By John Horgan Which is more fundamental, mind or matter? You would think, in our ultra-materialistic era, that debate would be settled. But a surprising number of philosophers and scientists still resist the idea that mind is a mere afterthought of matter. One is Bernardo Kastrup, a computer engineer and author of several books, including Why Materialism Is Baloney. In “Should Quantum Anomalies Make Us Rethink Reality?”, recently posted by Scientific American, Kastrup contends that quantum mechanics—as well as cognitive science, which suggests that minds construct rather than passively mirroring reality--undermines the assumption that the physical world exists independently of our observations. He calls for a new paradigm that makes mind “the essence—cognitively but also physically—of what we perceive when we look at the world around ourselves.” On Twitter, physicist Sean Carroll slammed Kastrup’s “bad article on quantum mechanics,” and science journalist Michael Moyer called it “voodoo.” That’s a bit harsh. Kastrup’s interpretation of quantum mechanics reminds me of that of the great physicist John Wheeler. Decades ago, Wheeler pointed out deep resonances between quantum mechanics and information theory. An electron behaves like a particle or a wave depending on how we interrogate it. Information theory, similarly, posits that all messages can be reduced to “binary units,” or bits, which are answers to yes or no questions. © 2018 Scientific American

Keyword: Consciousness
Link ID: 24949 - Posted: 05.07.2018

By Aaron E. Carroll The benefits and harms of medical marijuana can be debated, but more states are legalizing pot, even for recreational use. A new evaluation of marijuana’s risks is overdue. Last year, the National Academies of Sciences, Medicine and Engineering released a comprehensive report on cannabis use. At almost 400 pages long, it reviewed both potential benefits and harms. Let’s focus on the harms. The greatest concern with tobacco smoking is cancer, so it’s reasonable to start there with pot smoking. A 2005 systematic review in the International Journal of Cancer pooled the results of six case-control studies. No association was found between smoking marijuana and lung cancer. Another 2015 systematic review pooled nine case-control studies and could find no link to head and neck cancers. Another meta-analysis of three case-control studies of testicular cancer found a statistically significant link between heavier pot smoking and one type of testicular cancer. But this evidence was judged to be “limited” because of limitations in the research (all of which was from the 1990s). There’s no evidence, or not enough to say, of a link between pot use and esophageal cancer, prostate cancer, cervical cancer, non-Hodgkin’s lymphoma, penile cancer or bladder cancer. There’s also no evidence, or not enough to say, that pot has any effect on sperm or eggs that could increase the risk of cancer in any children of pot smokers. (Using marijuana while pregnant does pose other risks, as discussed below.) Heart disease Another major risk with cigarettes, heart disease, isn’t clearly seen with pot smoking. Only two studies quantified the risk between marijuana use and heart attacks. One found no relationship at all, and the other found that pot smoking may be a trigger for a heart attack in the hour after smoking. But this finding was based on nine patients, and may not be generalizable. © 2018 The New York Times Company

Keyword: Drug Abuse; Pain & Touch
Link ID: 24948 - Posted: 05.07.2018

Anna Gorman When 47-year-old Edward Vega arrived in jail, he couldn't quiet the voices in his head. He felt paranoid, as though he was losing control. "I knew if I didn't get my medication, I was going to hurt someone," says Vega. He was right. A week after being arrested for alleged drug possession, Vega says, he assaulted a fellow inmate and ended up in isolation, which only made him feel worse. Finally, a doctor prescribed drugs that Vega says helped. He had been taking them on the outside but ran out just before he was arrested. "The medication hasn't totally taken away the voices, but I am able to differentiate reality from fiction," says Vega, who was released three months ago. The number of inmates in California who've been prescribed psychiatric drugs has jumped about 25 percent in five years, according to a recent analysis of state data. These inmates now account for about a fifth of the county jail population across the state. The increase might be a reflection of the growing number of inmates with mental illness, though it also might stem from improved identification of people in need of treatment, say researchers from California Health Policy Strategies, a Sacramento-based consulting firm. Amid a severe shortage of psychiatric beds and community-based treatment throughout the state and nation, jails have become repositories for people in the throes of acute mental health crises. © 2018 npr

Keyword: Schizophrenia
Link ID: 24947 - Posted: 05.07.2018

By LISA SANDERS, M.D. The young woman rubbed her eyes. The numbers and letters on her computer screen jumped erratically. So did the world around her. This had happened before, but late at night when she was tired, never in the middle of the day. The light from the screen suddenly seemed too bright. And her headache, the one that was always present these days, tightened from a dull ache to a squeezing pressure on the back of her head and neck. Nearly in tears from pain and frustration, the 19-year-old called her mother. She couldn’t see; she couldn’t drive. Could her mother pick her up from work? The problems with her eyes began in grade school. Two years earlier, she nearly went blind. All she could see on the left was a rim of light. Everything else was blocked by a big black spot. And then a black dot appeared in her right eye as well. Her parents took her to see many eye doctors, only to be told that there was nothing wrong. One doctor told them that she had “emotional blindness.” The young woman’s vision somehow got a lot better on its own, and though the black dot still obstructed some of her vision, for the last eight months she’d been able to drive — so important in this small mountain town an hour north of San Diego. Now she couldn’t see for what seemed like a different reason. The young woman’s mother arranged for her to go to San Diego to see a neuro-ophthalmologist — a doctor who specializes in vision problems that originate in the brain. When they got to the office, though, the young woman’s vision and headache had returned to their imperfect but baseline state. She told the doctor that her symptoms were least intrusive in the morning; standing and walking seemed to make everything worse. Come back later, the doctor instructed. Mother and daughter walked around and shopped. When a couple of hours later the daughter’s eyes started jumping and her headache worsened, they hurried back to the office. © 2018 The New York Times Company

Keyword: Vision; Movement Disorders
Link ID: 24946 - Posted: 05.07.2018

by Erin Blakemore Want to cure Alzheimer’s? Get in line. Researchers have long been puzzled by the disease and vexed by how long it’s taking to unravel its mysteries. One group of scientists is helping speed up that process with assistance from the public. “Stall Catchers,” a game created by Cornell University’s Human Computation Institute, turns the hunt for a cure from frustrating to fun. In the game, players watch short movies — made using a multiphoton microscope — that show blood flowing through the brains of living mice. Players work on a data set of thousands of images to point out “stalls” — areas of reduced blood flow caused by white blood cells accumulating on the sides of the vessels. The films might seem far removed from the experience typical of people with Alzheimer’s disease: difficulty concentrating, jumbled speech and confusion. But they may be closely linked: It’s thought that reduced blood flow in the brain is at least partially responsible for Alzheimer’s symptoms. When a blood vessel in the brain gets stalled, blood doesn’t flow as it should. A single stalled capillary might seem like no big deal, but in mice with Alzheimer’s disease, up to 2 percent of brain capillaries can be stalled. Because vessels in the brain are so interconnected, that can restrict overall brain blood flow by up to 30 percent. Reduced blood flow has been found in the brains of humans with Alzheimer’s disease, too. © 1996-2018 The Washington Post

Keyword: Alzheimers
Link ID: 24945 - Posted: 05.07.2018

Susan Milius Pick an animal. Choose wisely because in this fantasy you’ll transform into the creature and duel against one of your own. If you care about survival, go for the muscular, multispiked stag roaring at a rival. Never, ever pick the wingless male fig wasp. Way too dangerous. This advice sounds exactly wrong. But that’s because many stereotypes of animal conflict get the real biology backward. All-out fighting to the death is the rule only for certain specialized creatures. Whether a species is bigger than a breadbox has little to do with lethal ferocity. Many creatures that routinely kill their own kind would be terrifying, if they were larger than a jelly bean. Certain male fig wasps unable to leave the fruit they hatch in have become textbook examples, says Mark Briffa, who studies animal combat. Stranded for life in one fig, these males grow “big mouthparts like a pair of scissors,” he says, and “decapitate as many other males as they possibly can.” The last he-wasp crawling has no competition to mate with all the females in his own private fruit palace. In contrast, big mammals that inspire sports-team mascots mostly use antlers, horns and other outsize male weaponry for posing, feinting and strength testing. Duels to the death are rare. |© Society for Science & the Public 2000 - 2018.

Keyword: Aggression
Link ID: 24944 - Posted: 05.05.2018

By Simon Baron-Cohen Five years ago, the American Psychiatric Association (APA) established autism spectrum disorder (ASD) as an umbrella term when it published the fifth edition of the Diagnostic and Statistical Manual (DSM-5), the primary guide to taxonomy in psychiatry. In creating this single diagnostic category, the APA also removed the subgroup called Asperger syndrome that had been in place since 1994. At the 2018 annual meeting of the International Society for Autism Research (INSAR), there will be plenty of discussion about diagnostic terminology: Despite the many advantages of a single diagnostic category, scientists will be discussing whether, to achieve greater scientific or clinical progress, we need subtypes. The APA created a single diagnostic label of ASD to recognize the important concept of the spectrum, since the way autism is manifested is highly variable. All autistic individuals share core features, including social and communication difficulties, unusually narrow interests, a strong need for repetition and, often, sensory issues. Yet these core features vary enormously in how they are manifested, and in how disabling they are. This variability provides one meaning of the term spectrum, and the single diagnostic label ASD makes space for this considerable variability. The term spectrum also refers to the heterogeneity in autism. There are huge disparities in many areas, such as language development or IQ, and in the presence or absence of co-occurring medical conditions and disabilities. This heterogeneity is also part of what is meant by a spectrum. And some autistic people also have very evident talents. This is another sense of the term spectrum, and the single diagnostic label makes room for this source of diversity, too. © 2018 Scientific America

Keyword: Autism
Link ID: 24943 - Posted: 05.05.2018

By Andrew Joseph, Researchers have been left empty-handed so far in their quest to uncover some measurable biological signal that could be used to diagnose autism spectrum disorder, leaving clinicians to identify the condition just based on a child’s behavior. But on Wednesday, scientists reported in the journal Science Translational Medicine that a hormone that regulates blood pressure could be one of those signposts. They found that low concentrations of the molecule—called arginine vasopressin, or AVP—in the cerebrospinal fluid corresponded to autism-like social behavior in male monkeys, while a high AVP concentration signaled the most social animals. And they discovered similar results when looking at AVP concentrations in the cerebrospinal fluid, or CSF, of a small group of boys. “It’s really exciting work,” said Dr. Mollie Meffert, a molecular neuroscientist at Johns Hopkins, who was not involved in the study. “One of the most interesting things is the finding that the vasopressin in the CSF correlates with sociality in the macaques and in autism with children.” Meffert said if vasopressin concentrations are confirmed to correspond to autism, they could perhaps be used to diagnose the condition and as a gauge to measure the effect of treatment candidates. And Karen Parker, the lead author of the study and associate professor of psychiatry and behavioral sciences at Stanford, said that the hormone could become a drug target if future studies show boosting its levels can assuage the social impairments of autism spectrum disorder. © 2018 Scientific American

Keyword: Autism; Hormones & Behavior
Link ID: 24942 - Posted: 05.05.2018

By Emily Underwood Getting old can be a real itch. In addition to having memory and muscle loss, many elderly people develop supersensitive skin that gets itchy at the lightest touch. Scientists don’t know what causes this miserable condition, called alloknesis, or how to treat it. Now, however, a study in mice has revealed a counterintuitive mechanism for the disorder: a loss of pressure-sensing cells in the skin. Although the findings have yet to be replicated in humans, the study raises the possibility that boosting the function of these cells could treat chronic itch in people, both young and old. Chronic itch is different from chemical itch, which occurs when the immune system reacts to a foreign substance, such as oil from a poison oak leaf or saliva in a mosquito bite. Instead, chronic—or mechanical—itch is usually triggered by light pressure, such as the brush of fibers from a sweater. The condition is maddening, and when people repeatedly scratch their fragile, dry skin, it can lead to major health problems, including infections, says study author Hongzhen Hu, an anesthesiology researcher at the Washington University School of Medicine in St. Louis, Missouri. Like people, mice visibly itch more with age. To find out why, Hu and colleagues used a hair-thin nylon filament to apply a precise amount of pressure to a patch of shaved skin on young and old rodents’ necks. Young mice didn’t respond much to the gentle touch, but the older mice scratched furiously at the spot. Analyzing skin samples from mice of both ages, the team found that older mice had far fewer pressure-sensing Merkel cells than young mice did. The fewer Merkel cells a mouse had, the more their touch-related itch problems increased in response to the filament, the researchers report today in Science. © 2018 American Association for the Advancement of Science.

Keyword: Pain & Touch; Development of the Brain
Link ID: 24941 - Posted: 05.05.2018

By Viviane Callier A human genetic variant in a gene involved in sensing cold temperatures became more common when early humans migrated out of Africa into colder climates between 20,000 and 30,000 years ago, a study published today (May 3) in PLOS Genetics shows. The advantage conferred by this variant isn’t definitively known, but the researchers suspect that it influences the gene’s expression levels, which in turn affect the degree of cold sensation. The observed pattern of positive selection strongly indicates that the allele was beneficial, but that benefit had a tradeoff—bringing with it a higher risk of getting migraines. “This paper is the latest in a series of papers showing that humans really have adapted to different environments after some of our ancestors migrated out of Africa,” explains evolutionary geneticist Rasmus Nieslen of the University of California, Berkeley, who was not involved in the study. “There are a number of adaptations associated with moving into an artic climate, but none with as clear a connection to cold as this one,” he adds. Although studies have demonstrated some striking examples of recent human adaptation, for instance, warding off infectious diseases such as malaria or having the ability to digest milk, relatively little was known about the evolutionary responses to fundamental features of the environment, namely, temperature and climate. “Obviously, humans lived in Africa for a long time, and one of the main environmental factors that changed as humans migrated north was temperature,” explains population geneticist Aida Andres. So she and Felix Key the Max Planck Institute in Leipzig homed in on a gene, TRPM8, that encodes a cation channel in the neurons that innervate the skin. It is activated by cold temperatures and necessary for sensing cold and for thermoregulation. If there was a place to look for human adaptation, this gene looked like a good candidate. © 1986-2018 The Scientist

Keyword: Pain & Touch; Evolution
Link ID: 24940 - Posted: 05.05.2018

Greg Chapman, research scientist, Boston University Twin Project Humans have succeeded as a species in large part because of our ability to cooperate and coordinate with each other. These skills are driven by a range of “moral emotions” such as guilt and empathy, which help us to navigate the nuance of social interactions appropriately. Those who lack moral emotions are classed as having “callous-unemotional” traits: persistent personality characteristics that make negotiating social situations difficult. The combination of callous-unemotional traits and antisocial behaviour in adolescents and adults is typically diagnosed as psychopathy. Moral emotions can be measured in children as young as three. Persistent personality traits aren’t measured in children this young, but recent research has begun to explore whether repeated callous-unemotional behaviours might be evident even in preschoolers. Such behaviours include parental observations that punishment doesn’t change behaviour, that the child shows little affection toward people and seems unresponsive to affection from others. At least half of children who exhibit callous-unemotional behaviours will naturally grow out of them. Only if they persist into adolescence do they become classified by psychiatrists as persistent personality traits. However, callous-unemotional behaviours in a young child in combination with other risk factors can be a warning sign for later social difficulties and behaviour disorders. For instance, callous-unemotional behaviours in early childhood have been shown to predict aggressive behaviours, attention deficit hyperactivity disorder and oppositional defiant disorder and are a risk factor for later psychopathy.

Keyword: Development of the Brain; Genes & Behavior
Link ID: 24939 - Posted: 05.05.2018

By Dana G. Smith The older you get the more difficult it is to learn to speak French like a Parisian. But no one knows exactly what the cutoff point is—at what age it becomes harder, for instance, to pick up noun-verb agreements in a new language. In one of the largest linguistics studies ever conducted—a viral internet survey that drew two thirds of a million respondents—researchers from three Boston-based universities showed children are proficient at learning a second language up until the age of 18, roughly 10 years later than earlier estimates. But the study also showed that it is best to start by age 10 if you want to achieve the grammatical fluency of a native speaker. To parse this problem, the research team, which included psychologist Steven Pinker, collected data on a person’s current age, language proficiency and time studying English. The investigators calculated they needed more than half a million people to make a fair estimate of when the “critical period” for achieving the highest levels of grammatical fluency ends. So they turned to the world’s greatest experimental subject pool: the internet. They created a short online grammar quiz called Which English? that tested noun–verb agreement, pronouns, prepositions and relative clauses, among other linguistic elements. From the responses, an algorithm predicted the tester’s native language and which dialect of English (that is, Canadian, Irish, Australian) they spoke. For example, some of the questions included phrases a Chicagoan would deem grammatically incorrect but a Manitoban would think is perfectly acceptable English. © 2018 Scientific American

Keyword: Language; Development of the Brain
Link ID: 24938 - Posted: 05.05.2018

By Edith Sheffer Millions of people are identified with Asperger’s syndrome, as a diagnosis, an identity and even an adjective. Asperger’s name has permeated our culture—yet I believe we should no longer invoke it. Naming medical diagnoses after individuals is an honor, meant to recognize those who discover conditions and to commend their work. While there is a move toward descriptive diagnostic labels in medicine, certain eponyms have entered our everyday language and will likely endure. Alzheimer’s and Parkinson’s diseases, for example. Hans Asperger, however, neither described Asperger syndrome as we understand it today nor merits commendation. I have spent seven years researching his past in Nazi Vienna, uncovering his complicity in the Nazi regime and its “euthanasia” program that murdered children considered to be disabled. Contrary to Asperger’s reputation as a resister in the Third Reich, he approved the transfer of dozens of children to Vienna's killing center, Spiegelgrund, where they perished. He publicly spoke—and published—about the need to send the most “difficult cases” to Spiegelgrund. He was also close colleagues with top euthanasia figures in Vienna, including Erwin Jekelius, the director of Spiegelgrund, who was engaged to Hitler’s sister. Nazi ideology shaped Asperger’s research. Children in the Third Reich were to display community spirit, being enthusiastic participants in collective activities such as the Hitler youth. In Germany in the 1930s, Nazi psychiatrists identified children whom they believed lacked social feeling, unable to join the national community. Asperger, in his early 30s, warned against classifying children, arguing that they should be regarded as individuals. But right after the Third Reich annexed Austria in 1938—and the purge of his Jewish and liberal associates from the University of Vienna—Asperger followed his senior colleagues in Nazi child psychiatry and introduced his own diagnosis of social detachment: “autistic psychopathy.” © 2018 Scientific American,

Keyword: Autism
Link ID: 24937 - Posted: 05.03.2018

By JANE E. BRODY I had hoped that by now most adults in this country would have completed an advance directive for medical care and assigned someone they trusted to represent their wishes if and when they are unable to speak for themselves. Alas, at last count, barely more than one-third have done so, with the rest of Americans leaving it up to the medical profession and ill-prepared family members to decide when and how to provide life-prolonging treatments. But even the many who, like me, have done due diligence — completed the appropriate forms, selected a health care agent and expressed their wishes to whoever may have to make medical decisions for them — may not realize that the documents typically do not cover a likely scenario for one of the leading causes of death in this country: dementia. Missing in standard documents, for example, are specific instructions about providing food and drink by hand as opposed to through a tube. Advanced dementia, including Alzheimer’s disease, is the sixth leading cause of death overall in the United States. It is the fifth leading cause for people over 65, and the third for those over 85. Yet once the disease approaches its terminal stages, patients are unable to communicate their desires for or against life-prolonging therapies, some of which can actually make their last days more painful and hasten their demise. End of Life Choices New York is trying to change that and has created an advance directive that it hopes will become a prototype for the rest of the country. (Washington State has already developed its own, though somewhat different, document.) © 2018 The New York Times Company

Keyword: Alzheimers
Link ID: 24936 - Posted: 05.03.2018

Beth Darnall Last month, the US National Institutes of Health (NIH) formally launched a multi-agency effort to combat the country’s opioid-addiction crisis. Funds for research into controlling opioid misuse and treating pain will nearly double in 2018, to US$1.1 billion. The forces behind this epidemic extend beyond overprescription: most of the tens of thousands of deaths caused by opioid overdose in the United States each year result from illicit use. Still, an inadequate understanding about how to treat pain has certainly contributed. We need to characterize patients better, and we need more studies that incorporate non-drug treatments alongside any form of medication. Consider this crucial question: what is the first treatment you should give a person for chronic pain, or even many acute injuries? Most clinicians now agree that the answer should not be opioids. Fewer recognize that the question is not which pill to use instead, but what system of interventions — including medication — and monitoring to implement. Too often, pain is treated as a purely biomedical problem. It is a biopsychosocial condition. Psychological treatment can be combined with medication to equip people with the tools to better control their pain experience. Psychological therapies can also lower risks such as addiction, because the emphasis is on engaging patients in managing their daily actions to help themselves to feel better in the long run, rather than relying solely on passive medications. Yet a common clinical practice is to recommend such psychosocial strategies for pain only after all medications have failed. © 2018 Macmillan Publishers Limited,

Keyword: Pain & Touch
Link ID: 24935 - Posted: 05.03.2018

By NICHOLAS BAKALAR Taking saunas may reduce the risk for stroke. Researchers studied 1,628 men and women aged 53 to 74, free of stroke at the start. They had data on body mass index, alcohol consumption, smoking, blood pressure, blood lipid levels, and other health and behavioral characteristics that affect cardiovascular health. The participants reported how often they took traditional Finnish saunas and how long they stayed in the sauna, and the researchers followed them for an average of 15 years. There were 155 strokes over the period. The study is in the journal Neurology. After adjusting for other variables, they found that compared with people who took saunas once a week, those who took them two to three times weekly were 12 percent less likely to have a stroke. People who took saunas four to seven times a week reduced their risk for stroke by 62 percent. Although the researchers found a strong effect independent of other variables, the study was observational and cannot prove causality. Still, there are plausible reasons saunas might be protective. “Temperature increases, even of 1 or 2 degrees Celsius, can limit inflammatory processes in the body and reduce arterial stiffness,” said the senior author, Dr. Jari A. Laukkanen, a professor of medicine at the University of Eastern Finland. “It’s possible that steam rooms or hot tubs could produce similar results.” © 2018 The New York Times Company

Keyword: Stroke
Link ID: 24934 - Posted: 05.03.2018

Jake Harper To the untrained, the evidence looks promising for a new medical device to ease opioid withdrawal. A small study shows that people feel better when the device, an electronic nerve stimulator called the Bridge, is placed behind their ear. The company that markets the Bridge is using the study results to promote its use to anyone who will listen: policymakers, criminal justice officials and health care providers. The message is working. In the face of a nationwide crisis of opioid addiction, people are eager for new solutions. Criminal justice officials in multiple states have started Bridge pilot programs. At least one such program in Indiana received state funds. Providers with a major hospital chain in Indiana began prescribing the Bridge. And politicians in Indiana, Utah and Ohio publicly touted the device. Innovative Health Solutions, the device maker, has marketed the Bridge for opioid withdrawal for more than a year, even before it had clearance for that use from the Food and Drug Administration. Then, last November, the Versailles, Ind.-based company got that, too. Citing the study, the FDA allowed the Bridge to be promoted for opioid withdrawal. Indiana State Sen. Jim Merritt, a Republican who is known for sponsoring legislation addressing the opioid crisis, held an effusive press conference after the FDA gave its OK to the Bridge. "People will detox," he told reporters. "They will withdraw from drugs if it's a simpler process, and this is it." © 2018 npr

Keyword: Drug Abuse
Link ID: 24933 - Posted: 05.02.2018

By Dana G. Smith You don’t remember it, but you woke up at least 100 times last night. These spontaneous arousals, lasting less than 15 seconds each, occur roughly every five minutes and don’t seem to affect how well-rested you feel. They are unrelated to waking up from a bad dream or your partner tossing and turning. Instead, they seem to be linked to some internal biological mechanism. Frequently waking up throughout the night may have protected early humans from predators by increasing their awareness of their surroundings during sleep. “The likelihood someone would notice an animal is higher [if they] wake up more often,” says Ronny Bartsch, a senior lecturer in the Department of Physics at Bar-Ilan University in Israel. “When you wake up, you’re more prone to hear things. In deep sleep, you’re completely isolated.” Sleep scientists, however, have been stumped as to what triggers these nocturnal disruptions. In a new Science Advances paper Bartsch proposes an innovative hypothesis that spontaneous arousals are due to random electrical activity in a specific set of neurons in the brain—aptly named the wake-promoting neurons. Even when you are asleep your brain cells continuously buzz with a low level of electrical activity akin to white noise on the radio. Occasionally, this electrical clamor reaches a threshold that triggers the firing of neurons. The new paper suggests that when random firing occurs in the wake-promoting neurons, a person briefly jerks awake. But this is countered by a suite of sleep-promoting neurons that helps one quickly fall back to sleep. © 2018 Scientific American

Keyword: Sleep
Link ID: 24932 - Posted: 05.02.2018

Nicola Davis MDMA, the main ingredient of the party drug ecstasy, could help reduce symptoms among those living with post-traumatic stress disorder, research suggests. Post-traumatic stress disorder is commonly treated with drugs, psychotherapies or both. However, some find little benefit, with certain talking therapies linked to high dropout rates. Now scientists have released the latest of several small studies showing that MDMA, when combined with talking therapies, could prove effective in reducing symptoms. “It is thought that the MDMA is catalysing the therapy, [rather than] just being effective on its own,” said Dr Allison Feduccia, co-author of the research by the MAPS Public Benefit Corporation, a US-based charity focused on research into MDMA and psychotherapy, which funded the study. Feduccia added that MDMA affected levels of certain chemicals in the brain and helped individuals become more emotionally engaged in the therapy. The study is one of six that has led the US Food and Drug Administration (FDA) to designate MDMA as a “breakthrough therapy” for PTSD and approve the next stage of clinical trials – so called “phase three”– which must be passed before the approach can be made available to patients. “We’re starting the first phase three trial [this month],” said Feduccia. © 2018 Guardian News and Media Limited

Keyword: Stress; Drug Abuse
Link ID: 24931 - Posted: 05.02.2018

By GRETCHEN REYNOLDS Small amounts of exercise could have an outsize effect on happiness. According to a new review of research about good moods and physical activity, people who work out even once a week or for as little as 10 minutes a day tend to be more cheerful than those who never exercise. And any type of exercise may be helpful. The idea that moving can affect our moods is not new. Many of us would probably say that we feel less cranky or more relaxed after a jog or visit to the gym. Science would generally agree with us. A number of past studies have noted that physically active people have much lower risks of developing depression and anxiety than people who rarely move. But that research centered on the relationships between exercise and psychological problems like depression and anxiety. Fewer past studies explored links between physical activity and upbeat emotions, especially in people who already were psychologically healthy, and those studies often looked at a single age group or type of exercise. On their own, they do not tell us much about the amounts or types of exercise that might best lift our moods, or whether most of us might expect to find greater happiness with regular exercise or only certain groups of people. So for the new review, which was published last month in The Journal of Happiness Studies, researchers at the University of Michigan decided to aggregate and analyze multiple past studies of working out and happiness. © 2018 The New York Times Company

Keyword: Depression
Link ID: 24930 - Posted: 05.02.2018