By Maria Temming The Terminator may be one step closer to reality. Researchers at the University of Tokyo have built a robotic finger that, much like Arnold Schwarzenegger’s titular cyborg assassin, is covered in living human skin. The goal is to someday build robots that look like real people — albeit for more altruistic applications. Super realistic-looking robots could more seamlessly interact with humans in medical care and service industries, say biohybrid engineer Shoji Takeuchi and his colleagues June 9 in Matter. (Whether cyborgs masked in living tissue would be more congenial or creepy is probably in the eye of the beholder.) To cover the finger in skin, Takeuchi and colleagues submerged the robotic digit in a blend of collagen and human skin cells called dermal fibroblasts. The mixture settled into a base layer of skin, or dermis, covering the finger. The team then poured a liquid containing human keratinocyte cells onto the finger, which formed an outer skin layer, or epidermis. After two weeks, skin covering the finger measured a few millimeters thick — comparable to the thickness of human skin. The lab-made skin was strong and stretchy enough to withstand the robotic finger bending. It could also heal itself: When researchers made a small cut on the robotic finger and covered it with a collagen bandage, the skin’s fibroblast cells merged the bandage with the rest of the skin within a week. Researchers at the University of Tokyo covered this robotic finger in living human skin to pave the way for ultrarealistic cyborgs. “This is very interesting work and an important step forward in the field,” says Ritu Raman, an MIT engineer who also builds machines with living components. “Biological materials are appealing because they can dynamically sense and adapt to their environments.” For instance, she’d like to see a future version of the living robot skin embedded with nerve cells to make robots more aware of their surroundings. © Society for Science & the Public 2000–2022.

Keyword: Pain & Touch; Robotics
Link ID: 28365 - Posted: 06.11.2022

Researchers from the National Eye Institute (NEI) have identified a new disease that affects the macula, a small part of the light-sensing retina needed for sharp, central vision. Scientists report their findings on the novel macular dystrophy, which is yet to be named, in JAMA Ophthalmology. NEI is part of the National Institutes of Health. Macular dystrophies are disorders that usually cause central visual loss because of mutations in several genes, including ABCA4, BEST1, PRPH2, and TIMP3. For example, patients with Sorsby Fundus Dystrophy, a genetic eye disease specifically linked to TIMP3 variants, usually develop symptoms in adulthood. They often have sudden changes in visual acuity due to choroidal neovascularization– new, abnormal blood vessels that grow under the retina, leaking fluid and affecting vision. TIMP3 is a protein that helps regulate retinal blood flow and is secreted from the retinal pigment epithelium (RPE), a layer of tissue that nourishes and supports the retina’s light-sensing photoreceptors. All TIMP3 gene mutations reported are in the mature protein after it has been “cut” from RPE cells in a process called cleavage. “We found it surprising that two patients had TIMP3 variants not in the mature protein, but in the short signal sequence the gene uses to ‘cut’ the protein from the cells. We showed these variants prevent cleavage, causing the protein to be stuck in the cell, likely leading to retinal pigment epithelium toxicity,” said Bin Guan, Ph.D., lead author. The research team followed these findings with clinical evaluations and genetic testing of family members to verify that the two new TIMP3 variants are connected to this atypical maculopathy.

Keyword: Vision
Link ID: 28364 - Posted: 06.11.2022

by Charles Q. Choi The primordial cells that give rise to most other brain cells do not proliferate in a typical way in autistic people — and that could explain how common traits emerge from a range of genetic origins, according to a new study. The idea that autism disrupts the proliferation of neural precursor cells isn’t new, but until now, few studies had investigated how that difference arises. In the new study, scientists fashioned neural precursor cells out of cord blood cells from five autistic boys ages 4 to 14 and, to serve as controls, either their non-autistic brothers or unrelated non-autistic people. Three of the autistic children have idiopathic cases, in which there is no known genetic cause for their autism; the other two have deletions in 16p11.2, a chromosomal region linked to autism and other neuropsychiatric conditions. Three of the autistic children have macrocephaly, or a large head. Neural precursors from the autistic boys all proliferated in atypical ways, the scientists found. Among children with macrocephaly, this growth was accelerated, leading to 28 to 55 percent more cells than in the non-autistic controls after six days. In contrast, cells from the other two boys, both with idiopathic autism, grew more slowly and more of those cells died, yielding 40 to 65 percent fewer cells than in controls after six days. “Despite the fact that these individuals are genetically distinct, especially the idiopathic individuals, it is amazing they have a common developmental process dysfunction — control of proliferation,” says study co-lead investigator Emanuel DiCicco-Bloom, professor of neuroscience, cell biology and pediatrics at Rutgers University in Piscataway, New Jersey. © 2022 Simons Foundation

Keyword: Autism; Genes & Behavior
Link ID: 28363 - Posted: 06.11.2022

ByRobert F. Service An experimental drug is raising new hopes for those with Parkinson’s disease. So far, the compound has only been tested in animals and in an initial safety assessment in humans. But results show it inhibits a cellular pathway that gives rise to the disease, which researchers have been working to target for nearly 20 years. Investigators are now launching expanded clinical trials. “This is a very, very important step forward,” says Patrick Lewis, a neuroscientist who studies the mechanisms of Parkinson’s at the University of London’s Royal Veterinary College. If further tests prove the compound is effective in humans, says Lewis, who was not involved with the new study, it would likely be given to patients as soon as they exhibit the first signs of developing the progressive disorder. “The hope is that [the new drug] would slow down the progression of disease.” Parkinson’s affects as many as 10 million people worldwide. It results when cells in the brain that produce the neurotransmitter dopamine stop working or die. Over time this causes a widespread decline in brain function, leading to shaking and loss of muscle control. Current drugs can help replace lost dopamine and reduce symptoms, but no therapies slow or halt disease progression itself. The new study focuses on a gene called leucine-rich repeat kinase 2 (LRRK2). People with mutations in this gene are at high risk for developing Parkinson’s. Among other roles, LRRK2 modifies a suite of proteins called Rab guanosine triphosphates, which act like air traffic controllers, orchestrating the flow of proteins in and out of cells. The mutations kick Rab into overdrive and reduce the efficiency of cellular structures called lysosomes, which chew up and recycle unwanted proteins. This creates a buildup of toxic byproducts that can kill neurons and lead to Parkinson’s, says Carole Ho, chief medical officer of Denali Therapeutics, a biotech startup in California. © 2022 American Association for the Advancement of Science.

Keyword: Parkinsons
Link ID: 28362 - Posted: 06.09.2022

By Christina Caron In recent years, the vagus nerve has become an object of fascination, especially on social media. The vagal nerve fibers, which run from the brain to the abdomen, have been anointed by some influencers as the key to reducing anxiety, regulating the nervous system and helping the body to relax. TikTok videos with the hashtag “#vagusnerve” have been viewed more than 64 million times and there are nearly 70,000 posts with the hashtag on Instagram. Some of the most popular ones feature simple hacks to “tone” or “reset” the vagus nerve, in which people plunge their faces into ice water baths or lie on their backs with ice packs on their chests. There are also neck and ear massages, eye exercises and deep-breathing techniques. Now, wellness companies have capitalized on the trend, offering products like “vagus massage oil,” vibrating bracelets and pillow mists, that claim to stimulate the nerve, but that have not been endorsed by the scientific community. Researchers who study the vagus nerve say that stimulating it with electrodes can potentially help improve mood and alleviate symptoms in those who suffer from treatment-resistant depression, among other ailments. But are there other ways to activate the vagus nerve? Who would benefit most from doing so? And what exactly is the vagus nerve, anyway? Here’s a look at what we know so far. The term “vagus nerve” is actually shorthand for thousands of fibers. They are organized into two bundles that run from the brain stem down through each side of the neck and into the torso, branching outward to touch our internal organs, said Dr. Kevin J. Tracey, a neurosurgeon and president of the Feinstein Institutes for Medical Research, Northwell Health’s research center in New York. Imagine something akin to a tree, whose limbs interact with nearly every organ system in the body. (The word “vagus” means “wandering” in Latin.) The vagus nerve picks up information about how the organs are functioning and also sends information from the brain stem back to the body, helping to control digestion, heart rate, voice, mood and the immune system. For those reasons, the vagus nerve — the longest of the 12 cranial nerves — is sometimes referred to as an “information superhighway.” Dr. Tracey compared it to a trans-Atlantic cable. “It’s not a mishmash of signals,” he said. “Every signal has a specific job.” © 2022 The New York Times Company

Keyword: Depression; Stress
Link ID: 28361 - Posted: 06.09.2022

Helena Horton Environment reporter Otters are able to learn from each other – but still prefer to solve some puzzles on their own, scientists have found. The semi-aquatic mammals are known to be very social and intelligent creatures, but a study by the University of Exeter has given new insight into their intellect. Researchers gave otters “puzzle boxes”, some of which contained familiar food, while others held unfamiliar natural prey – shore crab and blue mussels, which are protected by hard outer shells. For the familiar food – meatballs, a favourite with the Asian short-clawed otters in the study – the scientists had five different types of boxes, and the method to extract the food changed in each version, for example pulling a tab or opening a flap. The unfamiliar food presented additional problems because the otters did not know if the crab and mussels were safe to eat and had no experience of getting them out of their shells. In order to decide whether food was safe and desirable to eat, the otters, which live at Newquay zoo and the Tamar Otter and Wildlife Centre, watched intently as their companions inspected what was in the boxes and copied if the other otters sampled the treats. However, they spent more time trying to figure out how to remove the meat from the shells on their own and relied less on the actions of their companions. Of the 20 otters in the study, 11 managed to extract the meat from all three types of natural prey. © 2022 Guardian News & Media Limited

Keyword: Learning & Memory; Evolution
Link ID: 28360 - Posted: 06.09.2022

By Anna Gibbs Turns out there is rest for the wicked: Sleepy mosquitoes are more likely to catch up on missed z’s than drink blood, a new study finds. Most people are familiar with the aftermath of a poor night’s sleep. Insects also suffer; for instance, drowsy honeybees struggle to perform their signature waggle dance, and weary fruit flies show signs of memory loss. In the case of sleep-deprived mosquitoes, they give up valuable time for feeding in favor of sleeping overtime, researchers report June 1 in Journal of Experimental Biology. The preference for dozing over dining is surprising given that “we know that mosquitoes love blood a lot,” says Oluwaseun Ajayi, a disease ecologist at the University of Cincinnati. Scientists have long been interested in mosquitoes’ circadian rhythms, the internal clock that determines their sleep and awake times (SN: 10/2/17). Knowing when a mosquito is awake — and biting — is important for understanding and limiting disease transmission. For instance, malaria, often transmitted by nocturnal mosquitoes, is kept under control by slinging netting around beds. But new research suggests that mosquitoes that feed during the day may also spread the disease. It’s challenging to study sleeping bloodsuckers in the lab. That’s partly because awake mosquitoes are aroused by the presence of a meal — the experimenter. And when mosquitoes do fall asleep, they look rather similar to peers that are merely resting to conserve energy. © Society for Science & the Public 2000–2022.

Keyword: Sleep; Evolution
Link ID: 28359 - Posted: 06.09.2022

Daniel Lavelle With ADHD, thoughts and impulses intrude on my focus like burglars trying to break into a house. Sometimes these crooks carefully pick the backdoor lock before they silently enter and pilfer all the silverware. At other times, stealth goes out of the window; they’re kicking through the front door and taking whatever they like. Either way, I was supposed to be reading a book just now, but all I can think about is how great it would be if I waded into a river to save a litter of kittens from tumbling down a waterfall just in the nick of time. I’ve got the kittens in my hand, and the crowd has gone wild; the spectres of Gandhi, Churchill and Obi-Wan Kenobi hover over the riverbank, nodding their approval while fireworks crackle overhead … I snap back and realise I’ve read three pages, only I don’t remember a single line. I reread the same pages, but the same thing happens, only now I’m so hung up on concentrating that another fantasy has hijacked my attention. This time I’m imagining that I’m super-focused, so focused that Manchester United have called and told me they want me to be their special penalty taker. These Walter Mitty, borderline narcissistic episodes persist for a while until I give up and go and be distracted somewhere else. Advertisement Unfortunately, I don’t take Ritalin, a stimulant prescribed to daydreamers like me, so when it comes to focusing I need all the help I can get. Enter Swiss developer and typographic designer Renato Casutt, who has spent six years trying to develop a typographical trick that helps people read more quickly and efficiently. “Bionic reading” is a font people can use on their devices via apps for iPhone and other Apple products. It works by highlighting a limited number of letters in a word in bold, and allowing your brain – or, more specifically, your memory – to fill in the rest. © 2022 Guardian News & Media Limited

Keyword: ADHD; Dyslexia
Link ID: 28358 - Posted: 06.07.2022

Smriti Mallapaty Live-cell imaging of the eye’s transparent cornea has revealed a surprising resident — specialized immune cells that circle the tissue, ready to attack pathogens. “We thought that the central cornea was devoid of any immune cells,” says Esen Akpek, a clinician-scientist who works on immunological diseases of the cornea at Johns Hopkins University in Baltimore, Maryland. The study, published in Cell Reports1 on 24 May, could help researchers to better understand diseases that affect the eye and to develop therapies that target infections on the eye’s surface, says Tanima Bose, an immunologist at the pharmaceutical company Novartis in Kundl, Austria. Immune response The cornea has a dampened response to infection, in part because aggressive immune cells could damage the clear layer of tissue and obstruct vision, says co-author Scott Mueller, an immunologist at the University of Melbourne, Australia. For this reason, the immune cells that mount a quick but crude response to an infection, such as dendritic cells and macrophages, largely reside in the outer sections of the cornea and emerge only when needed. But in almost every tissue in the body are long-lived immune cells, known as T cells, that swiftly attack pathogens they have previously encountered — a process called ‘immune memory’. Mueller and his colleagues wondered whether such cells lived in the cornea. Using a powerful multiphoton microscope for studying living tissue, the researchers examined the corneas of mice whose eyes had been infected with herpes simplex virus. They saw that cytotoxic T cells and T-helper cells — precursors for immune memory — had infiltrated the cornea and persisted for up to a month after the infection. Further investigations, including more intrusive microscopy techniques, revealed that the cytotoxic T cells had developed into long-lived memory cells that resided in the cornea. © 2022 Springer Nature Limited

Keyword: Vision; Neuroimmunology
Link ID: 28357 - Posted: 06.07.2022

by Laura Dattaro Two new studies untangle how various classes of genetic variants underpin the vast differences in traits seen among people diagnosed with autism. The studies were published yesterday in Nature Genetics. “The fundamental question behind this is heterogeneity in autism,” says Varun Warrier, a postdoctoral researcher in Simon Baron-Cohen’s lab at the University of Cambridge in the United Kingdom and an investigator on one of the studies. The presence and intensity of core autism traits and co-occurring conditions vary widely among autistic people. The new studies, from largely independent teams, sought to unravel how different categories of genetic variants — rare, common, inherited and spontaneous — contribute to this heterogeneity. Though the two sets of findings conflict in some ways — potentially because of methodological differences — the papers add to the evidence that common and rare variants contribute to autism’s genetic architecture differently, says Yufeng Shen, associate professor of systems biology at Columbia University, who was not involved in either study. “When we say different, it’s not black and white,” Shen says. “They overlap, but it seems like, qualitatively, they have different contributions.” Warrier and his colleagues analyzed genetic and behavioral data from 12,893 autistic people. The data came from the Autism Genetic Resource Exchange, the Longitudinal European Autism Project, the Simons Simplex Collection and SPARK. (The Simons Simplex Collection and SPARK are funded by the Simons Foundation, Spectrum’s parent organization.) © 2022 Simons Foundation

Keyword: Autism; Genes & Behavior
Link ID: 28356 - Posted: 06.07.2022

By Colleen DeGuzman Jessica Oberoi, 13, cannot remember when her eyesight started getting blurry. All she knows is that she had to squint to see the whiteboard at school. It wasn’t until last fall when her eighth-grade class in Bloomington, Ind., got vision screenings that Jessica’s extreme nearsightedness and amblyopia, or lazy eye, were discovered. She has been going through intense treatment since then, and her optometrist, Katie Connolly, said Jessica has made great improvements — but her lazy eye, which causes depth perception problems, may never go away. The chances of it being completely corrected would have been much higher if her condition had been caught earlier, said Connolly, chief of pediatric and binocular vision service at Indiana University’s School of Optometry. Jessica is one of the countless students falling through the cracks of the nation’s fractured efforts to catch and treat vision problems among children. A mobile clinic is helping low-income students to see clearly — one pair of glasses at a time The Centers for Disease Control and Prevention estimates that more than 600,000 children and teens are blind or have a vision disorder. A recent opinion article published on JAMA Network notes that a large number of these children could be helped simply with glasses, but because of high costs and lack of insurance coverage, many are not getting them. Yet the National Survey of Children’s Health, funded by the U.S. Health Resources and Services Administration, found that in 2016-2017 a quarter of children were not regularly screened for vision problems. And a large majority of those vision impairments could be treated or cured if caught early, Connolly said. “Screenings are important for kids because kids don’t realize what’s abnormal,” Connolly said. “They don’t know what their peers around them — or even their parents — are seeing to realize their experience is different.” © 1996-2022 The Washington Post

Keyword: Vision
Link ID: 28355 - Posted: 06.07.2022

Viviane Callier Our human brains can seem like a crowning achievement of evolution, but the roots of that achievement run deep: The modern brain arose from hundreds of millions of years of incremental advances in complexity. Evolutionary biologists have traced that progress back through the branch of the animal family tree that includes all creatures with central nervous systems, the bilaterians, but it is clear that fundamental elements of the nervous system existed much earlier. How much earlier has now been made dramatically clear by a recent discovery by a team of researchers at the University of Exeter in the United Kingdom. They found that the chemical precursors of two important neurotransmitters, or signaling molecules used in nervous systems, appear in all the major animal groups that preceded creatures with central nervous systems. The big surprise, however, is that these molecules are also present in single-celled relatives of animals, called choanoflagellates. This finding shows that animal neuropeptides originated before the evolution of even the very first animals. The discovery “solves a long-standing question about when and how animal neuropeptides evolved,” said Pawel Burkhardt, who studies the evolutionary origin of neurons at the Sars International Center for Marine Molecular Biology in Norway. It also indicates that at least some of the signaling molecules fundamental to the operation of our brains first evolved for an entirely different purpose in organisms that consisted of only a single cell. Animal nervous systems are made of neurons that connect to each other, zipping information across synapses with a variety of small peptide neurotransmitters. These peptides are the language with which neurons speak to each other. All Rights Reserved © 2022

Keyword: Development of the Brain
Link ID: 28354 - Posted: 06.04.2022

Jon Hamilton An HIV drug — known as maraviroc — may have another, unexpected, use. The medication appears to restore a type of memory that allows us to link an event, like a wedding, with the people we saw there, a team reports in this week's issue of the journal Nature. Maraviroc's ability to improve this sort of memory was demonstrated in mice, but the drug acts on a brain system that's also found in humans and plays a role in a range of problems with the brain and nervous system. "You might have an effect in Alzheimer's disease, in stroke, in Parkinson's and also in spinal cord injuries," says Dr. S. Thomas Carmichael, chair of neurology at the University of California, Los Angeles, who was not involved in the study. The ability to link memories that occur around the same time is known as relational memory. It typically declines with age, and may be severely impaired in people with Alzheimer's disease. Problems with relational memory can appear in people who have no difficulty forming new memories, says Alcino Silva, an author of the new study and director of the Integrative Center for Learning and Memory at UCLA. "You learn about something, but you can't remember where you heard it. You can't remember who told you about it," Silva says. "These incidents happen more and more often as we go from middle age into older age." © 2022 npr

Keyword: Learning & Memory
Link ID: 28353 - Posted: 06.04.2022

Meghan Hoyer and Tim Meko When Vanderbilt University psychiatrist Jonathan Metzl learned that the perpetrator of the Uvalde, Tex., school massacre was a young man barely out of adolescence, it was hard not to think about the peculiarities of the maturing male brain. Salvador Rolando Ramos had just turned 18, eerily close in age to Nikolas Cruz, who had been 19 when he shot up a school in Parkland, Fla. And to Adam Lanza, 20, when he did the same in Newtown, Conn. To Seung-Hui Cho, 23, at Virginia Tech. And to Eric Harris, 18, and Dylan Klebold, 17, in Columbine, Colo. Teen and young adult males have long stood out from other subgroups for their impulsive behavior. They are far more reckless and prone to violence than their counterparts in other age groups, and their leading causes of death includes fights, accidents, driving too fast, or, as Metzl put it, “other impulsive kinds of acts.” “There’s a lot of research about how their brains are not fully developed in terms of regulation,” he said. Perhaps most significantly, studies show, the prefrontal cortex, which is critical to understanding the consequences of one’s actions and controlling impulses, does not fully develop until about age 25. In that context, Metzl said, a shooting “certainly feels like another kind of performance of young masculinity.” In coming weeks and months, investigators will dissect Ramos’s life to try to figure out what led him to that horrific moment at 11:40 a.m. Tuesday, May 24 when he opened fire on a classroom full of 9- and-10-year-olds at Robb Elementary School. Although clear answers are unlikely, the patterns that have emerged about mass shooters in the growing databases, school reports, medical notes and interview transcripts show a disturbing confluence between angry young men, easy access to weapons and reinforcement of violence by social media. © 1996-2022 The Washington Post

Keyword: Aggression; Hormones & Behavior
Link ID: 28352 - Posted: 06.04.2022

The Associated Press NEW YORK — Researchers are drawing attention to a rise in poisonings in children involving the sleep aid melatonin — including a big jump during the pandemic. Last year, U.S. poison control centers received more than 52,000 calls about children consuming worrisome amounts of the dietary supplement — a six-fold increase from about a decade earlier. Most such calls are about young children who accidentally got into bottles of melatonin, some of which come in the form of gummies for kids. Parents may think of melatonin as the equivalent of a vitamin and leave it on a nightstand, said Dr. Karima Lelak, an emergency physician at Children's Hospital of Michigan and the lead author of the study published Thursday by the Centers for Disease Control and Prevention. "But really it's a medication that has the potential to cause harm, and should be put way in the medicine cabinet," Lelak said. An increasingly popular over-the-counter sleep aid Melatonin is a hormone that helps control the body's sleep cycle. It has become a popular over-the-counter sleeping aid, with sales increasing 150% between 2016 and 2020, the authors said. In the U.S., melatonin is sold as a supplement, not regulated as a drug. Because melatonin is unregulated, the U.S. Food and Drug Administration doesn't have oversight over the purity of ingredients or the accuracy of dosage claims. Other researchers have found that what's on the label may not match what's actually in the bottle, and some countries have banned the sale of over-the-counter melatonin. © 2022 npr

Keyword: Biological Rhythms; Sleep
Link ID: 28351 - Posted: 06.04.2022

By Jack Tamisiea Sign up for Science Times Get stories that capture the wonders of nature, the cosmos and the human body. Get it sent to your inbox. Since the days of Charles Darwin, the long necks of giraffes have been a textbook example of evolution. The theory goes that as giraffe ancestors competed for food, those with longer necks were able to reach higher leaves, getting a leg — or neck — up over shorter animals. But a bizarre prehistoric giraffe relative reveals that fighting may have driven early neck evolution in addition to foraging. In a study published Thursday in Science, a team of paleontologists described Discokeryx xiezhi, a giraffe ancestor, as having helmet-like headgear and bulky neck vertebrae. Discokeryx was adapted to absorb and deliver skull-cracking collisions to woo mates and vanquish rivals. “It shows that giraffe evolution is not just elongating the neck,” said Jin Meng, a paleontologist at the American Museum of Natural History and co-author of the new study. “Discokeryx goes in a totally different direction.” Dr. Meng and his colleagues discovered the fossils in an outcrop of rock in northwestern China called the Junggar Basin. Around 17 million years ago, this area was an expanse of savannas and forests home to an array of large mammals like shovel-tusked elephants, short-horned rhinoceroses and burly bear dogs. While exploring this bonebed in 1996, Dr. Meng stumbled across a hunk of skull. He could tell it was a mammalian braincase, but the top was flattened like an iron press. Without more of the animal’s skeleton, Dr. Meng and his colleagues referred to it as the “strange beast.” © 2022 The New York Times Company

Keyword: Evolution; Aggression
Link ID: 28350 - Posted: 06.04.2022

By Tina Hesman Saey Dogs are as reliable as laboratory tests for detecting COVID-19 cases, and may be even better than PCR tests for identifying infected people who don’t have symptoms. A bonus: The canines are cuter and less invasive than a swab up the nose. In a study involving sweat samples from 335 people, trained dogs sniffed out 97 percent of the coronavirus cases that had been identified by PCR tests, researchers report June 1 in PLOS One. And the dogs found all 31 COVID-19 cases among 192 people who didn’t have symptoms. These findings are evidence that dogs could be effective for mass screening efforts at places such as airports or concerts and may provide friendly alternatives for testing people who balk at nasal swabs, says Dominique Grandjean, a veterinarian at the National School of Veterinary Medicine of Alfort in Maisons-Alfort, France. “The dog doesn’t lie,” but there are many ways PCR tests can go wrong, Grandjean says. The canines’ noses also identified more COVID-19 cases than did antigen tests (SN: 12/17/21), similar to many at-home tests, but sometimes mistook another respiratory virus for the coronavirus, Grandjean and colleagues found. What’s more, anecdotal evidence suggests the dogs can pick up asymptomatic cases as much as 48 hours before people test positive by PCR, he says. In the study, dogs from French fire stations and from the Ministry of the Interior of the United Arab Emirates were trained in coronavirus detection by rewarding them with toys — usually tennis balls. “It’s playtime for them,” Grandjean says. It takes about three to six weeks, depending on the dog’s experience with odor detection, to train a dog to pick out COVID-19 cases from sweat samples. © Society for Science & the Public 2000–2022.

Keyword: Chemical Senses (Smell & Taste)
Link ID: 28349 - Posted: 06.04.2022

The Age-Related Eye Disease Studies (AREDS and AREDS2) established that dietary supplements can slow progression of age-related macular degeneration (AMD), the most common cause of blindness in older Americans. In a new report, scientists analyzed 10 years of AREDS2 data. They show that the AREDS2 formula, which substituted antioxidants lutein and zeaxanthin for beta-carotene, not only reduces risk of lung cancer due to beta-carotene, but is also more effective at reducing risk of AMD progression, compared to the original formula. A report on the study, funded by the National Institutes of Health, published in JAMA Ophthalmology. “Because beta-carotene increased the risk of lung cancer for current smokers in two NIH-supported studies, our goal with AREDS2 was to create an equally effective supplement formula that could be used by anyone, whether or not they smoke,” said Emily Chew, M.D., director of the Division of Epidemiology and Clinical Application at the National Eye Institute (NEI), and lead author of the study report. “This 10-year data confirms that not only is the new formula safer, it’s actually better at slowing AMD progression.” AMD is a degenerative disease of the retina, the light-sensitive tissue at the back of the eye. Progressive death of retinal cells in the macula, the part of the retina that provides clear central vision, eventually leads to blindness. Treatment can slow or reverse vision loss; however, no cure for AMD exists. The original AREDS study, launched in 1996, showed that a dietary supplement formulation (500 mg vitamin C, 400 international units vitamin E, 2 mg copper, 80 mg zinc, and 15 mg beta-carotene) could significantly slow the progression of AMD from moderate to late disease. However, two concurrent studies also revealed that people who smoked and took beta-carotene had a significantly higher risk of lung cancer than expected.

Keyword: Vision
Link ID: 28348 - Posted: 06.04.2022

By Hilary Achauer I sat in a dark room, eyes closed, with a device strapped to my head that looked like a futuristic bike helmet. For 10 minutes, while I concentrated on not accidentally opening my eyes, the prongs sticking out of this gadget and onto my scalp measured a health marker I never thought to assess: my cognitive health. When I booked my brain wave recording (also known as electroencephalography, or EEG), I expected to pull up to an office park with medical clinic vibes, but instead my GPS led me to an ocean-view storefront decorated like a cross between a surf shop and a luxury spa, with a sign in the window promising “Mental Wellness, Reimagined.” Located in Cardiff-by-the-Sea, a wealthy coastal town north of San Diego, Wave Neuroscience promises to help your brain perform better with a noninvasive treatment that uses magnets on the brain. We’re talking mental clarity, improved focus and concentration, and even a shift in mood. As a 48-year-old whose work requires focus and creativity, I was intrigued, but also nervous. Should I mess with a brain that, while not perfect, functions reasonably well? Advertisement Getting the EEG, which costs $100, was like meditating with a device strapped to my head, but it was more relaxing than that sounds. The tech gave me periodic updates, letting me know how much time had elapsed, and afterward I was ushered into an office where I met with Alexander Ring, director of applied science at Wave Neuroscience, via Zoom. Together we reviewed my “braincare report,” a one-page analysis generated in five minutes, comparing my brain waves with Wave Neuroscience’s database of tens of thousands of EEGs. Ring said my brain was generally performing well and that I showed cognitive flexibility and a capability to focus under pressure, but that I had a little bit more theta activity, or slow brain waves, than they normally like to see. He also pointed out a slight frequency mismatch between the back and front of my brain, which might affect my concentration and cause me to have to reread a paragraph to absorb the information. Rude, but accurate. © 2022 The Slate Group LLC. All rights reserved.

Keyword: Brain imaging; Attention
Link ID: 28347 - Posted: 06.01.2022

By Peter Kendall As he gets ready for sleep each night, Don Tucker slips on an electrode cap and checks a little computer on his bedside table. Many workers at the private lab, run by the professor emeritus at the University of Oregon, follow the same routine. The experimental device monitors the nightly voyage through sleep. After sensing light sleep for a few minutes, it pulses electric current through the scalp and skull, nudging the brain into that nirvana known as deep sleep. The goal is not just a more restful slumber. Groundbreaking discoveries made in the past decade have revealed that the brain has a power-washing system that switches into high gear during deep sleep, flushing away harmful waste. This nightly cleanup is part of the restorative power of sleep and revives concentration, memory and motor skills. As we age, however, this cleansing system gets sloppier, and it can begin to leave behind some of the metabolic detritus of the day, including the amyloid beta proteins found in the plaque that characterize Alzheimer’s disease and other devastating neurological disorders. The controversial approval of an Alzheimer’s drug reignites the battle over the underlying cause of the disease The stunning revelation in 2012 of this previously unknown brain infrastructure — dubbed the glymphatic system — has ushered in a new age of research and invention not only about sleep but also aging, dementia and brain injury. Nearly 300 research papers were published last year on the glymphatic system. © 1996-2022 The Washington Post

Keyword: Sleep
Link ID: 28346 - Posted: 06.01.2022