may tinker with more than just your energy levels. A new study of women ages 18 to 44 found that drinking coffee and other caffeinated beverages can alter levels of estrogen. But the impact varies by race. In white women, for example, coffee appears to lower estrogen, while in Asian women it has the reverse effect, raising levels of the hormone. The study did not look at older women, but women of child-bearing age who enjoy a daily cuppa have little reason to fret, the researchers said. The effects of caffeine on estrogen are so minimal that in healthy women, it has no impact on ovulation or overall health, at least in the short term. “This is important physiologically because it helps us understand how caffeine is metabolized by different genetic groups,” said Dr. Enrique Schisterman, an author of the study and senior investigator at the National Institutes of Health. “But for women of reproductive age, drinking coffee will not alter their hormonal function in a clinically significant way.” The study, which was published in The American Journal of Clinical Nutrition, analyzed data on more than 250 women who were examined one to three times a week over two menstrual cycles. They provided blood samples along with details about behaviors like exercise, eating and smoking. On average, they consumed about 90 milligrams of caffeine a day, equivalent to roughly one cup of coffee. © 2012 The New York Times Company
By GRETCHEN REYNOLDS A newly discovered hormone produced in response to exercise may be turning people’s white fat brown, a groundbreaking new study suggests, and in the process lessening their susceptibility to obesity, diabetes and other health problems. The study, published on Wednesday in Nature and led by researchers at the Dana-Farber Cancer Institute and Harvard Medical School, provides remarkable new insights into how exercise affects the body at a cellular level. For the study, the researchers studied mouse and human muscle cells. Scientists have believed for some time that muscle cells influence biological processes elsewhere in the body, beyond the muscles themselves. In particular, they have suspected that muscle cells communicate biochemically with body fat. But how muscle cells “talk” to fat, what they tell the fat and what role exercise has in sparking or sustaining that conversation have been mysteries — until, in the new study, scientists closely examined the operations of a substance called PGC1-alpha, which is produced in abundance in muscles during and after exercise. “It seems clear that PGC1a stimulates many of the recognized health benefits of exercise,” said Bruce Spiegelman, the Stanley J. Korsmeyer professor of cell biology and medicine at the Dana-Farber Cancer Institute and Harvard Medical School, who led the study. Mice bred to produce preternaturally large amounts of PGC1a in their muscles are typically resistant to age-related obesity and diabetes, much as people who regularly exercise are. © 2012 The New York Times Company
Posted by Sarah Kliff Wired flags a new study that proves many mothers across the country right: For your own sake, you should call home more often. The research comes from Evolution and Human Behavior. It finds that a phone call to mom provides significant stress relief while instant message conversations won’t quell the nerves. The conversations happened after research subjects took a stressful test. As subjects spoke (or typed) with their mothers, the researchers measured changes in levels of cortisol (generally linked to stress) and oxytocin (a hormone linked to pleasure). When subjects talked on the phone, cortisol levels dropped and oxytocin went up. But IMing with Mom looked the same as having no contact at all: The study author tells Wired, “the results suggest that mom’s voice — its tones and intonations and rhythms, known formally as prosodics — trigger soothing effects, rather than what she specifically says.” To summarize in non-chart form: Call your mother! © 1996-2012 The Washington Post
Victoria Colliver, Chronicle Staff Writer Researchers are getting closer to being able to predict who might be more vulnerable to stress even before they experience trauma. A study of Bay Area and New York police academy recruits by researchers at the San Francisco Veterans Affairs Medical Center, UCSF and New York University is considered one of the first and largest studies to look at biological stress indicators before and after traumatic events. "This study is unique because it looks at people before they've actually been exposed to trauma," said lead author Sabra Inslicht, a psychologist at the San Francisco VA Medical Center and an assistant professor of psychiatry at UCSF. Nearly 300 academy recruits took samples of the waking levels of a stress hormone called cortisol. The results, published in last month's issue of the journal Biological Psychiatry, found that recruits with higher cortisol levels shortly after waking up in the morning were most likely to have stressful reactions to trauma years later as police officers. The new study is part of a larger body of research involving hundreds of recruits from the San Francisco, Oakland, San Jose and New York police departments that has been going on for seven years, said Dr. Charles Marmar, who spent 30 years at UCSF before taking over as chairman of the department of psychiatry at NYU's Langone Medical Center. © 2011 Hearst Communications Inc.
By NATALIE ANGIER VIEWED superficially, the part of youth that the psychologist Jean Piaget called middle childhood looks tame and uneventful, a quiet patch of road on the otherwise hairpin highway to adulthood. Said to begin around 5 or 6, when toddlerhood has ended and even the most protractedly breast-fed children have been weaned, and to end when the teen years commence, middle childhood certainly lacks the physical flamboyance of the epochs fore and aft: no gotcha cuteness of babydom, no secondary sexual billboards of pubescence. Yet as new findings from neuroscience, evolutionary biology, paleontology and anthropology make clear, middle childhood is anything but a bland placeholder. To the contrary, it is a time of great cognitive creativity and ambition, when the brain has pretty much reached its adult size and can focus on threading together its private intranet service — on forging, organizing, amplifying and annotating the tens of billions of synaptic connections that allow brain cells and brain domains to communicate. Subsidizing the deft frenzy of brain maturation is a distinctive endocrinological event called adrenarche (a-DREN-ar-kee), when the adrenal glands that sit like tricornered hats atop the kidneys begin pumping out powerful hormones known to affect the brain, most notably the androgen dihydroepiandrosterone, or DHEA. Researchers have only begun to understand adrenarche in any detail, but they see it as a signature feature of middle childhood every bit as important as the more familiar gonadal reveille that follows a few years later. © 2011 The New York Times Company
By Scicurious Hi. In a few minutes I’d like you to stand up and give a short public speech to a judgmental group of people. The speech will be about the current national and international effects of Marbury v Madison, with particular focus on violations of interstate commerce. You have 15 minutes to prepare and the speech will have to be 15 minutes long. I hope you’ve done your research. Nervous yet? If you are, you’re not alone. Fear of public speaking (glossophobia, or just stage fright) is one of the most common fears in the Western world. But it’s ok. We’re going to have you sit with your loved one, who will be able to give you encouragement as you prepare. Do you feel a little bit better? I bet you do. But do you really, actually feel better? Does your body react to stress differently when you’ve got a loved one with you to help you out? It turns out that it might. At least, if you’ve got a specific kind of oxytocin receptor gene. Oxytocin gets a lot of press. And well it should. Recent findings on oxytocin have shown effects on trust, on generosity, on behaviors in austistic children even. Not to mention all the effects that oxytocin has on parental bonding and on your sex life. While many of these studies have looked at levels of circulating oxytocin, or the effects of giving oxytocin (usually as a nasal spray) on behavior, people have recently started to look at the other side of oxytocin: the oxytocin receptor. © 2011 Scientific American,
By Bella English Jonas and Wyatt Maines were born identical twins, but from the start each had a distinct personality. Jonas was all boy. He loved Spiderman, action figures, pirates, and swords. Wyatt favored pink tutus and beads. At 4, he insisted on a Barbie birthday cake and had a thing for mermaids. On Halloween, Jonas was Buzz Lightyear. Wyatt wanted to be a princess; his mother compromised on a prince costume. Once, when Wyatt appeared in a sequin shirt and his mother’s heels, his father said: “You don’t want to wear that.’’ “Yes, I do,’’ Wyatt replied. “Dad, you might as well face it,’’ Wayne recalls Jonas saying. “You have a son and a daughter.’’ That early declaration marked, as much as any one moment could, the beginning of a journey that few have taken, one the Maineses themselves couldn’t have imagined until it was theirs. The process of remaking a family of identical twin boys into a family with one boy and one girl has been heartbreaking and harrowing and, in the end, inspiring — a lesson in the courage of a child, a child who led them, and in the transformational power of love. Wayne and Kelly Maines have struggled to know whether they are doing the right things for their children, especially for Wyatt, who now goes by the name Nicole. Was he merely expressing a softer side of his personality, or was he really what he kept saying: a girl in a boy’s body? Was he exhibiting early signs that he might be gay? Was it even possible, at such a young age, to determine what exactly was going on? © 2011 The New York Times Company
Prenatal steroids — given to pregnant women at risk for giving birth prematurely — appear to improve survival and limit brain injury among infants born as early as the 23rd week of pregnancy, according to a study by a National Institutes of Health research network. Current guidelines recommend giving prenatal steroids to women at risk of delivering between the 24th and 34th weeks of pregnancy. "These findings provide strong evidence that prenatal steroids can benefit infants born as early as the 23rd week of pregnancy," said study author Rosemary D. Higgins, M.D., of the NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The study was conducted by researchers participating in the NICHD Neonatal Research Network and led by Waldemar A. Carlo, director of the Division of Neonatology at the University of Alabama at Birmingham. The findings appear in the Dec. 7 Journal of the American Medical Association. When given to pregnant woman at risk for preterm delivery, steroid hormones help the fetus's lungs to mature. For infants born preterm, increased lung development improves the chances for survival and may decrease the risk of brain injury. Infants born in the 22nd through the 25th week of pregnancy — far earlier than the 40 weeks of a full term pregnancy — are the smallest, most frail category of newborns. Many die soon after birth, despite the best attempts to save them, including the most sophisticated newborn intensive care available. Some survive, and reach adulthood relatively unaffected. The rest will experience some degree of lifelong disability, including minor hearing loss, cerebral palsy, and intellectual disability.