Patients who take clozapine, the most effective antipsychotic drug, have significantly higher rates of metabolic syndrome, according to a first-of-a-kind study by University of Rochester Medical Center researchers. Metabolic syndrome is a group of conditions that increase the risk for heart disease, stroke and diabetes. The conditions include high blood pressure, excess body fat around the waist, abnormal levels of cholesterol and triglycerides and insulin resistance. Any one of the conditions increases the risk of serious disease. In combination, the risk grows greater. More than half the clozapine patients studied had metabolic syndrome while only about 20 percent of those in a comparison group did, researchers report in the July issue of The American Journal of Psychiatry. Patients with metabolic syndrome in this study would be expected to have a two-to-threefold increase in cardiovascular disease mortality, the Medical Center Department of Psychiatry researchers state. "Clozapine is the last hope for many people," said J. Steven Lamberti, M.D., associate professor of psychiatry and lead author of the journal article. "But there are long-term health implications. This study suggests that patients who need the most effective medication are between a rock and a hard place."

Keyword: Schizophrenia
Link ID: 9086 - Posted: 07.01.2006

Jennifer Viegas, Discovery News — People generally define intelligence in terms that place our own species at the apex, but recent studies on other animals suggest skills such as abstract thinking, problem solving, reasoning, and language — once thought unique to us — may not be so uncommon after all. "The closer we examine animals, the more they surprise us with their intelligence and awareness," said Jonathan Balcombe, a research scientist at Physicians Committee for Responsible Medicine in Washington, DC. "Chickens practice deception, pigeons can categorize images in photographs as quickly as we can, a gorilla plays a joke on a human teacher, and a tiny fish leaps from one tide pool to another using a mental map formed during high tide." Balcombe did admit that in the evolutionary lottery, humans got lucky. Factors such as climate, the need for socialization, and challenges associated with foraging for intermittently available food may have contributed to our unique skill set. Taken individually or in other combinations, though, these skills are being increasingly noticed in other creatures. © 2006 Discovery Communications Inc.

Keyword: Intelligence; Evolution
Link ID: 9085 - Posted: 06.24.2010

Eric Jaffe In the 1993 movie Jurassic Park, one human character tells another that a Tyrannosaurus rex can't see them if they don't move, even though the beast is right in front of them. Now, a scientist reports that T. rex had some of the best vision in animal history. This sensory prowess strengthens arguments for T. rex's role as predator instead of scavenger. Scientists had some evidence from measurements of T. rex skulls that the animal could see well. Recently, Kent A. Stevens of the University of Oregon in Eugene went further. He used facial models of seven types of dinosaurs to reconstruct their binocular range, the area viewed simultaneously by both eyes. The wider an animal's binocular range, the better its depth perception and capacity to distinguish objects—even those that are motionless or camouflaged. T. rex had a binocular range of 55°, which is wider than that of modern hawks, Stevens reports in the summer Journal of Vertebrate Paleontology. Moreover, over the millennia, T. rex evolved features that improved its vision: Its snout grew lower and narrower, cheek grooves cleared its sight lines, and its eyeballs enlarged. "It was a selective advantage for this animal to see three-dimensionally ahead of it," Stevens says. ©2006 Science Service.

Keyword: Vision; Evolution
Link ID: 9084 - Posted: 06.24.2010

Bruce Bower Birth order may steer some men toward homosexuality in a process that perhaps begins before birth. A new study finds that homosexuality grows more likely with the greater number of biological older brothers—those sharing both father and mother—that a male has. Men display this tendency toward homosexuality even if they weren't raised with biological older brothers, finds psychologist Anthony F. Bogaert of Brock University in St. Catharines, Ontario. No gay connection appears in men raised with half-brothers, stepbrothers, or adoptive brothers, all deemed non-biological by Bogaert. "The mechanism underlying this fraternal birth-order effect remains unknown," Bogaert says. It's possible that succeeding pregnancies with male fetuses trigger a maternal immune response. A mother's immune system may treat male fetuses as foreign bodies, attacking them with antibodies that alter sex-related brain development, the Canadian psychologist suggests. Scientists haven't yet looked for any specific immune reaction during pregnancy that targets later-born boys who become homosexual. ©2006 Science Service.

Keyword: Sexual Behavior
Link ID: 9083 - Posted: 06.24.2010

By Marcus Wraight Patients are being recruited for a trial to determine whether chemicals in cannabis can slow the impact of multiple sclerosis. Evidence suggests the drug may relieve symptoms but the three-year national trial is also to determine whether it slows the disease's progress. It is estimated that 85,000 people in the UK have multiple sclerosis (MS). Prof John Zajicek, of the Peninsula Medical School and Derriford Hospital in Plymouth, will lead the research. One component of cannabis, called THC, is now being tested in a trial, funded by a £2m grant from the Medical Research Council, along with charities the MS Society and MS Trust. "This trial will build on our previous study which, coupled with our work in the laboratory, suggested that THC could have a protective effect on nerves," said Prof Zajicek. "Multiple Sclerosis is a very unpredictable disease. Currently there are few medicines which are effective in treating MS and none have been shown to have any effect in the progressive stages of the disease." MS is caused when the patient's own body damages the protective covering of the nerves - affecting signals from the brain. Progressive MS is thought to be caused by damage to the nerves themselves. (C)BBC

Keyword: Multiple Sclerosis; Drug Abuse
Link ID: 9082 - Posted: 06.30.2006

by Mary-Russell Roberson In the animal world, a song is a specific type of vocalization. Many animals vocalize in one way or another, by grunting, snorting, or barking, for example. Some vocalizations have a communication function: Alarm calls alert others to the presence of a predator, agonistic calls communicate aggression, begging calls solicit food from parents, and mating calls advertise availability. Songs are also used for communication, but typically are much more elaborate than calls. The difference between a song and a call, while fairly easy to recognize intuitively, is difficult to explain, perhaps because "song" is such a well-worn word in everyday English. When asked to define song, scientists who study it usually give a disclaimer first. Richard Mooney, a neurobiologist at Duke University Medical Center, who studies how birds learn and produce song, says, "Song is a loaded word. It has many meanings to humans and most of those relate to special human behaviors." And Timothy Holy, assistant professor of neurobiology at Washington University in St. Louis, says, "I don't think there is a single definition that everyone subscribes to." Those caveats notwithstanding, most scientists agree that a song is longer and more complex than a call, and has a melodic and rhythmic structure, often involving repeated patterns over both short time periods (tens of milliseconds) and longer time periods (seconds). Songs typically also include more variation in frequency (pitch) and intensity (volume) than calls do. Call and song are really two ends of a continuum, and different people draw the dividing line at different places. Copyright 2006 Friends of the National Zoo.

Keyword: Language; Animal Communication
Link ID: 9081 - Posted: 06.30.2006

A study published today is providing the first peer-reviewed scientific evidence that driving and talking on a cell phone could be just as bad as drinking and driving. "If you do a carefully controlled study where you equate for the amount of time that people are driving and the driving conditions, you're actually worse off when you are using a cell phone than when you're legally drunk," says David Strayer, a psychologist at the University of Utah. Strayer had done several previous studies showing that talking on a cell phone significantly impaired driving, so he wanted to know how talking compared to the ultimate driving impairment. "So we had people come in one day and we got them legally drunk, with a blood alcohol level of .08," says Strayer. "And then we measured how they drive in our driving simulator." The simulator is a $100,000 virtual reality driving machine in which volunteers follow a pace car. The simulator measures how fast, accurately and aggressively the driver follows the route. At the same time an eye tracking device measures where the driver is looking the whole time. Forty volunteers drove the car on four different mornings: once while legally intoxicated, once while talking on a hands-free cell phone, once while talking on a hand-held cell phone, and once with no distractions. © ScienCentral, 2000-2006.

Keyword: Attention; Drug Abuse
Link ID: 9080 - Posted: 06.24.2010

Three Florida teenagers recently pleaded not guilty to the brutal beatings and in one case, death, of homeless men. One of the beatings was caught on surveillance video and in a most chilling way illustrates how people can degrade socially outcast individuals, enough to engage in mockery, physical abuse, and even murder. According to new research, the brain processes social outsiders as less than human; brain imaging provides accurate depictions of this prejudice at an unconscious level. A new study by Princeton University psychology researchers Lasana Harris and Susan Fiske shows that when viewing photographs of social out-groups, people respond to them with disgust, not a feeling of fellow humanity. The findings are reported in the article "Dehumanizing the Lowest of the Low: Neuro-imaging responses to Extreme Outgroups" in a forthcoming issue of Psychological Science, a journal of the Association for Psychological Science (previously the American Psychological Society). Twenty four Princeton University undergraduates viewed a large number of color photographs of different social groups (including Olympic athletes, business professionals, elderly people, and drug addicts), and images of objects (including the Space Shuttle, a sports car, a cemetery, and an overflowing toilet) that elicited the emotions of pride, envy, pity, or disgust. The four emotions were derived from the Stereotype Content Model (SCM), which predicts differentiated prejudices based on warmth and competence. Warmth was determined by friendliness, competence by capability. The two emotional extremes were pride and disgust; pride elicited high warmth and high perception of competence, and disgust elicited low warmth and low perception of competence.

Keyword: Emotions
Link ID: 9079 - Posted: 06.30.2006

By ANDREW POLLACK A drug that can restore eyesight to some elderly people, even allowing them to read or drive again, is expected to win federal approval this week. But for patients, doctors, Medicare and other insurers, the drug's arrival will pose a conundrum. That is because the medicine, Lucentis, is expected to be 10 to 100 times as expensive as a similar drug that many ophthalmologists say is every bit as good. Lucentis, made by Genentech, is the first drug demonstrated in clinical trials to improve vision in people with so-called wet macular degeneration, a form of bleeding behind the retina that is the leading cause of blindness in people over 65. The condition afflicts an estimated 1.2 million people in this country, with an 200,000 new cases each year. While the drug is not a cure and does not help everyone, specialists say it represents a breakthrough against a disease that once almost inexorably led to an incapacitating loss of eyesight. "I have people who are reading the paper every morning who would have been totally legally blind two years ago," said Dr. Julia A. Haller, a professor of ophthalmology at Johns Hopkins University, who has had patients testing Lucentis. Copyright 2006 The New York Times Company

Keyword: Vision
Link ID: 9078 - Posted: 06.29.2006

Around one in four readers of this column has their brain infected with a potentially lethal parasite. The single-celled creature, Toxoplasma gondii, a relative of the agent of malaria, attacks not just Daily Telegraph readers but those of Le Monde (the incidence in France is more than twice that in Britain), together with many other mammals. There is no cure but for nearly all its victims no symptoms either. Only people already weakened by disease, surgery or age are under threat; and for them the effects may be fatal. Pregnant women, too, are at risk, as their baby's eyesight or hearing may be affected by the invader. Fortunately, only one in 1,000 infants is born with any signs of damage, although more are at risk of eye infections later in life. Toxoplasma is a cunning little beast. It enters certain cells in the immune system and directs them to move to the brain. There, it is safe from antibodies and even uses human immune signals to put itself to sleep and out of harm's way. Like many parasites it needs a third party to complete its life cycle, for our friend the Toxoplasma needs our companion the cat in order to have sex (a tiger or lion also does the job, if one is available). © Copyright of Telegraph Group Limited 2006.

Keyword: Emotions
Link ID: 9077 - Posted: 06.24.2010

Brittleness is often seen as a sign of fragility. But in the case of infectious proteins called prions, brittleness makes for a tougher, more menacing pathogen. Howard Hughes Medical Institute researcher have discovered that brittle prion particles break more readily into new "seeds," which spread infection much more quickly. The discovery boosts basic understanding of prion infections, and could provide scientists with new ideas for designing drugs that discourage or prevent prion seeding, said the study's senior author Jonathan Weissman, a Howard Hughes Medical Institute investigator at the University of California, San Francisco (UCSF). Weissman and colleagues from UCSF reported their findings on June 28, 2006, in an advance online publication in Nature. The scientists studied yeast prions, which are similar to mammalian prions in that they act as infectious proteins. In recent years, mammalian prions have gained increasing notoriety for their roles in such fatal brain-destroying human diseases as Creutzfeldt-Jakob disease and kuru, and in the animal diseases, bovine spongiform encephalopathy ("mad cow" disease) and scrapie.

Keyword: Prions
Link ID: 9076 - Posted: 06.29.2006

A man's sexual orientation may be determined by conditions in the womb, according to a study. Previous research had revealed the more older brothers a boy has, the more likely he is to be gay, but the reason for this phenomenon was unknown. But a Canadian study has shown that the effect is most likely down to biological rather than social factors. The research is published in the journal of the Proceedings of the National Academy of Sciences. Professor Anthony Bogaert from Brock University in Ontario, Canada, studied 944 heterosexual and homosexual men with either "biological" brothers, in this case those who share the same mother, or "non-biological" brothers, that is, adopted, step or half siblings. He found the link between the number of older brothers and homosexuality only existed when the siblings shared the same mother. The amount of time the individual spent being raised with older brothers did not affect their sexual orientation. Writing in the journal, Professor Bogaert said: "If rearing or social factors associated with older male siblings underlies the fraternal birth-order effect [the link between the number of older brothers and male homosexuality], then the number of non-biological older brothers should predict men's sexual orientation, but they do not. "These results support a prenatal origin to sexual orientation development in men." He suggests the effect is probably the result of a "maternal memory" in the womb for male births. (C) BBC

Keyword: Sexual Behavior
Link ID: 9075 - Posted: 06.28.2006

By Marc Kaufman Secondhand smoke dramatically increases the risk of heart disease and lung cancer in nonsmokers and can be controlled only by making indoor spaces smoke-free, according to a comprehensive report issued yesterday by U.S. Surgeon General Richard H. Carmona. "The health effects of secondhand smoke exposure are more pervasive than we previously thought," Carmona said. "The scientific evidence is now indisputable: Secondhand smoke is not a mere annoyance. It is a serious health hazard that can lead to disease and premature death in children and nonsmoking adults." According to the report, the government's most detailed statement ever on secondhand smoke, exposure to smoke at home or work increases the nonsmokers' risk of developing heart disease by 25 to 30 percent and lung cancer by 20 to 30 percent. It is especially dangerous for children living with smokers and is known to cause sudden infant death syndrome, respiratory problems, ear infections and asthma attacks in infants and children. The report -- which was applauded and embraced by public-health and tobacco-control advocates -- found that nearly half of all nonsmoking Americans are still regularly exposed to smoke from others. It concludes that any exposure to secondhand smoke is a risk to nonsmokers, and as a result the only way to protect nonsmokers is to eliminate indoor smoking. © 2006 The Washington Post Company

Keyword: Drug Abuse
Link ID: 9074 - Posted: 06.24.2010

The earliest indictor yet of autism may be the presence of flawed cells in the placenta, scientists have discovered. The findings could lead to earlier diagnosis of the developmental disorder that affects approximately one in every 200 children and can result in learning difficulties, speech problems and difficulty relating to people. "The earlier we diagnose it, the more we'll understand the disease and the better and more potent our interventions may be," says research scientist Harvey Kliman of the Yale School of Medicine. Kliman and his team report their finding in the June 26 online issue of Biological Psychiatry. The research builds on Kliman's previous work, which described abnormal, microscopic pits in the skin of the placenta. In the past, these abnormalities have been linked with a long list of genetic defects, including Down's syndrome and Turner's syndrome. Kliman suspected that they may also be linked to autism. So in this study, he and other researchers at Yale used a microscope to examine tissue samples acquired from placenta saved by various research hospitals. Thirteen of the samples came from children later diagnosed with a form of autism; 61 samples came from children who were not diagnosed with the disease. When Kliman compared the two different kinds of tissue, he found that the placentas from the autistic children were three times more likely to have the abnormal microscopic pits. © 1996-2006 Scientific American, Inc.

Keyword: Autism
Link ID: 9073 - Posted: 06.24.2010

A protein associated with a disorder that causes deafness and blindness in people may be a key to unraveling one of the foremost mysteries of how we hear, says a study in the June 28 issue of the Journal of Neuroscience. Scientists with the National Institute on Deafness and Other Communication Disorders (NIDCD), one of the National Institutes of Health (NIH), and the University of Sussex, Brighton, United Kingdom, have identified protocadherin-15 as a likely player in the moment-of-truth reaction in which sound is converted into electrical signals. (Protocadherin-15 is a protein made by a gene that causes one form of type 1 Usher syndrome, the most common cause of deaf-blindness in humans.) The findings will not only provide insight into how hearing takes place at the molecular level, but also may help us figure out why some people temporarily lose their hearing after being exposed to loud noise, only to regain it a day or two later. “These findings offer a more precise picture of the complicated processes involved with our sense of hearing,” says Elias A. Zerhouni, M.D., director of the NIH. “With roughly 15 percent of American adults reporting some degree of hearing loss, it is increasingly vital that we continue making inroads into our understanding of these processes, helping us seek new and better treatments, and opening the doors to better hearing health for Americans.” Researchers have long known that hair cells, small sensory cells in the inner ear, convert sound energy into electrical signals that travel to the brain, a process called mechanotransduction. However, the closer one zooms in on the structures involved, the murkier our understanding becomes. When fluid in the inner ear is set into motion by vibrations emanating from the bones of the middle ear, the rippling effect causes bristly structures atop the hair cells to bump up against an overlying membrane and to deflect.

Keyword: Hearing; Vision
Link ID: 9072 - Posted: 06.24.2010

Lindsey Tanner, Associated Press — A study found that in a disturbing number of cases, embarrassing "senior moments" such as forgetting a recent conversation or drawing a blank on someone's name may really be a sign of Alzheimer's after all. Chicago scientists reached that conclusion after autopsies on the brains of 134 older people who had appeared to be mentally normal, apart from some subtle forgetfulness. Occasional forgetfulness is often written off as a normal part of growing old and nothing to get alarmed about. And in most cases, that is probably true. But the scientists found to their surprise that the brains of more than one-third of the participants were riddled with waxy protein clumps and other signs of degeneration that are hallmarks of Alzheimer's disease. The study "questions the acceptability of minor episodic memory loss in older adults as normal," said Dr. Carol Lippa, director of the memory disorders program at Drexel University College of Medicine in Philadelphia. She had no part in the study. The study appears in Tuesday's issue of Neurology, the American Academy of Neurology's scientific journal. © 2006 Discovery Communications Inc.

Keyword: Alzheimers; Learning & Memory
Link ID: 9071 - Posted: 06.24.2010

RICHLAND, Wash.--Parkinson's, Alzheimer's, Lou Gehrig's disease and other brain disorders are among a growing list of maladies attributed to oxidative stress, the cell damage caused during metabolism when the oxygen in the body assumes ever more chemically reactive forms. But the precise connection between oxidation and neurodegenerative diseases has eluded researchers. Now, a study by the Department of Energy's Pacific Northwest National Laboratory and UCLA's David Geffen School of Medicine reveals that damage is linked to a natural byproduct of oxidation called nitration. "We looked at a healthy brain and found nitration of proteins that are implicated in neurodegenerative disease," said Colette Sacksteder, PNNL scientist and lead author of the study, published in the July issue of the journal Biochemistry (online Wed., June 28). PNNL scientist Wei-Jun Qian was co-lead author. The results are from the most detailed proteomic analysis of a mammalian brain to date – that is, a survey of nearly 8,000 different, detectable proteins in the mouse brain. The research suggests that many neurodegenerative diseases leave a biochemical calling card, or biomarker, that could be used to predict the earliest stages of brain impairment. Many biomedical researchers believe that detecting disease states before symptoms occur is the key to reversing many as-yet-incurable diseases.

Keyword: Parkinsons
Link ID: 9070 - Posted: 06.24.2010

By Daniel Stark I am by nature impulsive. I was in the Virgin Islands on vacation with my daughter when I decided to have brain surgery. Being in such a heavenly place made me both optimistic about what life could be and intolerant of how Parkinson's disease was slowly eliminating my ability to enjoy it. When I returned home, I called my neurologist and told her I wanted to have deep brain stimulation, or DBS. DBS involves the implantation of electrodes into very specific areas of the brain. When connected to a power unit and to controllers implanted in the chest, the electrodes deliver signals that interfere with the Parkinson's-induced signals from the brain, reducing or at least temporarily eliminating the quaking, quivering, rigidity and slowness that characterize the disease. The device can be set in so many permutations that it takes weeks or months to program it correctly. Set the voltages too high, and your hands or feet feel electrified; too low, and you need to supplement them with more medication. "Just right" is supposed to feel pretty good. The benefit of the procedure lies in its ability to intervene electrically rather than chemically. As Parkinson's advances, the medication one needs increases to the point where the patient faces an unwelcome choice: Either take enough and deal with the shaking and gyrating movements the medication causes, or reduce the dosage and allow the Parkinson's symptoms, which can be similar to those side effects of the drugs, to take over your body. As time passes, your body veers between being difficult to move and moving uncontrollably, with less and less time in the comfort zone between. © 2006 The Washington Post Company

Keyword: Parkinsons
Link ID: 9069 - Posted: 06.24.2010

By Sandra G. Boodman Young children who stutter may be more emotionally sensitive and have greater difficulty regulating their feelings than children who don't have the common speech problem, according to a new study by Vanderbilt University researchers. Some experts say the finding may offer new clues to treating the frustrating and sometimes disabling disorder. Stuttering, characterized by the repetition or prolongation of words or the inability to start saying a word, affects about 3 million Americans and usually surfaces between the ages of 2 and 5. For reasons that are not well understood, the problem usually disappears by late childhood, especially in those who begin stuttering before their third birthdays. But in other cases, stuttering can persist into adulthood, causing serious social problems. There is no cure for stuttering; the most effective treatment involves speech therapy, which can last a few sessions or for years, depending on the severity and duration of the problem. Early intervention is believed to shorten both. Unlike some other speech problems, stuttering often waxes and wanes and can worsen in certain situations, such as public speaking. Scientists believe that the speech problem has a strong genetic component -- about 60 percent of stutterers have an affected family member -- and that it is three or four times more common in males. Those affected include actors James Earl Jones, Marilyn Monroe, Bruce Willis and Nicholas Brendon, singer Carly Simon, author John Updike, Rep. Frank Wolf (R-Va.), basketball star Kenyon Martin and basketball Hall of Famer Bill Walton, according to the nonprofit Stuttering Foundation, an advocacy group. © 2006 The Washington Post Company

Keyword: Language
Link ID: 9068 - Posted: 06.24.2010

Sabin Russell, Chronicle Medical Writer A boy's chances of growing up gay increase with the number of older brothers he has, and the Canadian researcher who spotted the trend a decade ago now believes he is closer to explaining why: It all starts in the womb. Brock University psychologist Anthony Bogaert first reported in 1996 the startling finding that a boy's probability of growing up gay increases by about one-third with each older brother in his family. It's a subtle phenomenon -- nearly all boys even in large families still grow up straight -- but subsequent research has affirmed that the "fraternal birth order effect" is real. Since that discovery, researchers have been trying to figure out what might explain it. The most likely answer, they thought, had something to do with how younger brothers are raised -- perhaps having many older brothers drives the youngest to adopt a different sex role. But in a study released Monday by the journal Proceedings of the National Academy of Sciences, Bogaert unearthed another surprise. The sexual orientation of younger brothers appears to be established before birth. "These results provide evidence that a prenatal mechanism ... affects men's sexual orientation development,'' he wrote. Bogaert came to his latest conclusion in a study involving the birth order and family history of 944 men -- about half identifying as straight and the other half gay or bisexual. ©2006 San Francisco Chronicle

Keyword: Sexual Behavior; Development of the Brain
Link ID: 9067 - Posted: 06.24.2010