Mark Napadano watched in horror as his 13-year-old son slammed head first into the hard ground after a motocross accident. In seconds he was at the side of his son, Sam, terrified by the sight of the junior high athlete so full of life just moments before lying limp in front of him - and not breathing. “It was like a nightmare,” Mark remembers. At the hospital doctors examined Sam and gave Mark the frightening news: Sam had a large pocket of blood pooling near the top of his head and two smaller bleeds in the front and two in the back. “They didn’t say he was going to die, but they didn’t say he was going to live,” recalls the 45-year-old car dealer from Butler, Pa. advertisement Sam was in a coma for days and in critical care for almost a month. By the time he was released to a rehab facility the 5-foot-4-inch teen had dropped from a trim and muscular 114 pounds to just 84. For months Mark and his wife, Sue, watched as their son learned to talk and walk for a second time. Now, three years after the wreck Sam is almost back to where he was before, Mark says. Sam returned to school three months after the accident and kept up his rehab for two years. He still has some short term memory problems and though his working memory has improved, it can be a challenge if too many commands are thrown his way at the same time. © 2012 msnbc.com

Keyword: Brain Injury/Concussion; Development of the Brain
Link ID: 16294 - Posted: 01.24.2012

By JAMES GORMAN Disgust is the Cinderella of emotions. While fear, sadness and anger, its nasty, flashy sisters, have drawn the rapt attention of psychologists, poor disgust has been hidden away in a corner, left to muck around in the ashes. No longer. Disgust is having its moment in the light as researchers find that it does more than cause that sick feeling in the stomach. It protects human beings from disease and parasites, and affects almost every aspect of human relations, from romance to politics. In several new books and a steady stream of research papers, scientists are exploring the evolution of disgust and its role in attitudes toward food, sexuality and other people. Paul Rozin, a psychologist who is an emeritus professor at the University of Pennsylvania and a pioneer of modern disgust research, began researching it with a few collaborators in the 1980s, when disgust was far from the mainstream. “It was always the other emotion,” he said. “Now it’s hot.” It still won’t wear glass slippers, which may be just as well, given the stuff it has to walk through. Nonetheless, its reach takes disgust beyond the realms of rot and excrement. © 2012 The New York Times Company

Keyword: Emotions; Evolution
Link ID: 16293 - Posted: 01.24.2012

By ANDREW POLLACK LOS ANGELES — A treatment for eye diseases that is derived from human embryonic stem cells might have improved the vision of two patients, bolstering the beleaguered field, researchers reported Monday. The report, published online in the medical journal The Lancet, is the first to describe the effect on patients of a therapy involving human embryonic stem cells. The paper comes two months after the Geron Corporation cast a pall over the field by abruptly halting the world’s first clinical trial based on embryonic stem cells — one aimed at treating spinal cord injury. Geron, which has not published results from the aborted trial, also said it would abandon the entire stem cell field. The results reported Monday could help lift some of that pall. They come from the second clinical trial involving the stem cells, using a therapy developed by Advanced Cell Technology to treat macular degeneration, a leading cause of blindness. “It’s a big step forward for regenerative medicine,” said Dr. Steven D. Schwartz, a retina specialist at the University of California, Los Angeles, who treated the two patients. Both patients, who were legally blind, said in interviews that they had gains in eyesight that were meaningful for them. One said she could see colors better and was able to thread a needle and sew on a button for the first time in years. The other said she was able to navigate a shopping mall by herself. © 2012 The New York Times Company

Keyword: Vision; Stem Cells
Link ID: 16292 - Posted: 01.24.2012

by Andy Coghlan It is the light we think we see that counts. Optical illusions designed to seem brighter than they are make your pupils constrict a little more. This suggests that we have evolved systems for anticipating dazzling light to protect our eyes. Our pupils' fast response to light appears to occur even without input from the brain. For example, it is seen in people with damage to the visual cortex. Appearances can be deceptive, though. Bruno Laeng of the University of Oslo in Norway measured tiny changes in pupil size as volunteers viewed various illusions that were all identical in brightness, though did not look so. If light levels alone dictated pupil size, they would have reacted identically whichever image a person viewed. Instead, people's pupils constricted more when they viewed the illusions designed to appear brightest. "What's surprising is that even something as simple as how bright we think our environment is will be affected by our expectations," says Stuart Peirson of the University of Oxford, who was not involved in the study. Previous studies show that the brain controls pupil size in other situations: our pupils dilate when we make decisions, for instance. Journal reference: Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.1118298109 © Copyright Reed Business Information Ltd.

Keyword: Vision
Link ID: 16291 - Posted: 01.24.2012

Erin Allday, Chronicle Staff Writer A Stanford study sheds new light on the old cliche about women having a higher tolerance for pain than men - according to tens of thousands of electronic patient records, women tend to report much more severe pain than men, no matter the source of the pain. The study being released today found that when asked to rate their pain on a scale of 0 to 10 - with 0 being no pain at all, and 10 being the worst pain imaginable - women on average scored their pain 20 percent more intense than men. The results held up across a wide variety of diseases and injuries, including back and neck pain, digestive disorders, sinus infections, and even ankle strains and sprains. In almost every category researchers looked at, women reported more pain than men. "We may have to adjust our thinking about how men and women report their pain. The killer question is: Do women actually feel more pain than men?" said Dr. Atul Butte, lead author of the study, which was published in the Journal of Pain. "That may be more philosophy than anything - how can we tell that for sure?" Of course, the fact that women report more pain overall doesn't necessarily mean they have more or less tolerance to pain than men, Butte said, adding that his results have been the source of some lighthearted debate with his wife. The study doesn't explain the reason for the difference, and researchers say it could include social, psychological or biological factors. Men may be more reluctant to confess intense pain to a female nurse, for example. Women are more likely than men to suffer from depression and anxiety, two psychological conditions that can increase susceptibility to pain. © 2012 Hearst Communications Inc.

Keyword: Pain & Touch; Sexual Behavior
Link ID: 16290 - Posted: 01.24.2012

By Carrie Arnold Put on a pair of headphones and turn up the volume so that you can’t even hear yourself speak. For those who stutter, this is when the magic happens. Without the ability to hear their own voice, people with this speech impediment no longer stumble over their words—as was recently portrayed in the movie The King’s Speech. This simple trick works because of the unusual way the brain of people who stutter is organized—a neural setup that affects other actions besides speech, according to a new study. Normal speech requires the brain to control movement of the mouth and vocal chords using the sound of the speaker’s own voice as a guide. This integration of movement and hearing typically happens in the brain’s left hemisphere, in a region of the brain known as the premotor cortex. In those who stutter, however, the process occurs in the right hemisphere—prob­ably because of a slight defect on the left side, according to past brain-imaging studies. Singing requires a similar integration of aural input and motor control, but the processing typically occurs in the right hemi­sphere, which may explain why those who stutter can sing as well as anyone else. (In a related vein, The King’s Speech also mentioned the common belief that people who stutter are often left-handed, but studies have found no such link.) In the new study, published in the September issue of Cortex, re­searchers found that the unusual neural organization underlying a stutter also includes motor tasks completely unrelated to speech. A group of 30 adults, half of whom stuttered and half of whom did not, tapped a finger in time to a metronome. When the sci­entists interfered with the function of their left hemisphere using trans­cranial magnetic stimulation, a non­invasive technique that temporarily dampens brain activity, nonstutterers found themselves unable to tap in time—but those who stuttered were unaffected. When the researchers interfered with the right hemisphere, the results were reversed: the stut­tering group was impaired, and the nonstutterers were fine. © 2012 Scientific American,

Keyword: Language; Attention
Link ID: 16289 - Posted: 01.24.2012

by Greg Miller Drugs like psilocybin, the active ingredient in hallucinogenic mushrooms, play all sorts of tricks on the mind. They distort the perception of time, space, and self, and even untether the senses. Some researchers thought these strange effects might result from the drugs overexciting the brain. But the first study to use functional magnetic resonance imaging (fMRI) to examine brain activity in people who've taken psilocybin finds that the drug reduces neural firing in key communication hubs, essentially disconnecting some brain regions from each other. In Central America and elsewhere, hallucinogenic drugs have been used for centuries in healing and religious ceremonies. Recent years have seen renewed interest in exploiting them to explore the neural basis of spirituality and potentially to treat depression, anxiety, and other mental illnesses. Yet neuroscientists know little about how these compounds act on the brain to cause such intensely altered experiences. Hallucinogenic drugs are tightly regulated, and few previous studies have tried to gauge their effects on the human brain. One study, using positron emission tomography (PET), found that psilocybin increases brain metabolism, especially in the frontal cortex. In the new work, published this week in the Proceedings of the National Academy of Sciences, researchers led by psychopharmacologists Robin Carhart-Harris and David Nutt of Imperial College London used a different method, fMRI, to scan the brains of 30 people who were under the influence of psilocybin. The tight confines and loud noises of the scanner could be scary for someone on psilocybin, Nutt says. To minimize the chances of anyone having a bad trip, the researchers recruited people who'd taken hallucinogens previously, and they delivered the drug intravenously so that it would have a faster—and shorter—effect than, say, eating magic mushrooms. © 2010 American Association for the Advancement of Science

Keyword: Drug Abuse
Link ID: 16288 - Posted: 01.24.2012

By Nathan Seppa Competing in vain for the attention of someone special or fretting over a mid-term exam may not be healthy. Such stress seems to boost a person’s supply of two proteins that cause inflammation, researchers report January 23 in the Proceedings of the National Academy of Sciences. These inflammatory triggers have been linked to an increased risk of heart disease, high blood pressure, cancer and depression. The new results add to a growing body of research that links social stress with biological risks. “We wanted to see how mental states such as optimism, or social relationships such as competition, get under the skin,” says study coauthor Shelley Taylor, a social neuroscientist at the UCLA School of Medicine. She and her colleagues looked at the relationship between day-to-day stress and two proteins that trigger inflammation in the body, called pro-inflammatory cytokines. The researchers asked 122 young, healthy adults to keep a diary of all positive and negative social interactions for eight days, as well as descriptions of any incidents that involved competition. “We picked young adults with no history of heart disease or inflammation disorders or depression [because] we wanted to look at the biological processes in a population that was healthy,” Taylor says. © Society for Science & the Public 2000 - 2012

Keyword: Stress
Link ID: 16287 - Posted: 01.24.2012

Katharine Sanderson An uncharted trawl through thousands of small molecules involved in the body's metabolism may have uncovered a potential route to treating pain caused by nerve damage. Neuropathic pain is a widespread and distressing condition, and is notoriously difficult to treat. So Gary Siuzdak, a chemist and molecular biologist at the Scripps Research Institute in La Jolla, California, and his team decided to take an unusual route to finding a therapy. Their results are published today in Nature Chemical Biology1. They took rats with surgically damaged paws, who were consequently suffering from neuropathic pain, and instead of analysing changes in gene expression and proteins in the animals, focused on metabolites – the biochemical intermediates and end-products of bodily processes such as respiration and the synthesis and breakdown of molecules. The science that looks at the body's metabolite composition is known as metabolomics. Using mass spectrometry, which can detect many different chemicals simultaneously, the researchers were able to identify the metabolites present in these animals 21 days after surgery. The team analysed samples of the injured rats’ blood plasma, of tissue near the injured paw, and of tissue from different areas of the spinal column, and compared the metabolites present with that of the same site in healthy rats. One particular area differed markedly between the two cases: the dorsal horn in the spinal column. © 2012 Nature Publishing Group,

Keyword: Pain & Touch
Link ID: 16286 - Posted: 01.23.2012

By JOSEPH LEDOUX You are taking a walk in the woods ― pleasant, invigorating, the sun shining through the leaves. Suddenly, a rattlesnake appears at your feet. You experience something at that moment. You freeze, your heart rate shoots up and you begin to sweat ― a quick, automatic sequence of physical reactions. That reaction is fear. A week later, you are taking the same walk again. Sunshine, pleasure, but no rattlesnake. Still, you are worried that you will encounter one. The experience of walking through the woods is fraught with worry. You are anxious. This simple distinction between anxiety and fear is an important one in the task of defining and treating of anxiety disorders, which affect many millions of people and account for more visits to mental health professionals each year than any of the other broad categories of psychiatric disorders. Scientists generally define fear as a negative emotional state triggered by the presence of a stimulus (the snake) that has the potential to cause harm, and anxiety as a negative emotional state in which the threat is not present but anticipated. We sometimes confuse the two: When someone says he is afraid he will fail an exam or get caught stealing or cheating, he should, by the definitions above, be saying he is anxious instead. © 2012 The New York Times Company

Keyword: Emotions; Stress
Link ID: 16285 - Posted: 01.23.2012

Analysis by Jennifer Viegas Humans are often obsessed with their weight, but nature seems to know exactly how fat each animal on the planet should be. The perfect weight depends on how each species solves the problem of avoiding both starving to death and being killed by predators, new research suggests. The study, published in The American Naturalist, explains how these causes of death often exert opposite pressures on animals. Storing a lot of fat, for example, helps animals survive periods without food but also slows their running speeds and so makes getting caught by a predator more likely. Animals can be stronger to compensate, but the energetic costs of extra muscle mean that the animal would starve more quickly during a food shortage. Andrew Higginson of Bristol University's School of Biological Sciences led the study, which used mathematical models to explore how much muscle and fat animals should have in their body to give themselves the best chances of survival. An important consideration was how much carrying fat increases the energetic costs of movement. The models revealed that the size of this cost influenced whether larger animals should have more fat than smaller animals, or vice versa. "Our results explain differences between different families of mammal. For example, larger bats carry proportionally less fat than small bats but larger carnivores carry more fat than small carnivores. Among rodents, it's the medium-sized species that carry around the most fat!" Higginson said in a press release. © 2012 Discovery Communications, LLC.

Keyword: Obesity; Evolution
Link ID: 16284 - Posted: 01.23.2012

Erin Allday, Chronicle Staff Writer Greg Moulton was getting ready for work one morning in 2006 when he suddenly lost all of the strength in his right arm, and he realized he was having a stroke. Thinking fast, he called his wife and left a message for her. Then he called his office to let his boss know that he was having a stroke and "would be in shortly," Moulton said. "I was very naive," said Moulton, 51, last week from his home in Fremont. "I knew what a stroke was, but I didn't know how serious it was." Fortunately for Moulton, his wife did know, and so did the paramedics who arrived at his home a few minutes later. Another lucky turn: Alameda County had just started a new emergency stroke response system, which meant that everyone from the 911 dispatcher Moulton's wife called to the emergency room doctors and nurses at the hospital where he was taken were ready for him and knew immediately how to treat him. Such stroke systems have been popping up all over California in the past six years, and there are now 11 regions in the state - including Alameda, Contra Costa, Santa Clara and San Mateo counties in the Bay Area - that provide coordinated emergency stroke care. Contra Costa was the most recent county to start a system, which launched earlier this month. © 2012 Hearst Communications Inc.

Keyword: Stroke
Link ID: 16283 - Posted: 01.23.2012

A suburban Chicago man accidentally shot a 3.25in (8.25cm) nail into his skull but is recovering after doctors successfully removed it from the centre of his brain. Dante Autullo, 34, was in his workshop when a nail gun recoiled near his head. But he had no idea the nail had entered his brain until the next day, when he began feeling nauseous. Doctors told Mr Autullo that the nail came within millimetres of the area used for motor function. His fiancee, Gail Glaenzer, told the Associated Press on Friday that he was in good spirits after the two-hour surgery to remove the nail at Advocate Christ Medical Center in Oak Lawn, Illinois. "He feels good. He moved all his limbs, he's talking normal, he remembers everything," she said. "It's amazing, a miracle." Ms Glaenzer said she had no idea the nail had entered his skull when she cleaned a cut on his forehead. BBC © 2012

Keyword: Miscellaneous
Link ID: 16282 - Posted: 01.23.2012

By Laura Sanders A night of shut-eye sears bad feelings into the brain, while waking hours take the emotional edge off, a new study finds. Though preliminary and somewhat inconsistent with earlier research, the results suggest that staying awake after something awful happens might be a way to blunt the emotional fallout of traumatic experiences, researchers report in the Jan. 18 Journal of Neuroscience. Sleep is known to lock in memories, particularly emotional ones, but scientists didn’t know whether accompanying feelings are locked in, too — a question that’s particularly relevant to people who suffer from post-traumatic stress disorder. “If we really want to know if this is relevant to trauma survivors, then we need to know if sleep not just changes the memory, but if it changes how you feel about it if you experience it again,” says study coauthor Rebecca Spencer of the University of Massachusetts Amherst. In the study, Spencer and her colleagues showed pictures of neutral scenes, such as a street, or negative scenes, such as an upsetting car crash, to 106 young adults. Participants then rated the emotion inspired by the image on a one-to-nine scale ranging from sad to happy. Afterward, participants were either sent to bed for a full night’s sleep or asked to stay awake for 12 hours. Then the researchers retested the participants by showing some of the same pictures mixed in with new images. As expected, the people who slept were better at remembering which images they had seen the day before. But the memory wasn’t the only thing that stuck around: Sleepers held on tighter to their feelings, while the sadness scores given by people who stayed awake tended to be weaker in the second session. © Society for Science & the Public 2000 - 2012

Keyword: Sleep; Emotions
Link ID: 16281 - Posted: 01.21.2012

by Sara Reardon Péos, Mininos, Cécil, Teha, and Amtan are performing dolphins at the Planète Sauvage dolphinarium in Port-Saint-Père, France. Every day, as music and sounds of the sea play in the background, they show off their swimming, jumping, and ball-catching skills for an adoring audience and squawk and whistle just like dolphins should. But at night, they make strange noises that researchers believe are imitations of humpback whale songs included in the performance soundtrack. If so, the identification of this unexpected repertoire would mark the first time that dolphins have been heard to rehearse new sounds hours after hearing them rather than right away, providing insights into how they store and process memories. Researchers discovered the dolphins' midnight melodies by accident. Ethologist Martine Hausberger of the University of Rennes 1 in France and her colleagues had hung underwater microphones in the tank because little is known about what dolphins sound like at night. One night, they suddenly heard 25 new sounds (see below) that the dolphins had never made before, although they weren't sure which of the five animals was talking. Because dolphins are known for mimicry, the researchers examined their complex daytime environment to determine where the noises might be coming from. They finally zeroed in on the new soundtrack that Planète Sauvage was playing during performances, which included music, sea gulls' calls, the dolphins' own whistles, and humpback whale calls. When the researchers used a computer program to compare auditory recordings of the whale calls with the mysterious nighttime noises, it showed that the two sounds were very similar. And because the dolphins had been captive their entire lives, they couldn't have picked them up from real whales. © 2010 American Association for the Advancement of Science.

Keyword: Animal Communication; Sleep
Link ID: 16280 - Posted: 01.21.2012

by Linda Geddes Schizophrenia could be a profound form of jetlag in which the brain's central clock runs out of kilter with peripheral clocks around the rest of the body. People with the illness often complain of sleeping difficulties, and last month a study of 20 people with schizophrenia confirmed that sleep disruption is common and not down to their medication or lifestyle (British Journal of Psychiatry), DOI: 10.1192/bjp.bp.111.096321). Now we may be closer to understanding why: a genetic mutation that triggers schizophrenia-like symptoms in mice also appears to disrupt their circadian rhythm or body clock. Russell Foster at the University of Oxford and his colleagues had been puzzling over the link between sleep disturbances and mental illness. So they investigated circadian patterns in mice with a defect in the SNAP25 gene, often used as an animal model to study the illness. SNAP25 has also been associated with schizophrenia in humans. When the mice were kept under a schedule of 12 hours of light followed by 12 hours of darkness, they were active when you would normally expect mice to be sleeping, suggesting that their circadian rhythms were disrupted. © Copyright Reed Business Information Ltd.

Keyword: Schizophrenia; Biological Rhythms
Link ID: 16279 - Posted: 01.21.2012

By BENEDICT CAREY Proposed changes in the definition of autism would sharply reduce the skyrocketing rate at which the disorder is diagnosed and might make it harder for many people who would no longer meet the criteria to get health, educational and social services, a new analysis suggests. The definition is now being reassessed by an expert panel appointed by the American Psychiatric Association, which is completing work on the fifth edition of its Diagnostic and Statistical Manual of Mental Disorders, the first major revision in 17 years. The D.S.M., as the manual is known, is the standard reference for mental disorders, driving research, treatment and insurance decisions. Most experts expect that the new manual will narrow the criteria for autism; the question is how sharply. The results of the new analysis are preliminary, but they offer the most drastic estimate of how tightening the criteria for autism could affect the rate of diagnosis. For years, many experts have privately contended that the vagueness of the current criteria for autism and related disorders like Asperger syndrome was contributing to the increase in the rate of diagnoses — which has ballooned to one child in 100, according to some estimates. The psychiatrists’ association is wrestling with one of the most agonizing questions in mental health — where to draw the line between unusual and abnormal — and its decisions are sure to be wrenching for some families. At a time when school budgets for special education are stretched, the new diagnosis could herald more pitched battles. © 2012 The New York Times Company

Keyword: Autism
Link ID: 16278 - Posted: 01.21.2012

Sean O'Neill, contributor Sue Savage-Rumbaugh is a primatologist who works at the Great Ape Trust in Des Moines, Iowa, where she explores the mental and linguistic skills of our primate cousins. As a graduate, you were all set to do a postdoc in psychology at Harvard University. What happened? Yes, I was due to go to Harvard to work with behaviourist B. F. Skinner and his famous pigeons. But before I left I happened to sit in on a class by primate researcher Roger Fouts, who brought a chimpanzee named Booee to class. Roger held up objects like a hat, a key and a pair of shoes, and Booee would make what Roger said were signs for those objects. I saw a chimpanzee doing what seemed to be a symbolic task and I was hooked. I said to myself: "Wait a minute, people are teaching chimpanzees human language, and I'm going to Harvard to study pigeons? You need to stay here, this is where it's at if you are interested in the origins of the human mind." I have worked with apes ever since. Your work on the linguistic capabilities of apes has taken you into uncharted territory... Yes, for better or for worse, I have gone to a place that other researchers have not. If I had had any inkling into the huge degree of linguistic, conceptual and social similarity between ourselves and bonobos when I started the work I would have been scared to death to do it. © Copyright Reed Business Information Ltd.

Keyword: Language; Evolution
Link ID: 16277 - Posted: 01.21.2012

By ABIGAIL SULLIVAN MOORE IN their undergrad uniforms of fleece and sweats, a clutch of Rutgers students gathered on the worn red couches of their dorm’s common room and told their stories. A good-looking, fun-loving 23-year-old named Greg described arriving at college freshman year with a daily pot-smoking habit and a close relationship with alcohol. He soon followed the lead of his alcoholic father and was binge drinking (five drinks or more in a row). “It was pretty scary,” he said. For his self-diagnosed anxiety and depression, he secretly began taking Klonopin, which he bought from another student. By sophomore year, he was taking six a day. And when it ran out, he wound up in a hospital to manage withdrawal, followed by nine months of rehab. Unlike the other students on the couch, Devin Fox, 26, gave permission to use his surname because of his career choice. He is pursuing a graduate degree in social work, hoping to work at a policy level in the mental illness field. Mr. Fox had been so despondent over his addiction to methamphetamine that he tried to overdose. Like Greg, he is now three years clean. The students live in one of two recovery dorms tucked away in anonymity on the sprawling New Brunswick, N.J., campus. In 1988, Rutgers started what is believed to be the first residential recovery program on a college campus, according to Lisa Laitman, director of its Alcohol and Other Drug Assistance Program. She helped create the program after seeing students struggle to abstain as dorm-mates partied. © 2012 The New York Times Company

Keyword: Drug Abuse
Link ID: 16276 - Posted: 01.21.2012

Caitlin Stier, video intern Want to freeze an object using the power of your mind? Watch the spinning objects in this video and they will suddenly appear to stop moving. However, they never actually freeze and are constantly turning at a steady rate. The illusion, created by researcher Max Dürsteler from University Hospital Zurich, uses a swaying background to trick our perception. When it rotates faster than the object in the foreground, and in the same direction, the object seems to slow down. But when the background moves in the opposite direction, the figure in the middle appears to speed up. In the first two examples, the background is distinct from the image on top of it. But in a third clip, the rotating figure blends in with the background, making the illusion more pronounced. In a final example, where background and foreground are contrasting once again, the backdrop rotates at a constant rate while the central figure sways back and forth. With this role reversal, the illusion is lost. While researchers are still investigating how this illusion works, Dürsteler suspects that our brain has a bias towards seeing objects as stationary. Motion is usually perceived in one of three states: either in or out of sync with its surroundings or stationary in relation to the observer The brain trick won the Best Illusion of the Year contest in 2006. © Copyright Reed Business Information Ltd.

Keyword: Vision
Link ID: 16275 - Posted: 01.21.2012