Chapter 9. Hearing, Vestibular Perception, Taste, and Smell
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By Bruce Bower Strange things happen when bad singers perform in public. Comedienne Roseanne Barr was widely vilified in 1990 after she screeched the national anthem at a major league baseball game. College student William Hung earned worldwide fame and a recording contract in 2004 with a tuneless version of Ricky Martin’s hit song “She Bangs” on American Idol. Several singers at karaoke bars in the Philippines have been shot to death by offended spectators for mangling the melody of Frank Sinatra’s “My Way.” For all the passion evoked by pitch-impaired vocalists, surprisingly little is known about why some people are cringe-worthy crooners. But now a rapidly growing field of research is beginning to untangle the mechanics of off-key singing. The new results may improve scientists’ understanding of how musical abilities develop and help create a toolbox of teaching strategies for aspiring vocalists. Glimpses are also emerging into what counts as “in tune” to the mind’s ear. It seems that listeners are more likely to label stray notes as in tune when those notes are sung as opposed to played on a violin. Running through this new wave of investigations is a basic theme: There is one way to carry a tune and many ways to fumble it. “It’s kind of amazing that any of us can vocally control pitch enough to sing well,” says psychologist Peter Pfordresher of the University at Buffalo, New York. Still, only about 10 percent of adults sing poorly, several reports suggest (although some researchers regard that figure as an underestimate). Some of those tune-challenged crooners have tone deafness, a condition called amusia, which afflicts about 4 percent of the population. Genetic and brain traits render these folks unable to tell different musical notes apart or to recognize a tune as common as “Happy Birthday.” Amusia often — but curiously, not always — results in inept singing. Preliminary evidence suggests that tone-deaf individuals register pitch changes unconsciously, although they can’t consciously decide whether one pitch differs from another. © Society for Science & the Public 2000 - 2013
Link ID: 18612 - Posted: 09.07.2013
Elizabeth Pennisi Dolphins and bats don't have much in common, but they share a superpower: Both hunt their prey by emitting high-pitched sounds and listening for the echoes. Now, a study shows that this ability arose independently in each group of mammals from the same genetic mutations. The work suggests that evolution sometimes arrives at new traits through the same sequence of steps, even in very different animals. The research also implies that this convergent evolution is common—and hidden—within genomes, potentially complicating the task of deciphering some evolutionary relationships between organisms. Nature is full of examples of convergent evolution, wherein very distantly related organisms wind up looking alike or having similar skills and traits: Birds, bats, and insects all have wings, for example. Biologists have assumed that these novelties were devised, on a genetic level, in fundamentally different ways. That was also the case for two kinds of bats and toothed whales, a group that includes dolphins and certain whales, that have converged on a specialized hunting strategy called echolocation. Until recently, biologists had thought that different genes drove each instance of echolocation and that the relevant proteins could change in innumerable ways to take on new functions. But in 2010, Stephen Rossiter, an evolutionary biologist at Queen Mary, University of London, and his colleagues determined that both types of echolocating bats, as well as dolphins, had the same mutations in a particular protein called prestin, which affects the sensitivity of hearing. Looking at other genes known to be involved in hearing, they and other researchers found several others whose proteins were similarly changed in these mammals. © 2012 American Association for the Advancement of Science
by Jennifer Viegas Goldfish not only listen to music, but they also can distinguish one composer from another, a new study finds. The paper adds to the growing body of evidence that many different animals understand music. For the study, published in the journal Behavioural Processes, Shinozuka and colleagues Haruka Ono and Shigeru Watanabe played two pieces of classical music near goldfish in a tank. The pieces were Toccata and Fugue in D minor by Johann Sebastian Bach and The Rite of Spring by Igor Stravinsky. The scientists trained the fish to gnaw on a little bead hanging on a filament in the water. Half of the fish were trained with food to gnaw whenever Bach played and the other half were taught to gnaw whenever Stravinsky music was on. The goldfish aced the test, easily distinguishing the two composers and getting a belly full of food in the process. The fish were more interested in the vittles than the music, but earlier studies on pigeons and songbirds suggest that Bach is the preferred choice, at least for birds. “These pieces can be classified as classical (Bach) and modern (Stravinsky) music,” Shinozuka explained. “Previously we demonstrated that Java sparrows preferred classical over modern music. Also, we demonstrated Java sparrows could discriminate between consonance and dissonance.” © 2013 Discovery Communications, LLC.
by Michael Marshall Life is tough when you're small. It's not just about getting trodden on by bigger animals. Some of the tiniest creatures struggle to make their bodies work properly. This leads to problems that us great galumphing humans will never experience. For instance, the smallest frogs are prone to drying out because water evaporates so quickly from their skin. Miniature animals can't have many offspring, because there is no room in their bodies to grow them. One tiny spider has even had to let its brain spill into its legs, because its head is too small to accommodate it. Gardiner's Seychelles frog is one of the smallest vertebrates known to exist, at just 11 millimetres long. Its tiny head is missing parts of its ears, which means it shouldn't be able to hear anything. It can, though, and that is thanks to its big mouth. One of only four species in the genus Sechellophryne, Gardiner's Seychelles frog is a true rarity. It is confined to a few square kilometres of two islands in the Seychelles, and even if you visit its habitat you're unlikely to see it. That's because the frog spends most of its time in moist leaf litter, so that it doesn't dry out. It eats tiny insects and other invertebrates. When it comes to hearing, it is sadly under-equipped. Unlike most frogs, it doesn't have an external eardrum. Inside its head, it does have the amphibian equivalent of a cochlea, which is the bit that actually detects sounds. But it doesn't have a middle ear to transmit the sound to the cochlea, and is also missing a bone called the columella that would normally help carry the sound. © Copyright Reed Business Information Ltd.
by Colin Barras Familiarity may breed contempt, and it also makes it easier to ignore our nearest and dearest. The human brain has an uncanny ability to focus on one voice in a sea of chatterSpeaker, for example, at a party, but exactly how it does so is still up for debate. "In the past, people have looked at the acoustic characteristics that enable the brain to do this," says Ingrid Johnsrude at Queen's University in Kingston, Ontario, Canada. "Things like differences in voice pitch or its timbre." Johnsrude and her colleagues wondered if the familiarity of the voice also plays a role. Can people focus on one voice in a crowd more effectively if it belongs to a close relation? And is a familiar voice more easily ignored if we want to listen to someone else? To find out, the team recruited 23 married couples. Each had been married and living together for at least 18 years. Individuals were played two sentences simultaneously and asked to report back details about one of them, such as the colour and number mentioned. They did this correctly 80 per cent of the time when their spouse spoke the target sentence and a stranger spoke the decoy sentence. If strangers spoke both, the success rate dropped to 65 per cent. © Copyright Reed Business Information Ltd
By Dina Fine Maron Using sensors tucked inside the ears of live gerbils, researchers from Columbia University are providing critical insights into how the ear processes sound. In particular, the researchers have uncovered new evidence on how the cochlea, a coiled portion of the inner ear, processes and amplifies sound. The findings could lay the initial building blocks for better hearing aids and implants. The research could also help settle a long-simmering debate: Do the inner workings of the ear function somewhat passively with sound waves traveling into the cochlea, bouncing along sensory tissue, and slowing as they encounter resistance until they are boosted and processed into sound? Or does the cochlea actively amplify sound waves? The study, published in Biophysical Journal, suggests the latter is the case. The team, led by Elizabeth Olson, a biomedical engineer of Columbia University, used sensors that simultaneously measured small pressure fluctuations and cell-generated voltages within the ear. The sensors allowed the researchers to pick up phase shifts—a change in the alignment of the vibrations of the sound waves within the ear—suggesting that some part of the ear was amplifying sound. What causes that phase shift is still unclear although the researchers think the power behind the phase shift comes from the outer hair cells. Apparently the hair cells’ movement serves to localize and sharpen the frequency region of amplification. The researchers wrote that the mechanism appears to be akin to a child swinging on the playground. If somebody pushes a swing just once, the oscillations will eventually die out. If a child pumps her legs at certain times, however, it will put energy into the oscillations—that is power amplification at work. © 2013 Scientific American
Link ID: 18544 - Posted: 08.22.2013
By C. CLAIBORNE RAY A. A widely discussed 2006 study of transit noise in New York City, measuring noise on buses as well as in subway cars and on platforms, was described at the time as the first such formal study published since the 1930s. Done by scientists at the Mailman School of Public Health at Columbia University and published in The Journal of Urban Health, the study concluded that noise levels at subway and bus stops could easily exceed recognized public health recommendations and had the potential to damage hearing, given sufficient exposure. For example, guidelines from the Environmental Protection Agency and the World Health Organization set a limit of 45 minutes’ exposure to 85 decibels, the mean noise level measured on subway platforms. And nearly 60 percent of the platform measurements exceeded that level. The maximum noise levels inside subway cars were even higher than those on the platforms, with one-fifth exceeding 100 decibels and more than two-thirds exceeding 90 decibels. The study recommended properly fitted earplugs and earmuff-type protectors in loud transit environments, saying they could cut noise levels significantly at the eardrum. And it warned that personal listening devices only increased the total noise and risk. © 2013 The New York Times Company
Link ID: 18495 - Posted: 08.13.2013
Josh Howgego When it comes to our sense of smell, we are all experiencing the world in very different ways. Scientists already know that humans' sensitivity to smelly molecules varies considerably from person to person (see: 'Soapy taste of coriander linked to genetic variants'). But evidence that genetic variations — as opposed to habit, culture or other factors — underlie these differences has been hard to come by. Geneticist Richard Newcomb of the New Zealand institute for Plant and Food Research in Auckland and his colleagues searched for olfactory genes by testing 187 people’s sensitivity to ten chemicals found in everyday food, including the molecules that give distinctive smells to blue cheese, apples and violets. They found that, as expected, the smelling abilities of their subjects varied. The team then sequenced the subjects’ genomes and looked for differences that could predict people’s ability to detect each chemical through smell. For four of the ten chemicals, the researchers identified clusters of genes that convincingly predicted smelling ability, as they report today in Current Biology1. The study could not conclude whether similar genetic associations exist for the other six compounds, or whether factors other than genes play a role in those cases. Previously, only five regions of the genome had been shown to affect olfactory ability when they undergo mutations, so Newcomb’s study has nearly doubled the number of genetic associations known to influence smell. And because there is nothing special about the chemicals they studied, Newcomb says that it is logical to think the findings would extend to lots of scents, meaning that people experience the plethora of chemicals surrounding them in endlessly different ways. © 2013 Nature Publishing Group
by Tanya Lewis, LiveScience In waters from Florida to the Caribbean, dolphins are showing up stranded or entangled in fishing gear with an unusual problem: They can't hear. More than half of stranded bottlenose dolphins are deaf, one study suggests. The causes of hearing loss in dolphins aren't always clear, but aging, shipping noise and side effects from antibiotics could play roles. "We're at a stage right now where we're determining the extent of hearing loss [in dolphins], and figuring out all the potential causes," said Judy St. Leger, director of pathology and research at SeaWorld in San Diego. "The better we understand that, the better we have a sense of what we should be doing [about it]." Whether the hearing loss is causing the dolphin strandings -- for instance, by steering the marine mammals in the wrong direction or preventing them from finding food -- is also still an open question. Dolphins are a highly social species. They use echolocation to orient themselves by bouncing high-pitched sound waves off of objects in their environment. They also "speak" to one another in a language of clicks and buzzing sounds. Because hearing is so fundamental to dolphins' survival, losing it can be detrimental. A 2010 study found that more than half of stranded bottlenose dolphins and more than a third of stranded rough-toothed dolphins had severe hearing loss. The animals' hearing impairment may have been a critical factor in their strandings, and all rescued cetaceans should be tested, the researchers said in the study, detailed in the journal PLOS ONE. © 2013 Discovery Communications, LLC.
Researchers have found in mice that supporting cells in the inner ear, once thought to serve only a structural role, can actively help repair damaged sensory hair cells, the functional cells that turn vibrations into the electrical signals that the brain recognizes as sound. The study in the July 25, 2013 online edition of the Journal of Clinical Investigation reveals the rescuing act that supporting cells and a chemical they produce called heat shock protein 70 (HSP70) appear to play in protecting damaged hair cells from death. Finding a way to jumpstart this process in supporting cells offers a potential pathway to prevent hearing loss caused by certain drugs, and possibly by exposure to excess noise. The study was led by scientists at the National Institutes of Health. Over half a million Americans experience hearing loss every year from ototoxic drugs — drugs that can damage hair cells in the inner ear. These include some antibiotics and the chemotherapy drug cisplatin. In addition, about 15 percent of Americans between the ages of 20 and 69 have noise-induced hearing loss, which also results from damage to the sensory hair cells. Once destroyed or damaged by noise or drugs, sensory hair cells in the inner ears of humans don’t grow back or self-repair, unlike the sensory hair cells of other animals such as birds and amphibians. This has made exploring potential pathways to protect or regrow hair cells in humans a major focus of hearing research.
By Emma Tracey BBC News, Ouch An online magazine for the deaf community, Limping Chicken, recently ran an item on how deaf and hearing people sneeze differently. The article by partially deaf journalist Charlie Swinbourne got readers talking - and the cogs started turning at Ouch too. Swinbourne observes that deaf people don't make the "achoo!" sound when they sneeze, while hearing people seem to do it all the time - in fact, he put it in his humorous list, The Top 10 Annoying Habits of Hearing People. Nor is "achoo" universal - it's what English-speaking sneezers say. The French sneeze "atchoum". In Japan, it's "hakashun" and in the Philippines, they say "ha-ching". Inserting words into sneezes - and our responses such as "bless you" - are cultural habits we pick up along the way. So it's not surprising that British deaf people, particularly users of sign language, don't think to add the English word "achoo" to this most natural of actions. For deaf people, "a sneeze is what it should be... something that just happens", says Swinbourne in his article. He even attempts to describe what an achoo-free deaf sneeze sounds like: "[There is] a heavy breath as the deep pre-sneeze breath is taken, then a sharper, faster sound of air being released." Very little deaf-sneeze research exists, but a study has been done on deaf people and their laughter. BBC © 2013
Link ID: 18355 - Posted: 07.08.2013
by Helen Fields When a bat moves in for the kill, some moths jiggle their genitals. Researchers made the observation by studying three species of hawk moths—big moths that can hover—in Malaysia. They snared the insects with bright lights, tied tiny leashes around their waists, and let them fly while bat attack sounds played. All three species responded to the noises with ultrasound—which they made by shaking their private parts, the team reports online today in Biology Letters. Males have a structure they use for hanging onto females when they mate; to make the sound, they scrape a patch of large scales on the structure against the very end of their abdomen , letting out two bursts of rapid clicks. Females also make a sound, but the researchers aren't sure how. The scientists don't know exactly what the sounds are for, either. The noise may warn the bats that they're trying to mess with a fast-moving, hard-to-catch piece of prey, or it might jam the bat's ultrasound signals. Either way, the racy display may save their lives. © 2010 American Association for the Advancement of Science
By Scicurious Sometimes, funny stories really bring out the wonder of the human body. You can get orgasms triggered in your feet, because of overlap in the sensory cortex. Receptors that are involved in narcolepsy are also involved in how much you eat. And knocking out receptors that regulate taste…can make you sterile? Who knew? Let’s start with taste. We taste because the chemicals in foods hit receptors on our tongues. Receptors for sweet, salt, bitter, sour, and umami (which can commonly be thought of as “savory”). Now, a receptor isn’t just a single protein, it’s actually several protein subunits working together to function. So, for example, the receptor subunit TAS1R3 is a subunit that can play two different tasting roles. When combined with one other subunit, it helps to sense sweet (like saccharin), and when combined with another, if helps you taste umami (like MSG, which is definitely umami flavored). If you get rid of the gene for TAS1R3, you end up with an animal that can’t detect either sweet or umami very well. There’s another subunit that is covered in this paper as well, GNAT3. GNAT3, instead of being specific for something like sweet or bitter, instead plays a role in “basic taste“. But these two protein subunits are not JUST expressed on the tongue and in the gastrointestinal tract. They are expressed elsewhere in the body…and especially in the testicles. © 2013 Scientific American
David Derbyshire Every year Robert Hodgson selects the finest wines from his small California winery and puts them into competitions around the state. And in most years, the results are surprisingly inconsistent: some whites rated as gold medallists in one contest do badly in another. Reds adored by some panels are dismissed by others. Over the decades Hodgson, a softly spoken retired oceanographer, became curious. Judging wines is by its nature subjective, but the awards appeared to be handed out at random. So drawing on his background in statistics, Hodgson approached the organisers of the California State Fair wine competition, the oldest contest of its kind in North America, and proposed an experiment for their annual June tasting sessions. Each panel of four judges would be presented with their usual "flight" of samples to sniff, sip and slurp. But some wines would be presented to the panel three times, poured from the same bottle each time. The results would be compiled and analysed to see whether wine testing really is scientific. The first experiment took place in 2005. The last was in Sacramento earlier this month. Hodgson's findings have stunned the wine industry. Over the years he has shown again and again that even trained, professional palates are terrible at judging wine. "The results are disturbing," says Hodgson from the Fieldbrook Winery in Humboldt County, described by its owner as a rural paradise. "Only about 10% of judges are consistent and those judges who were consistent one year were ordinary the next year. © 2013 Guardian News and Media Limited
By Helen Briggs BBC News Our perception of how food tastes is influenced by cutlery, research suggests. Size, weight, shape and colour all have an effect on flavour, says a University of Oxford team. Cheese tastes saltier when eaten from a knife rather than a fork; while white spoons make yoghurt taste better, experiments show. The study in the journal Flavour suggests the brain makes judgements on food even before it goes in the mouth. More than 100 students took part in three experiments looking at the influence of weight, colour and shape of cutlery on taste. The researchers found that when the weight of the cutlery confirms to expectations, this had an impact on how the food tastes. For example, food tasted sweeter on the small spoons that are traditionally used to serve desserts. Colour contrast was also an important factor - white yoghurt eaten from a white spoon was rated sweeter than white yoghurt tasted on a black spoon. Similarly, when testers were offered cheese on a knife, spoon, fork or toothpick, they found that the cheese from a knife tasted saltiest. "How we experience food is a multisensory experience involving taste, feel of the food in our mouths, aroma, and the feasting of our eyes," said Prof Charles Spence and Dr Vanessa Harrar. BBC © 2013
Keyword: Chemical Senses (Smell & Taste)
Link ID: 18315 - Posted: 06.26.2013
Melissa Dahl TODAY The video will melt your heart: A deaf little boy is stunned when he hears his father’s voice for the first time after receiving an auditory brainstem implant. “Daddy loves you,” Len Clamp tells his 3-year-old son, Grayson, in a video that was recorded May 21 but is going viral today. (He signs the words, too, to be sure the boy would understand.) Grayson was born without cochlear nerves, the “bridge” that carries auditory information from the inner ear to the brain. He’s now the among the first children in the U.S. to receive an auditory brainstem implant in a surgery done at the University of North Carolina in Chapel Hill, N.C., led by UNC head and neck surgeon Dr. Craig Buchman. The device is already being used in adults, but is now being tested in children at UNC as part of an FDA-approved trial. It’s similar to a cochlear implant, but instead of sending electrical stimulation to the cochlea, the electrodes are placed on the brainstem itself. Brain surgery is required to implant the device. "Our hope is, because we're putting it into a young child, that their brain is plastic enough that they'll be able to take the information and run with it," Buchman told NBCNews.com.
By NICHOLAS BAKALAR Obesity in adolescents is associated with a range of cardiovascular and other health risks. Now a new study adds one more: hearing loss. Several studies have demonstrated the association of obesity with hearing loss in adults, but now researchers examining records of a nationwide sample of 1,488 boys and girls ages 12 to 19 have found the same association in teenagers. The study appeared online in The Laryngoscope. The researchers controlled for various factors, including poverty, sex, race and previous exposure to loud noises. They found that being at or above the 95th percentile for body mass index — the definition of obesity in teenagers — was independently associated with poorer hearing over all frequencies, and with almost double the risk of low-frequency hearing loss in one ear. They suggest that this may represent an early stage of injury that will later progress to both ears, as it does in adults. The reason for the connection is not known, but the scientists suggest that inflammation induced by obesity may be a factor in organ damage. “It’s quite possible that early intervention could arrest the progression,” said the lead author, Dr. Anil K. Lalwani, a professor of otolaryngology at Columbia University. “This is another reason to lose weight — but not to lose hope.” Copyright 2013 The New York Times Company
By NICHOLAS BAKALAR Hearing loss in older adults increases the risk for hospitalization and poor health, a new study has found, even taking into account other risk factors. Researchers analyzed data on 529 men and women over 70 with normal hearing, comparing them with 1,140 whose hearing was impaired, most with mild or moderate hearing loss. The data were gathered in a large national health survey in 2005-6 and again in 2009-10. The results appeared in The Journal of the American Medical Association. After adjusting for race, sex, education, hypertension, diabetes, stroke, cardiovascular disease and other risks, the researchers found that people with poor hearing were 32 percent more likely to be hospitalized, 36 percent more likely to report poor physical health and 57 percent more likely to report poor emotional or mental health. The authors acknowledge that this is an association only, and that there may be unknown factors that could have affected the result. “There has been a belief that hearing loss is an inconsequential part of aging,” said the lead author, Dr. Frank R. Lin, an associate professor of otolaryngology at Johns Hopkins. “But it’s probably not. Everyone knows someone with hearing loss, and as we think about health costs, we have to take its effects into account.” Copyright 2013 The New York Times Company
Link ID: 18267 - Posted: 06.13.2013
A team of NIH-supported researchers is the first to show, in mice, an unexpected two-step process that happens during the growth and regeneration of inner ear tip links. Tip links are extracellular tethers that link stereocilia, the tiny sensory projections on inner ear hair cells that convert sound into electrical signals, and play a key role in hearing. The discovery offers a possible mechanism for potential interventions that could preserve hearing in people whose hearing loss is caused by genetic disorders related to tip link dysfunction. The work was supported by the National Institute on Deafness and Other Communication Disorders (NIDCD), a component of the National Institutes of Health. Stereocilia are bundles of bristly projections that extend from the tops of sensory cells, called hair cells, in the inner ear. Each stereocilia bundle is arranged in three neat rows that rise from lowest to highest like stair steps. Tip links are tiny thread-like strands that link the tip of a shorter stereocilium to the side of the taller one behind it. When sound vibrations enter the inner ear, the stereocilia, connected by the tip links, all lean to the same side and open special channels, called mechanotransduction channels. These pore-like openings allow potassium and calcium ions to enter the hair cell and kick off an electrical signal that eventually travels to the brain where it is interpreted as sound. The findings build on a number of recent discoveries in laboratories at NIDCD and elsewhere that have carefully plotted the structure and function of tip links and the proteins that comprise them. Earlier studies had shown that tip links are made up of two proteins — cadherin-23 (CDH23) and protocadherin-15 (PCDH15) — that join to make the link, with PCDH15 at the bottom of the tip link at the site of the mechanotransduction channel, and CDH23 on the upper end. Scientists assumed that the assembly was static and stable once the two proteins bonded.
Link ID: 18265 - Posted: 06.13.2013
By ROBERT J. ZATORRE and VALORIE N. SALIMPOOR MUSIC is not tangible. You can’t eat it, drink it or mate with it. It doesn’t protect against the rain, wind or cold. It doesn’t vanquish predators or mend broken bones. And yet humans have always prized music — or well beyond prized, loved it. In the modern age we spend great sums of money to attend concerts, download music files, play instruments and listen to our favorite artists whether we’re in a subway or salon. But even in Paleolithic times, people invested significant time and effort to create music, as the discovery of flutes carved from animal bones would suggest. So why does this thingless “thing” — at its core, a mere sequence of sounds — hold such potentially enormous intrinsic value? The quick and easy explanation is that music brings a unique pleasure to humans. Of course, that still leaves the question of why. But for that, neuroscience is starting to provide some answers. More than a decade ago, our research team used brain imaging to show that music that people described as highly emotional engaged the reward system deep in their brains — activating subcortical nuclei known to be important in reward, motivation and emotion. Subsequently we found that listening to what might be called “peak emotional moments” in music — that moment when you feel a “chill” of pleasure to a musical passage — causes the release of the neurotransmitter dopamine, an essential signaling molecule in the brain. When pleasurable music is heard, dopamine is released in the striatum — an ancient part of the brain found in other vertebrates as well — which is known to respond to naturally rewarding stimuli like food and sex and which is artificially targeted by drugs like cocaine and amphetamine. © 2013 The New York Times Company
Link ID: 18251 - Posted: 06.10.2013