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Analysis of a trial that used the drug canagliflozin found that as people lost weight, their appetite increased proportionately, leading to consumption of more calories and weight loss plateau (leveling off). The findings provide the first measurement in people of how strongly appetite counters weight loss as part of the body’s feedback control system regulating weight. Results are currently available on BioRxiv (link is external) and will publish in Obesity during Obesity Week 2016. A team led by the NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) analyzed data from a year-long, placebo-controlled, double-blind trial in people with type 2 diabetes who could eat and drink without restriction by the study. Of the 242 participants, 153 received canagliflozin, a drug that caused a substantial increase in the amount of glucose excreted in their urine. Those people were not directly aware of that calorie loss, which caused a gradual decrease in weight averaging about eight pounds. The team used a validated math model to calculate the changes in the amount of calories consumed during the study. They found no long-term calorie intake changes in the 89 people who got a placebo. However, for every pound of lost weight, the people treated with canagliflozin consumed about 50 calories per day more than they were eating before the study. This increase in appetite and calorie intake led to slowing of weight loss after about six months. The measurements are consistent with the researchers’ analysis of data from a separate trial on a commercial weight loss program not involving canagliflozin. In the weight loss program trial, despite the dieters’ consistent efforts to reduce calorie intake, their increased appetite resulted in a progressive increase in calorie intake — three times stronger than the changes in caloric expenditure that typically accompany weight loss — and weight loss plateau. Findings from the analyses suggest that persistent effort is required to avoid weight regain.

Keyword: Obesity
Link ID: 22756 - Posted: 10.15.2016

By Jessica Boddy You’d probably never notice a jumping spider across your living room, but it would surely notice you. The arachnids are known for their brilliant eyesight, and a new study shows they have even greater sensory prowess than we thought: Jumping spiders can hear sounds even though they don’t have ears—or even eardrums. To find this out, researchers implanted tiny electrodes in a region of spiders’ brains that would show whether sound was being processed. Then they placed the spiders on a specially designed box to eliminate any vibrations from below—most spiders sense their surroundings through vibrations—and scared the heck out of them with a speaker-produced buzz of one of their predators, the mud dauber wasp. An out-of-earshot, high-frequency buzz and a silent control elicited no response from the spiders. But the 80-hertz wasp buzz made them freeze and look around, startled, just as they would do in the wild. What’s more, data from the electrodes showed a spike in brain activity with each buzz, revealing that spiders actually hear sounds, from a swooping mud dauber wasp to you crunching potato chips on your couch. The researchers, who publish their work today in Current Biology, say further study is needed to see exactly how spiders receive sounds without eardrums, but they believe sensitive hairs on their legs play a part. © 2016 American Association for the Advancement of Science.

Keyword: Hearing
Link ID: 22755 - Posted: 10.15.2016

By Gary Stix The new mantra for researchers fighting Alzheimer’s disease is “go early,” before memory loss or other pathology appears. The rationale for this approach holds that by the time dementia sets in the disease may already be destroying brain cells, placing severe limits on treatment options. Some large clinical trials are now testing drugs intended to clear up the brain’s cellular detritus—the aggregations of amyloid and tau proteins that may ultimately destroy brain cells. So far this approach has had decidedly mixed results. Some researchers are choosing a different direction. They have begun to ask what happens in the brain before the plaques and tangles of amyloid and tau appear—and to look at interventions that might work at this incipient disease stage. The Alzheimer’s Disease Drug Discovery Foundation has focused in recent years on funding new agents that do not target amyloid but are intended to address other manifestations of the disease, such as inflammation and the energy metabolism of neurons. At a meeting last month in Jersey City, N.J., neuroscientist Grace Stutzmann of the Chicago Medical School at Rosalind Franklin University of Medicine and Science presented her work on restoring a basic cellular process—called calcium signaling—that goes off track in Alzheimer’s. Scientific American asked her recently about her work. © 2016 Scientific American,

Keyword: Alzheimers
Link ID: 22754 - Posted: 10.13.2016

By Smitha Mundasad Health reporter People who experience frequent drops in blood pressure or dizziness when suddenly standing up are at increased risk of dementia, scientists say. Writing in Plos Medicine they suggest that less blood reaches the brain during these moments, leading to brain cell damage over time. Dementia experts say this is a "robust study" and "plausible explanation" that needs further investigation. Charities point out that factors such as smoking carry higher risks. But they say the work adds to growing evidence that changes in blood pressure have an impact on the brain. Previous studies have linked high blood pressure to types of dementia. But in this paper scientists focused on transient periods of low blood pressure - also known as postural hypotension - which become more common in older age. These episodes can sometimes leave people feeling dizzy or give them "head rushes" when standing up suddenly. Researchers from the Erasmus Medical Center, in the Netherlands, tracked 6,000 people for an average of 15 years. They found those who suffered repeated periods of low blood pressure on standing were more likely to develop dementia in the years that followed. Researcher Dr Arfan Ikram said: "Even though the effect can be seen as subtle - with an increased risk of about 4% for people with postural hypotension compared to those without it - so many people suffer from postural hypotension as they get older that it could have a significant impact on the burden of dementia across the world." He told the BBC: "If people experience frequent episodes of dizziness on standing, particularly as they get older, they should see their GPs for advice." © 2016 BBC

Keyword: Alzheimers
Link ID: 22753 - Posted: 10.13.2016

Lauren Silverman It's been a wild ride for kratom lately. Since Aug. 31, when the Drug Enforcement Administration announced its intention to classify the plant as a Schedule I substance, a group of kratom vendors filed a lawsuit against the government to block the move, angry advocates took to social media in protest and scientists questioned whether they would be able to continue kratom research. Now, the DEA is withdrawing its notice of intent to put kratom in the most restrictive category of controlled substances, with drugs like LSD and heroin. The DEA says it will instead open an official public comment period — to last until Dec. 1, 2016 — for people to share their experiences using kratom as a medical treatment. It has also requested that the Food and Drug Administration expedite scientific research. DEA spokesman Russ Baer says the DEA received more than 2,000 phone calls since August, mostly in opposition to the plan to classify kratom as Schedule I. "So in a spirit of transparency, and to open this up to public dialogue, we withdrew our notice to temporarily schedule kratom," Baer says. "We will then give full consideration to those comments before we move forward with any action." Kratom is derived from the leaves of a tree native to Southeast Asia. It is a relative of the coffee plant. According to David Kroll, a pharmacologist and medical writer, farmers and indigenous people have used it for hundreds of years as both a stimulant to increase work output and also as a way to relax. © 2016 npr

Keyword: Drug Abuse
Link ID: 22752 - Posted: 10.13.2016

By MIKE IVES HONG KONG — President Rodrigo Duterte of the Philippines was elected in May after pledging to kill 100,000 criminals in his first six months in office, vowing that fish in Manila, the capital, would grow fat from eating the bodies of drug dealers and other “do nothings.” In Mr. Duterte’s first three months as president, his bloody campaign led to the killing of about 1,400 drug suspects by the police and hundreds of others by extrajudicial means, according to official estimates. He has also publicly accused thousands of government officials of being involved in the drug trade, in some cases offering no evidence. The campaign has taken particular aim at people who use or sell shabu, a cheap form of methamphetamine that has caused grave health and social problems across the country. Mr. Duterte has likened shabu addicts to zombies and claimed — absent evidence — that many are “no longer viable for rehabilitation” because abusing the drug shrinks their brains. What is methamphetamine? Methamphetamine is an addictive stimulant that can be made from ephedrine and other readily available chemicals. It typically comes in either tablets, called yaba in parts of Asia, or crystalline form. The first variety is common in mainland Southeast Asia, and the second — known as shabu, ice or crystal meth, among other names — is more popular in the Philippines and many other countries. It also tends to be more potent and more deeply intertwined with international drug manufacturing and smuggling networks, according to a report by the United Nations Office on Drugs and Crime. How does the drug affect people who use it? Smoking, snorting, ingesting or injecting methamphetamine can cause aggression, memory loss and a range of other health complications, including heart attack or sudden death. Links between methamphetamine abuse and crime, disease transmission and other social problems have also been documented. A study by the RAND Corporation found that the effects of methamphetamine abuse, including the burden of addiction and treatment, cost the United States $23.4 billion in 2005. © 2016 The New York Times Company

Keyword: Drug Abuse
Link ID: 22751 - Posted: 10.13.2016

By peering into the eyes of mice and tracking their ocular movements, researchers made an unexpected discovery: the visual cortex — a region of the brain known to process sensory information — plays a key role in promoting the plasticity of innate, spontaneous eye movements. The study, published in Nature, was led by researchers at the University of California, San Diego (UCSD) and the University of California, San Francisco (UCSF) and funded by the National Eye Institute (NEI), part of the National Institutes of Health. “This study elegantly shows how analysis of eye movement sheds more light on brain plasticity — an ability that is at the core of the brain’s capacity to adapt and function. More specifically, it shows how the visual cortex continues to surprise and to awe,” said Houmam Araj, Ph.D., a program director at NEI. Without our being aware of it, our eyes are in constant motion. As we rotate our heads and as the world around us moves, two ocular reflexes kick in to offset this movement and stabilize images projected onto our retinas, the light-sensitive tissue at the back of our eyes. The optokinetic reflex causes eyes to drift horizontally from side-to-side — for example, as we watch the scenery through a window of a moving train. The vestibulo-ocular reflex adjusts our eye position to offset head movements. Both reflexes are crucial to survival. These mechanisms allow us to see traffic while driving down a bumpy road, or a hawk in flight to see a mouse scurrying for cover.

Keyword: Vision
Link ID: 22750 - Posted: 10.13.2016

By Elizabeth Pennisi Although it has a face—and body—that only a mother could love, the naked mole rat has a lot to offer biomedical science. It lives 10 times longer than a mouse, almost never gets cancer, and doesn’t feel pain from injury and inflammation. Now, researchers say they’ve figured out how the rodents keep this pain away. “It’s an amazing result,” says Harold Zakon, an evolutionary neurobiologist at the University of Texas, Austin, who was not involved with the work. “This study points us to important areas … that might be targeted to reduce this type of pain.” Naked mole rats are just plain weird. They live almost totally underground in colonies structured like honey bee hives, with hundreds of workers servicing a single queen and her few consorts. To survive, they dig kilometers of tunnels in search of large underground tubers for food. It’s such a tough life that—to conserve energy—this member of the rodent family gave up regulating its temperature, and they are able to thrive in a low-oxygen, high–carbon dioxide environment that would suffocate or be very painful to humans. “They might as well be from another planet,” says Thomas Park, a neuroscientist at the University of Illinois, Chicago. Gary Lewin, a neuroscientist at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association in Berlin, began working with naked mole rats because a friend in Chicago was finding that the rodent's pain fibers were not the same as other mammals'. In 2008, the studies led to the finding that naked mole rats didn’t feel pain when they came into contact with acid and didn’t get more sensitive to heat or touch when injured, like we and other mammals do. Lewin was hooked and has been raising the rodents in his lab ever since. They are a little more challenging than rats or mice, he notes, because with just one female per colony producing young, he never really has quite enough individuals for his studies. © 2016 American Association for the Advancement of Science

Keyword: Pain & Touch; Evolution
Link ID: 22749 - Posted: 10.12.2016

By CASEY SCHWARTZ Have you ever been to Enfield? I had never even heard of it until I was 23 and living in London for graduate school. One afternoon, I received notification that a package whose arrival I had been anticipating for days had been bogged down in customs and was now in a FedEx warehouse in Enfield, an unremarkable London suburb. I was outside my flat within minutes of receiving this news and on the train to Enfield within the hour, staring through the window at the gray sky. The package in question, sent from Los Angeles, contained my monthly supply of Adderall. Adderall, the brand name for a mixture of amphetamine salts, is more strictly regulated in Britain than in the United States, where, the year before, in 2005, I became one of the millions of Americans to be prescribed a stimulant medication. The train to Enfield was hardly the greatest extreme to which I would go during the decade I was entangled with Adderall. I would open other people’s medicine cabinets, root through trash cans where I had previously disposed of pills, write friends’ college essays for barter. Once, while living in New Hampshire, I skipped a day of work to drive three hours each way to the health clinic where my prescription was still on file. Never was I more resourceful or unswerving than when I was devising ways to secure more Adderall. Adderall is prescribed to treat Attention Deficit Hyperactivity Disorder, a neurobehavioral condition marked by inattention, hyperactivity and impulsivity that was first included in the D.S.M. in 1987 and predominantly seen in children. That condition, which has also been called Attention Deficit Disorder, has been increasingly diagnosed over recent decades: In the 1990s, an estimated 3 to 5 percent of school-age American children were believed to have A.D.H.D., according to the Centers for Disease Control and Prevention; by 2013, that figure was 11 percent. It continues to rise. And the increase in diagnoses has been followed by an increase in prescriptions. In 1990, 600,000 children were on stimulants, usually Ritalin, an older medication that often had to be taken multiple times a day. By 2013, 3.5 million children were on stimulants, and in many cases, the Ritalin had been replaced by Adderall, officially brought to market in 1996 as the new, upgraded choice for A.D.H.D. — more effective, longer lasting. © 2016 The New York Times Company

Keyword: ADHD; Drug Abuse
Link ID: 22748 - Posted: 10.12.2016

By Gareth Cook According to the American Psychiatric Association, about 5 percent of American children suffer from Attention Deficit Hyperactivity Disorder (ADHD), yet the diagnosis is given to some 15 percent of American children, many of whom are placed on powerful drugs with lifelong consequences. This is the central fact of the journalist Alan Schwarz’s new book, ADHD Nation. Explaining this fact—how it is that perhaps two thirds of the children diagnosed with ADHD do not actually suffer from the disorder—is the book’s central mystery. The result is a damning indictment of the pharmaceutical industry, and an alarming portrait of what is being done to children in the name of mental health. What prompted you to write this book? In 2011, having spent four years exposing the dangers of concussions in the National Football League and youth sports for The New York Times, I wanted another project. I had heard that high school students in my native Westchester County (just north of New York City) were snorting Adderall before the S.A.T.'s to focus during the test. I was horrified and wanted to learn more. I saw it not as a "child psychiatry" story, and not as a "drug abuse" story, but one about academic pressure and the demands our children feel they're under. When I looked deeper, it was obvious that our nationwide system of ADHD treatment was completely scattershot—basically, many doctors were merely prescribing with little thought into whether a kid really had ADHD or not, and then the pills would be bought and sold among students who had no idea what they were messing with. I asked the ADHD and child-psychiatry establishment about this, and they denied it was happening. They denied that there were many false diagnoses. They denied that teenagers were buying and selling pills. They denied that the national diagnosis rates reported by the C.D.C.—then 9.5 percent of children aged 4-17, now 11 percent and still growing—were valid. They basically denied that anything about their world was malfunctioning at all. In the end, they doth protest too much. I wrote about 10 front-page stories for The New York Times on the subject from 2012-2014. © 2016 Scientific American,

Keyword: ADHD; Drug Abuse
Link ID: 22747 - Posted: 10.12.2016

By Christian Jarrett It’s been said that men and women are so unlike each other, it’s as if they’re from different planets – a claim that continues to amuse and irritate. John Gray’s original mega-selling book Men are from Mars, Women are from Venus, first published in the early 1990s, has sold millions, spawning numerous parodies (such as Katherine Black and Finn Contini’s Women May Be from Venus, But Men are Really from Uranus) and even comedy stage shows, such as Men are from Mars, Women are from Venus, Live! currently playing off Broadway.) While our physical differences in size and anatomy are obvious, the question of psychological differences between the genders is a lot more complicated and controversial. There are issues around how to reliably measure the differences. And when psychologists find them, there are usually arguments over whether the causes are innate and biological, or social and cultural. Are men and women born different or does society shape them that way? These questions are particularly thorny when you consider our differences in personality. Most research suggests that men and women really do differ on some important traits. But are these differences the result of biology or cultural pressures? And just how meaningful are they in the real world? One possibility is that most differences are tiny in size but that combined they can have important consequences. One of the most influential studies in the field, published in 2001 by pioneering personality researchers Paul Costa, Robert McCrae and Antonio Terracciano, involved over 23,000 men and women from 26 cultures filling out personality questionnaires. © 2016 BBC.

Keyword: Sexual Behavior
Link ID: 22746 - Posted: 10.12.2016

By Virginia Morell Human-produced noise in the ocean is likely harming marine mammals in numerous unknown ways, according to a comprehensive new report from the National Academies of Sciences, Engineering, and Medicine. That’s because there are insufficient data to determine how the ill effects of noise created by ships, sonar signals, and other activities interact with other threats, including pollution, climate change, and the loss of prey due to fishing. The report, which was sponsored by several government agencies and released on 7 October, provides a new framework for researchers to begin exploring these cumulative impacts. “There’s a growing recognition that interactions between stressors on marine mammals can’t right now be accurately assessed," said Peter Tyack, a marine mammal biologist at the University of St Andrews in the United Kingdom, in a webinar on the report. Tyack also chaired the committee that prepared the study, "Approaches to Understanding the Cumulative Effects of Stressors on Marine Mammals." Killer whales, for instance, are known to swim away from areas where they have encountered sonar signals of about 142 decibels, a sound level lower than currently allowed by the U.S. Navy for its ships, Tyack said, referring to a 2014 study in The Journal of the Acoustical Society of America that determined the mammals’ likely response. But scientists don’t yet know how other marine mammals might respond. They also don’t know whether or how other factors, such as encountering an oil spill or colliding with a ship, would—or would not—compound the cetaceans’ response to these sounds; or how or whether such combined stressors matter to the animals’ long-term health and overall population. © 2016 American Association for the Advancement of Science.

Keyword: Stress; Hearing
Link ID: 22745 - Posted: 10.12.2016

By GRETCHEN REYNOLDS Exercise may aid in weight control and help to fend off diabetes by improving the ability of fat cells to burn calories, a new study reports. It may do this in part by boosting levels of a hormone called irisin, which is produced during exercise and which may help to turn ordinary white fat into much more metabolically active brown fat, the findings suggest. Irisin (named for the Greek goddess Iris) entered the scientific literature in 2012 after researchers from Harvard and other universities published a study in Nature that showed the previously unknown hormone was created in working muscles in mice. From there, it would enter the bloodstream and migrate to other tissues, particularly to fat, where it would jump-start a series of biochemical processes that caused some of the fat cells, normally white, to turn brown. Brown fat, which is actually brown in color, burns calories. It also is known to contribute to improved insulin and blood sugar control, lessening the risk for Type 2 diabetes. Most babies, including human infants, are plump with brown fat, but we humans lose most of our brown fat as we grow up. By the time we are adults, we usually retain very little brown fat. In the 2012 study, the researchers reported that if they injected irisin into living mice, it not only turned some white fat into brown fat, it apparently also prevented the rodents from becoming obese, even on a high-fat, high-calorie diet. But in the years since, some scientists have questioned whether irisin affects fat cells in people to the same extent as it seems to in mice — and even whether the hormone exists in people at all. A study published last year in Cell Metabolism by the same group of researchers who had conducted the first irisin study, however, does seem to have established that irisin is produced in humans. They found some irisin in sedentary people, but the levels were much higher in those who exercise often. © 2016 The New York Times Company

Keyword: Obesity
Link ID: 22744 - Posted: 10.12.2016

Allison Aubrey The World Health Organization has already urged us to cut back on sugar, limiting added sugars to no more than 10 percent of our daily calories. So, how might policymakers get people to follow this advice? In a new report, the WHO is urging governments around the world to tax soda and other sugary drinks. In its report, the World Health Organization points to systematic reviews of policies aimed at improving diet and preventing lifestyle diseases, such as obesity and diabetes. "The evidence was strongest and most consistent for the effectiveness of sugar-sweetened beverage taxes in the range of 20-50% in reducing consumption," the WHO's meta-review concludes. Dr. Douglas Bettcher, director of the WHO's Department for the Prevention of Noncommunicable Diseases, says that "consumption of free sugars, including products like sugary drinks, is a major factor in the global increase of people suffering from obesity and diabetes." "If governments tax products like sugary drinks, they can reduce suffering and save lives. They can also cut healthcare costs and increase revenues to invest in health services," Bettcher was quoted as saying in a WHO release on the report. The International Council of Beverages Associations, which represents soda companies and other beverage-makers around the globe, says it's disappointed with the new WHO report. "We strongly disagree with the committee's recommendation to tax beverages, as it is an unproven idea that has not been shown to improve public health based on global experiences to date," an ICBA release concludes. © 2016 npr

Keyword: Obesity
Link ID: 22743 - Posted: 10.12.2016

By JAN HOFFMAN Our daily tug of leash war goes like this. I tell Chico we’re taking a left. He yanks right, wet black nostrils burrowing in loamy leaf piles. Me versus a 15-pound Havanese, incensed by scent. Today, I let him win. That’s because I have fresh appreciation for his sniffing behavior, after reading a new book, “Being a Dog: Following the Dog into a World of Smell,” by Alexandra Horowitz, a professor of cognitive science who runs the Dog Cognition Lab at Barnard College. In it, she explains the elegant engineering of the dog’s olfactory system and how familiar canine behaviors — licking, sneezing, tail-wagging — have associations with smell. Dr. Horowitz also describes how she trained herself to enhance her inferior human sniffing ability. On a recent afternoon at Riverside Park in Manhattan, I met Dr. Horowitz and Finn (short for Finnegan), her affable, glossy black 9-year-old mixed breed. There she — and he — shared some sniffing insights that have since made my walks with Chico more intriguing and fun. “There are many ways to sniff, and the human method is not the best,” Dr. Horowitz said. Sniff researchers (yes, you read that correctly) have found we have about six million olfactory receptors; dogs have 300 million. Humans sniff once per second-and-a-half; dogs, five to 10 times a second. “They even exhale better than we do,” Dr. Horowitz continued, describing a sort of doggy yoga breath. Dogs exhale through the side slits of their nostrils, so they keep a continuous flow of inhaled air in their snout for smelling. “This gives them a continuous olfactory view of the world.” © 2016 The New York Times Company

Keyword: Chemical Senses (Smell & Taste)
Link ID: 22742 - Posted: 10.11.2016

By Daisy Yuhas About 350 million people around the world suffer from depression. Therapists can use many different techniques to help, but none has more rigorous scientific evidence behind it than cognitive-behavioral therapy (CBT). This “inside-out” technique focuses primarily on thought patterns, training patients to recognize and reframe problematic thinking. Now, however, mental health professionals have another option: mounting evidence shows that a technique called behavioral-activation (BA) therapy is just as effective as CBT. BA is an outside-in technique in which therapists focus on modifying actions rather than thoughts. “The idea is that what you do and how you feel are linked,” says David Richards, a health services researcher at the University of Exeter in England. If a patient values nature and family, for example, a therapist might encourage him to schedule a daily walk in the park with his grandchildren. Doing so could increase the rewards of engaging more with the outside world, which can be a struggle for depressed people, and could create an alternative to more negative pastimes such as ruminating on loss. BA has existed for decades, and some of its elements are used in CBT, yet until now it had never been tested with the scale and rigor needed to assess its relative strength as a stand-alone approach. In one of the largest studies of its kind, Richards led a collaboration of 18 researchers working at three mental health centers in the U.K. who put BA and CBT head-to-head. They assigned 440 people with depression to about 16 weeks of one of the two approaches, then followed the patients' progress at six, 12 and 18 months after treatment began. As revealed in a paper, published online in July in the Lancet, the team found the treatments to be equally effective. A year on, about two thirds of the patients in both groups reported at least a 50 percent reduction in their symptoms. © 2016 Scientific American

Keyword: Depression
Link ID: 22741 - Posted: 10.11.2016

Alison Abbott Arrival in a foreign, hostile country causes many refugees great stress. On an ice-cold day in January, clinical psychologist Emily Holmes picked up a stack of empty diaries and went down to Stockholm’s central train station in search of refugees. She didn’t have to look hard. Crowds of lost-looking young people were milling around the concourse, in clothes too flimsy for the freezing air. “It struck me hard to see how thin some of the young men were,” she says. Holmes, who works at Stockholm’s Karolinska Institute, was seeking help with her research — a pilot project on post-traumatic stress disorder (PTSD), which is all too common in refugees. She wanted to see whether they would be willing to spend a week noting down any flashbacks — fragmented memories of a trauma that rush unbidden into the mind and torment those with PTSD. She easily found volunteers. And when they returned the diaries, Holmes was shocked to see that they reported an average of two a day — many more than the PTSD sufferers she routinely dealt with. “My heart went out to them,” she says. “They managed to travel thousands of kilometres to find their way to safety with this level of symptoms.” Europe is experiencing the largest movement of people since the Second World War. Last year, more than 1.2 million people applied for asylum in the European Union — and those numbers underestimate the scale of the problem. Germany, which has taken in the lion’s share of people, reckons that it received more than a million refugees in 2015, tens of thousands of whom have yet to officially apply for asylum. Most came from Syria, Afghanistan and Iraq. Many have experienced war, shock, upheaval and terrible journeys, and they often have poor physical health. The crisis has attracted global attention and sparked political tension as countries struggle to accommodate and integrate the influx. © 2016 Macmillan Publishers Limited

Keyword: Stress; Depression
Link ID: 22740 - Posted: 10.11.2016

By Clare Wilson Glug glug glug. I’m drinking a big glass of ice water after getting thirsty, and it’s flowing easily down my throat like a river. But a study of thirsty and well hydrated people suggests this isn’t always the case. We rarely pay attention to the business of swallowing, but it may play a subtle role in controlling our fluid intake, on top of our conscious feelings of thirst. If we are dehydrated, swallowing is effortless; if we are overhydrated, swallowing feels more difficult, putting us off drinking, according to a study by Michael Farrell at Monash University in Melbourne, Australia, and his team. “Normally it’s something we are not really conscious of – away it goes,” says Farrell. But when his team asked volunteers to rate the sensation of taking a small sip of water, they found that people who had recently drunk a lot of water said it took much more effort to swallow than those who were mildly hydrated – their difficult ratings rose from one out of ten to nearly five. Is eight really great? When people were overhydrated, brain scans showed that swallowing was linked with more activity in certain regions of the brain, including the prefrontal cortex, which is responsible for conscious thought processes. “It suggests a mechanism for inhibition of drinking that we don’t usually think about,” says Zachary Knight at the University of California, San Francisco. © Copyright Reed Business Information Ltd.

Keyword: Miscellaneous
Link ID: 22739 - Posted: 10.11.2016

Erin Ross The teenage brain has been characterized as a risk-taking machine, looking for quick rewards and thrills instead of acting responsibly. But these behaviors could actually make teens better than adults at certain kinds of learning. "In neuroscience, we tend to think that if healthy brains act in a certain way, there should be a reason for it," says Juliet Davidow, a postdoctoral researcher at Harvard University in the Affective Neuroscience and Development Lab and the lead author of the study, which was published Wednesday in the journal Neuron. But scientists and the public often focus on the negatives of teen behavior, so she and her colleagues set out to test the hypothesis that teenagers' drive for rewards, and the risk-taking that comes from it, exist for a reason. When it comes to what drives reward-seeking in teens, fingers have always been pointed at the striatum, a lobster-claw-shape structure in the brain. When something surprising and good happens — say, you find $20 on the street — your body produces the pleasure-related hormone dopamine, and the striatum responds. "Research shows that the teenage striatum is very active," says Davidow. This suggests that teens are hard-wired to seek immediate rewards. But, she adds, it's also shown that their prefrontal cortex, which helps with impulse control, isn't fully developed. Combined, these two things have given teens their risky rep. But the striatum isn't just involved in reward-seeking. It's also involved in learning from rewards, explains Daphna Shohamy, a cognitive neuroscientist at the Zuckerman Mind Brain Behavior Institute at Columbia University who worked on the study. She wanted to see if teenagers would be better at this type of learning than adults would. © 2016 npr

Keyword: Development of the Brain; Learning & Memory
Link ID: 22738 - Posted: 10.10.2016

Richard A. Friedman There’s a reason adults don’t pick up Japanese or learn how to kite surf. It’s ridiculously hard. In stark contrast, young people can learn the most difficult things relatively easily. Polynomials, Chinese, skateboarding — no problem! Neuroplasticity — the brain’s ability to form new neural connections and be influenced by the environment — is greatest in childhood and adolescence, when the brain is still a work in progress. But this window of opportunity is finite. Eventually it slams shut. Or so we thought. Until recently, the conventional wisdom within the fields of neuroscience and psychiatry has been that development is a one-way street, and once a person has passed through his formative years, experiences and abilities are very hard, if not impossible, to change. What if we could turn back the clock in the brain and recapture its earlier plasticity? This possibility is the focus of recent research in animals and humans. The basic idea is that during critical periods of brain development, the neural circuits that help give rise to mental states and behaviors are being sculpted and are particularly sensitive to the effects of experience. If we can understand what starts and stops these periods, perhaps we can restart them. Think of the brain’s sensitive periods as blown glass: The molten glass is very malleable, but you have a relatively brief time before it cools and becomes crystalline. Put it back into the furnace, and it can once again change shape. © 2016 The New York Times Company

Keyword: Development of the Brain; Learning & Memory
Link ID: 22737 - Posted: 10.10.2016