Links for Keyword: Glia
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A Way to Shrink Brain Tumors Patients with a particularly aggressive type of brain cancer typically don't have many treatment options. But a new technique tested in mice and rats might provide a tool to combat the lethal tumors, known as glioblastomas. The strategy is to deliver growth-suppressing drugs directly and sustainedly to the tumor. If it works in humans, the technique could prolong the lives of some brain cancer patients, and it might be applicable to other types of cancer as well. Glioblastomal tumors make up about one-quarter of the cases of brain cancer, and most patients survive for no more than 18 months past diagnosis. But the cancer's fast growth makes it a good candidate for tumor-shrinking compounds called angiogenesis inhibitors. These proteins, such as endostatin, inhibit the growth of blood vessels that the tumors need to grow and spread (ScienceNOW, 23 January 1997). Getting angiogenesis inhibitors into brain tumors and keeping them there, however, has been a problem. .... --JOHN S. MacNEIL Copyright © 2001 by the American Association for the Advancement of Science.
The brain's glial cells are starting to take over some of the spotlight that was once only focused on the brain's neurons. Traditionally, glial cells were considered ho-hum supporting actors to the star neurons that communicate with one another to process our thoughts. Now, following a group of recent studies, researchers have found an increasing amount of evidence that suggests a category of glial cells, termed astrocytes, play an active role in brain function by affecting the activity of neurons. The findings are providing new insights into how the brain functions as well as new targets for clinical interventions. Copyright © 2000 Society for Neuroscience. All rights reserved. No portion of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise without permission of the Society for Neuroscience.
Related chapters from BP7e: Chapter 2: Functional Neuroanatomy: The Nervous System and Behavior
Related chapters from MM:Chapter 2: Cells and Structures: The Anatomy of the Nervous System
Link ID: 133 - Posted: 10.20.2001