By Michael Schulson Two years ago, at a Stop & Shop in Rhode Island, the Danish neuroscientist and physician Henriette Edemann-Callesen visited an aisle stocked with sleep aids containing melatonin. She looked around in amazement. Then she took out her phone and snapped a photo to send to colleagues back home. “It was really pretty astonishing,” she recalled recently. In Denmark, as in many countries, the hormone melatonin is a prescription drug for treating sleep problems, mostly in adults. Doctors are supposed to prescribe it to children only if they have certain developmental disorders that make it difficult to sleep — and only after the family has tried other methods to address the problem. But at the Rhode Island Stop & Shop, melatonin was available over the counter, as a dietary supplement, meaning it receives slightly less regulatory scrutiny, in some respects, than a package of Skittles. Many of the products were marketed for children, in colorful bottles filled with liquid drops and chewable tablets and bright gummies that look and taste like candy. A quiet but profound shift is underway in American parenting, as more and more caregivers turn to pharmacological solutions to help children sleep. What makes that shift unusual is that it’s largely taking place outside the traditional boundaries of health care. Instead, it’s driven by the country’s sprawling dietary supplements industry, which critics have long said has little regulatory oversight — and which may get a boost from Secretary of Health and Human Services Robert F. Kennedy Jr., who is widely seen as an ally to supplement makers. Thirty years ago, few people were giving melatonin to children, outside of a handful of controlled experiments. Even as melatonin supplements grew in popularity among adults in the late 1990s in the United States and Canada, some of those products carried strict warnings not to give them to younger people. But with time, the age floor dropped, and by the mid-2000s, news reports and academic surveys suggest some early adopters were doing just that. (Try it for ages 11-and-up only, one CNN report warned at the time.) By 2013, according to a Wall Street Journal article, a handful of companies were marketing melatonin products specifically for kids.

Keyword: Biological Rhythms; Development of the Brain
Link ID: 29740 - Posted: 04.12.2025

Jon Hamilton Researchers created an assembloid by integrating four organoids that represent the four components of the human sensory pathway, along which pain stimuli signals are conveyed to the brain. Stimulation of the sensory organoid (top) by pain-inducing substances, such as capsaicin, triggers neuronal activity in that organoid which is then transmitted to the adjacent spinal-cord organoid, the thalamic organoid and, finally, to the cortical organoid (bottom) Researchers integrated four organoids that represent the four components of the human sensory pathway, along which pain signals are conveyed to the brain. Stimulation of the sensory organoid (top) by substances, such as capsaicin, triggers neuronal activity that is then transmitted throughout the rest of the organoids. Pasca lab/Stanford Medicine Scientists have re-created a pain pathway in the brain by growing four key clusters of human nerve cells in a dish. This laboratory model could be used to help explain certain pain syndromes, and offer a new way to test potential analgesic drugs, a Stanford team reports in the journal Nature. "It's exciting," says Dr. Stephen Waxman, a professor at Yale School of Medicine who was not involved in the research. © 2025 npr

Keyword: Pain & Touch; Development of the Brain
Link ID: 29739 - Posted: 04.12.2025

By Yasemin Saplakoglu Humans tend to put our own intelligence on a pedestal. Our brains can do math, employ logic, explore abstractions and think critically. But we can’t claim a monopoly on thought. Among a variety of nonhuman species known to display intelligent behavior, birds have been shown time and again to have advanced cognitive abilities. Ravens plan (opens a new tab) for the future, crows count and use tools (opens a new tab), cockatoos open and pillage (opens a new tab) booby-trapped garbage cans, and chickadees keep track (opens a new tab) of tens of thousands of seeds cached across a landscape. Notably, birds achieve such feats with brains that look completely different from ours: They’re smaller and lack the highly organized structures that scientists associate with mammalian intelligence. “A bird with a 10-gram brain is doing pretty much the same as a chimp with a 400-gram brain,” said Onur Güntürkün (opens a new tab), who studies brain structures at Ruhr University Bochum in Germany. “How is it possible?” Researchers have long debated about the relationship between avian and mammalian intelligences. One possibility is that intelligence in vertebrates — animals with backbones, including mammals and birds — evolved once. In that case, both groups would have inherited the complex neural pathways that support cognition from a common ancestor: a lizardlike creature that lived 320 million years ago, when Earth’s continents were squished into one landmass. The other possibility is that the kinds of neural circuits that support vertebrate intelligence evolved independently in birds and mammals. It’s hard to track down which path evolution took, given that any trace of the ancient ancestor’s actual brain vanished in a geological blink. So biologists have taken other approaches — such as comparing brain structures in adult and developing animals today — to piece together how this kind of neurobiological complexity might have emerged. © 2025 Simons Foundation

Keyword: Intelligence; Evolution
Link ID: 29738 - Posted: 04.09.2025

By Matt Richtel So sharp are partisan divisions these days that it can seem as if people are experiencing entirely different realities. Maybe they actually are, according to Leor Zmigrod, a neuroscientist and political psychologist at Cambridge University. In a new book, “The Ideological Brain: The Radical Science of Flexible Thinking,” Dr. Zmigrod explores the emerging evidence that brain physiology and biology help explain not just why people are prone to ideology but how they perceive and share information. What is ideology? It’s a narrative about how the world works and how it should work. This potentially could be the social world or the natural world. But it’s not just a story: It has really rigid prescriptions for how we should think, how we should act, how we should interact with other people. An ideology condemns any deviation from its prescribed rules. You write that rigid thinking can be tempting. Why is that? Ideologies satisfy the need to try to understand the world, to explain it. And they satisfy our need for connection, for community, for just a sense that we belong to something. There’s also a resource question. Exploring the world is really cognitively expensive, and just exploiting known patterns and rules can seem to be the most efficient strategy. Also, many people argue — and many ideologies will try to tell you — that adhering to rules is the only good way to live and to live morally. I actually come at it from a different perspective: Ideologies numb our direct experience of the world. They narrow our capacity to adapt to the world, to understand evidence, to distinguish between credible evidence and not credible evidence. Ideologies are rarely, if ever, good. Q: In the book, you describe research showing that ideological thinkers can be less reliable narrators. Can you explain? Remarkably, we can observe this effect in children. In the 1940s, Else Frenkel-Brunswik, a psychologist at the University of California, Berkeley, interviewed hundreds of children and tested their levels of prejudice and authoritarianism, like whether they championed conformity and obedience or play and imagination. When children were told a story about new pupils at a fictional school and asked to recount the story later, there were significant differences in what the most prejudiced children remembered, as opposed to the most liberal children. © 2025 The New York Times Company

Keyword: Emotions; Attention
Link ID: 29737 - Posted: 04.09.2025

By Rodrigo Pérez Ortega It’s clear a child’s early experiences can leave a lasting imprint on how their brain forms and functions. Now, a new study reveals how various environmental factors, including financial struggles and neighborhood safety, affect the quality of the brain’s white matter—the wiring that connects different brain regions—and in turn, a child’s cognitive abilities. The work, published today in the Proceedings of the National Academy of Sciences, also points to social factors that can boost resilience in a young brain. “It’s a really impressive, compelling paper about the long-term consequences of growing up in undersupported environments,” says John Gabrieli, a neuroscientist at the Massachusetts Institute of Technology who was not involved in the study. White matter consists of nerve fibers facilitating communication between brain regions. They are sheathed in an insulating material called myelin that gives white matter its color. Much of the research to date on how the brain supports cognition has focused on gray matter, tissue mostly made of the cell bodies of neurons that process information, which shows up as gray on brain scans. But complex cognitive tasks are “a symphony of a network” formed by multiple brain areas, Gabrieli says. “And the white matter is what mediates that communication.” Previous studies have linked poverty and childhood trauma—among other adverse environments—with a lower quality of white matter in children and lower scores on cognitive tests. However, these studies included a small number or participants and only looked at one or a few environmental variables at a time. For a more complete picture, developmental neuroscientist Sofia Carozza at Brigham and Women’s Hospital and colleagues analyzed data from more than 9000 participants in the Adolescent Brain Cognitive Development (ABCD) Study. Funded by the National Institutes of Health and established in 2015, ABCD is the largest longitudinal study of brain development in a representative group of U.S. children. Surveys of participants and their parents provide data on their home environment, including household income and parents’ level of education. At age 9 or 10, ABCD participants got a form of magnetic resonance imaging that measures the movement of water in the brain. From the strength of this directional signal, researchers can infer how robust and organized the bundles of white matter fibers are, and whether they have signs of deterioration or damage. © 2025 American Association for the Advancement of Science.

Keyword: Development of the Brain; Learning & Memory
Link ID: 29736 - Posted: 04.09.2025

Avram Holmes. Human thought and behavior emerge through complex and reciprocal interactions that link microscale molecular and cellular processes with macroscale functional patterns. Functional MRI (fMRI), one of the most common methods for studying the human brain, detects these latter patterns through the “blood oxygen level dependent,” or BOLD, signal, a composite measure of both neural and vascular signals that reflects an indirect measure of brain activity. Despite an enormous investment by scientific funders and the research community in the use of fMRI, though, researchers still don’t fully understand the underlying mechanisms that drive individual or population-level differences measured via in-vivo brain imaging, which limits our ability to interpret those data. For fMRI to meaningfully contribute to progress in neuroscience, we need to develop research programs that link phenomena across levels, from genes and molecules to cells, circuits, networks and behavior. Without a concerted effort in this direction, fMRI will remain a methodological spandrel, a byproduct of technological development rather than a tool explicitly designed to reveal neural mechanisms, generating isolated datapoints that are left unintegrated with broader scientific theory or progress. Recently, the human functional neuroimaging community has turned a critical eye toward its own methods and findings. These debates have led to field-wide initiatives calling for larger and more diverse study samples, better phenotypic reliability and findings that generalize across populations. But researchers have put relatively little emphasis on contextualizing the resulting work across levels of analysis or on deciphering the biological mechanism that may underpin changes to the BOLD signal across groups and individual people or over the lifespan. Appeals to better integrate the different levels of neuroscience are not new. But despite persuasive arguments, fMRI researchers have largely remained scientifically siloed, isolated by a nearly ubiquitous focus on a single level of analysis and a rigid adherence to a select set of imaging methods. Our work is typically presented inside of field-specific echo chambers—departmental or group seminars, topic-specific journals and society meetings—where our methodological and analytic choices go unchallenged. What progress can we expect to make if we remain isolated from other fields of study? © 2025 Simons Foundation

Keyword: Brain imaging
Link ID: 29735 - Posted: 04.09.2025

Alexandra Topping The benefits of taking drugs for attention deficit hyperactivity disorder outweigh the impact of increases in blood pressure and heart rate, according to a new study. An international team of researchers led by scientists from the University of Southampton found the majority of children taking ADHD medication experienced small increases in blood pressure and pulse rates, but that the drugs had “overall small effects”. They said the study’s findings highlighted the need for “careful monitoring”. Prof Samuele Cortese, the senior lead author of the study, from the University of Southampton, said the risks and benefits of taking any medication had to be assessed together, but for ADHD drugs the risk-benefit ratio was “reassuring”. “We found an overall small increase in blood pressure and pulse for the majority of children taking ADHD medications,” he said. “Other studies show clear benefits in terms of reductions in mortality risk and improvement in academic functions, as well as a small increased risk of hypertension, but not other cardiovascular diseases. Overall, the risk-benefit ratio is reassuring for people taking ADHD medications.” About 3 to 4% of adults and 5% of children in the UK are believed to have ADHD, a neurodevelopmental disorder with symptoms including impulsiveness, disorganisation and difficulty focusing, according to the National Institute for Health and Care Excellence (Nice). Doctors can prescribe stimulants, such as methylphenidate, of which the best-known brand is Ritalin. Other stimulant medications used to treat ADHD include lisdexamfetamine and dexamfetamine. Non-stimulant drugs include atomoxetine, an sNRI (selective norepinephrine reuptake inhibitor), and guanfacine. © 2025 Guardian News & Media Limited

Keyword: ADHD; Drug Abuse
Link ID: 29734 - Posted: 04.09.2025

is a psychologist, writer and professor in the history and philosophy of science programme at the University of Melbourne. She is the author of Delusions of Gender: How Our Minds, Society, and Neurosexism Create Difference (2010), Testosterone Rex: Myths of Sex, Science, and Society (2017) and Patriarchy Inc.: What We Get Wrong About Gender Equality – and Why Men Still Win at Work (2025). She lives in Melbourne, Australia. Carole Hooven is a human evolutionary biologist with a focus on behavioural endocrinology. She is a nonresident senior fellow at the American Enterprise Institute, an associate in Harvard’s Department of Psychology, and the author of T: The Story of Testosterone, the Hormone That Dominates and Divides Us (2021). She lives in Cambridge, Massachusetts. Does biology determine destiny, or is society the dominant cause of masculine and feminine traits? In this spirited exchange, the psychologist Cordelia Fine and the evolutionary biologist Carole Hooven unpack the complex relationship between testosterone and human behaviour. Fine emphasises variability, flexibility and context – seeing gender as shaped by social forces as much as it is by hormones. By contrast, Hooven stresses consistent patterns; while acknowledging the influence of culture and the differences between individuals, she maintains that biology explains why certain sex-linked behaviours persist across cultures. © Aeon Media Group Ltd. 2012-2025.

Keyword: Sexual Behavior; Evolution
Link ID: 29733 - Posted: 04.09.2025

Ian Sample Science editor Researchers who tracked cases of dementia in Welsh adults have uncovered the strongest evidence yet that the shingles vaccination reduces the risk of developing the devastating brain disease. Health records of more than 280,000 older adults revealed that those who received a largely discontinued shingles vaccine called Zostavax were 20% less likely to be diagnosed with dementia over the next seven years than those who went without. Pascal Geldsetzer, at Stanford University, said: “For the first time we are able to say much more confidently that the shingles vaccine causes a reduction in dementia risk. If this truly is a causal effect, we have a finding that’s of tremendous importance.” The researchers took advantage of a vaccination rollout that took place in Wales more than a decade ago. Public health policy dictated that from 1 September 2013, people born on or after 2 September 1933 became eligible for the Zostavax shot, while those who were older missed out. The policy created a natural experiment where the older population was sharply divided into two groups depending on their access to the vaccine. This allowed the researchers to compare dementia rates in older people born weeks apart but on either side of the vaccine eligibility divide. After accounting for the fact that not all those eligible for the vaccine received it, the researchers found vaccination led to a 20% reduction in dementia risk, with the strongest effect in women. Anupam Jena, a professor of healthcare policy at Harvard Medical School, said the implications were profound. © 2025 Guardian News & Media Limited

Keyword: Alzheimers; Neuroimmunology
Link ID: 29732 - Posted: 04.05.2025

By Smriti Mallapaty Neuroscientists have observed for the first time how structures deep in the brain are activated when the brain becomes aware of its own thoughts, known as conscious perception1. The brain is constantly bombarded with sights, sounds and other stimuli, but people are only ever aware of a sliver of the world around them — the taste of a piece of chocolate or the sound of someone’s voice, for example. Researchers have long known that the outer layer of the brain, called the cerebral cortex, plays a part in this experience of being aware of specific thoughts. The involvement of deeper brain structures has been much harder to elucidate, because they can be accessed only with invasive surgery. Designing experiments to test the concept in animals is also tricky. But studying these regions would allow researchers to broaden their theories of consciousness beyond the brain’s outer wrapping, say researchers. “The field of consciousness studies has evoked a lot of criticism and scepticism because this is a phenomenon that is so hard to study,” says Liad Mudrik, a neuroscientist at Tel Aviv University in Israel. But scientists have increasingly been using systematic and rigorous methods to investigate consciousness, she says. Aware or not In a study published in Science today1, Mingsha Zhang, a neuroscientist at Beijing Normal University, focused on the thalamus. This region at the centre of the brain is involved in processing sensory information and working memory, and is thought to have a role in conscious perception. Participants were already undergoing therapy for severe and persistent headaches, for which they had thin electrodes injected deep into their brains. This allowed Zhang and his colleagues to study their brain signals and measure conscious awareness. © 2025 Springer Nature Limited

Keyword: Consciousness
Link ID: 29731 - Posted: 04.05.2025

By Carl Zimmer After listening to hundreds of hours of ape calls, a team of scientists say they have detected a hallmark of human language: the ability to put together strings of sounds to create new meanings. The provocative finding, published Thursday in the journal Science, drew praise from some scholars and skepticism from others. Federica Amici, a primatologist at the University of Leipzig in Germany, said that the study helped place the roots of language even further back in time, to millions of years before the emergence of our species. “Differences between humans and other primates, including in communication, are far less distinct and well-defined than we have long assumed,” Dr. Amici said. But other researchers said that the study, which had been conducted on bonobos, close relatives of chimpanzees, had little to reveal about how we use words. “The present findings don’t tell us anything about the evolution of language,” said Johan Bolhuis, a neurobiologist at Utrecht University in the Netherlands. Many species can communicate with sounds. But when an animal makes a sound, it typically means just one thing. Monkeys, for instance, can make one warning call in reference to a leopard and a different one for an incoming eagle flying. In contrast, we humans can string words together in ways that combine their individual meanings into something new. Suppose I say, “I am a bad dancer.” When I combine the words “bad” and “dancer,” I no longer mean them independently; I’m not saying, “I am a bad person who also happens to dance.” Instead, I mean that I don’t dance well. Linguists call this compositionality, and have long considered it an essential ingredient of language. “It’s the force behind language’s creativity and productivity,” said Simon Townsend, a comparative psychologist at the University of Zurich in Switzerland. “Theoretically, you can come up with any phrase that has never been uttered before.” © 2025 The New York Times Company

Keyword: Language; Evolution
Link ID: 29730 - Posted: 04.05.2025

By Mitch Leslie Unlike the combative immune cells that protect us from pathogens, regulatory T cells (Tregs) are nurturers. They salve inflammation, promote healing of injured tissue, and rein in immune attacks to curb self-inflicted damage. Now, a study of mice reported today in Science suggests some Tregs also act on nerve cells to quell a specific type of pain—but only in females. Why only female rodents seem to benefit remains unclear, but researchers hope they might someday enlist these Tregs to address pain conditions, many of which disproportionately affect women. “It’s a very impressive paper,” says neuroscientist Gila Moalem-Taylor of the University of New South Wales Sydney, who wasn’t connected to the research. The study “uses elegant, sophisticated methods to conclusively demonstrate the mechanisms” by which the cells reduce one kind of sensitivity to pain, she says. Tregs, a type of white blood cell, are best known for their role in keeping the immune system in balance and preventing autoimmunity. But researchers have recently found that they also help control pain. For example, a 2021 study by neuroscientist Allan Basbaum of the University of California San Francisco (UCSF) and colleagues showed that Tregs reduce mice’s sensitivity to pain triggered by other immune cells that reside in the brain and spinal cord. That research and additional work suggested Tregs influence pain by targeting various immune cells and tamping down inflammation. But these studies left open the possibility that Tregs might also directly affect pain-sensing nerve cells. Basbaum, his postdoc Élora Midavaine, UCSF dermatologist Sakeen Kashem, and their colleagues launched the new study to nail down how the regulatory cells curb pain. They focused on Tregs that dwell in the meninges—the membranes that sheathe the brain and spinal cord—and in similar nearby membranes. The cells are much more abundant in these structures than elsewhere in the nervous system. To find out whether the cells affect pain perception, the scientists used genetically engineered mice whose Tregs are vulnerable to a toxin produced by the bacteria that cause diphtheria. Injecting this toxin into the meninges in the lower back killed about 90% of the Tregs in the membranes without harming Tregs in the rest of the body.

Keyword: Pain & Touch; Glia
Link ID: 29729 - Posted: 04.05.2025

By Nathan H. Lents For generations, anthropologists have argued whether humans are evolved for monogamy or some other mating system, such as polygyny, polyandry, or promiscuity. But any exploration of monogamy must begin with a bifurcation of the concept into two completely different phenomena: social monogamy and sexual monogamy. WHAT I LEFT OUT is a recurring feature in which book authors are invited to share anecdotes and narratives that, for whatever reason, did not make it into their final manuscripts. In this installment, author Nathan H. Lents, professor of biology at John Jay College, shares a story that didn’t make it into his recent book “The Sexual Evolution: How 500 Million Years of Sex, Gender, and Mating Shape Modern Relationships” (Mariner Books). Sexual monogamy is just what it sounds like: The restriction of sexual intercourse to within a bonded pair. Social monogamy, also known as economic monogamy, describes the bonding itself, a strong, neurohormone-driven attachment between two adults that facilitates food and territory sharing, to the exclusion of others, for at least one breeding season, and generally purposed towards raising offspring. Because these two aspects of monogamy are so often enjoined among humans, they are considered two sides of the same coin. But, as it turns out, they are entirely separable among animals. In fact, social monogamy is extremely common in birds and somewhat common in mammals, while sexual monogamy is vanishingly rare among any species. Because of the unique way their embryos develop — externally but with constant warmth required — birds are the real stars of monogamy and have thus borne the brunt of its misconceptions. The marriage (if you’ll pardon the pun) of two very different behaviors into one concept is — and always was — unsupported by evidence from the natural world. Monogamy, as it is commonly understood, was the invention of anthropomorphic bias. Naturalists in the 19th and 20th centuries documented how pairs of various bird species dutifully toiled together building a nest, protecting the eggs, mutually feeding each other and their offspring, before eventually flying off into the sunset together. These prim and proper Victorians didn’t have to squint very hard to see a perfect model in nature of what they valued most in human society — lifelong and sexually exclusive marriage.

Keyword: Sexual Behavior; Evolution
Link ID: 29728 - Posted: 04.05.2025

By Adam Nossiter Ralph Holloway, an anthropologist who pioneered the idea that changes in brain structure, and not just size, were critical in the evolution of humans, died on March 12 at his home in Manhattan. He was 90. His death was announced by Columbia University’s anthropology department, where he taught for nearly 50 years. Mr. Holloway’s contrarian idea was that it wasn’t necessarily the big brains of humans that distinguished them from apes or primitive ancestors. Rather, it was the way human brains were organized. Brains from several million years ago don’t exist. But Dr. Holloway’s singular focus on casts of the interiors of skull fossils, which he usually made out of latex, allowed him to override this hurdle. He “compulsively collected” information from these casts, he wrote in a 2008 paper. Crucially, they offered a representation of the brain’s exterior edges, which allowed scientists to get a sense of the brain’s structure. Using a so-called endocast, Dr. Holloway was able to establish conclusively, for instance, that a famous and controversial two-million-year-old hominid fossil skull from a South Africa limestone quarry, known as the Taung child, belonged to one of mankind’s distant ancestors. The Taung child’s brain was small, leading many to doubt the conclusion of Raymond Dart, the anatomist who discovered it in the 1920s, that it was a human ancestor. In 1969, Dr. Holloway took his family to South Africa to meet the elderly Dr. Dart, to examine the natural limestone endocast that the Taung child’s positioning in the quarry had created and to make an endocast of his own. “I became convinced that the Taung endocast needed independent study,” he wrote in 2008, in order to “find an objective method(s) for deciding whether the cortex was reorganized as Dart had previously claimed,” so many years before. Dr. Holloway focused on a crescent-shaped furrow, called the lunate sulcus, at the back of the endocast. In his view, it was positioned like a human’s, which suggested to him that Dr. Dart had been right all along. © 2025 The New York Times Company

Keyword: Evolution
Link ID: 29727 - Posted: 04.05.2025

Miryam Naddaf A brain-reading implant that translates neural signals into audible speech has allowed a woman with paralysis to hear what she intends to say nearly instantly. Researchers enhanced the device — known as a brain–computer interface (BCI) — with artificial intelligence (AI) algorithms that decoded sentences as the woman thought of them, and then spoke them out loud using a synthetic voice. Unlike previous efforts, which could produce sounds only after users finished an entire sentence, the current approach can simultaneously detect words and turn them into speech within 3 seconds. The findings, published in Nature Neuroscience on 31 March1, represent a big step towards BCIs that are of practical use. Older speech-generating BCIs are similar to “a WhatsApp conversation”, says Christian Herff, a computational neuroscientist at Maastricht University, the Netherlands, who was not involved with the work. “I write a sentence, you write a sentence and you need some time to write a sentence again,” he says. “It just doesn’t flow like a normal conversation.” BCIs that stream speech in real time are “the next level” in research because they allow users to convey the tone and emphasis that are characteristic of natural speech, he adds. The study participant, Ann, lost her ability to speak after a stroke in her brainstem in 2005. Some 18 years later, she underwent a surgery to place a paper-thin rectangle containing 253 electrodes on the surface of her brain cortex. The implant can record the combined activity of thousands of neurons at the same time. Researchers personalized the synthetic voice to sound like Ann’s own voice from before her injury, by training AI algorithms on recordings from her wedding video. During the latest study, Ann silently mouthed 100 sentences from a set of 1,024 words and 50 phrases that appeared on a screen. The BCI device captured her neural signals every 80 milliseconds, starting 500 milliseconds before Ann started to silently say the sentences. It produced between 47 and 90 words per minute (natural conversation happens at around 160 words per minute).

Keyword: Language; Robotics
Link ID: 29726 - Posted: 04.02.2025

Jon Hamilton New tests of blood and spinal fluid could help doctors quickly identify patients who would most benefit from treatment. New tests of blood and spinal fluid could help doctors quickly identify patients who would most benefit from treatment. Andrew Brookes/Getty Images When doctors suspect Alzheimer's, they can order a blood test to learn whether a patient's brain contains the sticky amyloid plaques that are a hallmark of the disease. But the results of that test won't tell the whole story, says Dr. Randall Bateman, a neurology professor at Washington University in St. Louis. "People can have a head full of amyloid, but no dementia or memory loss," Bateman says. So he and a team of scientists have developed a new blood test that can show whether Alzheimer's has actually begun to affect a person's thinking and memory. It joins another new test, this one of spinal fluid, that can predict whether the brain changes associated with Alzheimer's are likely to affect cognitive function. "It's a strong indicator of memory impairment," says Tony Wyss-Coray, a neurology professor at Stanford University. Both tests, described in the journal Nature Medicine, could help doctors identify patients who are likely to benefit from drugs that can clear the brain of amyloid plaques. Both were developed with funding from the National Institutes of Health. © 2025 npr

Keyword: Alzheimers
Link ID: 29725 - Posted: 04.02.2025

By Sergiu P. Pasca The unbearable inaccessibility of the human brain has been a major barrier to understanding both how the human nervous system assembles itself and how psychiatric and neurological disorders emerge. But thanks to new advances, it is becoming possible to access functional aspects of human brain development and function that were previously out of reach. This progress has been driven primarily by advances in stem cell technologies, which make it possible to recapitulate developmental processes outside the human body. The journey began decades ago with the ability to grow stem cells in a dish, followed by the use of developmental signals to guide them into becoming neural cells. The field was truly catalyzed by the discovery of cell reprogramming and the democratization of stem cell technologies it enabled. Starting more than 15 years ago, my team and others began creating neurons from patients—initially rather inefficiently, but then with increasing ease as culture systems became more sophisticated. For example, cortical neurons derived from people with Timothy syndrome—a genetic form of autism and epilepsy caused by a mutation in a calcium channel present in excitable cells—revealed calcium deficits following depolarization. Some of these defects became more apparent when moving beyond traditional 2D preparations, such as when looking at the morphology of human neurons. For more than a decade, we and others have developed methods for growing these cells into more complex 3D structures, known as organoids, that mimic some of the structure and function of regions of the nervous system, offering a new window into human neurobiology and disease. Giving cells this third dimension of freedom unleashes self-organization: Mirroring in-vivo development, organoids generate diverse neural and glial cell types, starting from radial glia to intermediate progenitors, deep and superficial layer neurons and then astrocytes. These organoids can be maintained in vitro for years. Fascinatingly, developmental timing in organoids is largely preserved. For example, neurons maintained in culture for about nine months can transition to a postnatal state simply by surviving long enough in the dish. This observation in organoids offers a fundamental insight into development: Brain cells have an intrinsic, species-specific developmental “timer.” © 2025 Simons Foundation

Keyword: Development of the Brain
Link ID: 29724 - Posted: 04.02.2025

By Christina Caron Health Secretary Robert F. Kennedy Jr. has often criticized prescription stimulants, such as Adderall, that are primarily used to treat attention deficit hyperactivity disorder. “We have damaged this entire generation,” he said last year during a podcast, referring to the number of children taking psychiatric medications. “We have poisoned them.” In February, the “Make America Healthy Again” commission, led by Mr. Kennedy, announced plans to evaluate the “threat” posed by drugs like prescription stimulants. But are they a threat? And if so, to whom? Like many medications, prescription stimulants have potential side effects, and there are people who misuse them. Yet these drugs are also considered some of the most effective and well-researched treatments that psychiatry has to offer, said Dr. Jeffrey H. Newcorn, the director of the Division of A.D.H.D. and Learning Disorders at the Icahn School of Medicine at Mount Sinai in New York. Here are some answers to common questions and concerns about stimulants. What are prescription stimulants? Prescription stimulants are drugs that help change the way the brain works by increasing the communication among neurons. They are divided into two classes: methylphenidates (like Ritalin, Focalin and Concerta) and amphetamines (like Vyvanse and Adderall). © 2025 The New York Times Company

Keyword: ADHD; Drug Abuse
Link ID: 29723 - Posted: 04.02.2025

By Veronique Greenwood Encased in the skull, perched atop the spine, the brain has a carefully managed existence. It receives only certain nutrients, filtered through the blood-brain barrier; an elaborate system of protective membranes surrounds it. That privileged space contains a mystery. For more than a century, scientists have wondered: If it’s so hard for anything to get into the brain, how does waste get out? The brain has one of the highest metabolisms of any organ in the body, and that process must yield by-products that need to be removed. In the rest of the body, blood vessels are shadowed by a system of lymphatic vessels. Molecules that have served their purpose in the blood move into these fluid-filled tubes and are swept away to the lymph nodes for processing. But blood vessels in the brain have no such outlet. Several hundred kilometers of them, all told, seem to thread their way through this dense, busily working tissue without a matching waste system. However, the brain’s blood vessels are surrounded by open, fluid-filled spaces. In recent decades, the cerebrospinal fluid, or CSF, in those spaces has drawn a great deal of interest. “Maybe the CSF can be a highway, in a way, for the flow or exchange of different things within the brain,” said Steven Proulx, who studies the CSF system at the University of Bern. A recent paper in Cell contains a new report about what is going on around the brain (opens a new tab) and in its hidden cavities. A team at the University of Rochester led by the neurologist Maiken Nedergaard (opens a new tab) asked whether the slow pumping of the brain’s blood vessels might be able to push the fluid around, among, and in some cases through cells, to potentially drive a system of drainage. In a mouse model, researchers injected a glowing dye into CSF, manipulated the blood vessel walls to trigger a pumping action, and saw the dye concentration increase in the brain soon after. They concluded that the movement of blood vessels might be enough to move CSF, and possibly the brain’s waste, over long distances. © 2025 Simons Foundation.

Keyword: Brain imaging; Sleep
Link ID: 29722 - Posted: 03.27.2025

Nora Bradford Scientists have created the first map of the crucial structures called mitochondria throughout the entire brain ― a feat that could help to unravel age-related brain disorders1. The results show that mitochondria, which generate the energy that powers cells, differ in type and density in different parts of the brain. For example, the evolutionarily oldest brain regions have a lower density of mitochondria than newer regions. The map, which the study’s authors call the MitoBrainMap, is “both technically impressive and conceptually groundbreaking”, says Valentin Riedl, a neurobiologist at Friedrich-Alexander University in Erlangen, Germany, who was not involved in the project. The brain’s mitochondria are not just bit-part players. “The biology of the brain, we know now, is deeply intertwined with the energetics of the brain,” says Martin Picard, a psychobiologist at Columbia University in New York City, and a co-author of the study. And the brain accounts for 20% of the human body’s energy usage2. Wielding a tool typically used for woodworking, the study’s authors divided a slice of frozen human brain ― from a 54-year-old donor who died of a heart attack ― into 703 tiny cubes. Each cube measured 3 × 3 × 3 millimetres, which is comparable to the size of the units that make up standard 3D images of the brain. “The most challenging part was having so many samples,” says Picard. The team used biochemical and molecular techniques to determine the density of mitochondria in each of the 703 samples. In some samples, the researchers also estimated the mitochondria’s efficiency at producing energy. To extend their findings beyond a single brain slab, the authors developed a model to predict the numbers and types of mitochondria across the entire brain. They fed it brain-imaging data and the brain-cube data. To check their model, they applied it to other samples of the frozen brain slice and found that it accurately predicted the samples’ mitochondrial make-up. © 2025 Springer Nature

Keyword: Brain imaging
Link ID: 29721 - Posted: 03.27.2025