Mark Peplow A miniature chemistry set the size of a penny looks set to deliver faster, cheaper imaging agents for positron emission tomography (PET) scans, which are used to see inside patients' bodies. The microfluidic chip uses a tiny network of channels to shuttle chemicals around, and has valves and purification filters to perform a sequence of chemical steps. The result can produce a chemical that is crucial for PET scans much more quickly and with fewer reagents than a standard lab. This should make scans simpler and cheaper for hospitals. Microreactors are not a new idea, and are increasingly being used in research laboratories. But many rely on a continuous flow of material from one end of a miniature pipe to the other, without valves and filters. These continuous flow reactors are plagued by cross-contamination of reagents from different chemical steps, says Hsian-Rong Tseng, a pharmacologist at the University of California, Los Angeles, and part of the team that developed the device. This is a significant barrier to using such chips to make pharmaceuticals or other complex chemicals, he says. The valve-based chip is so versatile that it could become one of the first microreactors in widespread use outside the research lab, says Tseng. ©2005 Nature Publishing Group

Keyword: Brain imaging
Link ID: 8316 - Posted: 06.24.2010

When your host offers you red or white wine at her annual holiday party this year, there may be a good reason to choose red. In a series of laboratory tests, researchers in New York found new evidence that an antioxidant found in red wine, called resveratrol, helps clear away the basic building blocks of Alzheimer plaques. The finding, published in the Journal of Biological Chemistry, contributes to the growing body of research that suggests moderate red wine consumption may help prevent a number of diseases, including age-related dementias, heart disease, and cancer. The researchers, led by neurobiologists Philippe Marambaud and Peter Davies, say their study also identifies a previously unknown chemical pathway that may one day be tapped to design new drugs to fight Alzheimer's disease. "This is potentially a protective [compound], a compound that we could give you at age 40 or 50, whatever age you'd like to start, to protect against the development of Alzheimer's disease," says professor Davies from the Albert Einstein College of Medicine, who was the senior author on the paper. The researchers tested several different antioxidants on cells filled with amyloid peptides. © ScienCentral, 2000-2005

Keyword: Alzheimers
Link ID: 8315 - Posted: 06.24.2010

By Mary Beckman SAN FRANCISCO, CALIFORNIA--Some cancers keep to themselves as compact tumors while others aren't content until they've spread through the body. What makes one more aggressive than the other? One explanation, according to new research, is the presence of a protein normally found in neurons. Experts say the work may offer a new target in the fight against colon and other types of cancers. As cells become cancerous, they produce more of a protein called b-catenin. The protein acts like a molecular switch, turning specific genes on and off. Reasoning that b-catenin might turn on other genes that help cancers along, such as those that make them spread, cancer biologists Avri Ben-Ze'ev and Nancy Gavert of the Weizman Institute of Science in Israel and colleagues set about looking for such genes. Colleagues of Ben-Ze'ev had examined the effect of turning off b-catenin on other, unrelated functions within cells. In the current study, they scanned some of the genes involved in these processes and found a gene called L1CAM, whose protein is well-known to wire nerve cells together. To determine whether L1CAM has a role in cancer, the researchers looked for its protein in normal skin cells, cultured noncancerous cells, and aggressive melanomas from 11 patients. While the normal cells contained no L1CAM protein, the cancers harbored quite a lot. When the team blocked the activity of L1CAM in cultured human colon cancer cells, the cells' growth slowed dramatically. © 2005 American Association for the Advancement of Science.

Keyword: Genes & Behavior; Development of the Brain
Link ID: 8314 - Posted: 06.24.2010

by MELISSA CALHOUN ATHENS, Ohio -- Bats have an “ear” for flying in the dark because of a remarkable auditory talent that allows them to determine their physical environment by listening to echoes. But an Ohio University neurobiology professor says bats have a “feel” for it, too. John Zook’s studies of bat flight suggest that touch-sensitive receptors on bats’ wings help them maintain altitude and catch insects in midair. His preliminary findings, presented at the recent Society for Neuroscience meeting, revive part of a long-forgotten theory that bats use their sense of touch for nighttime navigation and hunting. The theory that bats fly by feel was first proposed in the 1780s by French biologist Georges Cuvier, but faded in the 1930s when researchers discovered echolocation, a kind of biological sonar found in bats, dolphins and a few other animals. Bats use echolocation to identify and navigate their environment by emitting calls and listening to the echoes that return from various objects. Zook believes the touch-sensitive receptors on bats’ wings work in conjunction with echolocation to make bats better, more accurate nocturnal hunters. Echolocation helps bats detect their surroundings, while the touch-sensitive receptors help them maintain their flight path and snag their prey. © 2005 Ohio University.

Keyword: Pain & Touch
Link ID: 8313 - Posted: 06.24.2010

Scientists have managed to protect and regenerate the part of the brain that is damaged in Parkinson’s disease, by genetically engineering cells to bypass the blood-brain barrier. The study was conducted in animals, but the approach could one day be used to treat brain conditions in humans, the researchers say. The blood-brain barrier protects the brain from harmful substances, but also prevents drugs from entering, so experimental treatments have involved injecting drugs directly into the brain. Now Clive Svensden at the University of Wisconsin-Madison, US, and colleagues have devised an alternative – implanting cells that act as a Trojan horse, churning out the drug from inside the brain’s fortress. The team took human neural progenitor cells (hNPCs) from fetal tissue at 10 to 15 weeks’ gestation. These have a lot in common with stem cells, though they have already differentiated into specific neural cells. The researchers genetically modified the cells to produce a growth molecule called glial cell line-derived neurotrophic factor (GDNF). This is produced naturally by the brain at around eight weeks’ gestation in humans, but by 20 weeks it has all gone. Previous studies show that GDNF increases the survival and function of dopamine-producing cells, which are progressively destroyed in Parkinson’s disease. © Copyright Reed Business Information Ltd.

Keyword: Stem Cells; Parkinsons
Link ID: 8312 - Posted: 06.24.2010

Will the 3-hour special-effects-loaded remake of King Kong be a box office smash or a complete turkey? For movie producers, getting such questions right can be worth millions, and now they have a computer system to help them work it out before a film is even made. The idea comes from Ramesh Sharda, an information scientist at Oklahoma State University in Stillwater, who has trained an artificial neural network to recognise what makes a successful movie (Expert Systems with Applications, vol 30, p 243). Using data on 834 movies released between 1998 and 2002, Sharda found that the neural network can judge a film based on seven key parameters: the "star value" of the cast, the movie's age rating, the time of release against that of competitive movies, the film's genre, the degree of special effects used, whether it is a sequel or not, and the number of screens it is expected to open in. This allowed it to place a movie in one of nine categories, ranging from "flop" (total takings less than $1 million) to "blockbuster" (over $200 million). The system cannot take into account the intricacies of the plot, but Sharda says it can nonetheless get the revenue category spot-on 37 per cent of the time, and correct to within one category either side 75 per cent of the time. This is enough to make the system a "powerful decision aid", Sharda says. © Copyright Reed Business Information Ltd.

Keyword: Learning & Memory
Link ID: 8311 - Posted: 06.24.2010

Usually squids simply drop their eggs on the sea floor and leave them to survive on their own, although some species of octopus are known to guard their clutch. But scientists captured on film the parental care lavished by Gonatus onyx on its eggs. Biologist Brad Seibel, now at the University of Rhode Island, US, suspected that Gonatus onyx might do more than most for its offspring when in 1995 he and colleagues dredged up both an adult and a separate egg sac in the same net while probing the seas. A year later, he captured another adult and many baby squids in the same net, which led him and colleagues to hypothesise that the squid might be brooding its eggs until hatching. “But without direct observations, there were many that were sceptical,” he told New Scientist. Working with Bruce Robison and Steven Haddock at the Monterey Bay Aquarium Research Institute in California, US, Seibel has now captured images of the protective parent by delving to depths of 2500 metres in a submersible. You can view a video of the squid hatching its young by clicking here (mpg format, 6MB), and see the squid with its cumbersome egg sac fleeing from the submersible here (mpg format, 6MB). © Copyright Reed Business Information Ltd.

Keyword: Sexual Behavior
Link ID: 8310 - Posted: 06.24.2010

Carl T. Hall, Chronicle Science Writer Researchers in San Diego have designed mice containing fully functional human nerve cells as a novel way to study and potentially treat neurodegenerative diseases such as Parkinson's and Alzheimer's. The neurons were formed in the brains of mice that had been injected with human embryonic stem cells as 2-week-old embryos. Studies at the Salk Institute for Biological Sciences in La Jolla showed that the human cells migrated throughout the mouse brain and took on the traits of their mouse-cell neighbors. The results present direct evidence that primitive human stem cells can be cultured in the lab, be injected into an animal, and then develop into a particular type of desired cell. The report appears in this week's Proceedings of the National Academy of Sciences. Scientists said it was the first time cultured human embryonic stem cells have been shown to develop into a particular type of cell in the body of another living species. Creation of a so-called "mouse-human chimeric nervous system" stops well short of spawning a mouse with a human-like cerebral cortex. In fact, all the brain structures of the four mice used in the Salk experiments had been formed before the human cells were injected, and less than 0.1 percent of the mice brain cells were found to be of human origin. ©2005 San Francisco Chronicle

Keyword: Stem Cells; Parkinsons
Link ID: 8309 - Posted: 06.24.2010

A new study designed to test whether androgenic-anabolic steroids may be addictive found that hamsters exposed to the compounds demonstrated addictive behavior over time. The research, conducted by the University of Southern California's Keck School of Medicine was released at the American College of Neuropsychopharmacology's (ACNP) annual conference. "Most people use anabolic steroids to enhance their physical performance, but they deny that steroids may be addictive," noted lead researcher Ruth Wood, PhD, Professor of Cell and Neurobiology at USC. "Unlike other commonly abused drugs, the primary motivation for steroid users is not to get high, but rather to achieve enhanced athletic performance and increased muscle mass. The complex motivation for steroid use makes it difficult to determine the addictive properties of anabolic steroids in humans. Our goal was to create an experimental model of addiction where athletic performance and other reinforcing effects are irrelevant." Wood's study is among the first to examine the potential for anabolic steroid addiction. The research was modeled after well-established methods used to study highly addictive drugs, such as cocaine and heroin. Hamsters were implanted with small cannulas for self-administration of commonly abused steroids into their brains. The animals then spent four hours per day in a chamber with access to two delivery mechanisms. When the hamster operated the active mechanism, he received 1 microgram of testosterone, or one of several commonly abused steroids: nandrolone, drostanolone, stanozolol, or oxymetholone. The inactive mechanism produced no response. A computer recorded the number of times each animal used the active and inactive delivery mechanisms. Overall, the animals showed a marked preference for testosterone, nandrolone or drostanolone, engaging the active delivery mechanism twice as often as the control.

Keyword: Drug Abuse; Hormones & Behavior
Link ID: 8308 - Posted: 12.14.2005

Researchers have discovered a new drug that raises the level of endocannabinoids--the 'brain's own cannabis'--providing anti-depressant effects. The new research published in this week's Proceedings of the National Academy of Sciences (PNAS), suggests the new drug, called URB597, could represent a safer alternative to cannabis for the treatment of pain and depression, and open the door to new and improved treatments for clinical depression--a condition that affects around 20% of Canadians. In preclinical laboratory tests researchers found that URB597 increased the production of endocannabinoids by blocking their degradation, resulting in measurable antidepressant effects. "This is the first time it has been shown that a drug that increases endocannabinoids in the brain can improve your mood," says the lead investigator Dr. Gabriella Gobbi, an MUHC and Université de Montréal researcher. Endocannabinoids are chemicals released by the brain under certain conditions, like exercise; they stimulate specific brain receptors that can trigger feelings of well-being. The researchers, which included scientists from the University of California at Irvine, were able to measure serotonin and noradrenaline activity as a result of the increased endocannabinoids, and also conducted standard experiments to gauge the 'mood' of their subjects and confirm their findings.

Keyword: Depression; Drug Abuse
Link ID: 8307 - Posted: 12.14.2005

By Sally Squires Washington Post Staff Writer If you haven't heard of hoodia or green tea extract, you haven't been checking your e-mail or spending much time on the Web. Since the Food and Drug Administration (FDA) last year banned ephedra, the long-standing leader among supplements promoted to help people lose weight, hoodia and green tree extract have taken a high profile among the products being offered to fill the void. E-mail blasts promoting them are sent to millions of addresses, and Web sites promoting them are ubiquitous online. With two-thirds of U.S. adults overweight or obese and many of them unhappy about it, Americans' hunger for diet supplements is nothing new. Neither is the fact that little science has been done to prove that heavily promoted products are effective or even safe. Still, sales are huge. These herbal products offer the promise of a natural remedy for weight loss, and they're available without a prescription. Together, over-the-counter weight loss products -- which also include bitter orange, chitosan, guar gum, L-carnitine and dozens more -- account for nearly $2 billion in annual sales in the United States, according to the Nutrition Business Journal. Even ephedra, banned last year by the FDA after its use was linked to several deaths, is creeping back on the market, thanks to a federal court decision that opened a legal crack to manufacturers. © 2005 The Washington Post Company

Keyword: Obesity
Link ID: 8306 - Posted: 06.24.2010

By CARL ZIMMER I drove into New Haven on a recent morning with a burning question on my mind. How did my daughter do against the chimpanzees? A month before, I had found a letter in the cubby of my daughter Charlotte at her preschool. It was from a graduate student at Yale asking for volunteers for a psychological study. The student, Derek Lyons, wanted to observe how 3- and 4-year-olds learn. I was curious, so I got in touch. Mr. Lyons explained how his study might shed light on human evolution. His study would build on a paper published in the July issue of the journal Animal Cognition by Victoria Horner and Andrew Whiten, two psychologists at the University of St. Andrews in Scotland. Dr. Horner and Dr. Whiten described the way they showed young chimps how to retrieve food from a box. The box was painted black and had a door on one side and a bolt running across the top. The food was hidden in a tube behind the door. When they showed the chimpanzees how to retrieve the food, the researchers added some unnecessary steps. Before they opened the door, they pulled back the bolt and tapped the top of the box with a stick. Only after they had pushed the bolt back in place did they finally open the door and fish out the food. Copyright 2005The New York Times Company

Keyword: Learning & Memory; Development of the Brain
Link ID: 8305 - Posted: 12.13.2005

By WILLIAM J. BROAD For centuries, the tusk of the narwhal has fascinated and baffled. Narwhal tusks, up to nine feet long, were sold as unicorn horns in ages past, often for many times their weight in gold since they were said to possess magic powers. In the 16th century, Queen Elizabeth received a tusk valued at £10,000 - the cost of a castle. Austrian lore holds that Kaiser Karl the Fifth paid off a large national debt with two tusks. In Vienna, the Hapsburgs had one made into a scepter heavy with diamonds, rubies, sapphires and emeralds. Scientists have long tried to explain why a stocky whale that lives in arctic waters, feeding on cod and other creatures that flourish amid the pack ice, should wield such a long tusk. The theories about how the narwhal uses the tusk have included breaking ice, spearing fish, piercing ships, transmitting sound, shedding excess body heat, poking the seabed for food, wooing females, defending baby narwhals and establishing dominance in social hierarchies. But a team of scientists from Harvard and the National Institute of Standards and Technology has now made a startling discovery: the tusk, it turns out, forms a sensory organ of exceptional size and sensitivity, making the living appendage one of the planet's most remarkable, and one that in some ways outdoes its own mythology. The find came when the team turned an electron microscope on the tusk's material and found new subtleties of dental anatomy. The close-ups showed that 10 million nerve endings tunnel from the tusk's core toward its outer surface, communicating with the outside world. The scientists say the nerves can detect subtle changes of temperature, pressure, particle gradients and probably much else, giving the animal unique insights. Copyright 2005 The New York Times Company

Keyword: Pain & Touch
Link ID: 8304 - Posted: 12.13.2005

Working with mice, University of Wisconsin-Madison researchers have developed the basis for a therapeutic strategy that could provide hope for children afflicted with Krabbe's disease, a fatal nervous system disorder. Writing this week (Dec. 12, 2005) in the Proceedings of the National Academy of Sciences (PNAS), a team of researchers at the UW-Madison School of Veterinary Medicine describes experiments that effectively promoted the ability of defective cells to take up and utilize an enzyme that is essential for the maintenance of a critical sheathing of nerve fibers. The work centers on devising strategies to treat inherited diseases of the nervous system in which cells fail to maintain myelin, a protective sheathing that envelops nerve fibers and acts like the insulation on an electric wire. Myelin ensures the effective transmission of the signals routinely conducted by the nervous system. For those afflicted with Krabbe's disease, the loss of myelin results in arrested motor and mental development, seizures, paralysis and, ultimately, death. The Wisconsin experiments, led by Ian Duncan, a UW-Madison professor of medical sciences who is an expert on diseases of myelin, explored how cells obtained from a mouse model of Krabbe's disease could be reinvigorated by replacing a missing enzyme, and thus allow the healthy maintenance of myelin.

Keyword: Development of the Brain
Link ID: 8303 - Posted: 12.13.2005

DURHAM, N.C. -- Researchers have discovered the first brain regulatory gene that shows clear evidence of evolution from lower primates to humans. They said the evolution of humans might well have depended in part on hyperactivation of the gene, called prodynorphin (PDYN), that plays critical roles in regulating perception, behavior and memory. They reported that, compared to lower primates, humans possess a distinctive variant in a regulatory segment of the prodynorphin gene, which is a precursor molecule for a range of regulatory proteins called "neuropeptides." This variant increases the amount of prodynorphin produced in the brain. While the researchers do not understand the physiological implications of the activated PDYN gene in humans, they said their finding offers an important and intriguing piece of a puzzle of the mechanism by which humans evolved from lower primates. They also said that the discovery of this first evolutionarily selected gene is likely only the beginning of a new pathway of exploring how the pressure of natural selection influenced evolution of other genes. They also said their finding demonstrates how evolution can act more efficiently to alter the regulatory segments, or "promoters," that determine genes' activity, rather than on the gene segment that determines the structure of the protein it produces. Such regulatory alteration, they said, can more readily generate variability than the hit-or-miss mutations that alter protein structure and function.

Keyword: Evolution; Development of the Brain
Link ID: 8302 - Posted: 12.13.2005

CHICAGO – Testosterone replacement therapy may help improve the quality of life for elderly men with mild cases of Alzheimer's disease, according to a study posted online today that will appear in the February 2006 print issue of Archives of Neurology, one of the JAMA/Archives journals. "There is a compelling need for therapies that prevent, defer the onset, slow the progression, or improve the symptoms of Alzheimer disease (AD)," the authors provide as background information in the article. They note that hormonal therapies have been the focus of research attention in recent years since male aging is associated with a gradual progressive decline in testosterone levels. "The gradual decline in testosterone level is associated with decreased muscle mass and strength, osteoporosis, decreased libido, mood alterations, and changes in cognition, conditions that may be reversed with testosterone replacement." The authors add that the age-related decline in testosterone is potentially relevant to AD as previous studies have found significantly lower concentrations of the hormone in middle-aged and elderly men who developed AD. Po H. Lu, Psy.D., from the David Geffen School of Medicine, University of California, Los Angeles, and colleagues conducted a 24-week, randomized study to evaluate the effects of testosterone therapy on cognition, neuropsychiatric symptoms, and quality of life in 16 male patients with mild AD and 22 healthy elderly men who served as controls. The study participants were randomized to receive packets of gel to apply on their skin that either contained testosterone or a placebo. Standardized tests were administered at least twice (baseline and end) during the study for the assessment of cognitive functions and quality of life.

Keyword: Alzheimers; Hormones & Behavior
Link ID: 8301 - Posted: 06.24.2010

Depression and anxiety are common problems for people whose epilepsy cannot be controlled by medication. A new study found that depression and anxiety improve significantly after epilepsy surgery. The study, which is published in the December 13, 2005, issue of Neurology, the scientific journal of the American Academy of Neurology, found that the rate of depression and anxiety disorders decreased by more than 50 percent up to two years after the surgery. People who no longer experienced any seizures after surgery were even more likely to be free of depression and anxiety. "These results are important because depression and anxiety can significantly affect the quality of life," said study author Orrin Devinsky, MD, Professor of Neurology, Neurosurgery, and Psychiatry at New York University School of Medicine and Director of the NYU Comprehensive Epilepsy Center. "For people with refractory epilepsy, studies show that depression is more likely to affect their quality of life than how often they have seizures or how many drugs they have to take." The study involved 360 people in seven U.S. epilepsy centers who were undergoing epilepsy surgery to remove the area of the brain producing the seizures. Epilepsy surgery is generally reserved for those whose seizures cannot be adequately controlled by medication. The majority of participants had surgery on the brain's temporal lobe. The participants' mental health and any symptoms of depression and anxiety were evaluated before surgery and at three months, one year, and two years after surgery.

Keyword: Epilepsy; Depression
Link ID: 8300 - Posted: 12.13.2005

Roxanne Khamsi Eye cells transplanted into the brain have mitigated the symptoms of Parkinson's disease in a preliminary trial involving six patients. The findings of the small study suggest that injections of such cells can partly reverse the motion difficulties associated with the illness. The eye cells seem to produce a natural form of a drug that is frequently given to patients, but release it in a steady, even flow that prevents some of the nasty side-effects of the medicine. Parkinson's disease is a debilitating neurological disorder thought to affect brain cells' ability to produce the powerful cell-signalling molecule dopamine. For the past three decades, patients with this disorder have typically received a medication called levodopa (L-DOPA), which replaces lost dopamine. Doses of L-DOPA help to alleviate some of the symptoms of Parkinson's disease, which include tremor, muscle rigidity and slowed motion. But only for a while. Over time, patients respond less and less to L-DOPA. But upping the dosage can lead to a side-effect known as dyskinesias: involuntary movements resulting in fragmented or jerky motions. ©2005 Nature Publishing Group

Keyword: Parkinsons
Link ID: 8299 - Posted: 06.24.2010

Andreas von Bubnoff Researchers have managed to teach people suffering chronic pain to reduce their own discomfort simply by controlling their thoughts. It's unclear how long the effect lasts, but the researchers hope that this approach could one day be used to treat chronic pain, which affects tens of millions of people in the United States alone and is a major reason for sick leave. The team, led by Christopher deCharms, showed eight patients real-time functional magnetic resonance imaging, or fMRI, of the activity in their rostral anterior cingulate cortex (rACC), a part of the brain known to be involved with pain control. They asked participants to try to increase or decrease activity in this area, by focusing on their pain or by distracting themselves from it. After only a few training sessions, most patients could reduce the activity in their rACC on command. These patients said that their pain lessened by about 50%, the researchers report this week in the Proceedings of the National Academies of Sciences1. The method also worked with healthy people involved in the study who were given painful stimuli to their hands and asked to try and control their response. ©2005 Nature Publishing Group

Keyword: Pain & Touch
Link ID: 8298 - Posted: 06.24.2010

A brain mechanism that may link violent computer games with aggression has been discovered by researchers in the US. The work goes some way towards demonstrating a causal link between the two - rather than a simple association. Many studies have concluded that people who play violent video games are more aggressive, more likely to commit violent crimes, and less likely to help others. But critics argue these correlations merely prove that violent people gravitate towards violent games, not that games can change behaviour. Now psychologist Bruce Bartholow from the University of Missouri-Columbia and colleagues have found that people who play violent video games show diminished brain responses to images of real-life violence, such as gun attacks, but not to other emotionally disturbing pictures, such as those of dead animals, or sick children. And the reduction in response is correlated with aggressive behaviour. The brain activity they measured, called the P300 response, is a characteristic signal seen in an EEG (electroencephalogram) recording of brain waves as we register an image. The P300 reflects an evaluation of the emotional content of an image says Bartholow, being larger if people are surprised or disturbed by an image, or if something is novel. © Copyright Reed Business Information Ltd.

Keyword: Aggression; Emotions
Link ID: 8297 - Posted: 06.24.2010