By GINA KOLATA It is a question that plagues all who struggle with weight: Why do some of us manage to keep off lost pounds, while others regain them? Now, a study of 14 participants from the “Biggest Loser” television show provides an answer: physical activity — and much more of it than public health guidelines suggest. On average, those who managed to maintain a significant weight loss had 80 minutes a day of moderate activity, like walking, or 35 minutes a day of vigorous exercise, like running. The researchers conducting the new study did not distinguish between purposeful exercise, like going to the gym and working out, and exercise done over the course of the day, like walking to work or taking the stairs. Guidelines from the Centers for Disease Control and Prevention, by comparison, call for at least 150 minutes a week of moderate exercise, or 75 minutes a week of vigorous exercise for healthy adults. The study was published on Tuesday in the journal Obesity. The lead author, Kevin Hall, chief of the Integrative Physiology Section at the National Institute of Diabetes and Digestive and Kidney Diseases, and his colleagues also presented their work at the Obesity Society’s annual meeting. Although the study is very small and must be replicated, Dr. Hall said, it is the first to assess obese people years after they lost weight with state-of-the-art methods to measure the calories they had consumed and the amount of exercise they had done. The researchers did their measurements when the contestants were chosen, and again at six weeks, thirty weeks and six years after the contest began. “The findings here are important,” said Rena Wing, a psychiatry professor at Brown University and a founder of the National Weight Control Registry, which includes more than 10,000 people. The food eaten “is the key determinant of initial weight loss. And physical activity is the key to maintenance,” she said. © 2017 The New York Times Company

Keyword: Obesity
Link ID: 24267 - Posted: 10.31.2017

By Jessica Hamzelou Can you catch Alzheimer’s disease? Fear has been growing that the illness might be capable of spreading via blood transfusions and surgical equipment, but it has been hard to find any evidence of this happening. Now a study has found that an Alzheimer’s protein can spread between mice that share a blood supply, causing brain degeneration, and suggesting that the disease may transmissible in a similar way to Creutzfeldt-Jacob Disease (CJD). We already know from CJD that misfolded proteins can spread brain diseases. Variant CJD can spread through meat products or blood transfusions infected with so-called prion proteins, for example. Like CJD, Alzheimer’s also involves a misfolded protein called beta-amyloid. Plaques of this protein accumulate in the brains of people with the illness, although we still don’t know if the plaques cause the condition, or are merely a symptom. There has been evidence that beta-amyloid may spread like prions. Around 50 years ago, many people with a growth disorder were treated with growth hormone taken from cadavers. Many of the recipients went on to develop CJD, as these cadavers turned out to be carrying prions. But decades later, it emerged in postmortems that some of these people had also developed Alzheimer’s plaques, despite being 51 or younger at the time. The team behind this work suggested investigating whether beta-amyloid was spreading via blood products or surgical instruments, just as they can spread prions. © Copyright New Scientist Ltd

Keyword: Alzheimers; Prions
Link ID: 24266 - Posted: 10.31.2017

There is no good evidence that a nutrient drink being sold online in the UK to "help" people with early Alzheimer's actually slows the disease, say experts. Latest trial results in patients who took Souvenaid did not find it preserves memory and thinking. The authors say in Lancet Neurology that bigger studies are needed to show if the product can work as hoped. And consumers should be aware that the £3.49 per bottle drink "is not a cure". Manufacturer Nutricia says its drink should only be taken under the direction of a doctor, specialist nurse or pharmacist. Souvenaid comes in strawberry or vanilla flavour and contains a combination of fatty acids, vitamins and other nutrients. Taken once daily, the idea is that the boost of nutrients it provides will help keep Alzheimer's at bay in people with the earliest signs of this type of dementia. But the latest phase two clinical trial results do not prove this. What the trial found The study involved 311 patients with very early Alzheimer's or mild cognitive impairment. All of them were asked to take a daily drink, but only half were given Souvenaid - the other half received one with no added nutrients. After two years of participating, the patients were reassessed to see if there was any difference between the two groups in terms of dementia progression, measured by various memory and cognitive tests. The treatment did not appear to offer an advantage, although patients in the Souvenaid group did have slightly less brain shrinkage on scans, which the researchers say is promising because shrinkage in brain regions controlling memory is seen with worsening dementia. But experts remain cautious. Prof Tara Spires-Jones, a dementia expert at the University of Edinburgh, said: "Some of the other tests of brain structure and function were promising, but overall this study indicates that a specific change in nutrition is unlikely to make a large difference to people with Alzheimer's, even in the early stages. © 2017 BBC.

Keyword: Alzheimers
Link ID: 24265 - Posted: 10.31.2017

By Nicholas Kristof The colored parts of the image above, prepared by Columbia University scientists, indicate where a child’s brain is physically altered after exposure to this pesticide. This chemical, chlorpyrifos, is hard to pronounce, so let’s just call it Dow Chemical Company’s Nerve Gas Pesticide. Even if you haven’t heard of it, it may be inside you: One 2012 study found that it was in the umbilical cord blood of 87 percent of newborn babies tested. And now the Trump administration is embracing it, overturning a planned ban that had been in the works for many years. The Environmental Protection Agency actually banned Dow’s Nerve Gas Pesticide for most indoor residential use 17 years ago — so it’s no longer found in the Raid you spray at cockroaches (it’s very effective, which is why it’s so widely used; then again, don’t suggest this to Dow, but sarin nerve gas might be even more effective!). The E.P.A. was preparing to ban it for agricultural and outdoor use this spring, but then the Trump administration rejected the ban. That was a triumph for Dow, but the decision stirred outrage among public health experts. They noted that Dow had donated $1 million for President Trump’s inauguration. So Dow’s Nerve Gas Pesticide will still be used on golf courses, road medians and crops that end up on our plate. Kids are told to eat fruits and vegetables, but E.P.A. scientists found levels of this pesticide on such foods at up to 140 times the limits deemed safe. © 2017 The New York Times Company

Keyword: Neurotoxins; Development of the Brain
Link ID: 24264 - Posted: 10.30.2017

Nick Fraser I was just finishing a talk about documentaries I was giving in Soho. I’d been asked a question about why so many films are seriously depressing. I remember that I talked about the great neurosurgeon Henry Marsh and the documentary about him, The English Surgeon. The film followed him to Ukraine as he helped and taught the local surgeons, who often resorted to using rusty domestic power tools to work on their patients’ skulls. I’d talked about him for some time, enthusiastically explaining how awed Henry said he felt every time he opened a patient’s head, and about how beautiful the brain is. I wanted to say more – but suddenly I sat down, and couldn’t say or think anything. Something had happened to me. I had gone into a different world of not making sense. I was taken by ambulance to University College hospital and given a head CT scan. There was a blood clot on my brain. I’d had a stroke, a brain attack. Time is all-important to stroke patients, and fortunately I was within the time frame to be given serious clot-busting drugs. There was something else they could do, the doctor said, a procedure called a thrombectomy. UCH offered the procedure up until 6pm. The time was then around 8pm, but the doctor heroically fought through NHS protocols and secured me a trip to St George’s hospital in south-west London, the only UK location open 24/7 for thrombectomies. I was lucky. I remember meeting the neuro-radiologist who, after putting me under mild sedation, performed the extraordinary procedure that involved sending a very thin wire from my groin to my brain, and removing one small clot and one larger one from the left side of my brain. I could understand the details of the operation, but I couldn’t say anything. I wondered if I would be all right. © 2017 Guardian News and Media Limited o

Keyword: Stroke; Language
Link ID: 24263 - Posted: 10.30.2017

By KYLE SPENCER As other college students head out to party on a Saturday night, Julie Linneman, a sophomore at Villanova University, rides the subway to a small rowhouse in West Philadelphia to meet with “her people,” a posse of students who understand what it’s like to be taken down by opioids. Ms. Linneman is a bespectacled 22-year-old who favors shredded jeans. She is a fan of cooking shows, fantasy fiction and Paul McCartney. She spent her first attempt at sophomore year — the one at Northern Kentucky University — in her dorm room, high on heroin. Coming to terms with a habit that nearly killed her, she has found support at the Haven at Drexel, Drexel University’s housing for students in recovery. Seven students from colleges in the Philadelphia area — including the University of Pennsylvania, Temple and Villanova — live, eat and socialize here, where they can abstain without temptation. More converge during these Saturday night meetings. “Sometimes you just need to be around other students who know what you have gone through,” Ms. Linneman said. They share snacks, drink water instead of beer, and talk about their life-threatening addictions. Ms. Linneman, who agreed to be named because she hopes to pursue a career in recovery advocacy, got her first pills — Vyvanse and Adderall, stimulants for attention deficit hyperactivity disorder — in high school from the boy with the locker next to hers. She soon moved on to prescription painkillers like Percocet. The “warm blanket” effect alleviated debilitating anxiety and loneliness. Once at college, she replaced pills with bags of cheap heroin. Her roommate moved out. The drug rendered her friendless. “It was one of the most lonely times of my life,” she recalled. She grew thin and pale. She would sit in the cafeteria alone, barely eating, occasionally nodding off. The workers would ask, “Are you O.K.?” © 2017 The New York Times Company

Keyword: Drug Abuse
Link ID: 24262 - Posted: 10.30.2017

By Angela Clow, Nina Smyth, October is a dismal time of year. The clocks go back, which accelerates the onset of darker evenings and the “shorter days” inevitably lead to calls for the tradition of putting clocks forward or backward to stop. Of course, the annual return to Greenwich Mean Time (GMT) from British Summer Time (BST) doesn’t make the days any shorter, it merely shifts an hour of available daylight from the evening to the morning. For many, lighter evenings are a priority and little attention is given to the benefits of lighter mornings. Arguments over clock changes tend to revolve around benefits for easier travel in lighter evenings. Nevertheless research suggests that holding onto lighter mornings might have hitherto unforeseen advantages. Light in the morning – more than any other time of day – leads to powerful brain-boosting effects, helping us to function as best we can, despite the approaching winter. All life on Earth has evolved around the 24-hour cycle of light and dark. An obvious sign is our desire for night-time sleep, but most biological functions are fine-tuned around day and night. Our bodies are honed to environmental light via a biological chain reaction. Light intensity is detected by special cells in the retina and this information is relayed to the internal body clock, located deep in a part of the brain called the suprachiasmatic nucleus. This sits in the hypothalamus, responsible for regulation of internal body processes using the endocrine system, which is linked to hormone secretion, via the pituitary gland. We are unaware of these light messages as they have nothing to do with conscious vision. Their sole job is to internalise information about environmental light intensity. © 2017 Scientific American,

Keyword: Biological Rhythms
Link ID: 24261 - Posted: 10.30.2017

By Michael Ellenbogen Twenty years ago, at age 39, I began having memory and cognitive problems. My primary-care doctor and my neurologists said I was stressed and depressed. I also was diagnosed with mild cognitive impairment, or MCI. Ten years later, I received another diagnosis. Well, really two. One doctor said I had Alzheimer’s disease, and another thought it was semantic dementia. Alzheimer’s is a devastating chronic neurodegenerative disease. It is a progressive mental deterioration that advances to affect bodily functions such as walking and swallowing, and always leads to death. Semantic dementia leads to losses of vocabulary, fluency of speech and meanings of familiar words. It also is progressive. After another year of testing, physicians decided that I had Alzheimer’s. While it was a relief to finally get a diagnosis, I realized that I had been given a death sentence. There is no prevention or cure for Alzheimer’s, and no survivors. Overwhelmed, I decided to help the search for a cure by advocating for Alzheimer’s and dementia. I got involved with clinical trials and advocacy. My huge network on LinkedIn allowed me to connect with advocates and information. It gave me access to many tests, including gene tests, free. Two contacts — health-care professionals — even read my medical records and scans and gave me their opinions. Alzheimer’s is a complex disease to diagnose. The science is just not there yet. Sixty to 80 percent of dementia cases are said to be due to Alzheimer’s. But postmortem tests of elderly patients have found that dementia has several causes. s. © 1996-2017 The Washington Post

Keyword: Alzheimers
Link ID: 24260 - Posted: 10.30.2017

By JANE E. BRODY After two hourlong sessions focused first on body awareness and then on movement retraining at the Feldenkrais Institute of New York, I understood what it meant to experience an incredible lightness of being. Having, temporarily at least, released the muscle tension that aggravates my back and hip pain, I felt like I was walking on air. I had long refrained from writing about this method of countering pain because I thought it was some sort of New Age gobbledygook with no scientific basis. Boy, was I wrong! The Feldenkrais method is one of several increasingly popular movement techniques, similar to the Alexander technique, that attempt to better integrate the connections between mind and body. By becoming aware of how one’s body interacts with its surroundings and learning how to behave in less stressful ways, it becomes possible to relinquish habitual movement patterns that cause or contribute to chronic pain. The method was developed by Moshe Feldenkrais, an Israeli physicist, mechanical engineer and expert in martial arts, after a knee injury threatened to leave him unable to walk. Relying on his expert knowledge of gravity and the mechanics of motion, he developed exercises to help teach the body easier, more efficient ways to move. I went to the institute at the urging of Cathryn Jakobson Ramin, author of the recently published book “Crooked” that details the nature and results of virtually every current approach to treating back pain, a problem that has plagued me on and off (now mostly on) for decades. Having benefited from Feldenkrais lessons herself, Ms. Ramin had good reason to believe they would help me.

Keyword: Pain & Touch; Attention
Link ID: 24259 - Posted: 10.30.2017

Sara Reardon The 70 million neurons in the mouse brain look like a tangled mess, but researchers are beginning to unravel the individual threads that carry messages across the organ. A 3D brain map released on 27 October, called MouseLight, allows researchers to trace the paths of single neurons and could eventually reveal how the mind assembles information. The map contains 300 neurons and researchers plan to add another 700 in the next year. “A thousand is just beginning to scratch the surface,” says Nelson Spruston, a neuroscientist at the Howard Hughes Medical Institute (HHMI) Janelia Research Campus in Ashburn, Virginia. To create the maps, Spruston and HHMI neuroscientist Jayaram Chandrashekar injected mouse brains with viruses that infect only a few cells at a time, prompting them to produce fluorescent proteins1. The team made the organs transparent using a sugar-alcohol treatment to obtain an unobstructed view of the glowing neurons, and then scanned each brain with a high-resolution microscope. Computer programs created 3D models of the glowing neurons and their projections, called axons, which can be half a metre long and branch like a tree. MouseLight has already revealed new information, including the surprisingly extensive number of brain regions that a single axon can reach. For instance, four neurons associated with taste stretch into the region that controls movement and another area related to touch. Chandrashekar says the group is now working on identifying which genes each neuron expresses, which will help to pin down their function. © 2017 Macmillan Publishers Limited,

Keyword: Brain imaging
Link ID: 24258 - Posted: 10.28.2017

By MARK LUKACH For my son Jonas’s first Halloween, when he was 5 months old, I dressed the two of us as matching lumberjacks. For the second, we were characters from the movie “Up.” I was Carl, the old man, my wife was Ellie, and Jonas was Russell, the enthusiastic Wilderness Explorer. We tied a dozen balloons to our bulldog’s collar, to make him the house. In our version, the wife didn’t die at the beginning of the movie, and we all lived happily ever after. The next Halloween, Jonas wanted to be an elephant. He loved the scene in “The Jungle Book” where Mowgli tries to march with the elephants. We resisted, since we like family costumes and didn’t want to buy three elephant outfits, but conceded. We displayed his elephant costume in his room the week before Halloween so he could look at it in anticipation of the big day. My wife, Giulia, wasn’t there for the lumberjack Halloween. She was in the hospital. Giulia was there for the “Up” Halloween. But as we approached the elephant Halloween, I suspected she wasn’t going to dress up. Because, once again, she was going psychotic. Giulia was 27 when the first psychotic episode happened. It came out of nowhere. She got nervous about her new job; she lost her appetite; she stopped sleeping; she began having delusions. The first delusions were encouraging. She said she spoke to God, who told her that she was going to be fine. Giulia had never been very religious, so I was alarmed, but at least she was hearing things that were comforting. But then the delusions turned on her. The voices said she wasn’t going to make it, there was no point in even trying, she was better off not being here. That’s how she ended up in the hospital the first time. They gave her medication. The delusions eventually went away. She was depressed for a long time afterward. They gave her more medication, and then she got better. © 2017 The New York Times Company

Keyword: Schizophrenia
Link ID: 24257 - Posted: 10.28.2017

Robert Bruner & Filippa Lentzos The Netflix series Stranger Things, launching its second season today, centers on Eleven, a girl with psychic powers who has escaped a dark and psychologically abusive government program that seeks to harness and weaponize her powers. While Stranger Things is a work of science fiction, it is not as far removed from reality as it initially seems. The series is rooted in a decades-long (but long defunct) CIA research program called MKULTRA, which involved bizarre, top-secret research on how to deliberately produce behaviors and emotions—such as fear, anxiety, or confusion. While MKULTRA is infamous for its attempts to control the mind through hypnosis and paranormal phenomena, its researchers primarily concentrated on the use of pharmaceuticals and mind-bending drugs such as hallucinogenic mushrooms, marijuana, heroin, LSD, and truth serums to make intelligence targets more cooperative in questioning and more willing to act as agents of the United States. Ultimately, the project failed because of a lack of scientific understanding of the inner workings of the brain and how to manipulate it. But today, neuroscience appears to be breaking down previous technical barriers to the exogenous control of emotion, behavior, and ultimately the mind. Scientific breakthroughs in the understanding of the biological basis of behavior and cognition have given rise to numerous treatments for neurological and psychiatric disorders. These treatments have improved the quality of life for many people all over the world. But these technologies have dual-use potential. Psychiatric drugs used to treat anxiety, depression, or mania can force a person to experience those same emotions. These drugs work by returning overactive or underactive neural signaling associated with mental disease to normal levels. The same principles, however, can be used on healthy individuals to manipulate their brain chemistry and change their behavior and emotions. These drugs can be used on individuals as a form of psychological torture—or could be deployed on the battlefield to quickly incapacitate, or change the emotions of, a large group. Additionally, due to growing knowledge of the neural mechanisms active during memory formation, it may become possible to enhance or delete memories—or even, using emerging brain-stimulation techniques, transfer thoughts from one individual to another.

Keyword: Emotions; Drug Abuse
Link ID: 24256 - Posted: 10.28.2017

By Andy Coghlan For the first time, female dark-eyed juncos have been found to burst into song in the wild. Although many female tropical birds sing, singing females are rare among northern, temperate songbirds. However, the behaviour is now becoming more common, and climate change may mean it becomes even more widespread. Dustin Reichard of Ohio Wesleyan University knew that female dark-eyed juncos (Junco hyemalis) sometimes sang in captivity, but only after being injected with testosterone. To find out if they sang in the wild, he and his colleagues goaded them by placing a live, caged female in their territories. The researchers also played recordings of a soft trill that females make when they are receptive to mating. In all, 17 females, along with 25 males, interacted with the caged females. Half the females dived and lunged at them, and a minority also performed aggressive tail-spreads not normally seen in females. Three of the females sang songs similar to those of males. “The context in which the songs were observed – responding to a female intruder – suggests these songs have an aggressive, territorial function,” says Reichard. “But we can’t say whether female song is specific to female intruders without also measuring their response to male intruders.” The females also reacted badly to attempts by males to woo the intruder female, both with song and other courtship behaviours such as puffing up their feathers and spreading their tails. Dark-eyed juncos are monogamous, and the females sought to keep their mates faithful by aggressively chasing them away from the rival female. © Copyright New Scientist Ltd.

Keyword: Sexual Behavior; Animal Communication
Link ID: 24255 - Posted: 10.28.2017

A new study published in the journal Neuron sheds light on the normal function of LRRK2, the most common genetic cause for late-onset Parkinson’s disease. The study was supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health. For more than 10 years, scientists have known that mutations in the LRRK2 gene can lead to Parkinson’s disease, yet both its role in the disease and its normal function in the brain remain unclear. In a study in mice, researchers have now found that LRRK is necessary for the survival of dopamine-containing neurons in the brain, the cells most affected by Parkinson’s. Importantly, this finding could alter the design of treatments against the disease. “Since its discovery, researchers have been trying to define LRRK2 function and how mutations may lead to Parkinson’s disease,” said Beth-Anne Sieber, Ph.D., program director at NINDS. “The findings in this paper emphasize the importance of understanding the normal role for genes associated with neurodegenerative disorders.” LRRK2 is found along with a closely related protein, LRRK1, in the brain. A mutation in LRRK2 alone can eventually produce Parkinson’s disease symptoms and brain pathology in humans as they age. In mice, however, LRRK2 loss or mutation does not lead to the death of dopamine-producing neurons, possibly because LRRK1 plays a complementary or compensatory role during the relatively short, two-year mouse lifespan.

Keyword: Parkinsons
Link ID: 24254 - Posted: 10.28.2017

By Rachel Schraer & Joey D'Urso People across the UK will wake up having gained an hour's sleep on Sunday morning, as the clocks go back heralding darker evenings and shorter days. But how much do we know about sleep and its impact on our lives, from our health and mood, to how long we'll live? 1. We're told to get our eight hours We often hear that we should all be getting eight hours' sleep a night. Organisations from the NHS to the US National Sleep Foundation recommend it. But where does this advice come from? Studies carried out around the world, looking at how often diseases occur in different groups of people across a population, have come to the same conclusion: both short sleepers and long sleepers are more likely to have a range of diseases, and to live shorter lives. But it's hard to tell whether it is short sleep that is causing disease or whether it is a symptom of a less healthy lifestyle. Short sleepers are generally defined as those who regularly get less than six hours' sleep and long sleepers generally more than nine or 10 hours' a night. Pre-puberty, children are recommended to get as much as 11 hours' sleep a night, however, and up to 18 hours a day for newborn babies. Teenagers should sleep for up to 10 hours a night. Shane O'Mara, professor of experimental brain research at Trinity College Dublin, says that, while it's difficult to tell whether poor sleep is a cause or a symptom of poor health, these relationships feed off each other. © 2017 BBC.

Keyword: Sleep
Link ID: 24253 - Posted: 10.28.2017

By Matthew Hutson Artificial intelligence has taken us one baby step closer to the mind-reading machines of science fiction. Researchers have developed “deep learning” algorithms—roughly modeled on the human brain—to decipher, you guessed it, the human brain. First, they built a model of how the brain encodes information. As three women spent hours viewing hundreds of short videos, a functional MRI machine measured signals of activity in the visual cortex and elsewhere. A popular type of artificial neural network used for image processing learned to associate video images with brain activity. As the women watched additional clips, the algorithm’s predicted activity correlated with actual activity in a dozen brain regions. It also helped the scientists visualize which features each area of the cortex was processing. Another network decoded neural signals: Based on a participant’s brain activity, it could predict with about 50% accuracy what she was watching (by selecting one of 15 categories including bird, airplane, and exercise). If the network had trained on data from a different woman’s brain, it could still categorize the image with about 25% accuracy, the researchers report this month in Cerebral Cortex. The network could also partially reconstruct what a participant saw, turning brain activity into pixels, but the resulting images were little more than white blobs. The researchers hope their work will lead to the reconstruction of mental imagery, which uses some of the same brain circuits as visual processing. Translating from the mind’s eye into bits could allow people to express vivid thoughts or dreams to computers or to other people without words or mouse clicks, and could help those with strokes who have no other way to communicate. © 2017 American Association for the Advancement of Science

Keyword: Vision; Brain imaging
Link ID: 24252 - Posted: 10.28.2017

Nicola Davis Patients undergoing open heart surgery in the afternoon have a lower risk of potentially fatal complications than those undergoing operations in the morning, new research suggests. The study found that events including heart attacks and heart failure were less common among those who had undergone a valve replacement operation in the afternoon. The finding appears to be linked to the ability of the heart tissue to recover after being starved of blood supply during surgery – an effect the researchers say is influenced by the cells’ biological or “circadian” clock. Overweight patients less likely to die in hospital after heart operations Read more While the study suggests patients might fare better if they undergo afternoon surgery, Professor David Montaigne, first author of the research from the University of Lille in France, said it also highlighted another approach to reduce complications. “We have to find a drug that can alter the circadian clock to induce a jet lag,” he said, noting that it could also help to improve patient outcomes for heart attacks and organ transplantation. Writing the in Lancet, Montaigne and colleagues report how they looked at the outcomes of 596 patients, half of whom had valve surgery in the morning, and half in the afternoon. While 18% of morning surgery patients experienced a major cardiac event – such as a heart attack or heart failure –in the following 500 days, only 9% of those who had afternoon surgery experienced such events. © 2017 Guardian News and Media Limited

Keyword: Biological Rhythms
Link ID: 24251 - Posted: 10.27.2017

By RONI CARYN RABIN Can you be fit and healthy, even if you’re overweight? And will working out, despite the extra pounds, reduce your risk of a heart attack? The idea that you can be “fat but fit” has long been controversial. While health experts endorse physical activity as beneficial, many doctors view the concept of being “fat but fit” with suspicion. Now a new study, believed to be the largest of its kind, suggests that even when overweight or obese people are free of health complications, they are still more likely to develop heart disease than their peers who aren’t overweight. It didn’t matter whether obese people were free from diabetes, high blood pressure or high cholesterol, a condition sometimes referred to as “metabolically healthy obesity.” As long as they were obese, they were at modestly higher risk for having a stroke, at nearly 50 percent greater risk of coronary heart disease and had nearly double the risk of developing heart failure than people who were not overweight and in similar metabolic health. People who were metabolically healthy but considered merely overweight were at a 30 percent greater risk of coronary heart disease compared to their normal weight and metabolically healthy peers. “The bottom line is that metabolically healthy obesity doesn’t exist,” said Dr. Rishi Caleyachetty, of the College of Medical and Dental Sciences at the University of Birmingham in England, who was the lead author of the paper, published in the Journal of the American College of Cardiology. “Obesity is not a benign condition.” © 2017 The New York Times Company

Keyword: Obesity
Link ID: 24250 - Posted: 10.27.2017

Bill Chappell It has the power to save lives by targeting opioid overdoses — something that kills more than 140 Americans every day. And now Narcan, the nasal spray that can pull a drug user back from an overdose, is being carried by all of Walgreens' more than 8,000 pharmacies. "By stocking Narcan in all our pharmacies, we are making it easier for families and caregivers to help their loved ones by having it on hand in case it is needed," said Walgreens vice president Rick Gates. The pharmacy chain is making the move as America struggles to respond to an opioid epidemic that President Trump is declaring a national emergency on Thursday, hoping to fight the opioid crisis that has struck families and communities from rural areas to cities. Calling the Walgreens move "an important milestone," Seamus Mulligan, CEO of Narcan maker Adapt Pharma, said that letting people get the medicine "without an individual prescription in 45 states is critical in combating this crisis." In recent years, both Walgreens, the nation's No. 2 pharmacy chain, and CVS, the No. 1 chain, have moved to widen access to Narcan and other products that contain naloxone, a fast-acting overdose antidote. As of last month, CVS reportedly offered prescription-free naloxone in 43 states. The chain has said that its pharmacies "in most communities have naloxone on hand and can dispense it the same day or ordered for the next business day." © 2017 npr

Keyword: Drug Abuse
Link ID: 24249 - Posted: 10.27.2017

As a ballet dancer in a former life, countless rehearsal hours in pointe shoes once landed me in a podiatrist’s office with a particularly inflamed ingrown toenail. To my surprise – and the doctor’s – a typical injection of local anesthesia did nothing to numb the searing pain as his knife dug into my big toe. It was not until a second full injection made my toe the size of a golf ball that I became blissfully unaware of the pain. Was my hair color to blame? It is, after all, a rumor every redhead has heard: we feel more pain and need more painkillers. A look at the published research suggests that the genes that determine my hair color may play a role, but the science itself is murky. What makes a redhead? Our luster-filled locks derive from a pair of mutated genes. For most people, hair color is determined by the melanocortin-1 receptor, or MC1R gene that leads to the production of a brown-black melanin pigment called eumelanin. The more eumelanin created by this gene, the darker and blacker the hair. Most redheads have a recessive version of the MC1R gene caused by the pairing of three possible mutant alleles. The resulting gene expression shuts off eumelanin production, shifting the dominant pigment to the reddish-toned pheomelanin. McGill University behavioral neuroscientist Jeffrey Mogil examined the gene as part of his research on the perception and inhibition of pain. “The purpose of this MC1R gene is to produce dark pigments. If it works, it does, and if it doesn’t, it produces pigment that isn’t dark like it’s supposed to be. So, it really is a dysfunction,” he said.

Keyword: Pain & Touch; Genes & Behavior
Link ID: 24248 - Posted: 10.27.2017