Links for Keyword: Schizophrenia

Follow us on Facebook and Twitter, or subscribe to our mailing list, to receive news updates. Learn more.


Links 81 - 100 of 501

By Brian Vastag So-called atypical antipsychotic drugs have been blockbusters for the drug industry, pulling in $16 billion in 2010. Developed to treat schizophrenia and related disorders, physicians also prescribe these drugs “off label” for bipolar disorder, insomnia, and other problems the drugs are not approved to treat, as Sandra Boodman wrote in the Post on March 12. But a new report finds that psychiatrists have not been given a full picture of these drugs, which include big sellers like Abilify (aripiprazole), Zyprexa (olanzapine), Risperdal (risperidone), and Seroquel (quetiapine). When seeking approval for eight atypical antipsychotic drugs, drug companies performed 24 studies, according to a Food and Drug Administration database. But four of the studies were never published in professional journals — and all four were unflattering for the drug in question. Three of the unpublished studies showed that the new drug did not perform better than a sugar pill. The fourth study showed that while the antipsychotic drug helped patients more than a placebo, older, less expensive drugs helped patients even more. “That’s bad if you’re marketing the drug,” said Erick Turner, the psychiatrist at Oregon Health & Science University who conducted the new analysis, which was published Tuesday in the journal PLoS Medicine . © 1996-2012 The Washington Post

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders
Link ID: 16560 - Posted: 03.22.2012

by Peter Aldhous Just as many authors of the new psychiatry "bible" are tied to the drugs industry as those who worked on the previous version, a study has found, despite new transparency rules. The findings raise concerns over the independence of the revamped Diagnostic and Statistical Manual of Mental Disorders, or DSM, published by the American Psychiatric Association (APA) and scheduled for publication in May 2013. For the current rewrite, known as DSM-5, the APA for the first time required authors to declare their financial ties to industry. It also limited the amount they could receive from drug companies to $10,000 a year and their stock holdings to $50,000. "Transparency alone can't mitigate bias," says Lisa Cosgrove of Harvard University, who along with Sheldon Krimsky of Tufts University in Medford, Massachusetts, analysed the financial disclosures of 141 members of the "work groups" drafting the manual. They found that just as many contributors – 57 per cent – had links to industry as were found in a previous study of the authors of DSM-IV and an interim revision, published in 1994 and 2000 respectively. Cosgrove also points out that the $10,000-per-year limit on payments excludes research grants. "Nothing has really changed," she says. What's more, the work groups that had the most members with ties to the pharmaceutical industry were considering illnesses for which drugs are the front-line treatment – and for which proposed changes to diagnostic categories are especially controversial. © Copyright Reed Business Information Ltd.

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders
Link ID: 16519 - Posted: 03.15.2012

By Sandra G. Boodman, Adriane Fugh-Berman was stunned by the question: Two graduate students who had no symptoms of mental illness wondered if she thought they should take a powerful schizophrenia drug each had been prescribed to treat insomnia. “It’s a total outrage,” said Fugh-Berman, a physician who is an associate professor of pharmacology at Georgetown University. “These kids needed some basic sleep [advice], like reducing their intake of caffeine and alcohol, not a highly sedating drug.” Those Georgetown students exemplify a trend that alarms medical experts, policymakers and patient advocates: the skyrocketing increase in the off-label use of an expensive class of drugs called atypical antipsychotics. Until the past decade these 11 drugs, most approved in the 1990s, had been reserved for the approximately 3 percent of Americans with the most disabling mental illnesses, chiefly schizophrenia and bipolar disorder; more recently a few have been approved to treat severe depression. But these days atypical antipsychotics — the most popular are Seroquel, Zyprexa and Abilify — are being prescribed by psychiatrists and primary-care doctors to treat a panoply of conditions for which they have not been approved, including anxiety, attention-deficit disorder, sleep difficulties, behavioral problems in toddlers and dementia. These new drugs account for more than 90 percent of the market and have eclipsed an older generation of antipsychotics. Two recent reports have found that youths in foster care, some less than a year old, are taking more psychotropic drugs than other children, including those with the severest forms of mental illness. © 1996-2012 The Washington Post

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders; Chapter 14: Biological Rhythms, Sleep, and Dreaming
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders; Chapter 10: Biological Rhythms and Sleep
Link ID: 16504 - Posted: 03.13.2012

A cheap antibiotic normally prescribed to teenagers for acne is to be tested as a treatment to alleviate the symptoms of psychosis in patients with schizophrenia, in a trial that could advance scientific understanding of the causes of mental illness. The National Institute for Health Research is funding a £1.9m trial of minocycline, which will begin recruiting patients in the UK next month. The research follows case reports from Japan in which the drug was prescribed to patients with schizophrenia who had infections and led to dramatic improvements in their psychotic symptoms. The chance observation caused researchers to test the drug in patients with schizophrenia around the world. Trials in Israel, Pakistan and Brazil have shown significant improvement in patients treated with the drug. Scientists believe that schizophrenia and other mental illnesses including depression and Alzheimer's disease may result from inflammatory processes in the brain. Minocycline has anti-inflammatory and neuroprotective effects which they believe could account for the positive findings. Details of the trial were presented to the independent Schizophrenia Commission by Bill Deakin, professor of psychiatry at the University of Manchester, who is the lead investigator. The 12-member commission, set up by the mental health charity Rethink, is looking into the treatment and care of people with schizophrenia, and is due to report in the summer. The first account of minocycline's effects appeared in 2007 when a 23-year-old Japanese man was admitted to hospital suffering from persecutory delusions and paranoid ideas. He had no previous psychiatric history but became agitated and suffered auditory hallucinations, anxiety and insomnia. © independent.co.uk

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders
Link ID: 16468 - Posted: 03.03.2012

Erika Check Hayden The intersection of Mission and Sixth streets in San Francisco's South of Market neighbourhood is considered one of the most crime-riddled in the city. Liquor shops, adult bookshops and single-resident-occupancy hotels inhabit most of the buildings. Homeless people sit on the pavements or shuffle by, many of them showing symptoms of mental illness or drug abuse. Yet behind the walls of an unassuming outpatient psychiatric clinic, researchers are conducting experiments that they believe could fundamentally change the landscape of psychiatric care. Inside the San Francisco Citywide and Community Focus Center, in a room about the size of a large walk-in wardrobe, two people wearing headphones sit staring at computer screens. Despite the hubbub — the din of a nearby group session, clients milling in the hallway and the internal turmoil caused by their mental disorders — they are mesmerized by the games on the screens. Both have schizophrenia, and they are taking part in a study that aims to determine whether a controversial method of treatment can succeed where modern medicine has largely failed. The man behind the games is Michael Merzenich, an emeritus professor at the University of California, San Francisco, and a pioneering advocate for neuroplasticity — the notion that the brain can reshape and remodel its neural pathways even into adulthood. He has gained notoriety for his unabashed promotion of video games designed to tap into that plasticity. These have been marketed to treat everything from reading difficulties in children to driving impairment in elderly people. His zeal has, at times, attracted criticism. There is little solid evidence, say critics, that brain training makes a long-lasting difference in the lives of either ill or healthy people. © 2012 Nature Publishing Group

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders; Chapter 17: Learning and Memory
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders; Chapter 13: Memory, Learning, and Development
Link ID: 16463 - Posted: 03.01.2012

By BRIDGET O'SHEA The sounds of chaos bounce off the dim yellow walls. Everywhere there are prisoners wearing orange, red and khaki jumpsuits. An officer barks out orders as a thin woman tries to sleep on a hard bench in a holding cell. This is a harsh scene of daily life inside what has become the state’s largest de facto mental institution: the Cook County Jail. About 11,000 prisoners, a mix of suspects awaiting trial and those convicted of minor crimes, are housed at the jail at any one time, which is like stuffing the population of Palos Heights into an eight-block area on Chicago’s South Side. The Cook County sheriff, Tom Dart, estimated that about 2,000 of them suffer from some form of serious mental illness, far more than at the big state-owned Elgin Mental Health Center, which has 582 beds. Mr. Dart said the system “is so screwed up that I’ve become the largest mental health provider in the state of Illinois.” The situation is about to get worse, according to Mr. Dart and other criminal justice experts. The city plans to shut down 6 of its 12 mental health centers by the end of April, to save an estimated $2 million, potentially leaving many patients without adequate treatment — some of them likely to engage in conduct that will lead to arrests. “It will definitely have a negative impact on jail populations,” said Mr. Dart, who noted that the number of people coming into the jail with mental health problems was already increasing. “It will have direct consequences for us in my general jail population and some of the problems I have here, because a lot of the people with these issues act out more, as you would expect, so that’s a direct consequence.” © 2012 The New York Times Company

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders
Link ID: 16402 - Posted: 02.20.2012

by Linda Geddes Schizophrenia could be a profound form of jetlag in which the brain's central clock runs out of kilter with peripheral clocks around the rest of the body. People with the illness often complain of sleeping difficulties, and last month a study of 20 people with schizophrenia confirmed that sleep disruption is common and not down to their medication or lifestyle (British Journal of Psychiatry), DOI: 10.1192/bjp.bp.111.096321). Now we may be closer to understanding why: a genetic mutation that triggers schizophrenia-like symptoms in mice also appears to disrupt their circadian rhythm or body clock. Russell Foster at the University of Oxford and his colleagues had been puzzling over the link between sleep disturbances and mental illness. So they investigated circadian patterns in mice with a defect in the SNAP25 gene, often used as an animal model to study the illness. SNAP25 has also been associated with schizophrenia in humans. When the mice were kept under a schedule of 12 hours of light followed by 12 hours of darkness, they were active when you would normally expect mice to be sleeping, suggesting that their circadian rhythms were disrupted. © Copyright Reed Business Information Ltd.

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders; Chapter 14: Biological Rhythms, Sleep, and Dreaming
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders; Chapter 10: Biological Rhythms and Sleep
Link ID: 16279 - Posted: 01.21.2012

By NICHOLAS BAKALAR A new study has found that among immigrants, younger age at the time of migration predicts a higher incidence of psychotic disorders. The study, published in December in The American Journal of Psychiatry, was conducted from 1997 to 2005 in The Hague, where there are detailed records on almost everyone ages 15 to 54 who has made contact with the health care system for a possible psychotic disorder. The researchers found 273 immigrants, 119 second-generation citizens and 226 Dutch citizens who fit the criteria. In four ethnic groups — people from Suriname, the Netherlands Antilles, Turkey and Morocco — the risk of psychosis was most elevated among those who immigrated before age 4. There was no association of psychosis with age among immigrants from Western countries. The researchers, led by Dr. Wim Veling of the Parnassia Psychiatric Institute in The Hague, investigated various possible explanations — that social factors may be involved, that people may migrate because they are prone to psychosis, that a decision to migrate is influenced by the early appearance of psychosis, among many others. But the correlation between younger age of migration and the development of psychosis persisted. “We don’t know the reason,” said Dr. Ezra Susser, the senior author and a professor of epidemiology at Columbia University, “but it might be related to early social context, which we know has an important influence on later health and mental health.” © 2012 The New York Times Company

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders; Chapter 7: Life-Span Development of the Brain and Behavior
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders; Chapter 13: Memory, Learning, and Development
Link ID: 16255 - Posted: 01.14.2012

Reviewed by John M. Grohol, Psy.D. New research has discovered that people with schizophrenia have certain brain cells where their DNA stays too tightly wound. When DNA is too tightly wound, it can stop other genes from expressing themselves in their normal pattern. The new findings suggest that drugs already in development for other diseases might eventually offer hope as a treatment for schizophrenia and related conditions in the elderly. The research shows the deficit is especially pronounced in younger people. This suggests that treatment might be most effective early on at minimizing or even reversing symptoms of schizophrenia Schizophrenia is a usually-serious mental disorder characterized by hallucinations, delusions, and emotional difficulties, among other problems. “We’re excited by the findings,” said Scripps Research Associate Professor Elizabeth Thomas, a neuroscientist who led the study, “and there’s a tie to other drug development work, which could mean a faster track to clinical trials to exploit what we’ve found.” Working with lead author Bin Tang, a postdoctoral fellow in her lab, and Brian Dean, an Australian colleague at the University of Melbourne, Thomas obtained post-mortem brain samples from schizophrenic and healthy brains held at medical ”Brain Banks” in the United States and Australia. The brains come from either patients who themselves agreed to donate some or all of their bodies for scientific research after death, or from patients whose families agreed to such donations. © 1992-2012 Psych Central.

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders; Chapter 7: Life-Span Development of the Brain and Behavior
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders; Chapter 13: Memory, Learning, and Development
Link ID: 16203 - Posted: 01.03.2012

By BARRON H. LERNER, M.D. Most of us recall lobotomies as they were depicted in the movie “One Flew over the Cuckoo’s Nest”— horrifying operations inappropriately used to control mentally ill patients. But in the 1950s, surgeons also used them to treat severe pain from cancer and other diseases. Now a Yale researcher has uncovered surprising new evidence of a famous patient who apparently received a lobotomy for cancer pain during that time: Eva Perón, the first lady of Argentina, who was known as Evita. The story is an interesting, sad footnote in the history not only of lobotomy, but of pain control. The nature of Perón’s illness was initially shrouded in silence. Her doctors diagnosed advanced cervical cancer in August 1951, but as was common at the time, the patient was told only that she had a uterine problem. According to the biographers Nicholas Fraser and Marysa Navarro, secrecy was so paramount that an American specialist, Dr. George Pack, performed Perón’s cancer operation without her or the public ever knowing. He entered the operating suite after she was under anesthesia. Despite surgery, radiation and chemotherapy, Perón gradually worsened, dying in late July 1952 at age 33. Only then was it revealed that she had died of cervical cancer, although details of her treatment, including Dr. Pack’s involvement, remained concealed. In a 1972 biography, Erminda Duarte, Perón’s sister, claimed she had suffered intense pain and distress. © 2011 The New York Times Company

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders
Link ID: 16173 - Posted: 12.20.2011

Allen Frances, contributor "WE DON'T see things as they are, we see things as we are." This simple Talmudic saying summarises the essence of epistemology. Psychiatric disorders provide a striking example: they are not real things in nature, but labels we create to describe troubling aspects of human experience. Sometimes labels take on a life of their own. People mistakenly think that naming a psychiatric problem shapes it into a simple disease with a reductionist, biological explanation. Labelling mental disorders is useful in providing a common language and guide to treatment. But psychiatric disorders are remarkably heterogeneous and overlapping in their presentations and complex in their causation. The human brain rarely reveals its secrets in simple answers. All of which brings us to the wonderful book, American Madness, an artful analysis of the rise and fall of the label "dementia praecox" from its promising birth in 1896 to its unlamented death in 1927. Introduced by the German psychiatrist Emil Kraepelin, the term was used to describe an early onset of psychotic symptoms that presaged a tragic downhill course and poor outcome - as distinct from manic depressive illness, which has a more variable age of onset, cyclical course, and greater chance for a good outcome. The label dementia praecox spread like wildfire and was briefly the darling of psychiatry until it lost out to schizophrenia, a broader concept that included milder and earlier cases and did not necessarily imply such a bleak future or bad outcome. © Copyright Reed Business Information Ltd.

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders
Link ID: 16151 - Posted: 12.15.2011

By BENEDICT CAREY ATHENS, Ohio — She was gone for good, and no amount of meditation could resolve the grief, even out here in the deep quiet of the woods. “When I began to see the delusions in the context of things that were happening in my real life, they finally made some sense," Milt Greek said. "And understanding the story of my psychosis helped me see what I needed to stay well.” Milt Greek pushed to his feet. It was Mother’s Day 2006, not long after his mother’s funeral, and he headed back home knowing that he needed help. A change in the medication for his schizophrenia, for sure. A change in focus, too; time with his family, to forget himself. And, oh yes, he had to act on an urge expressed in his psychotic delusions: to save the world. So after cleaning the yard around his house — a big job, a gift to his wife — in the coming days he sat down and wrote a letter to the editor of the local newspaper, supporting a noise-pollution ordinance. Small things, maybe, but Mr. Greek has learned to live with his diagnosis in part by understanding and acting on its underlying messages, and along the way has built something exceptional: a full life, complete with a family and a career. He is one of a small number of successful people with a severe psychiatric diagnosis who have chosen to tell their story publicly. In doing so, they are contributing to a deeper understanding of mental illness — and setting an example that can help others recover. © 2011 The New York Times Company

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders
Link ID: 16081 - Posted: 11.26.2011

By BENEDICT CAREY Foster children are being prescribed cocktails of powerful antipsychosis drugs just as frequently as some of the most mentally disabled youngsters on Medicaid, a new study suggests. The report, published Monday in the journal Pediatrics, is the first to investigate how often youngsters in foster care are given two antipsychotic drugs at once, the authors said. The drugs include Risperdal, Seroquel and Zyprexa — among other so-called major tranquilizers — which were developed for schizophrenia but are now used as all-purpose drugs for almost any psychiatric symptoms. “The kids in foster care may come from bad homes, but they do not have the sort of complex medical issues that those in the disabled population do,” said Susan dosReis, an associate professor in the University of Maryland School of Pharmacy and the lead author. The implication, Dr. dosReis and other experts said: Doctors are treating foster children’s behavioral problems with the same powerful drugs given to people with schizophrenia and severe bipolar disorder. “We simply don’t have evidence to support this kind of use, especially in young children,” Dr. dosReis said. In recent years, doctors and policy makers have grown concerned about high rates of overall psychiatric drug use in the foster care system, the government-financed program that provides temporary living arrangements for 400,000 to 500,000 children and adolescents. Previous studies have found that children in foster care receive psychiatric medications at about twice the rate among children outside the system. © 2011 The New York Times Company

Related chapters from BP7e: Chapter 7: Life-Span Development of the Brain and Behavior; Chapter 16: Psychopathology: Biological Basis of Behavior Disorders
Related chapters from MM:Chapter 13: Memory, Learning, and Development; Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders
Link ID: 16061 - Posted: 11.21.2011

By Bruce Bower People with schizophrenia rapidly and intensely perceive phony replicas of hands as their own, possibly contributing to this mental ailment’s signature hallucinations, a new study suggests. In a series of tests, people with schizophrenia believed a rubber hand placed in front of them was theirs if the visible fake hand and the patient’s hidden, corresponding hand were simultaneously stroked with a paintbrush. Mentally healthy people took longer to experience a less dramatic version of this rubber-hand illusion than schizophrenia patients did, but the effect’s vividness increased among healthy volunteers who reported magical beliefs, severe social anxiety and other characteristics linked to a tendency to psychosis, psychologist Sohee Park of Vanderbilt University in Nashville and her colleagues report online October 31 in PLoS ONE. “Schizophrenia patients may have a more flexible internal representation of their bodies and a weakened sense of self,” Park says. “Even without psychosis, the rubber-hand illusion can be more pronounced in certain personality types.” Mental health clinicians have written for several decades about a disturbed sense of self in schizophrenia. A team led by psychiatrist Avi Peled of Sha’ar Menashe Mental Health Center in Hadera, Israel, first reported a powerful rubber-hand illusion in the illness in 2000. © Society for Science & the Public 2000 - 2011

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders; Chapter 8: General Principles of Sensory Processing, Touch, and Pain
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders; Chapter 5: The Sensorimotor System
Link ID: 16012 - Posted: 11.11.2011

Researchers have found a possible link between heavy use of methamphetamines and schizophrenia. Increased risk of the mental illness was discovered in meth users in a study of California hospital records for patients admitted between 1990 and 2000 with a diagnosis of drug dependence or abuse. Scientists at Toronto's Centre for Addiction and Mental Health compared the drug users to a control group of patients with appendicitis and no drug use. A drug addict prepares a combination of heroin and crystal meth. Scientists at Toronto's Centre for Addiction and Mental Health say people hospitalized for meth who didn't have a diagnosis of psychotic symptoms had about a 1.5- to threefold risk of being later diagnosed with schizophrenia.A drug addict prepares a combination of heroin and crystal meth. Scientists at Toronto's Centre for Addiction and Mental Health say people hospitalized for meth who didn't have a diagnosis of psychotic symptoms had about a 1.5- to threefold risk of being later diagnosed with schizophrenia. Guillermo Arias/Associated Press The hospital records were studied for readmissions for up to 10 years after the initial admission. Co-author Russell Callaghan says people hospitalized for meth who didn't have a diagnosis of psychotic symptoms at the start of the study period had about a 1.5- to threefold risk of being later diagnosed with schizophrenia, compared with groups of patients who used cocaine, alcohol or opioid drugs. © CBC 2011

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders; Chapter 4: The Chemistry of Behavior: Neurotransmitters and Neuropharmacology
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders; Chapter 4: The Chemistry of Behavior: Neurotransmitters and Neuropharmacology
Link ID: 16004 - Posted: 11.08.2011

By BENEDICT CAREY Researchers have long wondered how some people with schizophrenia can manage their symptoms well enough to build full, successful lives. But such people do not exactly line up to enroll in studies. For one thing, they are almost always secretive about their diagnosis. For another, volunteering for a study would add yet another burden to their stressful lives. But that is beginning to change, partly because of the unlikely celebrity of a fellow sufferer. In 2007, after years of weighing the possible risks, Elyn R. Saks, a professor of law at the University of Southern California, published a memoir of her struggle with schizophrenia, “The Center Cannot Hold.” It became an overnight sensation in mental health circles and a best seller, and it won Dr. Saks a $500,000 MacArthur Foundation “genius” award. For psychiatric science, the real payoff was her speaking tour. At mental health conferences here and abroad, Dr. Saks, 56, attracted not only doctors and therapists, but also high-functioning people with the same diagnosis as herself — a fellowship of fans, some of whom have volunteered to participate in studies. “People in the audience would stand up and self-disclose, or sometimes I would be on a panel with someone” who had a similar experience, Dr. Saks said. She also received scores of e-mails from people who had read the book and wanted to meet for lunch. She told many of them about the possibility of participating in a research project. © 2011 The New York Times Company

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders
Link ID: 15938 - Posted: 10.24.2011

By BENEDICT CAREY PASADENA, Calif. — The feeling of danger was so close and overwhelming that there was no time to find its source, no choice but to get out of the apartment, fast. Keris Myrick headed for her car, checked the time — just past midnight, last March — and texted her therapist. “You’re going to the Langham? The hotel?” the doctor responded. “No — you need to be in the hospital. I need you consulting with a doctor.” “What do you think I’m doing right now?” “Oh. Right,” he said. “Well, O.K., then we need to check in regularly.” “And that’s what we did,” said Ms. Myrick, 50, the chief executive of a nonprofit organization, who has a diagnosis of schizoaffective disorder, a close cousin of schizophrenia, and obsessive-compulsive disorder. “I needed to hide out, to be away for a while. I wanted to pamper myself — room service, great food, fluffy pillows, all that — and I was lucky to have a therapist who understood what was going on and went with it.” Researchers have conducted more than 100,000 studies on schizophrenia since its symptoms were first characterized. They have tested patients’ blood. They have analyzed their genes. They have measured perceptual skills, I.Q. and memory, and have tried perhaps thousands of drug treatments. © 2011 The New York Times Company

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders
Link ID: 15937 - Posted: 10.24.2011

By Carrie Arnold Mike (not his real name) had always been an unusual child. Even as a toddler, he had ­difficulties relating to others and making friends, and he seemed strikingly ­suspicious of other people. After he entered high school, Mike became increasingly angry, paranoid and detached. He worried that people were searching his room and his locker when he was not around. His grades plum­meted as he turned ­inward during class, sketch­ing outlandish scenes in his note­books and muttering to himself rather than listening to the instructor. Paranoia and difficulties connecting with others are signs of psychosis, a mental illness in which people lose touch with reality. Psychotic individuals usually have problems forming rational, coherent thoughts. They also may hear voices or hallucinate while believing that what they perceive is real. Often such delusions result in bizarre behavior and, in severe cases, an inability to ­manage every­day life. But a psychiatrist deemed Mike’s symptoms too mild to qualify him as psychotic. Mike obviously needed some kind of professional intervention, so he bounced among psychiatrists who could not figure out how to help him. Cases such as Mike’s have prompted some practitioners to propose the inclusion of a new psychosis risk diagnosis to the forthcoming fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM), the “bible” of mental health diagnoses. To receive this diagnosis, a patient would first need to report, for example, having delusions or hallucinations about once a week (as opposed to most of the time for at least one month for clinical psychosis). In addition, either the patient or a loved one must be significantly distressed by those symptoms. The idea of including such a diagnosis in the DSM is highly controversial, but supporters argue that patients such as Mike not only need immediate help, they are at increased risk for developing full-blown psychosis, an outcome doctors might be able to prevent with early intervention. © 2011 Scientific American,

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders; Chapter 7: Life-Span Development of the Brain and Behavior
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders; Chapter 13: Memory, Learning, and Development
Link ID: 15912 - Posted: 10.15.2011

By BENEDICT CAREY People with severe schizophrenia who have been isolated, withdrawn and considered beyond help can learn to become more active, social and employable by engaging in a type of talk therapy that was invented to treat depression, scientists reported on Monday. These new findings suggest that such patients have far more capability to improve their lives than was previously assumed and, if replicated, could change the way that doctors treat the one million patients for whom the disorder is profoundly limiting. The therapy — a variant of cognitive behavior therapy, which focuses on defusing self-defeating assumptions — increased motivation and reduced symptoms. In previous studies, researchers have used cognitive techniques to help people with schizophrenia manage their hallucinations and sharpen their attention and memory. The new study is the first to rigorously test using the therapy to combat so-called negative symptoms — the listlessness, exhaustion and emotional flatness that trap many people in solitary lives, playing out their days smoking in front of the TV or holed up in their homes. Dr. Bob Buchanan, a psychiatrist at the University of Maryland School of Medicine who was not involved in the study, said the results looked impressive. “This is a group of patients who have tried just about everything — drug treatments as well as psychosocial ones — and many clinicians and systems of care have essentially given up on them. If there’s an intervention out there that can make a difference, I think that’s an incredibly important development.” © 2011 The New York Times Company

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders
Link ID: 15873 - Posted: 10.04.2011

by Andy Coghlan TWIN studies have shown that people with schizophrenia and bipolar disorder have changes in gene activity caused by their environment. The finding provides the strongest evidence yet that such gene changes might cause the conditions. Jonathan Mill at the Institute of Psychiatry, King's College London, and colleagues scanned the genome of 22 pairs of identical twins - chosen because one twin in each pair was diagnosed with schizophrenia or bipolar disorder. As expected, the twins had identical DNA. However, they showed significant differences in chemical "epigenetic" markings - changes that do not alter the sequence of DNA but leave chemical marks on genes that dictate how active they are. These changes were on genes that have been linked with bipolar disorder and schizophrenia. Mill's team scanned for differences in the attachment of chemical methyl groups at 27,000 sites in the genome. Methylation normally switches genes off, and de-methylation turns them on. Regardless of which condition the twin had, the most significant differences, with variations of up to 20 per cent in the amount of methylation, were in the promoter "switch" for a gene called ST6GALNAC1, which has been linked with schizophrenia. Although the function of the gene isn't fully established, it is thought to add sugars to proteins, which could alter the speed or specificity of their usual function. © Copyright Reed Business Information Ltd.

Related chapters from BP7e: Chapter 16: Psychopathology: Biological Basis of Behavior Disorders; Chapter 7: Life-Span Development of the Brain and Behavior
Related chapters from MM:Chapter 12: Psychopathology: Biological Basis of Behavioral Disorders; Chapter 13: Memory, Learning, and Development
Link ID: 15865 - Posted: 10.01.2011