Chapter 8. General Principles of Sensory Processing, Touch, and Pain
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Things are heating up in the world of genetics. The hot pepper (Capsicum annuum) is one of the most widely grown spice crops globally, playing an important role in many medicines, makeups, and meals worldwide. Although the plant’s so-called capsaicin chemical is well known for spicing things up, until now the genetic spark responsible for the pepper’s pungency was unknown. A team of scientists recently completed the first high-quality reference genome for the hot pepper. Comparing the pepper’s genome with that of its tame cousin, the tomato, the scientists discovered the gene responsible for fiery capsaicin production appeared in both plants. While the tomato carried four nonfunctioning copies of the gene, the hot pepper carried seven nonfunctioning copies and one functioning copy, the team reports online today in Nature Genetics. The researchers believe the pepper’s capsaicin-creating gene appeared after five mutations occurred during DNA replication, with the final mutation creating a functional copy. The mouth-burning chemicals likely protected the mutant pepper’s seeds from grazing land animals millions of years ago, giving the mutant a reproductive advantage and helping the mutant gene spread. The team says the finding could help breeders boost the pepper’s heat, nutrition, and medicinal properties. One researcher even suggests that geneticists could activate one of the tomato’s dormant genes, enabling capsaicinoid production and creating a plant that makes ready-made salsa. © 2014 American Association for the Advancement of Science.
-- Bats and other animals use ultrasound to their advantage. Now a new study of humans suggests ultrasound can alter brain activity to boost people's sensory perception. First, researchers placed an electrode on the wrist of volunteers to stimulate the nerve that runs down the arm and into the hand. Before stimulating the radial nerve, they delivered ultrasound to the head -- to an area of the cerebral cortex that processes sensory information received from the hand. The participants' brain responses were recorded using electroencephalography (EEG). The ultrasound decreased the EEG signal and weakened the brain waves responsible for processing sensory input from the hands, according to the study published online Jan. 12 in the journal Nature Neuroscience. The Virginia Tech researchers then conducted two common neurological tests. One measures a person's ability to distinguish whether two pins placed close together and touching the skin are actually two distinct contact points. The other test measures sensitivity to the frequency of a series of air puffs. The scientists were surprised to discover that when they received ultrasound, the participants showed significant improvements in their ability to distinguish pins at closer distances and to identify small differences in the frequency of successive air puffs. The ultrasound may have changed the balance of inhibition and excitation between neighboring neurons within the cerebral cortex, resulting in a boost in sensory perception, explained study leader William Tyler, an assistant professor at Virginia Tech's Carilion Research Institute. © 2014 HealthDay
Keyword: Pain & Touch
Link ID: 19147 - Posted: 01.18.2014
By NICHOLAS BAKALAR Both acupuncture and sham acupuncture were effective in reducing menopausal symptoms in women being treated with aromatase inhibitors for breast cancer, a small randomized trial found. Joint and muscle pain, hot flashes and night sweats are common side effects of those estrogen-lowering drugs. The trial, published online in Cancer, randomized 47 breast cancer patients to eight weekly sessions of either real or sham acupuncture. Those assigned to real acupuncture received treatment with needles in recognized acupoints believed to be helpful in relieving menopausal symptoms. The controls got non-penetrating needles placed in sham acupuncture points. Patients and researchers did not know which patients had received which treatment. The patients kept daily diaries or filled out several questionnaires on the frequency and severity of hot flashes and other symptoms. Patient-reported symptoms, especially hot flashes, improved significantly after both sham and real treatment. There was no statistically significant difference between the two groups. The results may be attributable to a placebo effect, but the scientists suggest that the slight pricking of the skin could cause physiological changes. In any case, the lead author, Dr. Ting Bao, a medical oncologist at the University of Maryland, Baltimore, said there is no harm in trying acupuncture. “Acupuncture as a medical procedure has been practiced for thousands of years,” she said. “It has a minimal risk and potentially significant benefits.” Copyright 2013 The New York Times Company
Keyword: Pain & Touch
Link ID: 19074 - Posted: 12.28.2013
By Dana Smith Daniel Tammet has memorized Pi to the 22,514th digit. He speaks ten different languages, including one of his own invention, and he can multiply enormous sums in his head within a matter of seconds. However, he is unable to hold down a standard 9-to-5 job, in part due to his obsessive adherence to ritual, down to the precise times he has his tea every day. Daniel is a savant. He is also autistic. And he is a synesthete. Daniel experiences numbers as having color, as well as shape and texture. This helps him perform amazing mathematical feats seemingly without effort, the answer simply materializing to him rather than having to calculate it out. In an interview he gave with The Guardian, Daniel explained, “When I multiply numbers together, I see two shapes. The image starts to change and evolve, and a third shape emerges. That’s the answer. It’s mental imagery. It’s like maths without having to think.” Clearly this man has an extraordinary brain. However, Daniel is perhaps not entirely unique, and it appears that the link between autism and synesthesia is more common than originally thought. This suggests that there is a potential common mechanism between these two conditions, which may even help to explain some of Daniel’s special savant abilities. A new study published in the journal Molecular Autism from a team of researchers at the University of Cambridge now empirically shows that there is an almost three-fold higher occurrence of synesthesia in individuals with autism (18.9%), compared with that of the general population (7.2%). This increased prevalence implies that there is indeed a significant link between autism and synesthesia. © 2013 Scientific American
Link ID: 19008 - Posted: 12.06.2013
By RONI CARYN RABIN Women are more likely than men to die after a heart attack, and some researchers have suggested a reason: Doctors may be misdiagnosing women more often because their symptoms differ from those experienced by men. But a study published Monday indicates that too much has been made of gender differences in chest pain, the hallmark symptom of heart disease. Although the researchers found some distinctions, no pattern was clearly more characteristic of women or could be used to improve heart attack diagnosis in women, the authors concluded. “We should stop treating women differently at the emergency room when they present with chest pain and discomfort,” said Dr. Maria Rubini Gimenez, a cardiologist at University Hospital Basel and lead author of the new study, published in JAMA Internal Medicine. Instead, she said, all patients with acute chest pain must be evaluated for heart attack with appropriate diagnostics, including an electrocardiogram and blood tests. Roughly 80 percent of people who have chest pain and discomfort are suffering from indigestion, acid reflux or another relatively benign condition, said Dr. John G. Canto, director of the chest pain center at Lakeland Regional Medical Center in Lakeland, Fla., who has researched heart attack diagnosis. “The trick is, how do you figure out the 15 to 20 percent actually having a heart attack?” he said. The new research confirms “that there is a lot of overlap in symptoms between patients who are having a heart attack and those who aren’t, and there is a lot of overlap in symptoms between men and women.” The new study examined 2,475 patients, including 796 women, who reported to emergency rooms at nine hospitals in Switzerland, Spain and Italy complaining of acute chest pain between April 21, 2006, and Aug. 12, 2012. Copyright 2013 The New York Times Company
by Erika Engelhaupt If you had to have a prosthetic hand, would you want it to look like a real hand? Or would you prefer a gleaming metallic number, something that doesn’t even try to look human? A new study looks at one of the issues that prosthetic designers and wearers face in making this decision: the creepy factor. People tend to get creeped out by robots or prosthetic devices that look almost, but not quite, human. So Ellen Poliakoff and colleagues at the University of Manchester in England had people rate the eeriness of various prosthetic hands. Forty-three volunteers looked at photographs of prosthetic and real hands. They rated both how humanlike (realistic) the hands were and how eerie they were, defined as “mysterious, strange, or unexpected as to send a chill up the spine.” Real human hands were rated both the most humanlike and the least eerie (a good thing for humans). Metal hands that were clearly mechanical were rated the least humanlike, but less eerie overall than prosthetic hands made to look like real hands, the team reports in the latest issue of Perception. The realistic prosthetics, like the rubber hand shown above, fell into what's known as the uncanny valley. That term, invented by roboticist Matsuhiro Mori in 1970, describes how robots become unnerving as they come to look more humanlike. The superrealistic Geminoid DK robot and the animated characters in the movie The Polar Express suffer from this problem. They look almost human, but not quite, and this mismatch between expectation and reality is one of the proposed explanations for the uncanny valley. In particular, if something looks like a human but doesn’t quite move like one, it’s often considered eerie. © Society for Science & the Public 2000 - 2013
by Simon Makin "The only thing we have to fear is fear itself," said Franklin D. Roosevelt. He might have been onto something: research suggests that the anticipation of pain is actually worse than the pain itself. In other words, people are happy to endure a bit more pain, if it means they spend less time waiting for it. Classical theories of decision-making suppose that people bring rewards forward and postpone punishments, because we give far-off events less weight. This is called "temporal discounting". But this theory seems to go out the window when it comes to pain. One explanation for this is that the anticipation of pain is itself unpleasant, a phenomenon that researchers have appropriately termed "dread". To investigate how dread varies with time, Giles Story at University College London, and his colleagues, hooked up 33 volunteers to a device that gave them mild electric shocks. The researchers also presented people with a series of choices between more or less mildly painful shocks, sooner or later. During every "episode" there was a minimum of two shocks, which could rise to a maximum of 14, but before they were given them, people had to make a choice such as nine extra shocks now or six extra shocks five episodes from now. The number of shocks they received each time was determined by these past choices. Although a few people always chose to experience the minimum pain, 70 per cent of the time, on average, participants chose to receive the extra shocks sooner rather than a smaller number later. By varying the number of shocks and when they occurred, the team was able to figure out that the dread of pain increased exponentially as pain approached in time. Similar results occurred in a test using hypothetical dental appointments. © Copyright Reed Business Information Ltd.
By Helen Briggs BBC News A condition where people experience a mixing of the senses, such as tasting words, has been linked with autism. Research suggests synaesthesia is nearly three times as common in adults with autism spectrum disorder than in the general population. The two conditions may share common features such as unusual wiring of the brain, say UK scientists. The study helps understanding of how people with autism experience life, says the National Autistic Society. Synaesthesia is a condition where one sense automatically triggers another. Some people experience tastes when they read or hear words, some perceive numbers as shapes, others see colours when they hear music. People with synaesthesia might say: "The letter q is dark brown," or: "The word 'hello' tastes like coffee," for example. Following anecdotal evidence of links between synaesthesia and Asperger's syndrome, researchers at the Autism Research Centre at Cambridge University set out to test the idea. More than 200 study participants - 164 adults diagnosed with high-functioning autism or Asperger's syndrome, and 97 adults without autism - were asked to fill in questionnaires to measure synaesthesia and autism traits. The study found one in five adults with autism spectrum conditions - a range of related developmental disorders, including autism and Asperger's syndrome - had synaesthesia compared with about 7% of people with no signs of the disorders. Prof Simon Baron-Cohen, who led the research, told BBC News: "Synaesthesia involves a mixing of the senses and it's a very subjective private experience, so the only way we know it's happening is if you ask people to report on their experiences. BBC © 2013
Link ID: 18948 - Posted: 11.20.2013
By BARRY MEIER Addiction experts protested loudly when the Food and Drug Administration approved a powerful new opioid painkiller last month, saying that it would set off a wave of abuse much as OxyContin did when it first appeared. An F.D.A. panel had earlier voted, 11 to 2, against approval of the drug, Zohydro, in part because unlike current versions of OxyContin, it is not made in a formulation designed to deter abuse. Now a new issue is being raised about Zohydro. The drug will be manufactured by the same company, Alkermes, that makes a popular medication called Vivitrol, used to treat patients addicted to painkillers or alcohol. In addition, the company provides financial support to a leading professional group that represents substance abuse experts, the American Society of Addiction Medicine. For some critics, the company’s multiple roles in the world of painkillers is troubling. Dr. Gregory L. Jones, an addiction specialist in Louisville, Ky., said he had long been concerned about financial links between the group and the drug industry, adding that the Zohydro situation amplified those potential conflicts. Dr. Stuart Gitlow, the current president of the American Society of Addiction Medicine, said he had been unaware until now of Alkermes’s involvement with Zohydro. Dr. Gitlow, who is affiliated with Mount Sinai Hospital in New York City, said that the group would seek more information from Alkermes about the situation and then decide what, if anything, to do next. Officials of Alkermes appear to recognize the issue they face. In recent years, the company has been trying to increase sales of Vivitrol, a form of a drug called naltrexone, that is used to treat both alcoholism and opioid addiction. © 2013 The New York Times Company
By JANE E. BRODY Marijuana has been used medically, recreationally and spiritually for about 5,000 years. Known botanically as cannabis, it has been called a “crude drug”: marijuana contains more than 400 chemicals from 18 chemical families. More than 2,000 compounds are released when it is smoked, and as with tobacco, there are dangers in smoking it. Medical marijuana clinics operate in 20 states and the District of Columbia, and its recreational use is now legal in Colorado and Washington. A Gallup poll conducted last month found that 58 percent of Americans support the legalization of marijuana. Yet researchers have been able to do relatively little to test its most promising ingredients for biological activity, safety and side effects. The main reason is marijuana’s classification by Congress in 1970 as an illegal Schedule I drug, defined as having a potential for abuse and addiction and no medical value. American scientists seeking clarification of marijuana’s medical usefulness have long been stymied by this draconian classification, usually reserved for street drugs like heroin with a high potential for abuse. Dr. J. Michael Bostwick, a psychiatrist at the Mayo Clinic in Rochester, Minn., said the classification was primarily political and ignored more than 40 years of scientific research, which has shown that cellular receptors for marijuana’s active ingredients are present throughout the body. Natural substances called cannabinoids bind to them to influence a wide range of body processes. In a lengthy report entitled “Blurred Boundaries: The Therapeutics and Politics of Medical Marijuana,” published last year in Mayo Clinic Proceedings, Dr. Bostwick noted that the so-called endocannabinoid system has an impact on the “autonomic nervous system, immune system, gastrointestinal tract, reproductive system, cardiovascular system and endocrine network.” Copyright 2013 The New York Times Company
If you were stung by a bark scorpion, the most venomous scorpion in North America, you’d feel something like the intense, painful jolt of being electrocuted. Moments after the creature flips its tail and injects venom into your skin, the intense pain would be joined by a numbness or tingling in the body part that was stung, and you might experience a shortness of breath. The effect of this venom on some people—small children, the elderly or adults with compromised immune systems—can even trigger frothing at the mouth, seizure-like symptoms, paralysis and potentially death. Based solely on its body size, the four-inch-long furry grasshopper mouse should die within minutes of being stung—thanks to the scorpion’s venom, which causes temporary paralysis, the muscles that allow the mouse to breathe should shut down, leading to asphyxiation—so you’d think the rodent would avoid the scorpions at all costs. But if you put a mouse and a scorpion in the same place, the rodent’s reaction is strikingly brazen. If stung, the four-inch-long rodent might jump back for a moment in surprise. Then, after a brief pause, it’ll go in for the kill and devour the scorpion piece by piece: This predatory behavior isn’t the result of remarkable toughness. As scientists recently discovered, the mouse has evolved a particularly useful adaptation: It’s immune to both the pain and paralytic effects that make the scorpion’s venom so toxic. Although scientists long knew that the mouse, native to the deserts of the American Southwest, preys upon a range of non-toxic scorpions, “no one had ever really asked whether they attack and kill really toxic scorpions,” says Ashlee Rowe of Michigan State University, who led the new study published today in Science.
Who would win in a fight: a bark scorpion or a grasshopper mouse? It seems like an easy call. The bark scorpion (Centruroides sculpturatus) delivers one of the most painful stings in the animal kingdom—human victims have compared the experience to being branded. The 25-gram grasshopper mouse (Onychomys torridus) is, well, a mouse. But as you can see in the video above, grasshopper mice routinely kill and eat bark scorpions, blissfully munching away even as their prey sting them repeatedly (and sometimes right in the face). Now, scientists have discovered why the grasshopper mice don’t react to bark scorpion stings: They simply don’t feel them. Evolutionary neurobiologist Ashlee Rowe at the University of Texas, Austin, has been studying the grasshopper mice’s apparent superpower since she was in graduate school. For the new study, she milked venom from nearly 500 bark scorpions and started experimenting. When she injected the venom into the hind paws of regular laboratory mice, the mice furiously licked the site for several minutes. But when she injected the same venom into grasshopper mice, they licked their paws for just a few seconds and then went about their business, apparently unfazed. In fact, the grasshopper mice appeared to be more irritated by injections of the saline solution Rowe used as a control. Rowe knew that grasshopper mice weren’t entirely impervious to pain—they reacted to injections of other painful chemicals such as formalin, just not the bark scorpion venom. To find out what was going on, she and her team decided to determine how the venom affects the grasshopper mouse’s nervous system, in particular the parts responsible for sensing pain. © 2013 American Association for the Advancement of Science
by Alyssa Botelho A sense of touch lets you connect with loved ones, makes your limbs feel your own, and helps you to interact with your surroundings. But people who are paraplegics or have lost limbs have to navigate the world without this most fundamental of sensory inputs. Sliman Bensmaia at the University of Chicago, Illinois, is working to change that with a new model for transmitting a sense of touch to the brain that bypasses regular routes. He hopes it will be a blueprint for constructing prosthetics that convey touch in the same way that natural limbs do. To start, Bensmaia and his colleagues trained rhesus macaques to focus their gaze in different directions depending on whether their index finger or fourth finger were being prodded. Microelectrodes were then placed in an area of the brain called the primary somatosensory cortex. This area represents an entire map of the body, with each neuron responsible for sensing when a different part of the skin is touched. Microelectrodes record the activity pattern of neurons. They can also be used in reverse – to deliver electrical stimulation to make neurons fire. Fourth finger exercise Next, the team recorded what activity occurred and where it registered in the somatosensory cortex when a monkey had its index or fourth finger poked. Then they stimulated the brain using the same pattern of activity. The monkeys reacted as if they had been touched – fixing their gaze in the direction they been taught in response to a poke. © Copyright Reed Business Information Ltd.
By Stephen L. Macknik and Susana Martinez-Conde Dennis Rogers is an unassuming guy. He's on the short side. And though muscular, he doesn't come across as the kind of towering Venice Beach, muscle-bound Arnold that you might expect from someone billed as the World's Strongest Man. Rather he has the kind of avuncular intensity you find in a great automobile mechanic—a mechanic who happens to be able to lift an engine with one hand while using the fingertips of the other hand to wrench the spark plugs out. Like it's nothing. Rogers, who has been known to keep two U.S. Air Force fighter planes from blasting away in opposite directions by holding them back with his bare hands, performed at the most recent Gathering for Gardner—a conference that celebrates the interests of one of Scientific American's greatest columnists, the late mathemagician Martin Gardner. We asked Rogers about the source of his incredible powers after the show, and we were surprised to learn that he did not know. Bill Amonette of the University of Houston–Clear Lake found that Rogers could recruit an abnormally high number of muscle fibers. But was this ability because of a freak genetic mutation? Another possibility, which Rogers thinks is more likely, is the way he processes pain when he strains those muscles. What if, instead of superpowered muscles, Rogers has a normal—though extremely well exercised—body, and his abilities arise because he can withstand more pain than most mere mortals? He claims that he does feel pain and is actually scared of dentists. In fact, during one stunt in which he held back four souped-up Harley motorbikes with straps, he bit down so hard he split a tooth from top to bottom. Rather than taking his chances at the dentist, he reached into his mouth, clamped his viselike fingertips onto the broken tooth, and extracted it, root and all. Rogers reasons that, unlike in the dentist's office—where he has no control over the pain that is inflicted on him—he has direct executive control over pain that he inflicts on himself. “I know it's coming, I have an idea of what to expect and I can decide to ignore it,” he says. © 2013 Scientific American
By NICHOLAS BAKALAR Black and Hispanic children who go to an emergency room with stomach pain are less likely than white children to receive pain medication, a new study reports, and more likely to spend long hours in the emergency room. The analysis, published in the October issue of Pediatrics, examined the records of 2,298 emergency room visits by people under 21, a nationally representative sample from a large survey conducted by the Centers for Disease Control and Prevention. About 53 percent were white, 24 percent non-Hispanic black, 21 percent Hispanic, and the rest from other ethnic or racial groups. Over all, 27.1 percent of white children with severe pain received analgesics, but only 15.8 percent of blacks, 18.9 percent of Hispanics and 7.1 percent of children of other races did. Black children were about 68 percent more likely than white children to spend longer than six hours in the emergency room, although there were no statistically significant differences among races in results for any diagnostic test. “This data set will not answer the question of why,” said the lead author, Dr. Tiffani J. Johnson, an instructor at the University of Pennsylvania School of Medicine. “It could be that white parents are more likely to ask for pain meds, or that minority patients are likely to get care in E.R.’s that have longer wait times. And it could be racial bias.” Copyright 2013 The New York Times Company
The Conservative government is launching a $1.3-billion free market in medical marijuana on Tuesday, eventually providing an expected 450,000 Canadians with quality weed. Health Canada is phasing out an older system on Monday that mostly relied on small-scale, homegrown medical marijuana of varying quality, often diverted illegally to the black market. In its place, large indoor marijuana farms certified by the RCMP and health inspectors will produce, package and distribute a range of standardized weed, all of it sold for whatever price the market will bear. The first sales are expected in the next few weeks, delivered directly by secure courier. "We're fairly confident that we'll have a healthy commercial industry in time," Sophie Galarneau, a senior official with the department, said in an interview. "It's a whole other ball game." The sanctioned birth of large-scale, free-market marijuana production comes as the Conservatives pillory Liberal Leader Justin Trudeau's campaign to legalize recreational marijuana. Health Canada is placing no limits on the number of these new capital-intensive facilities, which will have mandatory vaults and security systems. Private-dwelling production will be banned. Imports from places such as the Netherlands will be allowed. Already 156 firms have applied for lucrative producer and distributor status since June, with the first two receiving licences just last week. © CBC 2013
by Michael Slezak How do you convince someone that a finger they can't see or feel – one they don't even know is there – is actually part of their body? Turns out it's all in the wrist. The technique is a spin on the rubber hand illusion, developed almost 15 years ago. To perform the original trick, sit someone at a table and somehow hide one of their hands from their view. Then put a corresponding rubber hand on the table in front of them and stroke it while also stroking the real hand unseen. Bizarrely, they will often feel that the rubber hand is their own. Besides being a cool party trick, this illusion revealed a novel insight into how the brain develops its sense of "owning" body parts. It quickly led to treatments for conditions in which that sense is disrupted, such as phantom limb syndrome. Since then, the illusion has been tested thoroughly to find exactly what is needed for it to occur. We now know that the trick works using a rubber hand with a different colour skin to the participant and even without a rubber hand at all. You can do it just by making a person think you're going to stroke their hand. It's even been done in virtual reality. The theory emerging from these experiments is that if two different senses – like sight and touch – both suggest a rubber hand is yours, then your brain is convinced. © Copyright Reed Business Information Ltd.
Keyword: Pain & Touch
Link ID: 18700 - Posted: 09.25.2013
By NICHOLAS BAKALAR Many people use copper bracelets and magnetic wrist straps to alleviate the pain of arthritis, but a new randomized, double-blinded, placebo-controlled study concludes they do not work. British researchers randomized 65 patients with rheumatoid arthritis to receive one of four treatments: wearing a powerful magnetic wrist strap, a weak magnetic strap, a non-magnetic strap and a copper bracelet. Each patient wore each device for five weeks and completed pain surveys. The study appears in the September issue of PLoS One. The patients reported pain levels using a visual scale, ranging from “no pain” to “worst pain ever,” and recorded how often their joints felt tender and swollen. Researchers used questionnaires to assess physical limitations, and tested for inflammation by measuring blood levels of C-reactive protein and plasma viscosity. There was no statistically significant difference in any of these measures regardless of which type of device patients were wearing. Stewart J. Richmond, a researcher at the University of York who led the study, acknowledged that the devices may have some benefits as a placebo. “People swear by these things,” he said. “Is it ethically correct to allow patients to live in blissful ignorance? Or is it better to provide them with the facts? We can’t deceive patients. We have to be honest with them.” Copyright 2013 The New York Times Company
Keyword: Pain & Touch
Link ID: 18695 - Posted: 09.24.2013
By JOHN SCHWARTZ Candace Pert, a neuroscientist who helped discover a fundamental element of brain chemistry as a graduate student and went on to become a major proponent of alternative medicine, died on Sept. 12 at her home in Potomac, Md. She was 67. The cause was cardiac arrest, said her sister, Deane Beebe. Dr. Pert was working at the Johns Hopkins University School of Medicine in the 1970s when a team she was on found one of the most sought-after objects in brain research: the receptor in the brain that opiates like morphine fit into, like a key in a lock, allowing the drug’s effects to work. The discovery of the opioid receptor would, in 1978, earn the coveted Albert Lasker Award, often a precursor to the Nobel Prize. The award went to Solomon H. Snyder, who headed the lab. Neither Dr. Pert nor any of the other lab assistants was cited. Such omissions are common in the world of science; the graduate student in the lab rarely gets credit beyond being the first name on the papers describing the research. But Dr. Pert did something unusual: she protested, sending a letter to the head of the foundation that awards the prize, saying she had “played a key role in initiating the research and following it up” and was “angry and upset to be excluded.” Her letter caused a sensation in the field. Some saw her exclusion as an example of the burdens and barriers women face in science careers. In a 1979 article about Dr. Pert in the The Washington Post, Dr. Snyder, who had lauded Dr. Pert’s contributions in his Lasker acceptance speech, argued that “that’s the way the game is played,” adding that today’s graduate students will be tomorrow’s lab chiefs, and that “when they have students, it will be the same.” © 2013 The New York Times Company
Keyword: Pain & Touch
Link ID: 18685 - Posted: 09.21.2013
By William Saletan In much of this country, over the last three years, pro-lifers have banned abortions 20 weeks after fertilization. They’ve justified these bans by asserting—contrary to the most authoritative studies—that fetuses at this stage of development can feel pain. Their assertions, in turn, are based on research by several doctors. But the doctors don’t buy the pro-lifers’ conclusions. They say their research doesn’t support the bans. The 12 state bans (several of which have been blocked or limited by courts) begin with legislative “findings.” The findings parrot a 33-page report posted by the National Right to Life Committee and other pro-life organizations. The report cites the work of a number of researchers. Pam Belluck, an enterprising New York Times correspondent, contacted the researchers and asked them about the abortion bans. It turns out there’s a big gap between the science and the legislation. The pro-life report cites Dr. Nicholas Fisk, a former president of the International Fetal Medicine and Surgery Society, 27 times. According to the report, Fisk’s work shows fetal “stress responses” that imply sensitivity to pain. But Fisk tells Belluck that he doesn’t buy the inference from stress hormones and cerebral blood flow to pain. Neural studies, he says, have persuaded him that until 24 weeks gestation—the current abortion limit in many states—fetal pain “is not possible at all.” The report also cites Dr. Mark Rosen, a fetal anesthesia pioneer, 16 times. Rosen’s work, the report suggests, shows that painkillers and anesthesia are common during fetal surgery because unborn children can feel pain. But Rosen tells Belluck that the real purpose of such drugs during fetal surgery is to minimize dangerous movement and harmful stress hormones, thereby facilitating recovery. The drugs don’t signify medical belief in fetal pain. Dr. Scott Adzick, another fetal surgery expert cited in the pro-life report, makes the same point. © 2013 The Slate Group, LLC